[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100608578":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":11,"centralContacts":22,"locations":32,"responsibleParty":50,"collaborators":11,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":54,"sex":60,"minAge":61,"maxAge":11,"enrollmentInfo":62,"targetDuration":11,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":11,"overallStatus":35,"whyStopped":11,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"University of Utah","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Exercise Intervention","EXPERIMENTAL",null,[13],"Other: Whole-body resistance training and aerobic exercise",{"label":15,"type":16,"description":11,"interventionNames":11},"Usual Care","NO_INTERVENTION",[18],{"type":6,"name":19,"description":20,"armGroupLabels":21,"otherNames":11},"Whole-body resistance training and aerobic exercise","A 12-week individualized, home-based, unsupervised, whole-body resistance training and aerobic exercise routine will be provided to each study participant.",[9],[23,28],{"name":24,"role":25,"phone":26,"phoneExt":11,"email":27},"Janna Espinosa","CONTACT","801-585-0571","Janna.Espinosa@hci.utah.edu",{"name":29,"role":25,"phone":30,"phoneExt":11,"email":31},"Roma Bhatia, MD","801-585-0255","Roma.bhatia@hci.utah.edu",[33],{"facility":34,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Huntsman Cancer Institute at University of Utah","RECRUITING","Salt Lake City","Utah","84112","United States","US",{"type":42,"coordinates":43},"Point",[44,45],-111.89105,40.76078,{"lat":45,"lon":44},[48,49],{"name":24,"role":25,"phone":26,"phoneExt":11,"email":27},{"name":29,"role":25,"phone":30,"phoneExt":11,"email":31},{"type":51,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100608578","phase-2-nurturing-exercise-routine-for-greater-improvement-in-zest-and-energy-on-enhertu-100608578",false,"NCT07203378","Nurturing Exercise Routine for Greater Improvement in Zest and Energy on Enhertu","ENERGIZE: Engagement With a Nurturing Exercise Routine for Greater Improvement in Zest and Energy on Enhertu: A Single-Center Pilot Study","ENERGIZE","Inclusion Criteria:\n\n* Subject aged ≥ 18 years\n* Diagnosis of locally advanced\u002Funresectable or metastatic breast cancer. Note: Patients with High-Risk HER-2 + breast cancer after completion of neoadjuvant chemotherapy requiring adjuvant Enhertu are allowed at the discretion of the treating physician.\n* Has received 3 or 4 cycles of Enhertu and is expected to continue treatment for at least 12 weeks. Note: HER-2 targeted systemic therapy (e.g. Trastuzumab and\u002For Pertuzumab) in conjunction with Enhertu is allowed.\n* Able and willing to participate in the interventional aerobic exercise and resistance exercises.\n* Currently following standard of care contraception requirements and willing to continue following these requirements for the duration of therapy.\n* Able to provide informed consent and willing to sign an approved consent form that conforms to federal and institutional guidelines.\n* Experiencing clinical fatigue symptoms in the opinion of the investigator.\n* Subject has completed the ACSM exercise preparticipation health screening and is, in the opinion of the investigator, fit to participate in this study.\n\nExclusion Criteria:\n\n-Currently adhering to national physical activity guidelines for resistance training, as defined as participating in structured resistance training ≥ two days per week.\n\n* Structured is defined as time set aside in the subject's day to workout.\n* Resistance training is defined as exercises which use weights, bands, or body weight (e.g., squats or push-ups).\n\nAND Currently participating in structured moderate-intensity aerobic exercise for ≥ 150 minutes per week.\n\n* Moderate-intensity exercise is defined as activities where the subject can talk but not sing.\n* Aerobic exercise includes, but is not limited to, walking, swimming, cycling, running, rowing, hiking, and elliptical.\n\n  * Medical, psychiatric, cognitive, or other conditions that may compromise the participant's ability to understand the participant information, give informed consent, comply with the study protocol or complete the study.\n  * Participants taking prohibited medications as described in Section 7.4.1.","ALL","18 Years",{"count":63,"type":64},80,"ESTIMATED","INTERVENTIONAL",[67],"PHASE2","The goal of this study is to test the efficacy of using a 12-week, home-based, unsupervised aerobic and resistance training exercise program for changes in cancer-related fatigue in patients with metastatic breast cancer who are receiving Enhertu.",[70],"Metastatic Breast Cancer","2026-08-18",{"date":73,"type":74},"2026-08-20","ACTUAL",{"date":76,"type":74},"2025-11-04",{"date":78,"type":64},"2028-11",{"name":5,"class":6},1]