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Children's Clinical Research Facility - Pulmonology","Nottingham",{"type":95,"coordinates":2581},[2582,2583],-1.15047,52.9536,{"lat":2583,"lon":2582},{"type":2586,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100463298","phase-2-phase-23-adaptive-study-of-vx-147-in-adult-and-pediatric-participants-with-apol1-mediated-proteinuric-kidney-disease-100463298",false,"NCT05312879","Phase 2\u002F3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1-Mediated Proteinuric Kidney Disease","A Phase 2\u002F3 Adaptive, Double-blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of VX-147 in Adult and Pediatric Subjects With APOL1-mediated Proteinuric Kidney Disease","AMPLITUDE","Key Inclusion Criteria:\n\nPart A:\n\n* APOL1 genotype of G1\u002FG1, G2\u002FG2, or G1\u002FG2\n* Proteinuric kidney disease\n\nPart B:\n\n\\- Completion of Treatment Period in Part A and no permanent discontinuation of study drug.\n\nKey Exclusion Criteria:\n\nPart A:\n\n* Solid organ or bone marrow transplant\n* Uncontrolled hypertension\n* History of diabetes mellitus\n* Known underlying cause of kidney disease including but not limited to sickle cell disease\n\nPart B:\n\n* ESKD (End Stage Kidney Disease) as defined in the protocol.\n* Any lab abnormality that may pose a safety risk to the participant, as judged by the investigator.\n\nOther protocol defined Inclusion\u002FExclusion criteria will apply.","ALL","10 Years","65 Years",{"count":2599,"type":2600},466,"ESTIMATED","INTERVENTIONAL",[2603,2604],"PHASE2","PHASE3","The purpose of this study is to evaluate the efficacy, safety, tolerability, and pharmacokinetics (PK) of VX-147 in adult and pediatric participants with apolipoprotein L1 (APOL1)-mediated proteinuric kidney disease.",[2607],"Proteinuric Kidney Disease",[2609],"APOL1-mediated kidney disease (AMKD)","2026-08-03",{"date":2612,"type":2613},"2026-08-04","ACTUAL",{"date":2615,"type":2613},"2022-03-30",{"date":2617,"type":2600},"2030-05-07",{"name":5,"class":6},318]