[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646044":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":32,"locations":38,"responsibleParty":53,"collaborators":26,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":26,"enrollmentInfo":66,"targetDuration":26,"studyType":69,"phases":70,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":41,"whyStopped":26,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Oxford University Hospitals NHS Trust","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Standalone PCI","ACTIVE_COMPARATOR","Standalone OCT guided PCI",[13],"Procedure: Percutaneous Coronary Intervention",{"label":15,"type":16,"description":17,"interventionNames":18},"PCI & Sustained thrombectomy","EXPERIMENTAL","OCT guided PCI \\& Sustained Thrombectomy",[19,13],"Device: Sustained thrombectomy",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Sustained thrombectomy","Sustained thrombectomy with the Indigo® System CAT™ RX aspiration catheter",[15],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"PROCEDURE","Percutaneous Coronary Intervention","Optical Coherence Tomography guided Percutaneous Coronary Intervention",[15,9],[33],{"name":34,"role":35,"phone":36,"phoneExt":26,"email":37},"Giovanni Luigi De Maria, MD","CONTACT","+44 18655 528364","GiovanniLuigi.DeMaria@ouh.nhs.uk",[39],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":26},"Oxford Heart Centre - John Radcliffe Hospital","RECRUITING","Oxford","Oxfordshire","OX3 9DU","United Kingdom","UK",{"type":48,"coordinates":49},"Point",[50,51],-1.25596,51.75222,{"lat":51,"lon":50},{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Giovanni Luigi De Maria","Primary Investigator","100646044","phase-2-comparative-evaluation-of-sustained-mechanical-aspiration-thrombectomy-and-no-thrombus-modification-for-pre-stent-thrombus-burden-reduction-in-patients-with-acute-myocardial-infarction-study-the-capture-ami-study-100646044",false,"NCT07687576","Comparative Evaluation of Sustained meChanical AsPiration Thrombectomy and no Thrombus Modification for Pre-stent Thrombus bUrden Reduction in Patients With Acute Myocardial Infarction Study: the CAPTURE AMI Study","CAPTURE AMI","Inclusion Criteria:\n\n* Primary PCI patient with ST elevation myocardial infarction\n* Angiographic criteria:\n\n  * TIMI 0\u002F1 flow at presentation\n  * Angiographic thrombus score ≥ 4\n  * Vessel diameter at site of occlusion ≥ 3.0mm (determined by coronary angiography)\n\nExclusion Criteria:\n\n* Female participant who is pregnant or lactating\n* Unconscious at presentation\n* Late STEMI presentation (symptoms onset to wire time \\> 12 h)\n* Clinically\u002Fhaemodynamically unstable patients\n* Known diagnosis of severe renal disease (CKD stage 4-5)\n* Suspected spontaneous coronary artery dissection\n* Previous CABG\n* Previous history on STEMI in the same culprit territory\n* Known moderate-severe anaemia (Hb \\\u003C 9)","ALL","18 Years",{"count":67,"type":68},60,"ESTIMATED","INTERVENTIONAL",[71,72],"PHASE2","PHASE3","The CAPTURE AMI trial is an investigator-initiated, single-centre, two-arm, randomised controlled trial. Patients aged ≥ 18 years who present with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI) will be enrolled after angiographic evidence of a high thrombus burden (TIMI thrombus grade ≥ 4) and meeting the inclusion criteria laid out in section 9.2 will be 1:1 randomised to receive either standalone PCI (Arm 1) or adjunct sustained mechanical thrombectomy + PCI (Arm 2).\n\nThe CAPTURE AMI study will enrol specifically patients with:\n\nA. Evidence of high thrombus burden on coronary angiography (TIMI thrombus grade ≥ 4) B. Culprit in an artery with a diameter of 3.0 mm or more. The trial is designed to evaluate the efficacy of sustained mechanical thrombectomy versus standalone PCI in patients with a large thrombus burden assessed angiographically, with a pre-stent thrombus burden (%) as the primary imaging endpoint.",[75],"STEMI - ST Elevation Myocardial Infarction",[77,78,79,80],"Thrombus","Thrombectomy","Optical Coherence Tomography","Microvascular Injury","2026-07-08",{"date":83,"type":84},"2026-07-10","ACTUAL",{"date":81,"type":84},{"date":87,"type":68},"2028-01-08",{"name":5,"class":6},1]