[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649203":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":23,"centralContacts":24,"locations":30,"responsibleParty":49,"collaborators":23,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":23,"eligibilityCriteria":58,"healthyVolunteers":54,"sex":59,"minAge":60,"maxAge":23,"enrollmentInfo":61,"targetDuration":23,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":72,"overallStatus":32,"whyStopped":23,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Summit Hyperbarics and Wellness","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"HBOT Follow-Up Cohort","EXPERIMENTAL","Veterans who previously completed a standardized Hyperbaric Oxygen Therapy (HBOT) treatment protocol and undergo follow-up assessments approximately 12 weeks after their final treatment session to evaluate the long-term durability of cognitive, psychological, and quality-of-life outcomes.",[13],"Drug: Hyperbaric Oxygen Therapy (HBOT)",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DRUG","Hyperbaric Oxygen Therapy (HBOT)","Hyperbaric Oxygen Therapy (HBOT): Participants will receive 100% medical oxygen (USP) administered under hyperbaric conditions at 2.0 atmospheres absolute (ATA) for 60 minutes with a scheduled air break over 40 treatment sessions.",[9],[21,22],"Hyperbaric Oxygen","Hyperbaric Oxygen Treatment",null,[25],{"name":26,"role":27,"phone":28,"phoneExt":23,"email":29},"Troy Nickel, PhD","CONTACT","208-813-9541","tnickel@shwidaho.org",[31],{"facility":5,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"RECRUITING","Boise","Idaho","83716","United States","US",{"type":39,"coordinates":40},"Point",[41,42],-116.20345,43.6135,{"lat":42,"lon":41},[45,46],{"name":26,"role":27,"phone":28,"phoneExt":23,"email":29},{"name":47,"role":48,"phone":23,"phoneExt":23,"email":23},"Steven Wyman, MD","PRINCIPAL_INVESTIGATOR",{"type":48,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"Steve Wyman","Principal Investigator","100649203","phase-2-long-term-outcomes-following-hbot-100649203",false,"NCT07732374","Long-Term Outcomes Following HBOT","Assessing Follow-Up Effects Post-Discontinuation of Hyperbaric Oxygen Therapy on Cognitive Function, Mental Health, and Quality of Life in Veterans","Inclusion Criteria:\n\n1. At least 18 years of age.\n2. Veteran status\n3. Clinically diagnosed with a mTBI, PCS, PTSD, Anxiety, or Depression disorder.\n4. Successfully completed the parent Hyperbaric Oxygen Therapy (HBOT) intervention, consisting of the full study treatment protocol (40 HBOT sessions).\n5. Willing and able to read, understand, and provide written informed consent for participation in the 12-week follow-up study. Additionally, the Participant has clear consciousness and the ability to express self-feelings independently.\n6. Completed cognitive and psychological measurements.\n7. Clinical diagnoses cause significant impairment in social or occupational functioning or some other functional capacity.\n8. Stability on any current psychoactive medications (antidepressants, anti-anxiety medications, antipsychotics, stimulants, and mood stabilizers).\n\nExclusion Criteria:\n\n1. Acute medical illness or infection\n2. Severe or unstable physical disorders or major cognitive deficits\n3. Current manic, psychotic episodes, or serious suicidal ideations\n4. Non-English speakers\n5. Inability to attend scheduled follow-up visits\n6. Significant life events, new neurological injury, or new psychiatric diagnosis or hospitalization occurring after completion of the HBOT intervention that, in the opinion of the investigator, could confound cognitive, psychological, or quality-of-life outcomes.\n7. Participation in another interventional clinical study or receipt of a therapeutic intervention following completion of HBOT that could influence cognitive, psychological, or quality-of-life outcomes.","ALL","18 Years",{"count":62,"type":63},35,"ESTIMATED","INTERVENTIONAL",[66],"PHASE2","This study is designed to better understand the long-term effects of hyperbaric oxygen therapy (HBOT). Our goal is to determine whether improvements after treatment are maintained over time and whether additional benefits appear months after treatment has ended. We will evaluate changes in cognitive function, mental health, and daily functioning to help strengthen the scientific evidence supporting the use of HBOT and guide future treatment recommendations.",[69,70,71],"Traumatic Brain Injury","Post-Concussive Symptoms","Post-Traumatic Stress Disorder",[73,74,75,76,77,78,69,79],"Hyperbaric Oxygen Therapy","Treatment Durability","Cognitive Function","Mental Health","Quality of Life","Veterans","Persistent Post-Concussive Symptoms (PCS)","2026-07-23",{"date":82,"type":83},"2026-07-28","ACTUAL",{"date":85,"type":83},"2026-06-18",{"date":87,"type":63},"2027-06-18",{"name":5,"class":6},1]