[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650512":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":37,"centralContacts":45,"locations":12,"responsibleParty":54,"collaborators":12,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":12,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":12,"studyType":71,"phases":72,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":84,"whyStopped":12,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":12},{"fullName":5,"class":6},"Ain Shams University","OTHER",[8,13,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Microneedling","NO_INTERVENTION","microneedling into the peri-implant soft tissue site",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Microneedling with Hyaluronic Acid (HA)","EXPERIMENTAL","Microneedling into the peri-implant soft tissue site in addition to the use of HA, repeated 3 times with 7 days gap in between.",[18],"Drug: Hyaluronic Acid (HA)",{"label":20,"type":15,"description":21,"interventionNames":22},"Microneedling with injectable platelet rich fibrin (I-PRF)","Microneedling into the peri-implant soft tissue site, in addition to the use of I-PRF, repeated 3 times with 7 days gap in between.",[23],"Biological: Platelet rich fibrin",[25,30],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":12},"DRUG","Hyaluronic Acid (HA)","Hyaluronic acid (HA) is a genuine linear glycosaminoglycan that is present within the extracellular matrix of connective, epithelial, and neural tissues.",[14],{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"BIOLOGICAL","Platelet rich fibrin","Injectable PRF (i-PRF) is a notable method in enhancing soft tissue phenotypes, relying on its injectable form that can be well delivered to targeted areas to ensure proper distribution of growth factors and cytokines.",[20],[36],"(I-PRF)",[38,42],{"name":39,"affiliation":40,"role":41},"Doaa A. Khattab, Associate Professor","Ain Shams Univeristy","STUDY_CHAIR",{"name":43,"affiliation":5,"role":44},"Suzan Sarhan, Associate Professor","STUDY_DIRECTOR",[46,51],{"name":47,"role":48,"phone":49,"phoneExt":12,"email":50},"Rahaf A. Khattab, Principal investigator","CONTACT","+201120008982","RahafZayn@dent.asu.edu.eg",{"name":39,"role":48,"phone":52,"phoneExt":12,"email":53},"+201006814258","doaadel12345@yahoo.com",{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"PRINCIPAL_INVESTIGATOR","Rahaf Medhat Zayn","Principal investigator","100650512","phase-2-hyaluronic-acid-vs-i-prf-with-microneedling-in-enhancing-peri-implant-soft-tissue-100650512",false,"NCT07750756","Hyaluronic Acid vs I-PRF With Microneedling in Enhancing Peri-implant Soft Tissue","Hyaluronic Acid Versus I-PRF Combined With Microneedling for Peri Implant Soft Tissue Enhancement: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Patients with delayed implants placed in the maxillary esthetic region in correct positioning and angulation\n* Patients with peri-implant gingival thickness ≤ 1 mm\n* Patients with healthy gingiva and who can maintain good oral hygiene around implants\n\nExclusion Criteria:\n\n* Marginal bone loss ≤ 2 mm\n* Patients with peri-implantitis or periodontitis\n* Patients with systemic conditions or diseases impairing healing or soft tissue metabolism\n* Pregnant or lactating females\n* Patients taking medications affecting the gingiva","ALL","21 Years","50 Years",{"count":69,"type":70},42,"ESTIMATED","INTERVENTIONAL",[73,74],"PHASE2","PHASE3","This study aims to compare the use of microneedling alone versus with hyaluronic acid or i-PRF in conjunction with microneedling in peri-implant mucosa in the esthetic zone to test the superior increase in gingival thickness.",[77],"Peri-implant Mucosa Thickness",[79,80,81,82,83],"microneedling","hyaluronic acid","I-PRF","gingival thickness","peri-implant","NOT_YET_RECRUITING","2026-08-14",{"date":87,"type":88},"2026-08-17","ACTUAL",{"date":90,"type":70},"2026-10-30",{"date":92,"type":70},"2028-05-30",{"name":5,"class":6}]