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On stable and well-tolerated Hydroxyurea (HU) regimen for at least 30 days before Screening.\n* or\n* b. HU was discontinued or refused (eg, due to concern of side effects or lack of effect).\n\nExclusion Criteria:\n\n* Absolute neutrophil count less than (\\\u003C) 2.5 ×10\\^9 cells\u002FLitre at Screening or Baseline (Week 1 Day 1).\n* If on SCD preventive medication, dose is not stable in the 30 days before Screening.","ALL","18 Years",{"count":207,"type":208},63,"ESTIMATED","INTERVENTIONAL",[211],"PHASE2","This is a phase 2a, global, multicenter, randomized, double-blind, placebo-controlled study investigating the safety of anumigilimab administered subcutaneously (SC) at the maximum tolerated dose (MTD) in adult participants with SCD.\n\nThe primary aim of the study is to assess the safety of anumigilimab in participants with SCD. 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