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Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adults With Uncontrolled Asthma on Medium-to-High Dose Inhaled Corticosteroids","A Phase IIb, Multicentre, Double-blind, Placebo-controlled Dose Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adult Participants With Uncontrolled Asthma on Medium-to High Dose Inhaled Corticosteroids","Umbriel","Inclusion Criteria:\n\n1. Provision of signed and dated written informed consent prior to any study-specific procedures.\n2. Adults aged 18-75, inclusive when signing the informed consent.\n3. Documented physician-diagnosis of asthma for at least 12 months.\n4. Treated with medium or high dose ICS in combination with LABA.\n5. Demonstration of uncontrolled asthma through ACQ-6 score ≥ 1.5 .\n6. Pre-bronchodilator FEV1 ≥ 40% to ≤ 90% of predicted normal.\n7. Documented exacerbation history in the last 12 months and biomarker requirements of:\n\n   1. 2 severe exacerbations OR\n   2. 1 severe exacerbation and:\n\n   (i) Eosinophils ≥ 150 cells\u002Fµl or (ii) FeNo ≥ 25 ppb\n8. Participants need to demonstrate a ≥70% compliance for Asthma Daily Diary.\n9. Women of Child Bearing Potential (WOCBP) must have a negative pregnancy test.\n10. Contraceptive use by males and females should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies.\n\nExclusion Criteria:\n\n1. Completed treatment for respiratory infection with antibiotics in the 4 weeks prior to Visit 1.\n2. Clinically significant pulmonary disease other than asthma .\n3. Current smokers, former smokers with \\>10 pack-years history.\n4. Clinically significant aortic stenosis or pulmonary arterial hypertension.\n5. Active tuberculosis, hepatitis, HIV, or current diagnosis of cancer or immune complex disease.\n6. Unstable cardiovascular disorders.","ALL","18 Years","75 Years",{"count":1759,"type":1760},540,"ESTIMATED","INTERVENTIONAL",[1763],"PHASE2","This is a dose-range finding, double-blind, placebo-controlled, phase IIb study designed to assess efficacy and safety of tozorakimab administered subcutaneously in adult participants with uncontrolled asthma receiving medium-to-high dose inhaled corticosteroids.",[1766],"Asthma","2026-07-17",{"date":1769,"type":1770},"2026-07-20","ACTUAL",{"date":1772,"type":1770},"2025-03-26",{"date":1774,"type":1760},"2028-02-28",{"name":5,"class":6},221]