[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649065":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":22,"centralContacts":23,"locations":29,"responsibleParty":73,"collaborators":22,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":22,"eligibilityCriteria":81,"healthyVolunteers":77,"sex":82,"minAge":22,"maxAge":22,"enrollmentInfo":83,"targetDuration":22,"studyType":86,"phases":87,"briefSummary":89,"conditions":90,"keywords":22,"overallStatus":92,"whyStopped":22,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Alterity Therapeutics","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"ATH434 75mg BID","EXPERIMENTAL","Participants who completed the prior ATH434-201 Phase 2 trial will receive ATH434 75 mg orally twice daily (BID). Treatment consists of an initial 12-month treatment phase, followed by an ongoing extension phase based on investigator assessment of continued clinical benefit, safety, and tolerability",[13],"Drug: ATH434",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DRUG","ATH434","ATH434 75 mg tablets administered orally twice daily (BID).",[9],[21],"PBT434",null,[24],{"name":25,"role":26,"phone":27,"phoneExt":22,"email":28},"Alterity Clinical Trials","CONTACT","+1 888-556-7582","clinicaltrials@alteritytx.com",[30,43,53,63],{"facility":31,"status":22,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":22},"Hôpital Pierre-Paul Riquet","Toulouse","Midi-Pyrenees","31300","France","FR",{"type":38,"coordinates":39},"Point",[40,41],1.44367,43.60426,{"lat":41,"lon":40},{"facility":44,"status":22,"city":45,"state":46,"zip":47,"country":35,"countryCode":36,"cosmosGeoPoint":48,"geoPoint":52,"contacts":22},"Centre Hospitalier Universitaire de Bordeaux","Bordeaux","New Aquitaine","33076",{"type":38,"coordinates":49},[50,51],-0.58046,44.84124,{"lat":51,"lon":50},{"facility":54,"status":22,"city":55,"state":56,"zip":57,"country":35,"countryCode":36,"cosmosGeoPoint":58,"geoPoint":62,"contacts":22},"Hôpital de la Timone","Marseille","Provence-Alpes-Côte d'Azur Region","13005",{"type":38,"coordinates":59},[60,61],5.38107,43.29695,{"lat":61,"lon":60},{"facility":64,"status":22,"city":65,"state":66,"zip":67,"country":35,"countryCode":36,"cosmosGeoPoint":68,"geoPoint":72,"contacts":22},"Hôpital Universitaire Pitié Salpêtrière","Paris","Île-de-France Region","75013",{"type":38,"coordinates":69},[70,71],2.3488,48.85341,{"lat":71,"lon":70},{"type":74,"investigatorFullName":22,"investigatorTitle":22,"investigatorAffiliation":22,"oldNameTitle":22,"oldOrganization":22},"SPONSOR","100649065","phase-2-open-label-access-to-ath434-for-patients-who-completed-study-ath434-201-in-france-100649065",false,"NCT07729852","Open-Label Access to ATH434 for Patients Who Completed Study ATH434-201 in France","Open-Label Extension Study to Provide Access to ATH434 in Patients With Multiple System Atrophy","Inclusion Criteria:\n\n* Completed Alterity protocol ATH434-201.\n* Expected to benefit from treatment from treatment with ATH434, in the opinion of the Investigator.\n\nExclusion Criteria:\n\n* Discontinued prior ATH434 treatment (ATH434-201) for any reason.\n* Significant medical or psychiatric condition that may decrease the benefit-risk ratio of participation in this program to an unacceptable level, as per the Investigator's opinion.","ALL",{"count":84,"type":85},5,"ESTIMATED","INTERVENTIONAL",[88],"PHASE2","This multicenter open-label extension study conducted in France is designed to provide ATH434 orally BID to eligible patients who completed the Phase 2 study ATH434-201, and who may benefit from this treatment according to the evaluation by the Investigator.",[91],"Multiple System Atrophy","NOT_YET_RECRUITING","2026-07-22",{"date":95,"type":96},"2026-07-28","ACTUAL",{"date":98,"type":85},"2026-07",{"date":100,"type":85},"2029-07",{"name":5,"class":6},4]