[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100498175":3},{"organization":4,"outcomesModule":7,"designInfo":71,"detailedDescription":18,"studyPopulation":18,"armGroups":77,"interventions":84,"overallOfficials":89,"centralContacts":94,"locations":100,"responsibleParty":475,"collaborators":18,"id":477,"slug":478,"hasResults":479,"nctId":480,"briefTitle":481,"officialTitle":482,"acronym":18,"eligibilityCriteria":483,"healthyVolunteers":479,"sex":484,"minAge":485,"maxAge":486,"enrollmentInfo":487,"targetDuration":18,"studyType":490,"phases":491,"briefSummary":493,"conditions":494,"keywords":18,"overallStatus":103,"whyStopped":18,"lastUpdateSubmitDate":496,"lastUpdatePostDateStruct":497,"startDateStruct":500,"completionDateStruct":502,"leadSponsor":504,"locationsCount":505},{"fullName":5,"class":6},"Vifor Pharma","INDUSTRY",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":18},[9],{"measure":10,"description":11,"timeFrame":12},"Change in potassium levels (mmol\u002FL)","May be measured as serum, plasma, whole blood, potassium","From baseline to Day 28",[14,16,20,22,24,26,28,30,32,34,36,38,40,42,44,46,48,51,53,55,57,59,61,64,66,68],{"measure":10,"description":11,"timeFrame":15},"From baseline to Day 3, Day 7, Day 14, Day 28, and during Part 2: up to 52 weeks",{"measure":17,"description":18,"timeFrame":19},"Occurrence of treatment-emergent adverse events (TEAEs)",null,"Part 1: Day 1 up to end of treatment (Day 28 ±3 Days); Part 2: Day 1 up to follow-up visit (Up to 54 weeks)",{"measure":21,"description":18,"timeFrame":19},"Occurrence of serious adverse events (SAEs)",{"measure":23,"description":18,"timeFrame":15},"Change from baseline in resting heart rate (beats per minute)",{"measure":25,"description":18,"timeFrame":15},"Change from baseline in systolic blood pressure (mmHg)",{"measure":27,"description":18,"timeFrame":15},"Change from baseline in diastolic blood pressure (mmHg)",{"measure":29,"description":18,"timeFrame":15},"Change from baseline in body temperature (Celsius)",{"measure":31,"description":18,"timeFrame":15},"Number of patients with ECG abnormalities",{"measure":33,"description":18,"timeFrame":15},"Change from baseline in chemistry laboratory evaluation: Calcium (mg\u002FdL)",{"measure":35,"description":18,"timeFrame":15},"Change from baseline in chemistry laboratory evaluation: Phosphate (mg\u002FdL)",{"measure":37,"description":18,"timeFrame":15},"Change from baseline in chemistry laboratory evaluation: Magnesium (mg\u002FdL)",{"measure":39,"description":18,"timeFrame":15},"Change from baseline in chemistry laboratory evaluation: Potassium (mEq\u002FL)",{"measure":41,"description":18,"timeFrame":15},"Change from baseline in chemistry laboratory evaluation: Sodium (mEq\u002FL)",{"measure":43,"description":18,"timeFrame":15},"Change from baseline in chemistry laboratory evaluation: Creatinine (mg\u002FdL)",{"measure":45,"description":18,"timeFrame":15},"Change from baseline in chemistry laboratory evaluation: Serum bicarbonate (mEq\u002FL)",{"measure":47,"description":18,"timeFrame":15},"Change from baseline in chemistry laboratory evaluation: Blood urea nitrogen (mEq\u002FL)",{"measure":49,"description":18,"timeFrame":50},"Change from baseline in haematology laboratory evaluation: White blood cells (10^9\u002FL)","From baseline to Day 7, Day 14, Day 28, and EoT visit for Part 2 (week 52)",{"measure":52,"description":18,"timeFrame":50},"Change from baseline in haematology laboratory evaluation: Red blood cells count (10^12\u002FL)",{"measure":54,"description":18,"timeFrame":50},"Change from baseline in haematology laboratory evaluation: Haemoglobin (10^12\u002FL)",{"measure":56,"description":18,"timeFrame":50},"Change from baseline in haematology laboratory evaluation: Haematocrit (%)",{"measure":58,"description":18,"timeFrame":50},"Change from baseline in haematology laboratory evaluation: Platelet count (10^9\u002FL)",{"measure":60,"description":18,"timeFrame":50},"Change from baseline in haematology laboratory evaluation: Blood fluoride (ng\u002FmL)",{"measure":62,"description":18,"timeFrame":63},"Occurrence of blood potassium below the lower limit of normal (LLN) (mmol\u002FL)","Part 1: Screening up to end of treatment (Day 28 ±3 Days); Part 2: Day 1 up to end of treatment (Up to 52 weeks)",{"measure":65,"description":18,"timeFrame":63},"Occurrence of blood potassium above the upper limit of normal (ULN) (mmol\u002FL)",{"measure":67,"description":18,"timeFrame":63},"Occurrence of blood magnesium at levels specified in protocol (mmol\u002FL)",{"measure":69,"description":70,"timeFrame":63},"Occurrence of abnormal clinical laboratory value findings","Occurrence of clinical laboratory value findings that are outside of normal range of the respective age for: serum calcium, phosphate, fluoride, creatinine, bicarbonate, and blood urea nitrogen levels",{"allocation":72,"interventionModel":73,"interventionModelDescription":18,"primaryPurpose":74,"observationalModel":18,"timePerspective":18,"maskingInfo":75},"NA","SINGLE_GROUP","TREATMENT",{"masking":76,"maskingDescription":18,"whoMasked":18},"NONE",[78],{"label":79,"type":80,"description":81,"interventionNames":82},"Patiromer","EXPERIMENTAL","4-week pharmacodynamic \u002Fdose-ranging period\n\nCohort 1: 6 to less than(\\<)12 years of age\n\nCohort 2: 2 to \\<6 years of age\n\nCohort 3: 0 to \\<2 years of age; In Cohort 3, a minimum of 3 study participants will be assessed in the subgroup of 0 to \\<6 months and another 3 study participants in the subgroup 6 to \\<24 months of age.",[83],"Drug: Patiromer",[85],{"type":86,"name":79,"description":87,"armGroupLabels":88,"otherNames":18},"DRUG","Patiromer will be given once daily; In Cohort 3, depending on the dose and the study participant's age, the total daily dose might be split",[79],[90],{"name":91,"affiliation":92,"role":93},"Julian Platon, MD, PhD","Vifor Pharma, Inc.","STUDY_DIRECTOR",[95],{"name":96,"role":97,"phone":98,"phoneExt":18,"email":99},"EMERALD-2 Clinical Study Team","CONTACT","+41 58 851 80 00","clinicaltrials@cslbehring.com",[101,115,126,135,144,154,164,174,184,194,204,214,224,234,245,254,263,277,286,297,311,322,331,343,353,364,368,379,388,399,410,421,431,442,453,459,465],{"facility":102,"status":103,"city":104,"state":105,"zip":106,"country":107,"countryCode":108,"cosmosGeoPoint":109,"geoPoint":114,"contacts":18},"Children's Hospital Colorado","RECRUITING","Aurora","Colorado","80045","United States","US",{"type":110,"coordinates":111},"Point",[112,113],-104.83192,39.72943,{"lat":113,"lon":112},{"facility":116,"status":117,"city":118,"state":119,"zip":120,"country":107,"countryCode":108,"cosmosGeoPoint":121,"geoPoint":125,"contacts":18},"UF Health Pediatric Multispecialty Center Site","TERMINATED","Jacksonville","Florida","32207",{"type":110,"coordinates":122},[123,124],-81.65565,30.33218,{"lat":124,"lon":123},{"facility":127,"status":103,"city":128,"state":119,"zip":129,"country":107,"countryCode":108,"cosmosGeoPoint":130,"geoPoint":134,"contacts":18},"Miller School of Medicine, University of Miami","Miami","33124",{"type":110,"coordinates":131},[132,133],-80.19366,25.77427,{"lat":133,"lon":132},{"facility":136,"status":103,"city":137,"state":119,"zip":138,"country":107,"countryCode":108,"cosmosGeoPoint":139,"geoPoint":143,"contacts":18},"Arnold Palmer Hospital for Children","Orlando","32806",{"type":110,"coordinates":140},[141,142],-81.37924,28.53834,{"lat":142,"lon":141},{"facility":145,"status":103,"city":146,"state":147,"zip":148,"country":107,"countryCode":108,"cosmosGeoPoint":149,"geoPoint":153,"contacts":18},"Augusta University - Children's Hospital of Georgia","Augusta","Georgia","30912",{"type":110,"coordinates":150},[151,152],-81.97484,33.47097,{"lat":152,"lon":151},{"facility":155,"status":103,"city":156,"state":157,"zip":158,"country":107,"countryCode":108,"cosmosGeoPoint":159,"geoPoint":163,"contacts":18},"University of Illinois College of Medicine","Peoria","Illinois","61605",{"type":110,"coordinates":160},[161,162],-89.58899,40.69365,{"lat":162,"lon":161},{"facility":165,"status":103,"city":166,"state":167,"zip":168,"country":107,"countryCode":108,"cosmosGeoPoint":169,"geoPoint":173,"contacts":18},"Boston Children's Hospital","Boston","Massachusetts","02115",{"type":110,"coordinates":170},[171,172],-71.05977,42.35843,{"lat":172,"lon":171},{"facility":175,"status":103,"city":176,"state":177,"zip":178,"country":107,"countryCode":108,"cosmosGeoPoint":179,"geoPoint":183,"contacts":18},"Children's Mercy Hospitals and Clinics","Kansas City","Missouri","64108",{"type":110,"coordinates":180},[181,182],-94.57857,39.09973,{"lat":182,"lon":181},{"facility":185,"status":186,"city":187,"state":187,"zip":188,"country":107,"countryCode":108,"cosmosGeoPoint":189,"geoPoint":193,"contacts":18},"Northwell Health Cohen Children's Medical Center","NOT_YET_RECRUITING","New York","11042",{"type":110,"coordinates":190},[191,192],-74.00597,40.71427,{"lat":192,"lon":191},{"facility":195,"status":103,"city":196,"state":197,"zip":198,"country":107,"countryCode":108,"cosmosGeoPoint":199,"geoPoint":203,"contacts":18},"Duke University Hospital","Durham","North Carolina","27710",{"type":110,"coordinates":200},[201,202],-78.89862,35.99403,{"lat":202,"lon":201},{"facility":205,"status":103,"city":206,"state":207,"zip":208,"country":107,"countryCode":108,"cosmosGeoPoint":209,"geoPoint":213,"contacts":18},"The Children's Hospital of Philadelphia","Philadelphia","Pennsylvania","19104",{"type":110,"coordinates":210},[211,212],-75.16362,39.95238,{"lat":212,"lon":211},{"facility":215,"status":103,"city":216,"state":217,"zip":218,"country":107,"countryCode":108,"cosmosGeoPoint":219,"geoPoint":223,"contacts":18},"Vanderbilt Children's Hospital Neurology","Nashville","Tennessee","37232",{"type":110,"coordinates":220},[221,222],-86.78444,36.16589,{"lat":222,"lon":221},{"facility":225,"status":117,"city":226,"state":227,"zip":228,"country":107,"countryCode":108,"cosmosGeoPoint":229,"geoPoint":233,"contacts":18},"Texas Tech University Health Sciences Center Amarillo","Amarillo","Texas","79106",{"type":110,"coordinates":230},[231,232],-101.8313,35.222,{"lat":232,"lon":231},{"facility":235,"status":103,"city":236,"state":18,"zip":237,"country":238,"countryCode":239,"cosmosGeoPoint":240,"geoPoint":244,"contacts":18},"Monash Medical Centre Clayton","Clayton","3168","Australia","AU",{"type":110,"coordinates":241},[242,243],145.11667,-37.91667,{"lat":243,"lon":242},{"facility":246,"status":103,"city":247,"state":18,"zip":248,"country":238,"countryCode":239,"cosmosGeoPoint":249,"geoPoint":253,"contacts":18},"The Royal Children's Hospital (RCH)","Parkville","3052",{"type":110,"coordinates":250},[251,252],144.95,-37.78333,{"lat":252,"lon":251},{"facility":255,"status":103,"city":256,"state":18,"zip":257,"country":238,"countryCode":239,"cosmosGeoPoint":258,"geoPoint":262,"contacts":18},"Children's Hospital Westmead Centre for Kidney Research","Westmead","2145",{"type":110,"coordinates":259},[260,261],150.98768,-33.80383,{"lat":261,"lon":260},{"facility":264,"status":103,"city":265,"state":18,"zip":266,"country":267,"countryCode":268,"cosmosGeoPoint":269,"geoPoint":273,"contacts":274},"Universitair Ziekenhuis Gent","Ghent","9000","Belgium","BE",{"type":110,"coordinates":270},[271,272],3.71667,51.05,{"lat":272,"lon":271},[275],{"name":276,"role":97,"phone":18,"phoneExt":18,"email":18},"Central Contract",{"facility":278,"status":103,"city":279,"state":18,"zip":280,"country":267,"countryCode":268,"cosmosGeoPoint":281,"geoPoint":285,"contacts":18},"UZ Leuven","Leuven","3000",{"type":110,"coordinates":282},[283,284],4.70093,50.87959,{"lat":284,"lon":283},{"facility":287,"status":186,"city":288,"state":18,"zip":289,"country":290,"countryCode":291,"cosmosGeoPoint":292,"geoPoint":296,"contacts":18},"Helsingin Yliopistollinen Keskussairaala Uusi Lastensairaala","Helsinki","00290","Finland","FI",{"type":110,"coordinates":293},[294,295],24.93545,60.16952,{"lat":295,"lon":294},{"facility":298,"status":103,"city":299,"state":18,"zip":300,"country":301,"countryCode":302,"cosmosGeoPoint":303,"geoPoint":307,"contacts":308},"CHRU Montpellier - Arnaud de Villeneuve","Montpellier","34090","France","FR",{"type":110,"coordinates":304},[305,306],3.87635,43.61093,{"lat":306,"lon":305},[309],{"name":310,"role":97,"phone":18,"phoneExt":18,"email":18},"Central Contact",{"facility":312,"status":103,"city":313,"state":18,"zip":314,"country":301,"countryCode":302,"cosmosGeoPoint":315,"geoPoint":319,"contacts":320},"Assistance Publique-Hopitaux de Paris Robert-Debre","Paris","75019",{"type":110,"coordinates":316},[317,318],2.3488,48.85341,{"lat":318,"lon":317},[321],{"name":310,"role":97,"phone":18,"phoneExt":18,"email":18},{"facility":323,"status":103,"city":324,"state":18,"zip":325,"country":301,"countryCode":302,"cosmosGeoPoint":326,"geoPoint":330,"contacts":18},"Hôpital des Enfants - Toulouse","Toulouse","31300",{"type":110,"coordinates":327},[328,329],1.44367,43.60426,{"lat":329,"lon":328},{"facility":332,"status":103,"city":333,"state":333,"zip":18,"country":334,"countryCode":335,"cosmosGeoPoint":336,"geoPoint":340,"contacts":341},"Ippokratio Thessaloniki General Hospital","Thessaloniki","Greece","GR",{"type":110,"coordinates":337},[338,339],22.93493,40.64072,{"lat":339,"lon":338},[342],{"name":276,"role":97,"phone":18,"phoneExt":18,"email":18},{"facility":344,"status":103,"city":345,"state":18,"zip":18,"country":334,"countryCode":335,"cosmosGeoPoint":346,"geoPoint":350,"contacts":351},"Pan and Aglaia Kyriakou Children's Hospital","Athens",{"type":110,"coordinates":347},[348,349],23.72784,37.98376,{"lat":349,"lon":348},[352],{"name":310,"role":97,"phone":18,"phoneExt":18,"email":18},{"facility":354,"status":103,"city":355,"state":18,"zip":356,"country":357,"countryCode":358,"cosmosGeoPoint":359,"geoPoint":363,"contacts":18},"Shaare Zedek Medical Center","Jerusalem","9103102","Israel","IL",{"type":110,"coordinates":360},[361,362],35.21633,31.76904,{"lat":362,"lon":361},{"facility":365,"status":103,"city":366,"state":18,"zip":367,"country":357,"countryCode":358,"cosmosGeoPoint":18,"geoPoint":18,"contacts":18},"Schneider Children's Medical Center of Israel","Petach Tikvah","4920235",{"facility":369,"status":103,"city":370,"state":18,"zip":371,"country":372,"countryCode":373,"cosmosGeoPoint":374,"geoPoint":378,"contacts":18},"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","Milan","20122","Italy","IT",{"type":110,"coordinates":375},[376,377],9.18951,45.46427,{"lat":377,"lon":376},{"facility":380,"status":103,"city":381,"state":18,"zip":382,"country":372,"countryCode":373,"cosmosGeoPoint":383,"geoPoint":387,"contacts":18},"IRCCS Ospedale Pediatrico Bambino Gesù","Rome","00165",{"type":110,"coordinates":384},[385,386],12.51133,41.89193,{"lat":386,"lon":385},{"facility":389,"status":103,"city":390,"state":18,"zip":391,"country":392,"countryCode":393,"cosmosGeoPoint":394,"geoPoint":398,"contacts":18},"Helse Bergen HF Haukeland Universitetssjukehus","Bergen","5009","Norway","NO",{"type":110,"coordinates":395},[396,397],5.32415,60.39299,{"lat":397,"lon":396},{"facility":400,"status":186,"city":401,"state":18,"zip":402,"country":403,"countryCode":404,"cosmosGeoPoint":405,"geoPoint":409,"contacts":18},"Uniwersytecki Szpital Kliniczny we Wrocławiu","Wroclaw","50-369","Poland","PL",{"type":110,"coordinates":406},[407,408],17.03006,51.10286,{"lat":408,"lon":407},{"facility":411,"status":103,"city":412,"state":18,"zip":413,"country":414,"countryCode":415,"cosmosGeoPoint":416,"geoPoint":420,"contacts":18},"Unidade Local de Saude de Santo Antonio, E.P.E.","Porto","4050-342","Portugal","PT",{"type":110,"coordinates":417},[418,419],-8.61097,41.1485,{"lat":419,"lon":418},{"facility":422,"status":186,"city":423,"state":18,"zip":18,"country":424,"countryCode":425,"cosmosGeoPoint":426,"geoPoint":430,"contacts":18},"Sidra Medicine","Doha","Qatar","QA",{"type":110,"coordinates":427},[428,429],51.53096,25.28545,{"lat":429,"lon":428},{"facility":432,"status":103,"city":433,"state":18,"zip":434,"country":435,"countryCode":436,"cosmosGeoPoint":437,"geoPoint":441,"contacts":18},"Spitalul Clinic de Urgenta pentru Copii Louis Turcanu Timisoara","Timișoara","300011","Romania","RO",{"type":110,"coordinates":438},[439,440],21.22571,45.75372,{"lat":440,"lon":439},{"facility":443,"status":103,"city":444,"state":18,"zip":445,"country":446,"countryCode":447,"cosmosGeoPoint":448,"geoPoint":452,"contacts":18},"King Saud University","Riyadh","11451","Saudi Arabia","SA",{"type":110,"coordinates":449},[450,451],46.72185,24.68773,{"lat":451,"lon":450},{"facility":454,"status":103,"city":444,"state":18,"zip":455,"country":446,"countryCode":447,"cosmosGeoPoint":456,"geoPoint":458,"contacts":18},"King Faisal Specialist Hospital & Research Centre","12713",{"type":110,"coordinates":457},[450,451],{"lat":451,"lon":450},{"facility":460,"status":103,"city":444,"state":18,"zip":461,"country":446,"countryCode":447,"cosmosGeoPoint":462,"geoPoint":464,"contacts":18},"King Abdulaziz Medical City","14611",{"type":110,"coordinates":463},[450,451],{"lat":451,"lon":450},{"facility":466,"status":103,"city":467,"state":18,"zip":18,"country":468,"countryCode":469,"cosmosGeoPoint":470,"geoPoint":474,"contacts":18},"Al Jalila Children's Hospital","Dubai","United Arab Emirates","AE",{"type":110,"coordinates":471},[472,473],55.30927,25.07725,{"lat":473,"lon":472},{"type":476,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100498175","phase-2-patiromer-for-treatment-of-hyperkalaemia-in-children-under-12-years-of-age-100498175",false,"NCT05766839","Patiromer for Treatment of Hyperkalaemia in Children Under 12 Years of Age","A 2-Part, Open-Label, Phase 2, Multiple Dose Study to Evaluate the Pharmacodynamic Effects, Safety, and Tolerability of Patiromer in Children Under 12 Years of Age With Hyperkalaemia (EMERALD2)","Inclusion Criteria:\n\n* Paediatric participants (\\\u003C12 years of age) with hyperkalaemia at screening.\n* Participant's age should not reach 12 years during the 28 days of the pharmacodynamic\u002Fdose-ranging period.\n* Participant is able to receive regular external feeding and medication, including via tubes, i.e., percutaneous endoscopic gastrostomy (PEG) or entero-gastric feeding tube.\n* At screening\u002Fbaseline, the results from 2 separate and consecutive potassium assessments using the same measurement method (whole blood, plasma, or serum) need to be above the age-appropriate upper limit of normal (ULN).\n* If taking any renin-angiotensin aldosterone system inhibitors (RAASi), beta blockers, fludrocortisone, or diuretic medications, must be on a stable dose for at least 14 days prior to screening.\n* Parent(s) or legally authorised representative(s) or another appropriate person delegated by the legally authorised representatives must be available to help the study-site personnel ensure follow-up; accompany the participant to the study site on each assessment day; accurately and reliably dispense investigational product as directed.\n* Females of childbearing potential must be non-lactating, must have a negative pregnancy test at screening, and must have used an effective, acceptable form of contraception (e.g., abstinence) for at least 1 month before patiromer administration. Females of childbearing potential must agree to continue using contraception throughout the study and for 1 month after the last dose of patiromer.\n* If undergoing peritoneal dialysis, participants must be on a stable treatment plan for a minimum of 4 weeks prior to screening, or at least 8 weeks prior to screening if newly initiated on peritoneal dialysis.\n\nExclusion Criteria:\n\n* Preterm birth infants with \\\u003C37 weeks of gestation cannot be included in Cohort 3.\n* Participants who due to their general condition, e.g., anaemia or low body weight, are not suitable to have blood volume withdrawn.\n* Any of the following renal conditions: maintenance haemodialysis, renal artery stenosis, and acute kidney injury (defined by 2012 Kidney Disease Improving Global Outcomes) or a history of acute renal insufficiency in the past 3 months. Note: Chronic kidney disease (CKD) is not excluded.\n* A history of or current diagnosis of a severe gastrointestinal (GI) diagnosis or surgery that could affect GI transit of the drug (delayed gastric emptying), such as a severe swallowing disorder, severe gastroesophageal reflux, uncorrected pyloric stenosis, intussusception, any other intestinal obstruction (e.g., Hirschsprung disease, chronic intestinal pseudo-obstruction, clinically significant postsurgical abdominal adhesions) or any gut-shortening surgical procedure prior to screening. Pre-gastric above-mentioned pathologies may be disregarded in case of existence of a PEG or entero-gastric feeding tube, as the PEG or entero-gastric feeding tube will serve for nutrition and investigational product administration.\n* Active cancer, currently on cancer treatment, or history of cancer in the past 2 years (except for non-melanoma skin cancer).\n* Scheduled for kidney transplant procedure during the first 28 days after Day 1.\n* History of sudden infant death in a sibling (only for participants \\\u003C2 years of age at screening).\n* Use of the following medications if doses have not been stable for at least 14 days prior to screening or if doses are anticipated to change during the 4-week pharmacodynamic\u002F\n* Dose-ranging period: digoxin, bronchodilators, theophylline, heparins (including low molecular heparins), tacrolimus, mycophenolate mofetil, cyclosporine, trimethoprim, or cotrimoxazole.\n* Use of any investigational product for an unapproved indication within 30 days prior to screening or within 5 half-lives, whichever is longer.\n* Known hypersensitivity to patiromer or its components.\n* If the child is being breastfed:\n\n  1. There is suspicion of current alcohol or substance misuse\u002Fabuse in breastfeeding mother.\n  2. The breastfeeding mother is taking potassium supplements\n* Other protocol defined Inclusion\u002FExclusion criteria may apply.","ALL","0 Years","11 Years",{"count":488,"type":489},32,"ESTIMATED","INTERVENTIONAL",[492],"PHASE2","A study to evaluate the pharmacodynamic effects, safety, and tolerability of patiromer in children under 12 years of age with hyperkalaemia.",[495],"Hyperkalemia","2026-07-27",{"date":498,"type":499},"2026-07-28","ACTUAL",{"date":501,"type":499},"2025-04-06",{"date":503,"type":489},"2030-12-01",{"name":92,"class":6},37]