[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650866":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":60,"collaborators":26,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":26,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":26,"enrollmentInfo":73,"targetDuration":26,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":89,"whyStopped":26,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Ain Shams University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A (Curcumin Group)","EXPERIMENTAL","The experimental group will receive Organic Nation Curcumin® oral coated tablets, administered once daily for 3 months, containing 1,200 mg of standardized curcumin (95% turmeric extract) combined with 10 mg of piperine (95% black pepper extract), in addition to the standard treatment.",[13],"Dietary Supplement: Curcumin - Piperine",{"label":15,"type":16,"description":17,"interventionNames":18},"Group B (Placebo Group)","PLACEBO_COMPARATOR","Participants will receive identical-appearing tablets containing inert excipients once daily for 3 months, in addition to the standard treatment.",[19],"Other: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Curcumin - Piperine","The experimental group will receive Organic Nation Curcumin® oral coated tablets, administered once daily for 3 months, containing 1,200 mg of standardized curcumin (95% turmeric extract) combined with 10 mg of piperine (95% black pepper extract).",[9],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo","the placebo group will receive matching oral placebo tablet containing inert excipients for the same duration. The placebo tablets will be identical in appearance, size, color, and packaging to the active supplement to maintain blinding.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Marina W Khalil","CONTACT","+201222157176","marina12william@gmail.com",[38],{"facility":39,"status":26,"city":40,"state":26,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Suez Canal University hospitals","Ismailia","41511","Egypt","EG",{"type":45,"coordinates":46},"Point",[47,48],32.27225,30.60427,{"lat":48,"lon":47},[51,54,57],{"name":52,"role":34,"phone":53,"phoneExt":26,"email":26},"Rheumatology and Rehabilitation Outpatient Clinic","+201277884948",{"name":55,"role":56,"phone":26,"phoneExt":26,"email":26},"marina w khalil, M.Sc candidate","PRINCIPAL_INVESTIGATOR",{"name":58,"role":59,"phone":26,"phoneExt":26,"email":26},"Maha Abd El-Fattah, Associate Professor of Rheumat","SUB_INVESTIGATOR",{"type":56,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":63,"oldNameTitle":26,"oldOrganization":26},"Marina Khalil","Teaching Assistant, Department of pharmacy practice, faculty of pharmacy, Sinai University","Sinai University","100650866","phase-2-effects-of-curcumin-piperine-supplementation-in-fibromyalgia-100650866",false,"NCT07753018","Effects of Curcumin-Piperine Supplementation in Fibromyalgia","Evaluation of the Effect of Curcumin and Piperine Supplementation on Clinical Outcome in Fibromyalgia Patients.","Inclusion Criteria:\n\n* Adult women aged ≥18 years.\n* Patients with confirmed diagnosis of fibromyalgia, according to 2022 ACR Fibromyalgia criteria.\n\nExclusion Criteria:\n\n* Diabetic patients (HbA1c ≥ 6.5).\n* Patients with chronic inflammatory or autoimmune diseases other than FM.\n* Patients allergic to curcumin or piperine.\n* Patients receiving other anti-inflammatory medications.\n* Severe hepatic or renal impairment.\n* Patients receiving anticoagulant medications (e.g., clopidogrel).\n* Pregnancy or lactation.\n* Participation in another clinical trial","FEMALE","18 Years",{"count":74,"type":75},80,"ESTIMATED","INTERVENTIONAL",[78],"PHASE2","The goal of this clinical trail is to evaluate the effectiveness and safety of curcumin-piperine supplementation in patients with fibromyalgia over 3 months compared to placebo.\n\nParticipants will:\n\nBe randomly assigned to receive either curcumin and piperine supplements or a placebo.\n\nAttend scheduled clinic visits for clinical assessments and blood sample collection.\n\nComplete study questionnaires before and after treatment time frame.\n\nThe primary question the study aim to answer is:\n\nDoes Curcumin-piperine supplementation reduce pain intensity by Visual Analog Scale (VAS), compared with placebo?\n\nThe secondary questions this study aims to answer are:\n\nDoes supplementation improve fibromyalgia disease impact and quality of life? Does supplementation improve inflammatory biomarkers and oxidative stress? Does supplementation improve insulin resistance? Is curcumin and piperine supplementation safe and well tolerated?",[81],"Fibromyalgia (FM)",[83,84,85,86,87,88],"Fibromyalgia syndrome","Curcumin- Piperine","MDA","Insulin Resistance","Inflammation","Oxidative stress","NOT_YET_RECRUITING","2026-08-09",{"date":92,"type":93},"2026-08-11","ACTUAL",{"date":95,"type":75},"2026-08-01",{"date":97,"type":75},"2027-08-01",{"name":5,"class":6},1]