[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652584":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":30,"centralContacts":35,"locations":41,"responsibleParty":260,"collaborators":30,"id":264,"slug":265,"hasResults":266,"nctId":267,"briefTitle":268,"officialTitle":269,"acronym":30,"eligibilityCriteria":270,"healthyVolunteers":266,"sex":271,"minAge":272,"maxAge":273,"enrollmentInfo":274,"targetDuration":30,"studyType":277,"phases":278,"briefSummary":280,"conditions":281,"keywords":30,"overallStatus":44,"whyStopped":30,"lastUpdateSubmitDate":283,"lastUpdatePostDateStruct":284,"startDateStruct":287,"completionDateStruct":289,"leadSponsor":291,"locationsCount":292},{"fullName":5,"class":6},"West China Hospital","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"JWK001 3×10^10 vg\u002Feye group","EXPERIMENTAL","Participants assigned to this arm will receive a single subretinal injection of JWK001 at a dose of 3 × 10\\^10 vector genomes (vg) in one study eye.",[13],"Drug: JWK001",{"label":15,"type":10,"description":16,"interventionNames":17},"JWK001 6×10^10 vg\u002Feye group","Participants assigned to this arm will receive a single subretinal injection of JWK001 at a dose of 6 × 10\\^10 vector genomes (vg) in one study eye.",[13],{"label":19,"type":20,"description":21,"interventionNames":22},"Aflibercept Active Comparator Group","ACTIVE_COMPARATOR","Participants assigned to this arm will receive aflibercept 2 mg by intravitreal injection at Weeks 2, 10, 18, 26, 34, 42, and 50 after randomization.",[23],"Drug: Aflibercept (2.0 mg)",[25,31],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DRUG","JWK001","JWK001 will be administered as a single subretinal injection in one study eye.",[9,15],null,{"type":26,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"Aflibercept (2.0 mg)","Aflibercept 2 mg will be administered by intravitreal injection at Weeks 2, 10, 18, 26, 34, 42, and 50 after randomization, for a total of seven injections.",[19],[36],{"name":37,"role":38,"phone":39,"phoneExt":30,"email":40},"Lu","CONTACT","86-0288542538","lufang@wchscu.cn",[42,61,71,85,99,113,127,141,155,168,182,195,209,219,232,246],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Beijing Hospital","RECRUITING","Beijing","Beijing Municipality","100000","China","CN",{"type":51,"coordinates":52},"Point",[53,54],116.39723,39.9075,{"lat":54,"lon":53},[57],{"name":58,"role":38,"phone":59,"phoneExt":30,"email":60},"Yu","86-010-85132160","genevector@jwksw.com",{"facility":62,"status":63,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":64,"geoPoint":66,"contacts":67},"Peking University People's Hospital","NOT_YET_RECRUITING",{"type":51,"coordinates":65},[53,54],{"lat":54,"lon":53},[68],{"name":69,"role":38,"phone":70,"phoneExt":30,"email":60},"Zhao","86-010-88326666",{"facility":72,"status":63,"city":73,"state":74,"zip":75,"country":48,"countryCode":49,"cosmosGeoPoint":76,"geoPoint":80,"contacts":81},"The Second Hospital of Jilin University","Jilin City","Changchun","130000",{"type":51,"coordinates":77},[78,79],126.5608,43.84652,{"lat":79,"lon":78},[82],{"name":83,"role":38,"phone":84,"phoneExt":30,"email":60},"Xiao","86-0431-81136888",{"facility":86,"status":63,"city":87,"state":88,"zip":89,"country":48,"countryCode":49,"cosmosGeoPoint":90,"geoPoint":94,"contacts":95},"Southwest Hospital, Army Medical University（Southwest Hospital）","Chongqing","Chongqing Municipality","400000",{"type":51,"coordinates":91},[92,93],106.55771,29.56026,{"lat":93,"lon":92},[96],{"name":97,"role":38,"phone":98,"phoneExt":30,"email":60},"Liu","86-023-68766241",{"facility":100,"status":63,"city":101,"state":102,"zip":103,"country":48,"countryCode":49,"cosmosGeoPoint":104,"geoPoint":108,"contacts":109},"Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong","Shantou","Guangdong","515000",{"type":51,"coordinates":105},[106,107],116.67876,23.35489,{"lat":107,"lon":106},[110],{"name":111,"role":38,"phone":112,"phoneExt":30,"email":60},"Chen","86-0754-88393527",{"facility":114,"status":63,"city":115,"state":116,"zip":117,"country":48,"countryCode":49,"cosmosGeoPoint":118,"geoPoint":122,"contacts":123},"Zhejiang Provincial People's Hospital","Zhejiang","Hangzhou","310000",{"type":51,"coordinates":119},[120,121],105.583,25.3238,{"lat":121,"lon":120},[124],{"name":125,"role":38,"phone":126,"phoneExt":30,"email":60},"Shen","86-0571-87666666",{"facility":128,"status":63,"city":129,"state":130,"zip":131,"country":48,"countryCode":49,"cosmosGeoPoint":132,"geoPoint":136,"contacts":137},"The Second Affiliated Hospital of Harbin Medical University","Harbin","Heilongjiang","150000",{"type":51,"coordinates":133},[134,135],126.65,45.75,{"lat":135,"lon":134},[138],{"name":139,"role":38,"phone":140,"phoneExt":30,"email":60},"Sun","028-0451-86605469",{"facility":142,"status":63,"city":143,"state":144,"zip":145,"country":48,"countryCode":49,"cosmosGeoPoint":146,"geoPoint":150,"contacts":151},"Henan Provincial People's Hospital","Zhengzhou","Henan","450000",{"type":51,"coordinates":147},[148,149],113.64861,34.75778,{"lat":149,"lon":148},[152],{"name":153,"role":38,"phone":154,"phoneExt":30,"email":60},"Song","86-0371-87160551",{"facility":156,"status":63,"city":157,"state":158,"zip":159,"country":48,"countryCode":49,"cosmosGeoPoint":160,"geoPoint":164,"contacts":165},"General Hospital of Central Theater Command, Chinese People's Liberation Army","Wuhan","Hubei","430000",{"type":51,"coordinates":161},[162,163],114.26667,30.58333,{"lat":163,"lon":162},[166],{"name":153,"role":38,"phone":167,"phoneExt":30,"email":60},"86-027-50773333",{"facility":169,"status":63,"city":170,"state":171,"zip":172,"country":48,"countryCode":49,"cosmosGeoPoint":173,"geoPoint":177,"contacts":178},"Jiangsu Provincial People's Hospital, The First Affiliated Hospital of Nanjing Medical University","Nanjing","Jiangsu","210000",{"type":51,"coordinates":174},[175,176],118.77778,32.06167,{"lat":176,"lon":175},[179],{"name":180,"role":38,"phone":181,"phoneExt":30,"email":60},"Yuan","86-025-83714511",{"facility":183,"status":63,"city":184,"state":185,"zip":186,"country":48,"countryCode":49,"cosmosGeoPoint":187,"geoPoint":191,"contacts":192},"Ruijin Hospital, Shanghai Jiao Tong University School of Medicine","Shanghai","Shanghai Municipality","200000",{"type":51,"coordinates":188},[189,190],121.45806,31.22222,{"lat":190,"lon":189},[193],{"name":125,"role":38,"phone":194,"phoneExt":30,"email":60},"86-021-64370045",{"facility":196,"status":63,"city":197,"state":198,"zip":199,"country":48,"countryCode":49,"cosmosGeoPoint":200,"geoPoint":204,"contacts":205},"Shanxi Bethune Hospital","Taiyuan","Shanxi","'030000",{"type":51,"coordinates":201},[202,203],112.56028,37.86944,{"lat":203,"lon":202},[206],{"name":207,"role":38,"phone":208,"phoneExt":30,"email":60},"Duan","86-0351-8368114",{"facility":210,"status":63,"city":197,"state":198,"zip":211,"country":48,"countryCode":49,"cosmosGeoPoint":212,"geoPoint":214,"contacts":215},"Shanxi Eye Hospital","030000",{"type":51,"coordinates":213},[202,203],{"lat":203,"lon":202},[216],{"name":217,"role":38,"phone":218,"phoneExt":30,"email":60},"Zhang","86-0351-8823009",{"facility":220,"status":44,"city":221,"state":222,"zip":223,"country":48,"countryCode":49,"cosmosGeoPoint":224,"geoPoint":228,"contacts":229},"West China Hospital, Sichuan University","Chengdu","Sichuan","610000",{"type":51,"coordinates":225},[226,227],104.06667,30.66667,{"lat":227,"lon":226},[230],{"name":37,"role":38,"phone":231,"phoneExt":30,"email":40},"86-02885422538",{"facility":233,"status":63,"city":234,"state":235,"zip":236,"country":48,"countryCode":49,"cosmosGeoPoint":237,"geoPoint":241,"contacts":242},"Tianjin Eye Hospital","Tianjin","Tianjin Municipality","300000",{"type":51,"coordinates":238},[239,240],117.17667,39.14222,{"lat":240,"lon":239},[243],{"name":244,"role":38,"phone":245,"phoneExt":30,"email":60},"Han","86-022-27313336",{"facility":247,"status":63,"city":248,"state":249,"zip":250,"country":48,"countryCode":49,"cosmosGeoPoint":251,"geoPoint":255,"contacts":256},"The First People's Hospital of Yunnan Province","Kunming","Yunnan","650000",{"type":51,"coordinates":252},[253,254],102.71833,25.03889,{"lat":254,"lon":253},[257],{"name":258,"role":38,"phone":259,"phoneExt":30,"email":60},"Ni","86-0871-63662173",{"type":261,"investigatorFullName":262,"investigatorTitle":263,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Fang Lu","Professor and Chief Physician","100652584","phase-2-phase-ii-study-of-subretinal-jwk001-for-neovascular-age-related-macular-degeneration-100652584",false,"NCT07776522","Phase II Study of Subretinal JWK001 for Neovascular Age-Related Macular Degeneration","A Phase II Study to Evaluate the Safety and Preliminary Efficacy of Subretinal Administration of JWK001 in Patients With Neovascular Age-Related Macular Degeneration (nAMD)","Inclusion Criteria:\n\n1. Written informed consent and ability to comply with the study protocol.\n2. Male or female, aged 50-85 years.\n3. Active subfoveal MNV secondary to nAMD requiring anti-VEGF treatment.\n4. Demonstrated clinical response to aflibercept treatments in the study eye confirmed by the Reading Center;\n5. Study-eye BCVA of 19-78 ETDRS letters.\n6. Pseudophakic study eye.\n\nExclusion Criteria:\n\n1. Any ocular condition other than nAMD that may affect vision, study assessments, treatment safety, or interpretation of results.\n2. Intraocular surgery or intraocular corticosteroid treatment within 4 weeks at screening.\n3. Any ocular condition making the study eye unsuitable for subretinal injection.\n4. Active ocular infection or inflammation, or a history of idiopathic or autoimmune uveitis.\n5. Monocular status or non-study-eye BCVA \\\u003C19 ETDRS letters.\n6. Clinically significant systemic disease or infection, malignancy, prohibited concomitant treatment, prior gene therapy, or recent participation in another clinical trial.\n7. Any other condition considered by the investigator to make the subject unsuitable for participation.","ALL","50 Years","85 Years",{"count":275,"type":276},50,"ESTIMATED","INTERVENTIONAL",[279],"PHASE2","This is a Phase II, randomized, open-label, active-controlled study designed to evaluate the preliminary efficacy and safety of a single subretinal administration of JWK001 at different dose levels in patients with neovascular age-related macular degeneration.",[282],"Neovascular Age-Related Macular Degeneration (nAMD) Wet AMD","2026-08-17",{"date":285,"type":286},"2026-08-20","ACTUAL",{"date":288,"type":276},"2026-08-31",{"date":290,"type":276},"2032-01-14",{"name":5,"class":6},16]