[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100615059":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":23,"centralContacts":27,"locations":34,"responsibleParty":742,"collaborators":23,"id":744,"slug":745,"hasResults":746,"nctId":747,"briefTitle":748,"officialTitle":749,"acronym":23,"eligibilityCriteria":750,"healthyVolunteers":746,"sex":751,"minAge":752,"maxAge":23,"enrollmentInfo":753,"targetDuration":23,"studyType":756,"phases":757,"briefSummary":759,"conditions":760,"keywords":762,"overallStatus":79,"whyStopped":23,"lastUpdateSubmitDate":771,"lastUpdatePostDateStruct":772,"startDateStruct":775,"completionDateStruct":777,"leadSponsor":779,"locationsCount":780},{"fullName":5,"class":6},"Mediar Therapeutics","INDUSTRY",[8,13],{"label":9,"type":10,"description":9,"interventionNames":11},"MTX-474","EXPERIMENTAL",[12],"Biological: MTX-474",{"label":14,"type":15,"description":14,"interventionNames":16},"Placebo","PLACEBO_COMPARATOR",[17],"Other: Placebo",[19,24],{"type":20,"name":9,"description":21,"armGroupLabels":22,"otherNames":23},"BIOLOGICAL","Dosage level: 4 mg\u002Fkg Unit dose strength: 50mg\u002Fml MTX-474 is a human immunoglobulin G1 (IgG1) monoclonal antibody that binds the human EphrinB2 with high specificity and high affinity. MTX-474 is being developed as a therapy for patients with systemic sclerosis (SSc).",[9],null,{"type":25,"name":14,"description":14,"armGroupLabels":26,"otherNames":23},"OTHER",[14],[28],{"name":29,"role":30,"phone":31,"phoneExt":32,"email":33},"Jeffrey Bornstein, MD","CONTACT","(617) 936-0960","803","jeffrey@mediartx.com",[35,54,66,77,92,108,119,135,151,162,176,188,204,220,232,244,256,268,280,292,303,319,334,345,359,370,384,397,408,419,430,441,452,465,476,487,498,509,520,533,548,559,572,583,594,601,614,625,632,643,656,663,674,685,696,709,720,731],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"EncompaSSc site in Phoenix, AZ","NOT_YET_RECRUITING","Phoenix","Arizona","85054","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-112.07404,33.44838,{"lat":47,"lon":46},[50],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},"EncompaSSc contact","617-802-6568","EncompaSSc@mediartx.com",{"facility":55,"status":37,"city":56,"state":57,"zip":58,"country":41,"countryCode":42,"cosmosGeoPoint":59,"geoPoint":63,"contacts":64},"EncompaSSc site in La Jolla, CA","La Jolla","California","92037",{"type":44,"coordinates":60},[61,62],-117.2742,32.84727,{"lat":62,"lon":61},[65],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":67,"status":37,"city":68,"state":57,"zip":69,"country":41,"countryCode":42,"cosmosGeoPoint":70,"geoPoint":74,"contacts":75},"EncompaSSc site in Loma Linda, CA","Loma Linda","92350",{"type":44,"coordinates":71},[72,73],-117.26115,34.04835,{"lat":73,"lon":72},[76],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":78,"status":79,"city":80,"state":57,"zip":81,"country":41,"countryCode":42,"cosmosGeoPoint":82,"geoPoint":86,"contacts":87},"University of California Los Angeles Scleroderma Center","RECRUITING","Los Angeles","90095",{"type":44,"coordinates":83},[84,85],-118.24368,34.05223,{"lat":85,"lon":84},[88,89],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"name":90,"role":91,"phone":23,"phoneExt":23,"email":23},"Elizabeth Volkmann","PRINCIPAL_INVESTIGATOR",{"facility":93,"status":79,"city":94,"state":57,"zip":95,"country":41,"countryCode":42,"cosmosGeoPoint":96,"geoPoint":100,"contacts":101},"NewportNativeMD, Inc.","Newport Beach","92663",{"type":44,"coordinates":97},[98,99],-117.92895,33.61891,{"lat":99,"lon":98},[102,106],{"name":103,"role":30,"phone":104,"phoneExt":23,"email":105},"Jennifer Gonzolez","617 802 6568","jennifer@newportnativemd.com",{"name":107,"role":91,"phone":23,"phoneExt":23,"email":23},"Ryan Klein",{"facility":109,"status":37,"city":110,"state":57,"zip":111,"country":41,"countryCode":42,"cosmosGeoPoint":112,"geoPoint":116,"contacts":117},"EncompaSSc site in Palo Alto, CA","Palo Alto","94304",{"type":44,"coordinates":113},[114,115],-122.14302,37.44188,{"lat":115,"lon":114},[118],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":120,"status":79,"city":121,"state":122,"zip":123,"country":41,"countryCode":42,"cosmosGeoPoint":124,"geoPoint":128,"contacts":129},"University of Colorado Center for Lungs\u002FBreathing\u002FScleroderma Clinic","Aurora","Colorado","80045",{"type":44,"coordinates":125},[126,127],-104.83192,39.72943,{"lat":127,"lon":126},[130,133],{"name":131,"role":30,"phone":52,"phoneExt":23,"email":132},"Chong Pedrick","CHONG.PEDRICK@CUANSCHUTZ.EDU",{"name":134,"role":91,"phone":23,"phoneExt":23,"email":23},"Melissa Griffith",{"facility":136,"status":79,"city":137,"state":138,"zip":139,"country":41,"countryCode":42,"cosmosGeoPoint":140,"geoPoint":144,"contacts":145},"Clinical Research of West Florida","Clearwater","Florida","33765",{"type":44,"coordinates":141},[142,143],-82.8001,27.96585,{"lat":143,"lon":142},[146,149],{"name":147,"role":30,"phone":104,"phoneExt":23,"email":148},"Amber Tipker","atipker@crwf.com",{"name":150,"role":91,"phone":23,"phoneExt":23,"email":23},"Rodney Daniel",{"facility":152,"status":37,"city":153,"state":138,"zip":154,"country":41,"countryCode":42,"cosmosGeoPoint":155,"geoPoint":159,"contacts":160},"EncompaSSc site in Sarasota, FL","Sarasota","34239",{"type":44,"coordinates":156},[157,158],-82.53065,27.33643,{"lat":158,"lon":157},[161],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":136,"status":79,"city":163,"state":138,"zip":164,"country":41,"countryCode":42,"cosmosGeoPoint":165,"geoPoint":169,"contacts":170},"Tampa","33606",{"type":44,"coordinates":166},[167,168],-82.45843,27.94752,{"lat":168,"lon":167},[171,174],{"name":172,"role":30,"phone":104,"phoneExt":23,"email":173},"Michelle Villela","mvillela@crwf.com",{"name":175,"role":91,"phone":23,"phoneExt":23,"email":23},"John Carter",{"facility":177,"status":37,"city":178,"state":179,"zip":180,"country":41,"countryCode":42,"cosmosGeoPoint":181,"geoPoint":185,"contacts":186},"EncompaSSc site in Kansas City, KS","Kansas City","Kansas","66103",{"type":44,"coordinates":182},[183,184],-94.62746,39.11417,{"lat":184,"lon":183},[187],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":189,"status":79,"city":190,"state":191,"zip":192,"country":41,"countryCode":42,"cosmosGeoPoint":193,"geoPoint":197,"contacts":198},"Johns Hopkins University","Baltimore","Maryland","21205",{"type":44,"coordinates":194},[195,196],-76.61219,39.29038,{"lat":196,"lon":195},[199,202],{"name":200,"role":30,"phone":104,"phoneExt":23,"email":201},"Gwen Leatherman","gleathe1@jh.edu",{"name":203,"role":91,"phone":23,"phoneExt":23,"email":23},"Laura Hummers",{"facility":205,"status":79,"city":206,"state":207,"zip":208,"country":41,"countryCode":42,"cosmosGeoPoint":209,"geoPoint":213,"contacts":214},"Brigham and Women's Hospital","Boston","Massachusetts","02115",{"type":44,"coordinates":210},[211,212],-71.05977,42.35843,{"lat":212,"lon":211},[215,218],{"name":216,"role":30,"phone":52,"phoneExt":23,"email":217},"Joyce Shen","jshen0@bwh.harvard.edu",{"name":219,"role":91,"phone":23,"phoneExt":23,"email":23},"Avery LaChance",{"facility":221,"status":79,"city":206,"state":207,"zip":222,"country":41,"countryCode":42,"cosmosGeoPoint":223,"geoPoint":225,"contacts":226},"Boston Medical Center","02118",{"type":44,"coordinates":224},[211,212],{"lat":212,"lon":211},[227,230],{"name":228,"role":30,"phone":104,"phoneExt":23,"email":229},"Kimberly Finch","kimtobin@bu.edu",{"name":231,"role":91,"phone":23,"phoneExt":23,"email":23},"Andreea Bujor",{"facility":233,"status":37,"city":234,"state":235,"zip":236,"country":41,"countryCode":42,"cosmosGeoPoint":237,"geoPoint":241,"contacts":242},"EncompaSSc site in Minneapolis, MN","Minneapolis","Minnesota","55455",{"type":44,"coordinates":238},[239,240],-93.26384,44.97997,{"lat":240,"lon":239},[243],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":245,"status":37,"city":246,"state":247,"zip":248,"country":41,"countryCode":42,"cosmosGeoPoint":249,"geoPoint":253,"contacts":254},"EncompaSSc site in Brooklyn, NY","Brooklyn","New York","11201",{"type":44,"coordinates":250},[251,252],-73.94958,40.6501,{"lat":252,"lon":251},[255],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":257,"status":37,"city":258,"state":259,"zip":260,"country":41,"countryCode":42,"cosmosGeoPoint":261,"geoPoint":265,"contacts":266},"EncompaSSc site in Cleveland, OH","Cleveland","Ohio","44195",{"type":44,"coordinates":262},[263,264],-81.69541,41.4995,{"lat":264,"lon":263},[267],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":269,"status":37,"city":270,"state":271,"zip":272,"country":41,"countryCode":42,"cosmosGeoPoint":273,"geoPoint":277,"contacts":278},"EncompaSSc site in Oklahoma City, OK","Oklahoma City","Oklahoma","73104",{"type":44,"coordinates":274},[275,276],-97.51643,35.46756,{"lat":276,"lon":275},[279],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":281,"status":37,"city":282,"state":283,"zip":284,"country":41,"countryCode":42,"cosmosGeoPoint":285,"geoPoint":289,"contacts":290},"EncompaSSc site in Philadelphia, PA","Philadelphia","Pennsylvania","19107",{"type":44,"coordinates":286},[287,288],-75.16362,39.95238,{"lat":288,"lon":287},[291],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":293,"status":37,"city":294,"state":283,"zip":295,"country":41,"countryCode":42,"cosmosGeoPoint":296,"geoPoint":300,"contacts":301},"EncompaSSc site in Pittsburgh, PA","Pittsburgh","15219",{"type":44,"coordinates":297},[298,299],-79.99589,40.44062,{"lat":299,"lon":298},[302],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":304,"status":79,"city":305,"state":306,"zip":307,"country":41,"countryCode":42,"cosmosGeoPoint":308,"geoPoint":312,"contacts":313},"Stryde Research - DFW","Allen","Texas","75013",{"type":44,"coordinates":309},[310,311],-96.67055,33.10317,{"lat":311,"lon":310},[314,317],{"name":315,"role":30,"phone":52,"phoneExt":23,"email":316},"Moraima Avalos","patients@stryderesearch.com",{"name":318,"role":91,"phone":23,"phoneExt":23,"email":23},"John Lavery",{"facility":320,"status":79,"city":321,"state":306,"zip":322,"country":41,"countryCode":42,"cosmosGeoPoint":323,"geoPoint":327,"contacts":328},"Baylor Scott & White Research Institute","Dallas","75246",{"type":44,"coordinates":324},[325,326],-96.80667,32.78306,{"lat":326,"lon":325},[329,332],{"name":330,"role":30,"phone":52,"phoneExt":23,"email":331},"Felicia Padilla","felicia.padilla@bswhealth.org",{"name":333,"role":91,"phone":23,"phoneExt":23,"email":23},"Susan Mathai",{"facility":335,"status":37,"city":336,"state":306,"zip":337,"country":41,"countryCode":42,"cosmosGeoPoint":338,"geoPoint":342,"contacts":343},"EncompaSSc site in Houston, TX","Houston","77030",{"type":44,"coordinates":339},[340,341],-95.36327,29.76328,{"lat":341,"lon":340},[344],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":346,"status":37,"city":347,"state":348,"zip":349,"country":350,"countryCode":351,"cosmosGeoPoint":352,"geoPoint":356,"contacts":357},"EncompaSSc site in Southport, Australia","Southport","Queensland","4222","Australia","AU",{"type":44,"coordinates":353},[354,355],153.39796,-27.96724,{"lat":355,"lon":354},[358],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":360,"status":37,"city":361,"state":348,"zip":362,"country":350,"countryCode":351,"cosmosGeoPoint":363,"geoPoint":367,"contacts":368},"EncompaSSc site in Woolloongabba, Australia","Woolloongabba","4102",{"type":44,"coordinates":364},[365,366],153.03655,-27.48855,{"lat":366,"lon":365},[369],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":371,"status":79,"city":372,"state":373,"zip":374,"country":350,"countryCode":351,"cosmosGeoPoint":375,"geoPoint":379,"contacts":380},"Austin Health","Heidelberg","Victoria","3084",{"type":44,"coordinates":376},[377,378],145.06667,-37.75,{"lat":378,"lon":377},[381,382],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"name":383,"role":91,"phone":23,"phoneExt":23,"email":23},"Jessica Leung",{"facility":385,"status":37,"city":386,"state":23,"zip":387,"country":388,"countryCode":389,"cosmosGeoPoint":390,"geoPoint":394,"contacts":395},"EncompaSSc site in La Tronche, France","La Tronche","38700","France","FR",{"type":44,"coordinates":391},[392,393],5.74629,45.20507,{"lat":393,"lon":392},[396],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":398,"status":37,"city":399,"state":23,"zip":400,"country":388,"countryCode":389,"cosmosGeoPoint":401,"geoPoint":405,"contacts":406},"EncompaSSc site in Montpellier, France","Montpellier","34090",{"type":44,"coordinates":402},[403,404],3.87635,43.61093,{"lat":404,"lon":403},[407],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":409,"status":37,"city":410,"state":23,"zip":411,"country":388,"countryCode":389,"cosmosGeoPoint":412,"geoPoint":416,"contacts":417},"EncompaSSc site in Paris, France","Paris","75014",{"type":44,"coordinates":413},[414,415],2.3488,48.85341,{"lat":415,"lon":414},[418],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":420,"status":37,"city":421,"state":23,"zip":422,"country":388,"countryCode":389,"cosmosGeoPoint":423,"geoPoint":427,"contacts":428},"EncompaSSc site in Strasbourg, France","Strasbourg","67000",{"type":44,"coordinates":424},[425,426],7.74553,48.58392,{"lat":426,"lon":425},[429],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":431,"status":37,"city":432,"state":23,"zip":433,"country":388,"countryCode":389,"cosmosGeoPoint":434,"geoPoint":438,"contacts":439},"EncompaSSc site in Toulouse, France","Toulouse","31059",{"type":44,"coordinates":435},[436,437],1.44367,43.60426,{"lat":437,"lon":436},[440],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":442,"status":37,"city":443,"state":23,"zip":444,"country":388,"countryCode":389,"cosmosGeoPoint":445,"geoPoint":449,"contacts":450},"EncompaSSc site in Vandœuvre-lès-Nancy, France","Vandœuvre-lès-Nancy","54500",{"type":44,"coordinates":446},[447,448],6.17114,48.66115,{"lat":448,"lon":447},[451],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":453,"status":37,"city":454,"state":23,"zip":455,"country":456,"countryCode":457,"cosmosGeoPoint":458,"geoPoint":462,"contacts":463},"EncompaSSc site in Ancona, Italy","Ancona","60126","Italy","IT",{"type":44,"coordinates":459},[460,461],13.5103,43.60717,{"lat":461,"lon":460},[464],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":466,"status":37,"city":467,"state":23,"zip":468,"country":456,"countryCode":457,"cosmosGeoPoint":469,"geoPoint":473,"contacts":474},"EncompaSSc site in Catania, Italy","Catania","95123",{"type":44,"coordinates":470},[471,472],15.07041,37.49223,{"lat":472,"lon":471},[475],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":477,"status":37,"city":478,"state":23,"zip":479,"country":456,"countryCode":457,"cosmosGeoPoint":480,"geoPoint":484,"contacts":485},"EncompaSSc site in Genoa, Italy","Genoa","16132",{"type":44,"coordinates":481},[482,483],8.94439,44.40478,{"lat":483,"lon":482},[486],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":488,"status":37,"city":489,"state":23,"zip":490,"country":456,"countryCode":457,"cosmosGeoPoint":491,"geoPoint":495,"contacts":496},"EncompaSSc site in Milan, Italy","Milan","20122",{"type":44,"coordinates":492},[493,494],9.18951,45.46427,{"lat":494,"lon":493},[497],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":499,"status":37,"city":500,"state":23,"zip":501,"country":456,"countryCode":457,"cosmosGeoPoint":502,"geoPoint":506,"contacts":507},"EncompaSSc site in Modena, Italy","Modena","41124",{"type":44,"coordinates":503},[504,505],10.92539,44.64783,{"lat":505,"lon":504},[508],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":510,"status":37,"city":511,"state":23,"zip":512,"country":456,"countryCode":457,"cosmosGeoPoint":513,"geoPoint":517,"contacts":518},"EncompaSSc site in Roma, Italy","Roma","00128",{"type":44,"coordinates":514},[515,516],11.10642,44.99364,{"lat":516,"lon":515},[519],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":521,"status":37,"city":522,"state":23,"zip":523,"country":524,"countryCode":525,"cosmosGeoPoint":526,"geoPoint":530,"contacts":531},"EncompaSSc site in Groningen, Netherlands","Groningen","9713 GZ","Netherlands","NL",{"type":44,"coordinates":527},[528,529],6.56667,53.21917,{"lat":529,"lon":528},[532],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":534,"status":79,"city":535,"state":23,"zip":536,"country":537,"countryCode":538,"cosmosGeoPoint":539,"geoPoint":543,"contacts":544},"Aotearoa Clinical Trials","Auckland","2025","New Zealand","NZ",{"type":44,"coordinates":540},[541,542],174.76349,-36.84853,{"lat":542,"lon":541},[545,546],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"name":547,"role":91,"phone":23,"phoneExt":23,"email":23},"Mark Sapsford",{"facility":549,"status":37,"city":550,"state":23,"zip":551,"country":537,"countryCode":538,"cosmosGeoPoint":552,"geoPoint":556,"contacts":557},"EncompaSSc site in Hamilton, NZ","Hamilton","3204",{"type":44,"coordinates":553},[554,555],175.28333,-37.78333,{"lat":555,"lon":554},[558],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":560,"status":37,"city":561,"state":23,"zip":562,"country":563,"countryCode":564,"cosmosGeoPoint":565,"geoPoint":569,"contacts":570},"EncompaSSc site in Bydgoszcz, Poland","Bydgoszcz","85-168","Poland","PL",{"type":44,"coordinates":566},[567,568],18.00762,53.1235,{"lat":568,"lon":567},[571],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":573,"status":37,"city":574,"state":23,"zip":575,"country":563,"countryCode":564,"cosmosGeoPoint":576,"geoPoint":580,"contacts":581},"EncompaSSc site in Nowa Sól, Poland","Nowa Sól","67-100",{"type":44,"coordinates":577},[578,579],15.71702,51.80333,{"lat":579,"lon":578},[582],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":584,"status":37,"city":585,"state":23,"zip":586,"country":563,"countryCode":564,"cosmosGeoPoint":587,"geoPoint":591,"contacts":592},"EncompaSSc site in Warszawa, Poland","Warsaw","00-874",{"type":44,"coordinates":588},[589,590],21.01178,52.22977,{"lat":590,"lon":589},[593],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":584,"status":37,"city":585,"state":23,"zip":595,"country":563,"countryCode":564,"cosmosGeoPoint":596,"geoPoint":598,"contacts":599},"02-507",{"type":44,"coordinates":597},[589,590],{"lat":590,"lon":589},[600],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":602,"status":37,"city":603,"state":23,"zip":604,"country":605,"countryCode":606,"cosmosGeoPoint":607,"geoPoint":611,"contacts":612},"EncompaSSc site in Brasov, Romania","Brasov","500283","Romania","RO",{"type":44,"coordinates":608},[609,610],25.60613,45.64861,{"lat":610,"lon":609},[613],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":615,"status":37,"city":616,"state":23,"zip":617,"country":605,"countryCode":606,"cosmosGeoPoint":618,"geoPoint":622,"contacts":623},"EncompaSSc site in Bucharest, Romania","Bucharest","030463",{"type":44,"coordinates":619},[620,621],26.10626,44.43225,{"lat":621,"lon":620},[624],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":615,"status":37,"city":616,"state":23,"zip":626,"country":605,"countryCode":606,"cosmosGeoPoint":627,"geoPoint":629,"contacts":630},"041303",{"type":44,"coordinates":628},[620,621],{"lat":621,"lon":620},[631],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":633,"status":37,"city":634,"state":23,"zip":635,"country":605,"countryCode":606,"cosmosGeoPoint":636,"geoPoint":640,"contacts":641},"EncompaSSc site in Timişoara, Romania","Timișoara","300133",{"type":44,"coordinates":637},[638,639],21.22571,45.75372,{"lat":639,"lon":638},[642],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":644,"status":37,"city":645,"state":23,"zip":646,"country":647,"countryCode":648,"cosmosGeoPoint":649,"geoPoint":653,"contacts":654},"EncompaSSc site in Barcelona, Spain","Barcelona","08003","Spain","ES",{"type":44,"coordinates":650},[651,652],2.15899,41.38879,{"lat":652,"lon":651},[655],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":644,"status":37,"city":645,"state":23,"zip":657,"country":647,"countryCode":648,"cosmosGeoPoint":658,"geoPoint":660,"contacts":661},"08025",{"type":44,"coordinates":659},[651,652],{"lat":652,"lon":651},[662],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":664,"status":37,"city":665,"state":23,"zip":666,"country":647,"countryCode":648,"cosmosGeoPoint":667,"geoPoint":671,"contacts":672},"EncompaSSc site in Córdoba, Spain","Córdoba","14004",{"type":44,"coordinates":668},[669,670],-4.77275,37.89155,{"lat":670,"lon":669},[673],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":675,"status":37,"city":676,"state":23,"zip":677,"country":647,"countryCode":648,"cosmosGeoPoint":678,"geoPoint":682,"contacts":683},"EncompaSSc site in Malaga, Spain","Málaga","29004",{"type":44,"coordinates":679},[680,681],-4.42034,36.72016,{"lat":681,"lon":680},[684],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":686,"status":37,"city":687,"state":23,"zip":688,"country":647,"countryCode":648,"cosmosGeoPoint":689,"geoPoint":693,"contacts":694},"EncompaSSc site in Valencia, Spain","Valencia","46026",{"type":44,"coordinates":690},[691,692],-0.37966,39.47391,{"lat":692,"lon":691},[695],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":697,"status":37,"city":698,"state":23,"zip":699,"country":700,"countryCode":701,"cosmosGeoPoint":702,"geoPoint":706,"contacts":707},"EncompaSSc site in Walsgrave Coventry, UK","Coventry","CV2 2DX","United Kingdom","UK",{"type":44,"coordinates":703},[704,705],-1.51217,52.40656,{"lat":705,"lon":704},[708],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":710,"status":37,"city":711,"state":23,"zip":712,"country":700,"countryCode":701,"cosmosGeoPoint":713,"geoPoint":717,"contacts":718},"EncompaSSc site in Liverpool, UK","Liverpool","L7 8XP",{"type":44,"coordinates":714},[715,716],-2.97794,53.41058,{"lat":716,"lon":715},[719],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"facility":721,"status":37,"city":722,"state":23,"zip":723,"country":700,"countryCode":701,"cosmosGeoPoint":724,"geoPoint":728,"contacts":729},"EncompaSSc site in London, UK","London","SW8 3RN",{"type":44,"coordinates":725},[726,727],-0.12574,51.50853,{"lat":727,"lon":726},[730],{"name":51,"role":30,"phone":104,"phoneExt":23,"email":53},{"facility":732,"status":37,"city":733,"state":23,"zip":734,"country":700,"countryCode":701,"cosmosGeoPoint":735,"geoPoint":739,"contacts":740},"EncompaSSc site in Westcliff-on-Sea, UK","Westcliff-on-Sea","SS0 0RY",{"type":44,"coordinates":736},[737,738],0.69179,51.54424,{"lat":738,"lon":737},[741],{"name":51,"role":30,"phone":52,"phoneExt":23,"email":53},{"type":743,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR","100615059","phase-2-encompassc-evaluation-of-mtx-474-in-participants-with-diffuse-cutaneous-systemic-sclerosis-dcssc-100615059",false,"NCT07287670","EncompaSSc: Evaluation of MTX-474 in Participants With Diffuse Cutaneous Systemic Sclerosis (dcSSc)","A Phase 2 Randomized, Double-blind, Placebo-Controlled Study to Assess the Safety and Efficacy of MTX-474 in the Treatment of Participants With Diffuse Cutaneous Systemic Sclerosis (dcSSc)","Inclusion Criteria:\n\n1. Diagnosis of diffuse cutaneous systemic sclerosis, classified according to 2013 American College of Rheumatology\u002FEuropean League Against Rheumatism (ACR\u002FEULAR)\n2. Participant is either:\n\n   1. Within 2 years of their first non-Raynaud's symptom and their mRSS is \\>7; OR\n   2. \\>2 and ≤5 years from their first non-Raynaud's symptom, their mRSS is between 10 and 30, they are negative for the RNA polymerase 3 autoantibody, and (1) they have never had any previous spontaneous improvement in skin thickening of ≥4 points by mRSS on exams performed by the same clinician, or (2) they were never clinically noted to have a meaningful spontaneous reduction in skin thickness if mRSS was never done; OR\n   3. \\>5 and ≤10 years from their first non-Raynaud's symptom, their mRSS is between \\>15 and ≤25, they are negative for the RNA polymerase 3 autoantibody, and (1) they have never had any previous spontaneous improvement in skin thickening of ≥4 points by mRSS, or (2) were never clinically noted to have a meaningful spontaneous reduction in skin thickness if mRSS was never done.\n3. Participant is ≥18 years of age at time of signing the ICF.\n4. Able to understand the study and provide a signed, written ICF\n5. Able to read and understand the language of the ICF and other study-related materials\n6. Forced vital capacity (FVCpp) of ≥45 pp10\n7. Have diffusing capacity of the lungs for carbon monoxide (DLCO) of ≥30 percent predicted at Screening\n8. Willing and able to complete all protocol-required study visits and procedures\n9. Participants of childbearing potential must have a negative serum pregnancy test at Screening.\n10. All participants with reproductive potential must agree to use and follow medically approved, highly effective methods of contraception during treatment and until 5 half-lives or 125 days after the last dose, whichever is longer\n\nExclusion Criteria:\n\n1. Concomitantly have another serious medical illness, which, in the opinion of the Investigator, would interfere with the participant's ability to complete the study\n2. Participant is currently on immunosuppressive therapy, systemic glucocorticoids or other antifibrotic agents detailed as follows:\n\n   1. Immunosuppresive agents: Cyclophosphamide (IV or oral if used in the 6 months prior to Screening), calcineurin inhibitors (if used in the 30 days prior to Screening), azathioprine (if used in the 30 days prior to Screening), Janus-kinase inhibitors (if used in the 30 days prior to Screening), rituximab (if used in the 6 months prior to Screening), tocilizumab (if used in the 60 days prior to Screening) or any other biologic Disease-Modifying Antirheumatic Drugs (DMARD, if used in the last 30 days or 3 half-lives prior to Screening, whichever is longer)\n   2. Antifibrotic agents: nintedanib or pirfenidone (if used in the 30 days prior to Screening). Also, exclusionary if used within 3 months of Screening are tyrosine-kinase inhibitors with recognized anti-fibrotic activity (imatinib, nilotinib, etc.)\n   3. Systemic glucocorticoids: equivalent doses of prednisone greater than 10 mg\u002Fday (≤10 mg\u002Fday allowed). Has received any pulse intramuscular (IM) or intravenous (IV) steroid within 1 month of Screening\n   4. Other agents:\n\n   i. mycophenolate mofetil unless on a stable dose for at least 6 months prior to Screening and there are no plans to adjust the dose during the study; ii. mycophenolic acid unless on a stable dose for at least 6 months prior to Screening and there are no plans to adjust the dose during the study; iii. hydroxychloroquine unless on a stable dose for at least 3 months prior to Screening and there are no plans to adjust the dose during the study; and iv. methotrexate unless on a stable dose for at least 3 months prior to Screening and there are no plans to adjust the dose during the study.\n3. Previous or planned hematopoietic stem cell or solid organ transplantation\n4. Previous treatment with chimeric antigen receptor (CAR)-T\u002FCAR-NK therapy\n5. Clinically significant PAH as determined by the Investigator at, or prior to first day of dosing (Baseline)\n6. Current use of PAH medication (endothelin receptor antagonists, prostacyclin analogues, soluble guanylate cyclase stimulators) excluding calcium channel blockers and phosphodiesterase-5 inhibitors\n7. Pregnant or currently breastfeeding\n8. Aspartate transaminase (AST) or alanine transaminase (ALT) \\>2.0 upper limit of normal\n9. Creatinine clearance \\\u003C45mL\u002Fmin\n10. History of myocardial infarction, angina or congestive heart failure\n11. International normalized ratio \\>2 or partial thromboplastin time \\>1.5 × upper limit of normal\n12. Active infection with human immunodeficiency virus (HIV), hepatitis B, or hepatitis C\n13. History of clinically significant thrombotic event within 12 months prior to Screening\n14. Positive anticentromere antibody\n15. Systemic sclerosis renal crisis within 12 months prior to Screening\n16. Confirmed diagnosis of overlap syndrome, systemic lupus erythematosus with anti-double strand (ds)DNA antibody, rheumatoid arthritis with anti-cyclic citrullinated peptide (anti-CCP) antibody, or systemic sclerosis mimics (eosinophilic fasciitis, scleromyxedema) at the time of inclusion in the study\n17. Known malignancy or history of malignancy within 5 years of Screening other than non-melanoma skin cancer and in situ cervical cancer\n18. Major surgery within 8 weeks prior to Screening or planned surgery during study period\n19. Unable to routinely access veins for blood draws and IV infusions\n20. Currently receiving another experimental agent or participating in another clinical trial. If a participant has recently received another experimental agent, then the last dose must have been at least 5 half-lives or 30 days (whichever is longer) prior to Screening\n21. History of myocardial infarction, angina or congestive heart failure","ALL","18 Years",{"count":754,"type":755},85,"ESTIMATED","INTERVENTIONAL",[758],"PHASE2","A Phase 2 Randomized, Double-blind, Placebo-Controlled Study of the Safety and Efficacy of MTX-474 in Participants with Diffuse Cutaneous Systemic Sclerosis (dcSSc)",[761],"Diffuse Cutaneous Systemic Sclerosis",[763,9,761,764,765,766,767,768,769,770],"MTX-474-S201","dcSSc participants","dcSSc","Adult","mRSS","EncompaSSc","monoclonal antibody","EphrinB2","2026-08-03",{"date":773,"type":774},"2026-08-05","ACTUAL",{"date":776,"type":774},"2026-04-16",{"date":778,"type":755},"2028-12",{"name":5,"class":6},58]