[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636050":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":29,"centralContacts":34,"locations":29,"responsibleParty":40,"collaborators":29,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":46,"sex":52,"minAge":53,"maxAge":29,"enrollmentInfo":54,"targetDuration":29,"studyType":57,"phases":58,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":71,"whyStopped":29,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":29},{"fullName":5,"class":6},"Hospital Universitario Getafe","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Conventional Electrical Cardioversion","ACTIVE_COMPARATOR","Conventional ECV with single pad configurataion in antero-lateral or antero-posterior location. Energy deliver: 200J",[13],"Procedure: Conventional Electrical Cardioversion",{"label":15,"type":16,"description":17,"interventionNames":18},"Dual-Shock 400J","EXPERIMENTAL","ECV with dual shock technique. Double pad configuration with electrodes both in antero-lateral and antero-posterior location. Total energy deliver: 400J.",[19],"Procedure: Dual-shock Electrical Cardioversion",{"label":21,"type":16,"description":22,"interventionNames":23},"Dual-Shock 200J","ECV with dual shock technique. Double pad configuration with electrodes both in antero-lateral and antero-posterior location. Total energy deliver: 200J.",[19],[25,30],{"type":26,"name":9,"description":27,"armGroupLabels":28,"otherNames":29},"PROCEDURE","Defibrillation pads will be placed in the anteroposterior or anterolateral position. An initial biphasic shock of 200 J will be delivered. If sinus rhythm is not restored, a second dual shock of 400 J (crossover) will be administered.\n\nThe procedures will be performed in the designated area for such procedures at each center, under deep sedation in accordance with each center's standard protocols. The choice of medication used for sedation will be at the investigator's discretion. All shocks will be delivered using biphasic energy and ECG-synchronized.",[9],null,{"type":26,"name":31,"description":32,"armGroupLabels":33,"otherNames":29},"Dual-shock Electrical Cardioversion","Two pairs of defibrillation pads connected to two different defibrillators will be used. One pair of pads will be placed in the anterolateral position and the second pair in the anteroposterior position. Both defibrillators will be programmed to deliver a biphasic shock of 100 J each (200 J group) or 200 J each (400 J group) simultaneously. The maximum number of CVE attempts per patient will be 3.\n\nThe procedures will be performed in the designated area for such procedures at each center, under deep sedation in accordance with each center's standard protocols. The choice of medication used for sedation will be at the investigator's discretion. All shocks will be delivered using biphasic energy and synchronized with the QRS complex.",[21,15],[35],{"name":36,"role":37,"phone":38,"phoneExt":29,"email":39},"Martín Negreira-Caamaño, MD, PhD","CONTACT","+34 916839360","martin.negcam@gmail.com",{"type":41,"investigatorFullName":42,"investigatorTitle":43,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"SPONSOR_INVESTIGATOR","Martín Negreira Caamaño, MD, PhD","Principal Investigator and Sponsor.","100636050","phase-2-restoring-sinus-rhythm-using-dual-shock-technique-in-patients-with-atrial-fibrillation-100636050",false,"NCT07560644","Restoring Sinus Rhythm Using Dual-Shock Technique in Patients With Atrial Fibrillation","Restoring Sinus Rhythm Using DUAL-electrical SHOCK Technique: the DUAL-SHOCK Trial","DUAL-SHOCK","Inclusion Criteria:\n\n* Diagnosis of persistent AF.\n* Effective anticoagulation for at least 3 weeks prior to the procedure or exclusion of intra-atrial thrombus by transesophageal echocardiography within the last 24 hours.\n* Informed consent obtained.\n\nExclusion Criteria:\n\n* Long-standing persistent atrial fibrillation (more than 1 year of uninterrupted AF rhythm).\n* Emergency indication (hemodynamic instability).\n* Cardiac defibrillation following catheter ablation procedures. Cardiac defibrillation performed during the same procedure will be permitted if it is carried out prior to ablation.\n* Pregnancy.\n* Age \\\u003C18 years or legal incapacity.","ALL","18 Years",{"count":55,"type":56},177,"ESTIMATED","INTERVENTIONAL",[59,60],"PHASE2","PHASE3","The goal of this clinical trial is to assess the efficacy and acute safety of the dual electrical cardioversion (ECV) technique compared with the conventional ECV in patients with persistent atrial fibrillation. The main question it aims to answer are:\n\n* Is dual ECV more effective than conventional ECV to achieve sinus rhythm restoration?\n* Is dual ECV safe compared with conventional ECV?\n* Which are the main factors associated with cardioversion success?\n\nResearchers will compare a dual ECV technique with 400J with dual ECV with 200J and conventional ECV.\n\nParticipants will be randomized to one ECV configuration. The primary efficacy endpoint will be considered the percentage of patients with successful cardioversion with the first shock. The coprimary safety endpoint will be the occurrence of adverse events during ECV.",[63,64],"Atrial Fibrillation (AF)","Atrial Fibrillation",[66,67,68,69,70],"Atrial fibrillation","Persistant atrial fibrillation","Electrical Cardioversion","Dual-Shock","Sinus Rhythm","NOT_YET_RECRUITING","2026-07-25",{"date":74,"type":75},"2026-07-28","ACTUAL",{"date":77,"type":56},"2026-08-01",{"date":79,"type":56},"2028-02-27",{"name":42,"class":6}]