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The Villages \u002FID# 282376","The Villages","32162",{"type":117,"coordinates":262},[263,264],-81.95994,28.93408,{"lat":264,"lon":263},{"facility":267,"status":110,"city":268,"state":190,"zip":269,"country":114,"countryCode":115,"cosmosGeoPoint":270,"geoPoint":274,"contacts":48},"Metabolic Research Institute \u002FID# 282350","West Palm Beach","33401",{"type":117,"coordinates":271},[272,273],-80.05337,26.71534,{"lat":273,"lon":272},{"facility":276,"status":110,"city":277,"state":190,"zip":278,"country":114,"countryCode":115,"cosmosGeoPoint":279,"geoPoint":283,"contacts":48},"Encore Medical Research - Weston \u002FID# 282044","Weston","33331",{"type":117,"coordinates":280},[281,282],-80.39977,26.10037,{"lat":282,"lon":281},{"facility":285,"status":110,"city":286,"state":287,"zip":288,"country":114,"countryCode":115,"cosmosGeoPoint":289,"geoPoint":293,"contacts":48},"Elite Clinical Trials - Blackfoot \u002FID# 282042","Blackfoot","Idaho","83221",{"type":117,"coordinates":290},[291,292],-112.34498,43.19047,{"lat":292,"lon":291},{"facility":295,"status":110,"city":296,"state":297,"zip":298,"country":114,"countryCode":115,"cosmosGeoPoint":299,"geoPoint":303,"contacts":48},"Great Lakes Clinical Trials - 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Morehead city \u002FID# 283264","Morehead City","28557",{"type":117,"coordinates":358},[359,360],-76.72604,34.72294,{"lat":360,"lon":359},{"facility":363,"status":110,"city":364,"state":337,"zip":365,"country":114,"countryCode":115,"cosmosGeoPoint":366,"geoPoint":370,"contacts":48},"Lucas Research - New Bern \u002FID# 282747","New Bern","28562",{"type":117,"coordinates":367},[368,369],-77.04411,35.10849,{"lat":369,"lon":368},{"facility":372,"status":110,"city":373,"state":337,"zip":374,"country":114,"countryCode":115,"cosmosGeoPoint":375,"geoPoint":379,"contacts":48},"Accellacare - Tradd Court - Wilmington \u002FID# 282200","Wilmington","28401",{"type":117,"coordinates":376},[377,378],-77.94604,34.23556,{"lat":378,"lon":377},{"facility":381,"status":110,"city":382,"state":383,"zip":384,"country":114,"countryCode":115,"cosmosGeoPoint":385,"geoPoint":389,"contacts":48},"Lillestol Research LLC \u002FID# 281978","Fargo","North Dakota","58104",{"type":117,"coordinates":386},[387,388],-96.7898,46.87719,{"lat":388,"lon":387},{"facility":391,"status":110,"city":392,"state":393,"zip":394,"country":114,"countryCode":115,"cosmosGeoPoint":395,"geoPoint":399,"contacts":48},"CTI Clinical Research Center \u002FID# 282043","Cincinnati","Ohio","45212-3784",{"type":117,"coordinates":396},[397,398],-84.51439,39.12711,{"lat":398,"lon":397},{"facility":401,"status":110,"city":402,"state":403,"zip":404,"country":114,"countryCode":115,"cosmosGeoPoint":405,"geoPoint":409,"contacts":48},"Holston Medical Group - Bristol \u002FID# 282045","Bristol","Tennessee","37620",{"type":117,"coordinates":406},[407,408],-82.18874,36.59511,{"lat":408,"lon":407},{"facility":411,"status":110,"city":412,"state":403,"zip":413,"country":114,"countryCode":115,"cosmosGeoPoint":414,"geoPoint":418,"contacts":48},"New Phase Research & Development \u002FID# 282131","Knoxville","37909",{"type":117,"coordinates":415},[416,417],-83.92074,35.96064,{"lat":417,"lon":416},{"facility":420,"status":110,"city":412,"state":403,"zip":421,"country":114,"countryCode":115,"cosmosGeoPoint":422,"geoPoint":424,"contacts":48},"Summit Medical Group- Halls Family Physicians \u002FID# 282435","37938",{"type":117,"coordinates":423},[416,417],{"lat":417,"lon":416},{"facility":426,"status":110,"city":427,"state":403,"zip":428,"country":114,"countryCode":115,"cosmosGeoPoint":429,"geoPoint":433,"contacts":48},"Clinical Research Associates - Nashville \u002FID# 282161","Nashville","37203",{"type":117,"coordinates":430},[431,432],-86.78444,36.16589,{"lat":432,"lon":431},{"facility":435,"status":110,"city":436,"state":437,"zip":438,"country":114,"countryCode":115,"cosmosGeoPoint":439,"geoPoint":443,"contacts":48},"Amarillo Medical Specialists \u002FID# 282380","Amarillo","Texas","79124",{"type":117,"coordinates":440},[441,442],-101.8313,35.222,{"lat":442,"lon":441},{"facility":445,"status":110,"city":446,"state":437,"zip":447,"country":114,"countryCode":115,"cosmosGeoPoint":448,"geoPoint":452,"contacts":48},"Velocity Clinical Research - Dallas \u002FID# 282734","Dallas","75230",{"type":117,"coordinates":449},[450,451],-96.80667,32.78306,{"lat":451,"lon":450},{"facility":454,"status":110,"city":455,"state":437,"zip":456,"country":114,"countryCode":115,"cosmosGeoPoint":457,"geoPoint":461,"contacts":48},"PlanIt Research \u002FID# 282204","Houston","77079-2204",{"type":117,"coordinates":458},[459,460],-95.36327,29.76328,{"lat":460,"lon":459},{"facility":463,"status":110,"city":464,"state":437,"zip":465,"country":114,"countryCode":115,"cosmosGeoPoint":466,"geoPoint":470,"contacts":48},"Dcol Center For Clinical Research \u002FID# 281961","Longview","75605",{"type":117,"coordinates":467},[468,469],-94.74049,32.5007,{"lat":469,"lon":468},{"facility":472,"status":110,"city":473,"state":474,"zip":475,"country":114,"countryCode":115,"cosmosGeoPoint":476,"geoPoint":480,"contacts":48},"Washington Center For Weight Management And Research \u002FID# 282047","Arlington","Virginia","22206",{"type":117,"coordinates":477},[478,479],-77.10428,38.88101,{"lat":479,"lon":478},{"facility":482,"status":110,"city":483,"state":474,"zip":484,"country":114,"countryCode":115,"cosmosGeoPoint":485,"geoPoint":489,"contacts":48},"Sovah Health - Danville \u002FID# 282876","Danville","24541",{"type":117,"coordinates":486},[487,488],-79.39502,36.58597,{"lat":488,"lon":487},{"facility":491,"status":110,"city":492,"state":474,"zip":493,"country":114,"countryCode":115,"cosmosGeoPoint":494,"geoPoint":498,"contacts":48},"Health Research Of Hampton Roads \u002FID# 282014","Newport News","23606",{"type":117,"coordinates":495},[496,497],-76.42975,36.98038,{"lat":497,"lon":496},{"facility":500,"status":110,"city":501,"state":474,"zip":502,"country":114,"countryCode":115,"cosmosGeoPoint":503,"geoPoint":507,"contacts":48},"National Clinical Research \u002FID# 282007","Richmond","23294",{"type":117,"coordinates":504},[505,506],-77.46026,37.55376,{"lat":506,"lon":505},{"facility":509,"status":110,"city":510,"state":48,"zip":511,"country":512,"countryCode":513,"cosmosGeoPoint":514,"geoPoint":518,"contacts":48},"Isis Clinical Res. Ctr P.S.C. \u002FID# 282252","Guaynabo","00968","Puerto Rico","PR",{"type":117,"coordinates":515},[516,517],-66.111,18.35745,{"lat":517,"lon":516},{"facility":520,"status":110,"city":521,"state":48,"zip":522,"country":512,"countryCode":513,"cosmosGeoPoint":523,"geoPoint":527,"contacts":48},"Latin Clinical Trial Center - San Juan - Avenida Ponce De Leon \u002FID# 282248","San Juan","00909",{"type":117,"coordinates":524},[525,526],-66.10572,18.46633,{"lat":526,"lon":525},{"type":529,"investigatorFullName":48,"investigatorTitle":48,"investigatorAffiliation":48,"oldNameTitle":48,"oldOrganization":48},"SPONSOR","100650895","phase-2-safety-and-efficacy-of-abbv-295-in-adults-with-obesity-or-overweight-with-weight-related-comorbidities-100650895",false,"NCT07752979","Safety and Efficacy of ABBV-295 in Adults With Obesity or Overweight With Weight-Related Comorbidities","A Phase 2 Dose-Finding Study to Assess the Safety and Efficacy of ABBV-295 in Adults With Obesity or Overweight With Weight-Related Comorbidities","Inclusion Criteria:\n\n* BMI ≥ 30.0 kg\u002Fm2 at Screening (BMI is calculated as weight in kg divided by the square of height measured in meters) OR\n* BMI ≥ 27.0 to \\\u003C 30.0 kg\u002Fm2 at Screening (BMI is calculated as weight in kg divided by the square of height measured in meters) with at least one of the following weight-related comorbidities: hypertension, dyslipidemia, obstructive sleep apnea, cardiovascular disease, metabolic dysfunction-associated steatotic liver disease (MASLD).\n\nExclusion Criteria:\n\n* Self-reported change in body weight ≥ 5% within 3 months prior to Screening\n* Hemoglobin A1c (HbA1c) ≥ 6.5% (48 mmol\u002Fmol) at Screening\n* Fasting glucose ≥126 mg\u002FdL (7.0 mmol\u002FL) or random glucose test ≥ 200 mg\u002FdL (11.1 mmol\u002FL)\n* History of type 1 or type 2 diabetes mellitus\n* Treatment with any medication or product used for obesity or weight management within 180 days prior to Screening Unstable or severe cardiovascular disease (e.g., myocardial infarction, stroke, hospitalization for: unstable angina pectoris, transient ischemic attack, or heart failure) within 180 days prior to Screening.\n* The participant has a concurrent disease, condition, or is in a situation which, in the investigator's opinion, may put the participant at significant risk, may confound the study results, or may interfere significantly with the participant's participation in the study.","ALL","18 Years","75 Years",{"count":541,"type":542},360,"ESTIMATED","INTERVENTIONAL",[545],"PHASE2","Obesity is a condition where a person has excessive body fat, defined by a body mass index (BMI) of 30 kg\u002Fm2 or higher. The goal of this study is to evaluate the effect of various doses of ABBV-295 compared to placebo on reducing body weight at Week 32 in participants with obesity or overweight with weight-related comorbidities.\n\nABBV-295 is an investigational long-acting amylin analog being developed for chronic weight management. Participants are placed into multiple treatment groups with different dosing paradigms of ABBV-295 or placebo. Participants will not know which treatment they are receiving, and there is a chance of being assigned to placebo. Adults with obesity or overweight (as defined by BMI) with weight-related comorbidities will be enrolled. Approximately 360 participants will be enrolled in the study at approximately 70 sites in the United States and Puerto Rico.\n\nParticipants will receive subcutaneous (SC) injections of ABBV-295 solution for injection or matching placebo administered via pre-filled syringes for 52 weeks during the Double-Blind Period.\n\nThere may be higher treatment burden for participants in this trial compared to their standard of care due to study procedures. Participants will attend regular visits during the study at a hospital or clinic. The effects of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.",[548,549],"Obesity","Overweight",[548,549,92],"2026-09-16",{"date":553,"type":554},"2026-09-18","ACTUAL",{"date":556,"type":554},"2026-08-04",{"date":558,"type":542},"2028-03",{"name":5,"class":6},45]