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Leeds Teaching Hospitals Nhs Trust","Leeds","LS9 7TF",{"type":106,"coordinates":1645},[1646,1647],-1.54785,53.79648,{"lat":1647,"lon":1646},{"facility":1650,"status":99,"city":1651,"state":50,"zip":1652,"country":1615,"countryCode":1616,"cosmosGeoPoint":1653,"geoPoint":1657,"contacts":50},"Guy'S Hospital - Guy'S & St Thomas' Nhs Foundation Trust","London","SE1 9RT",{"type":106,"coordinates":1654},[1655,1656],-0.12574,51.50853,{"lat":1656,"lon":1655},{"facility":1659,"status":99,"city":1660,"state":50,"zip":1661,"country":1615,"countryCode":1616,"cosmosGeoPoint":1662,"geoPoint":1666,"contacts":50},"Northern Centre For Cancer Care - the Newcastle Upon Tyne Hospitals Nhs Foundation Trust","Newcastle upon Tyne","NE7 7DN",{"type":106,"coordinates":1663},[1664,1665],-1.61396,54.97328,{"lat":1665,"lon":1664},{"facility":1668,"status":99,"city":1669,"state":50,"zip":1670,"country":1615,"countryCode":1616,"cosmosGeoPoint":1671,"geoPoint":1675,"contacts":50},"Cancer and Haematology Centre-the Churchill Hospital-Oxford University Hospitals","Oxford","OX3 7LJ",{"type":106,"coordinates":1672},[1673,1674],-1.25596,51.75222,{"lat":1674,"lon":1673},{"facility":1677,"status":99,"city":1678,"state":50,"zip":1679,"country":1615,"countryCode":1616,"cosmosGeoPoint":1680,"geoPoint":1684,"contacts":50},"Royal Cornwall Hospital - Royal Cornwall Hospitals Nhs Trust","Penzance","TR18 2PF",{"type":106,"coordinates":1681},[1682,1683],-5.53715,50.11861,{"lat":1683,"lon":1682},{"type":1686,"investigatorFullName":50,"investigatorTitle":50,"investigatorAffiliation":50,"oldNameTitle":50,"oldOrganization":50},"SPONSOR","100643299","phase-3-a-phase-3-study-of-inca033989-versus-best-available-therapy-in-participants-with-essential-thrombocythemia-100643299",false,"NCT07623200","A Phase 3 Study of INCA033989 Versus Best Available Therapy in Participants With Essential Thrombocythemia","A Phase 3, Randomized, Open-Label Study of INCA033989 Versus Best Available Therapy in Participants With Essential Thrombocythemia and a CALR Mutation Previously Treated With Cytoreductive Therapy (EXCALIBUR-ET2)","EXCALIBUR-ET2","Inclusion Criteria:\n\n* Confirmed diagnosis of high-risk ET.\n* Presence of mutCALR.\n* Prior treatment with at least 1 cytoreductive therapy.\n\nExclusion Criteria:\n\n* Presence of any hematologic malignancy other than ET.\n* Major bleeding or thrombosis within the last 3 months prior to study enrollment.\n* Any prior allogenic or autologous stem-cell transplantation.\n* Unresolved toxicity ≥ Grade 2 from previous therapy except for stable chronic toxicities (Grade 2) not expected to resolve, such as stable Grade 2 peripheral neuropathy.\n* Prior nonhematologic malignancy except for the following: Malignancy treated with curative intent and with no evidence of active disease for more than 2 years before screening. Adequately treated carcinoma in situ without current evidence of disease.\n\nOther protocol-defined Inclusion\u002FExclusion Criteria apply.","ALL","18 Years",{"count":1698,"type":1699},426,"ESTIMATED","INTERVENTIONAL",[1702],"PHASE3","This study is being conducted to evaluate INCA033989 versus best available therapy in participants with essential thrombocythemia and a CALR mutation previously treated with cytoreductive therapy.",[1705],"Essential Thrombocythemia",[1707,1708],"calreticulin (CALR)","mutCALR","2026-10-06",{"date":1711,"type":1712},"2026-10-08","ACTUAL",{"date":1714,"type":1712},"2026-09-08",{"date":1716,"type":1699},"2030-11-01",{"name":5,"class":6},178]