[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100610775":3},{"organization":4,"outcomesModule":7,"designInfo":30,"detailedDescription":29,"studyPopulation":29,"armGroups":39,"interventions":51,"overallOfficials":61,"centralContacts":65,"locations":71,"responsibleParty":85,"collaborators":29,"id":88,"slug":89,"hasResults":90,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":29,"eligibilityCriteria":94,"healthyVolunteers":90,"sex":95,"minAge":96,"maxAge":97,"enrollmentInfo":98,"targetDuration":29,"studyType":101,"phases":102,"briefSummary":105,"conditions":106,"keywords":29,"overallStatus":107,"whyStopped":29,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},{"fullName":5,"class":6},"Mayo Clinic","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":16,"otherOutcomes":29},[9,13],{"measure":10,"description":11,"timeFrame":12},"Blood Pressure","Blood pressure is the force exerted by circulating blood on the walls of the arteries as it is pumped through the body. Blood pressure will be measured as a ratio of systolic\u002Fdiastolic (mmHg).","Baseline, 30 days",{"measure":14,"description":15,"timeFrame":12},"Heart Rate","Heart Rate is the number of contractions (beats) that the heart makes per minute. This will be measured in bpm (beats per minute)",[17,20,23,26],{"measure":18,"description":19,"timeFrame":12},"Baroreflex Sensitivity","Baroreflex sensitivity will be assessed using beat-by-beat blood pressure, heart rate, and Sympathetic nerve activity collected continuously for at least 5min. This will be measured in ms\u002FmmHg.",{"measure":21,"description":22,"timeFrame":12},"Sympathetic control","Sympathetic control will be measured by microneurography of peroneal or fibular nerve, reported as bursts of sympathetic activity per minute or normalized to 100 heart beats",{"measure":24,"description":25,"timeFrame":12},"Flow Mediated Dilation","Flow Mediated Dilation will be measured by ultrasonography of brachial artery, reported as an absolute change in arterial diameter from resting baseline",{"measure":27,"description":28,"timeFrame":12},"Aortic Wave Reflection","Aortic Wave Reflection will be measured via arterial tonometry, reported as aortic augmentation index",null,{"allocation":31,"interventionModel":32,"interventionModelDescription":29,"primaryPurpose":33,"observationalModel":29,"timePerspective":29,"maskingInfo":34},"RANDOMIZED","CROSSOVER","TREATMENT",{"masking":35,"maskingDescription":29,"whoMasked":36},"DOUBLE",[37,38],"PARTICIPANT","INVESTIGATOR",[40,47],{"label":41,"type":42,"description":43,"interventionNames":44},"Dronabinol Group","ACTIVE_COMPARATOR","Patients taking Dronabinol first and Placebo second",[45,46],"Drug: Dronabinol","Drug: Placebo",{"label":48,"type":42,"description":49,"interventionNames":50},"Placebo Group","Patients taking Placebo first and Dronabinol second",[45,46],[52,57],{"type":53,"name":54,"description":55,"armGroupLabels":56,"otherNames":29},"DRUG","Dronabinol","Patients will take one 10 mg dose of Dronabinol.",[41,48],{"type":53,"name":58,"description":59,"armGroupLabels":60,"otherNames":29},"Placebo","Patients will take one 10mg dose of a Placebo Pill.",[41,48],[62],{"name":63,"affiliation":5,"role":64},"Virend Somers","PRINCIPAL_INVESTIGATOR",[66],{"name":67,"role":68,"phone":69,"phoneExt":29,"email":70},"Nicholas Wozniak","CONTACT","507-255-8794","wozniak.nicholas@mayo.edu",[72],{"facility":73,"status":29,"city":74,"state":75,"zip":76,"country":77,"countryCode":78,"cosmosGeoPoint":79,"geoPoint":84,"contacts":29},"Mayo Clinic in Rochester","Rochester","Minnesota","55905","United States","US",{"type":80,"coordinates":81},"Point",[82,83],-92.4699,44.02163,{"lat":83,"lon":82},{"type":64,"investigatorFullName":86,"investigatorTitle":87,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"Virend Somers, MD, PhD","Principal Investigator","100610775","phase-2-synthetic-thc-and-blood-pressure-100610775",false,"NCT07231965","Synthetic THC And Blood Pressure","Effects Of Cannabis Products On Blood Pressure Control","Inclusion Criteria\n\n* Recreational occasional Cannabis use (Consuming THC less than 2 times a week)\n* 21 - 40 years of age\n* Biological male or female\n\nExclusion Criteria\n\n* BMI \\> 35 kg\u002Fm2\n* Diagnosed psychiatric disorders\n* Hypotension\n* History of seizures\n* History of substance abuse or recreational drug use or positive urine drug screen\n* History of uncontrolled disease including:\n\n  * Cardiovascular\n  * Pulmonary\n  * Gastrointestinal\n  * Pancreatic\n  * Hepatic\n  * Renal\n  * Hematological\n  * Endocrine (including Type I Diabetes)\n  * Neurological\n  * Urological\n  * Sleep disorders\n* Pregnant or breastfeeding\n* Use of certain antimicrobial, chemotherapeutic, anticoagulant, hypoglycemic, anti-inflammatory, psychotropic, and antihistamine drugs\n* Prescribed CYP2C9 and\u002For CYP3A4 inhibitors\n* History of shift work or rotating shifts within 1 month","ALL","21 Years","40 Years",{"count":99,"type":100},50,"ESTIMATED","INTERVENTIONAL",[103,104],"PHASE2","PHASE3","To investigate the effects of Dronabinol use on blood pressure and neurovascular physiology",[10],"NOT_YET_RECRUITING","2026-09-09",{"date":110,"type":111},"2026-09-11","ACTUAL",{"date":113,"type":100},"2026-10",{"date":115,"type":100},"2027-12",{"name":5,"class":6},1]