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258343",{"facility":2429,"status":68,"city":2430,"state":2431,"zip":2432,"country":2418,"countryCode":2419,"cosmosGeoPoint":2433,"geoPoint":2437,"contacts":2438},"Royal Free Hospital ( Site 2601)","London","London, City of","NW3 2QG",{"type":75,"coordinates":2434},[2435,2436],-0.12574,51.50853,{"lat":2436,"lon":2435},[2439],{"name":82,"role":61,"phone":2440,"phoneExt":63,"email":63},"+44207794 050031911",{"facility":2442,"status":68,"city":69,"state":63,"zip":2443,"country":2418,"countryCode":2419,"cosmosGeoPoint":2444,"geoPoint":2448,"contacts":2449},"Queen Elizabeth Hospital Birmingham ( Site 2612)","B15 2TH",{"type":75,"coordinates":2445},[2446,2447],-1.89983,52.48142,{"lat":2447,"lon":2446},[2450],{"name":82,"role":61,"phone":2451,"phoneExt":63,"email":63},"+441213712000",{"facility":2453,"status":68,"city":2454,"state":63,"zip":2455,"country":2418,"countryCode":2419,"cosmosGeoPoint":2456,"geoPoint":2460,"contacts":2461},"Leicester Royal Infirmary ( Site 2610)","Leicester","LE1 5WW",{"type":75,"coordinates":2457},[2458,2459],-1.13169,52.6386,{"lat":2459,"lon":2458},[2462],{"name":82,"role":61,"phone":2463,"phoneExt":63,"email":63},"+4401162587605",{"type":2465,"investigatorFullName":63,"investigatorTitle":63,"investigatorAffiliation":63,"oldNameTitle":63,"oldOrganization":63},"SPONSOR","100607568","phase-3-a-clinical-study-of-calderasib-mk-1084-and-other-treatments-for-participants-with-non-small-cell-lung-cancer-mk-1084-007kandlelit-007-100607568",false,"NCT07190248","A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007\u002FKANDLELIT-007)","A Phase 3, Randomized, Open-label, Multicenter Clinical Study to Evaluate the Safety and Efficacy of MK-1084 in Combination With Subcutaneous Pembrolizumab and Berahyaluronidase Alfa (MK-3475A) Versus MK-3475A in Combination With Pemetrexed\u002FPlatinum (Carboplatin or Cisplatin) Chemotherapy as First-line Treatment of Participants With KRAS G12C-Mutant, Advanced or Metastatic Nonsquamous NSCLC (KANDLELIT-007)","Inclusion Criteria:\n\nThe main inclusion criteria include but are not limited to the following:\n\n* Has nonsquamous NSCLC (Stage IIIB, Stage IIIC) not eligible for curative resection or chemoradiation or Stage IV: M1a, M1b, or M1c\n* If human immunodeficiency virus (HIV) positive, must have well controlled HIV on antiretroviral therapy (ART)\n\nExclusion Criteria:\n\nThe main exclusion criteria include but are not limited to the following:\n\n* Has diagnosis of small cell lung cancer or, for mixed tumors, presence of small cell elements\n* Has active inflammatory bowel disease requiring immunosuppressive medication or previous clear history of inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis, or chronic diarrhea)\n* Has uncontrolled, significant cardiovascular disease or cerebrovascular disease\n* Has a gastrointestinal disorder affecting absorption\n* Is HIV positive and has a history of Kaposi's sarcoma and\u002For Multicentric Castleman's Disease\n* Has received prior systemic anticancer therapy for their advanced or metastatic NSCLC\n* Has known additional malignancy that is progressing or has required active treatment within the past 3 years\n* Has known active central nervous system (CNS) metastases and\u002For carcinomatous meningitis\n* Has active autoimmune disease that has required systemic treatment in the past 2 years\n* History of (noninfectious) pneumonitis\u002Finterstitial lung disease that required steroids or has current pneumonitis\u002Finterstitial lung disease\n* Has active infection requiring systemic therapy except those specified by protocol\n* Has history of stem cell\u002Fsolid organ transplant\n* Has not adequately recovered from major surgery or has ongoing surgical complications","ALL","18 Years",{"count":2476,"type":2477},675,"ESTIMATED","INTERVENTIONAL",[2480],"PHASE3","Researchers want to learn if the study medicines calderasib and subcutaneous (SC) pembrolizumab can be used to treat non-small cell lung cancer (NSCLC) when given together. Calderasib is a targeted therapy for the KRAS G12C mutation.\n\nThe goal of this study is to learn if people who receive calderasib with SC pembrolizumab live longer without the cancer growing or spreading than in people who receive SC pembrolizumab with chemotherapy.",[2483],"Non-small Cell Lung Cancer","2026-08-20",{"date":2486,"type":2487},"2026-08-21","ACTUAL",{"date":2489,"type":2487},"2025-10-08",{"date":2491,"type":2477},"2032-08-06",{"name":5,"class":6},200]