[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646026":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":36,"locations":46,"responsibleParty":63,"collaborators":40,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":40,"eligibilityCriteria":71,"healthyVolunteers":67,"sex":72,"minAge":73,"maxAge":40,"enrollmentInfo":74,"targetDuration":40,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":49,"whyStopped":40,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Washington University School of Medicine","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Liposomal Bupivacaine","EXPERIMENTAL","Participants randomized to the experimental arm will receive bilateral supraorbital and infraorbital nerve blocks using liposomal bupivacaine at the end of surgery.",[13],"Drug: Liposomal Bupivacaine",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard Bupivacaine","ACTIVE_COMPARATOR","The control arm will receive standard bupivacaine nerve blocks using the same injection sites and volumes appropriate for safe regional anesthesia",[19],"Drug: Standard Bupivacaine",[21,27],{"type":22,"name":15,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Volume: 4 mL of 0.75% bupivacaine hydrochloride",[15],[26],"Marcaine",{"type":22,"name":9,"description":28,"armGroupLabels":29,"otherNames":30},"Volume: 1.5 mL of 0.75% bupivacaine hydrochloride and 2.5 mL of liposomal bupivacaine",[9],[31],"Exparel",[33],{"name":34,"affiliation":5,"role":35},"Matthew Wu, MD","PRINCIPAL_INVESTIGATOR",[37,42],{"name":34,"role":38,"phone":39,"phoneExt":40,"email":41},"CONTACT","314-362-0524",null,"mjwu@wustl.edu",{"name":43,"role":38,"phone":44,"phoneExt":40,"email":45},"Sara Kukuljan, BS, RN","314-362-7563","kukuljas@wustl.edu",[47],{"facility":48,"status":49,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Washington University","RECRUITING","St Louis","Missouri","63110","United States","US",{"type":56,"coordinates":57},"Point",[58,59],-90.19789,38.62727,{"lat":59,"lon":58},[62],{"name":43,"role":38,"phone":44,"phoneExt":40,"email":45},{"type":64,"investigatorFullName":40,"investigatorTitle":40,"investigatorAffiliation":40,"oldNameTitle":40,"oldOrganization":40},"SPONSOR","100646026","phase-2-liposomal-bupivacaine-vs-standard-bupivacaine-for-post-rhinoplasty-analgesia-100646026",false,"NCT07689162","Liposomal Bupivacaine vs Standard Bupivacaine for Post-Rhinoplasty Analgesia","Liposomal Bupivacaine vs Standard Bupivacaine for Post-Rhinoplasty Analgesia: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Adult patients (≥18 years) undergoing open rhinoplasty of any indication or complexity (e.g., primary, revision, functional, or cosmetic), including autologous grafting of any type (e.g., septal or costal cartilage) or cadaveric grafting.\n\nExclusion Criteria:\n\n* Chronic pain condition requiring ongoing or scheduled analgesic therapy, or any diagnosis associated with chronic pain (e.g., fibromyalgia, chronic headache\u002Fmigraine, neuropathic pain, complex regional pain syndrome), long-term opioid use (≥3 months, any agent), allergy or contraindication to local anesthetics, acetaminophen, ibuprofen \u002F NSAIDs, tramadol, ketamine, Medrol (methylprednisolone) dose pack\n* Concurrent non-nasal surgery planned","ALL","18 Years",{"count":75,"type":76},45,"ESTIMATED","INTERVENTIONAL",[79],"PHASE2","The purpose of this study is to find out which pain medication is more effective in reducing pain after nose surgery (rhinoplasty). The investigators are looking to find the best treatment to reduce discomfort and improve the healing process for patients having nose surgery.",[82],"Pain, Postoperative",[84,85,86,9],"Otolaryngology","Rhinoplasty","Bupivacaine","2026-08-17",{"date":89,"type":90},"2026-08-18","ACTUAL",{"date":92,"type":90},"2026-08-01",{"date":94,"type":76},"2027-07",{"name":5,"class":6},1]