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Hospital of Yinchuan","Ningxia","Yinchuan","750001",{"facility":597,"status":11,"city":321,"state":598,"zip":599,"country":79,"countryCode":80,"cosmosGeoPoint":600,"geoPoint":602,"contacts":11},"Zaozhuang Municipal Hospital","Zaozhuang","277102",{"type":82,"coordinates":601},[326,327],{"lat":327,"lon":326},{"facility":604,"status":11,"city":401,"state":605,"zip":606,"country":79,"countryCode":80,"cosmosGeoPoint":607,"geoPoint":609,"contacts":11},"Zhengzhou People's Hospital","Zhengzhou","450003",{"type":82,"coordinates":608},[406,407],{"lat":407,"lon":406},{"facility":611,"status":11,"city":401,"state":605,"zip":612,"country":79,"countryCode":80,"cosmosGeoPoint":613,"geoPoint":615,"contacts":11},"The Second People's Hospital of Zhengzhou","450015",{"type":82,"coordinates":614},[406,407],{"lat":407,"lon":406},{"facility":617,"status":11,"city":401,"state":605,"zip":618,"country":79,"countryCode":80,"cosmosGeoPoint":619,"geoPoint":621,"contacts":11},"The First Affiliated Hospital of Zhengzhou University","450052",{"type":82,"coordinates":620},[406,407],{"lat":407,"lon":406},{"facility":623,"status":11,"city":159,"state":624,"zip":625,"country":79,"countryCode":80,"cosmosGeoPoint":626,"geoPoint":628,"contacts":11},"Zhuzhou Central Hospital","Zhuzhou","412007",{"type":82,"coordinates":627},[164,165],{"lat":165,"lon":164},{"facility":630,"status":11,"city":233,"state":631,"zip":632,"country":79,"countryCode":80,"cosmosGeoPoint":633,"geoPoint":635,"contacts":11},"The First People's Hospital of Zigong","Zigong","643000",{"type":82,"coordinates":634},[238,239],{"lat":239,"lon":238},{"type":637,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100653818","phase-2-efficacy-and-safety-of-br005-036c-tablets-for-the-acute-treatment-of-migraine-in-adults-100653818",false,"NCT07792681","Efficacy and Safety of BR005-036C Tablets for the Acute Treatment of Migraine in Adults","A Multicenter, Randomized, Double-blind, Placebo-controlled Phase II\u002FIII Clinical Study Evaluating the Efficacy and Safety of BR005-036C Tablets in the Acute Treatment of Migraine in Adults","Inclusion Criteria:\n\n1. Male or female Participants aged 18 years or older.\n2. Patients diagnosed with migraine with or without aura in accordance with the International Classification of Headache Disorders, 3rd Edition (ICHD-3), with a disease history of at least 1 year.\n3. Onset age of migraine shall be less than 50 years old.\n4. At least 2-8 moderate-to-severe migraine attacks per month within 3 months prior to screening visit.\n5. Fewer than 15 headache days (migraine or non-migraine) per month within 3 months prior to screening visit.\n6. Patients on prophylactic migraine medication are permitted to remain on therapy provided they have been on a stable dose for at least 3 months prior to study entry.\n\nExclusion Criteria:\n\n1. Patient with a history of or diagnosed with brainstem aura migraine, hemiplegic migraine, retinal migraine, new-daily-persistent headache, trigeminal autonomic cephalalgias or cranial neuralgia.\n2. Patient with clinically significant cardiovascular, cerebrovascular, hematological, endocrine, hepatic, renal, pulmonary, gastrointestinal, neurological or psychiatric disorders; patient with other confounding acute or chronic pain syndromes, dementia, epilepsy, or other diseases (other than migraine) that may interfere with study assessments.\n3. Patient with a history of acute hepatitis within 6 months prior to screening, or any chronic liver diseases including non-alcoholic fatty liver disease, chronic viral hepatitis, liver cirrhosis.\n4. Patient with a history of hematological or solid malignant neoplasms within 5 years prior to screening.\n5. Abnormal electrocardiogram findings at screening: QTcF \\>450 msec for male subjects; QTcF \\>470 msec for female subjects.\n6. Patient with uncontrolled hypertension.\n7. History of alcohol or substance abuse within 6 months prior to screening.\n8. Clinically significant laboratory abnormalities at screening: ALT, AST or total bilirubin \\>1.5 × upper limit of normal (ULN); estimated glomerular filtration rate (eGFR) \\\u003C60 mL\u002Fmin\u002F1.73 m².\n9. Use of CGRP receptor antagonists within 1 month prior to screening or randomization; use of anti-CGRP or anti-CGRP-receptor monoclonal antibodies within 6 months prior to screening or randomization.\n10. Use of acute migraine treatment medications for more than 10 days per month in 3 months prior to randomization (refer to Concomitant Medications section).","ALL","18 Years",{"count":648,"type":649},2079,"ESTIMATED","INTERVENTIONAL",[652,653],"PHASE2","PHASE3","The purpose of this study is to compare the efficacy and safety of BR005-036C versus placebo in subjects with Acute Migraines",[656],"Migraine, With or Without Aura","NOT_YET_RECRUITING","2026-09-15",{"date":660,"type":661},"2026-09-16","ACTUAL",{"date":658,"type":649},{"date":664,"type":649},"2028-07-31",{"name":5,"class":6},83]