[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636125":3},{"organization":4,"outcomesModule":7,"designInfo":18,"detailedDescription":28,"studyPopulation":17,"armGroups":29,"interventions":41,"overallOfficials":17,"centralContacts":52,"locations":58,"responsibleParty":82,"collaborators":17,"id":84,"slug":85,"hasResults":86,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":17,"eligibilityCriteria":90,"healthyVolunteers":91,"sex":92,"minAge":93,"maxAge":94,"enrollmentInfo":95,"targetDuration":17,"studyType":98,"phases":99,"briefSummary":102,"conditions":103,"keywords":17,"overallStatus":105,"whyStopped":17,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":115},{"fullName":5,"class":6},"University of Alberta","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":17},[9],{"measure":10,"description":11,"timeFrame":12},"Changes in muscle mass","The primary outcome of the study is the change in muscle mass. It is hypothesized that participants consuming yeast protein will show an increase in appendicular lean mass similar to that observed with whey protein.","16 weeks",[14],{"measure":15,"description":16,"timeFrame":12},"Changes in muscle function, resting energy expenditure, inflammatory biomarkers, oxidative stress markers, gut microbiota, and metabolites","The secondary outcomes of the study include changes in muscle function, which will be assessed through one-repetition maximum (1RM) testing for both the bench press and leg press. Additionally, the investigators will evaluate resting energy expenditure, inflammatory biomarkers, specifically plasma cytokines, as well as oxidative stress markers such as glutathione, total antioxidant capacity, and protein carbonyl levels. The study will also investigate gut microbiota and metabolites. The investigators hypothesize that the secondary outcomes will show similar effects in participants taking yeast protein compared to those taking whey protein.",null,{"allocation":19,"interventionModel":20,"interventionModelDescription":17,"primaryPurpose":21,"observationalModel":17,"timePerspective":17,"maskingInfo":22},"RANDOMIZED","PARALLEL","BASIC_SCIENCE",{"masking":23,"maskingDescription":17,"whoMasked":24},"TRIPLE",[25,26,27],"PARTICIPANT","INVESTIGATOR","OUTCOMES_ASSESSOR","This is a double-blinded randomized clinical trial of a 16-week nutrition intervention with yeast and whey protein in 72 people (36 per group; 18 male and 18 female) between the ages of 18 and 35, recruited from the University of Alberta campus, Edmonton, Canada. Consenting participants will be randomly assigned to one of two groups: whey protein or yeast protein by the study coordinator, who will not collect study outcome measurements or analyze the data.\n\nThe goal of the trial is to determine if consumption of 40 g per day of yeast protein produces similar effects to 40 g supplementation with whey protein. It is anticipated that daily yeast protein consumption will show similar gains in muscle mass and improvement in immune function, increased diversity in gut microbiota, and amino acid-derived metabolites compared to whey protein.",[30,36],{"label":31,"type":32,"description":17,"interventionNames":33},"Whey Protein","ACTIVE_COMPARATOR",[34,35],"Other: Resistance Training Exercises","Dietary Supplement: Whey Protein",{"label":37,"type":38,"description":17,"interventionNames":39},"Yeast Protein","EXPERIMENTAL",[40,34],"Dietary Supplement: Yeast Protein",[42,46,50],{"type":43,"name":37,"description":44,"armGroupLabels":45,"otherNames":17},"DIETARY_SUPPLEMENT","60g of protein supplement (40g of protein). Oral administration, 30g during exercise and anytime after exercise, or 30g in the morning and evening if no exercise is performed for a period of 16 weeks.",[37],{"type":6,"name":47,"description":48,"armGroupLabels":49,"otherNames":17},"Resistance Training Exercises","Lower and upper body resistance training exercises 3 times a week for 16 weeks",[31,37],{"type":43,"name":31,"description":44,"armGroupLabels":51,"otherNames":17},[31],[53],{"name":54,"role":55,"phone":56,"phoneExt":17,"email":57},"Kashimbi Mbuta","CONTACT","(780) 492-6885","muslmass@ualberta.ca",[59],{"facility":60,"status":17,"city":61,"state":62,"zip":63,"country":64,"countryCode":65,"cosmosGeoPoint":66,"geoPoint":71,"contacts":72},"The University of Alberta North Campus","Edmonton","Alberta","T6G 2R3","Canada","CA",{"type":67,"coordinates":68},"Point",[69,70],-113.46871,53.55014,{"lat":70,"lon":69},[73,76,78,80],{"name":74,"role":55,"phone":56,"phoneExt":17,"email":75},"Jianping Wu, PhD","jwu3@ualberta.ca",{"name":74,"role":77,"phone":17,"phoneExt":17,"email":17},"PRINCIPAL_INVESTIGATOR",{"name":79,"role":77,"phone":17,"phoneExt":17,"email":17},"Vera Mazurak, PhD",{"name":81,"role":77,"phone":17,"phoneExt":17,"email":17},"Normand Bouleé, PhD",{"type":83,"investigatorFullName":17,"investigatorTitle":17,"investigatorAffiliation":17,"oldNameTitle":17,"oldOrganization":17},"SPONSOR","100636125","phase-2-yeast-protein-for-muscle-mass-100636125",false,"NCT07561619","Yeast Protein for Muscle Mass","Yeast Protein for Muscle Anabolism: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Participants must have the ability to read, understand, and sign an informed consent form and must be willing to comply with study treatment and follow-up.\n* Prior resistance training experience (defined as performing resistance exercises \\>1\u002Fweek for the past 3 months or longer) to enable them to reach a large training stimulus relatively quickly and to avoid the longer phase of neuromuscular adaptations\n* ≥18 years and \\\u003C35 years of age\n\nExclusion Criteria:\n\n* Diabetes, musculoskeletal disease, cancer, Crohn's disease, or any other acute or chronic condition that interferes (or the medication prescribed for those conditions) with muscle anabolism.\n* Diagnosed with or being treated for heart disease, stroke, high blood pressure 130\u002F80 mmHg or higher\n* Pain\u002Fdiscomfort\u002Fpressure in the chest during activities of daily living or physical activity\n* Pregnant or not on adequate contraception.\n* A known hypersensitivity\u002Fallergy to ingredients in the supplements.\n* Inflammatory bowel diseases\n* Enrolment in any other clinical protocol or investigational study that may interfere with study procedures\n* Taking antibiotics and monoamine oxidase inhibitor (MAOI) antidepressant therapy\n* Use of high-dose protein supplements or other workout supplements and not willing to go one week without the supplements before beginning the study\n* Liver and kidney disorders\n* Abnormal laboratory results (after the first study visit)",true,"ALL","18 Years","35 Years",{"count":96,"type":97},72,"ESTIMATED","INTERVENTIONAL",[100,101],"PHASE2","PHASE3","Protein supplementation is said to be one of the cost-efficient and practical strategies to meet protein needs for growth and exercise, and can help maximize muscle gain from resistance exercise. It facilitates faster recovery from stress-induced tissue damage and enhances performance output. Protein sources derived from animal products are generally recognized as the highest quality protein. However, altering the protein composition of a protein source can improve the protein quality. The yeast protein supplement the investigators will use in this study has a similar amino acid composition to whey protein, which is derived from an animal product, but it is produced more sustainably. The study aims to compare the effects of yeast and whey protein on muscle mass over 16 weeks.",[104],"Healthy Adult Participants","NOT_YET_RECRUITING","2026-10-02",{"date":108,"type":109},"2026-10-07","ACTUAL",{"date":111,"type":97},"2026-11",{"date":113,"type":97},"2029-07",{"name":5,"class":6},1]