[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100592642":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":37,"centralContacts":38,"locations":43,"responsibleParty":562,"collaborators":37,"id":564,"slug":565,"hasResults":566,"nctId":567,"briefTitle":568,"officialTitle":569,"acronym":570,"eligibilityCriteria":571,"healthyVolunteers":566,"sex":572,"minAge":573,"maxAge":37,"enrollmentInfo":574,"targetDuration":37,"studyType":577,"phases":578,"briefSummary":580,"conditions":581,"keywords":583,"overallStatus":46,"whyStopped":37,"lastUpdateSubmitDate":588,"lastUpdatePostDateStruct":589,"startDateStruct":592,"completionDateStruct":594,"leadSponsor":596,"locationsCount":597},{"fullName":5,"class":6},"Kodiak Sciences Inc","INDUSTRY",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"KSI-101 5 mg","EXPERIMENTAL","Intravitreal injection of KSI-101 5 mg once every 4 weeks for 6 monthly doses followed by individualized dosing",[13],"Drug: KSI-101",{"label":15,"type":10,"description":16,"interventionNames":17},"KSI-101 10 mg","Intravitreal injection of KSI-101 10 mg once every 4 weeks for 6 monthly doses followed by individualized dosing",[13],{"label":19,"type":20,"description":21,"interventionNames":22},"Sham","SHAM_COMPARATOR","Sham injection once every 4 weeks for 6 monthly doses followed by individualized sham dosing",[23],"Other: Sham Comparator",[25,32],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DRUG","KSI-101","Intravitreal injection",[15,9],[31],"tabirafusp alfa",{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":37},"OTHER","Sham Comparator","Sham injections",[19],null,[39],{"name":5,"role":40,"phone":41,"phoneExt":37,"email":42},"CONTACT","(650) 281-0850","ClinicalTrials@kodiak.com",[44,58,67,77,86,95,104,113,123,132,140,146,155,166,172,182,191,200,210,219,228,238,248,253,263,273,283,293,303,313,322,332,341,351,360,370,380,389,399,408,418,428,434,444,453,459,468,477,486,495,504,513,522,532,541,551],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":37},"AZ Retina & Vitreous Consultants","RECRUITING","Phoenix","Arizona","85016","United States","US",{"type":53,"coordinates":54},"Point",[55,56],-112.07404,33.44838,{"lat":56,"lon":55},{"facility":59,"status":46,"city":60,"state":48,"zip":61,"country":50,"countryCode":51,"cosmosGeoPoint":62,"geoPoint":66,"contacts":37},"Research Network Arizona","Scottsdale","85255",{"type":53,"coordinates":63},[64,65],-111.89903,33.50921,{"lat":65,"lon":64},{"facility":68,"status":46,"city":69,"state":70,"zip":71,"country":50,"countryCode":51,"cosmosGeoPoint":72,"geoPoint":76,"contacts":37},"California Retina Consultants (Bakersfield)","Bakersfield","California","93309",{"type":53,"coordinates":73},[74,75],-119.01871,35.37329,{"lat":75,"lon":74},{"facility":78,"status":46,"city":79,"state":70,"zip":80,"country":50,"countryCode":51,"cosmosGeoPoint":81,"geoPoint":85,"contacts":37},"Global Research Management, Inc.","Glendale","91204",{"type":53,"coordinates":82},[83,84],-118.25508,34.14251,{"lat":84,"lon":83},{"facility":87,"status":46,"city":88,"state":70,"zip":89,"country":50,"countryCode":51,"cosmosGeoPoint":90,"geoPoint":94,"contacts":37},"UCSD\u002FJacobs Retina Center","La Jolla","92093",{"type":53,"coordinates":91},[92,93],-117.2742,32.84727,{"lat":93,"lon":92},{"facility":96,"status":46,"city":97,"state":70,"zip":98,"country":50,"countryCode":51,"cosmosGeoPoint":99,"geoPoint":103,"contacts":37},"UCLA Stein Eye Institute","Los Angeles","90095",{"type":53,"coordinates":100},[101,102],-118.24368,34.05223,{"lat":102,"lon":101},{"facility":105,"status":46,"city":106,"state":70,"zip":107,"country":50,"countryCode":51,"cosmosGeoPoint":108,"geoPoint":112,"contacts":37},"California Retina Consultants (Oxnard)","Oxnard","93036",{"type":53,"coordinates":109},[110,111],-119.17705,34.1975,{"lat":111,"lon":110},{"facility":114,"status":115,"city":116,"state":70,"zip":117,"country":50,"countryCode":51,"cosmosGeoPoint":118,"geoPoint":122,"contacts":37},"Stanford Byers Eye Institute","NOT_YET_RECRUITING","Palo Alto","94303",{"type":53,"coordinates":119},[120,121],-122.14302,37.44188,{"lat":121,"lon":120},{"facility":124,"status":46,"city":125,"state":70,"zip":126,"country":50,"countryCode":51,"cosmosGeoPoint":127,"geoPoint":131,"contacts":37},"California Eye Specialists Medical Group, Inc.","Pasadena","91107",{"type":53,"coordinates":128},[129,130],-118.14452,34.14778,{"lat":130,"lon":129},{"facility":124,"status":46,"city":133,"state":70,"zip":134,"country":50,"countryCode":51,"cosmosGeoPoint":135,"geoPoint":139,"contacts":37},"Redlands","92373",{"type":53,"coordinates":136},[137,138],-117.18254,34.05557,{"lat":138,"lon":137},{"facility":141,"status":46,"city":133,"state":70,"zip":142,"country":50,"countryCode":51,"cosmosGeoPoint":143,"geoPoint":145,"contacts":37},"Retina Consultants of Southern California","92374",{"type":53,"coordinates":144},[137,138],{"lat":138,"lon":137},{"facility":147,"status":46,"city":148,"state":70,"zip":149,"country":50,"countryCode":51,"cosmosGeoPoint":150,"geoPoint":154,"contacts":37},"Retinal Consultants Medical Group Inc","Sacramento","95841",{"type":53,"coordinates":151},[152,153],-121.4944,38.58157,{"lat":153,"lon":152},{"facility":156,"status":157,"city":158,"state":159,"zip":160,"country":50,"countryCode":51,"cosmosGeoPoint":161,"geoPoint":165,"contacts":37},"Retina Specialists of Colorado (RSC)","WITHDRAWN","Denver","Colorado","80222",{"type":53,"coordinates":162},[163,164],-104.9847,39.73915,{"lat":164,"lon":163},{"facility":167,"status":46,"city":158,"state":159,"zip":168,"country":50,"countryCode":51,"cosmosGeoPoint":169,"geoPoint":171,"contacts":37},"Rocky Mountain Uveitis","80246",{"type":53,"coordinates":170},[163,164],{"lat":164,"lon":163},{"facility":173,"status":46,"city":174,"state":175,"zip":176,"country":50,"countryCode":51,"cosmosGeoPoint":177,"geoPoint":181,"contacts":37},"Coastal Eye Surgeons","Greenwich","Connecticut","06830",{"type":53,"coordinates":178},[179,180],-73.62846,41.02649,{"lat":180,"lon":179},{"facility":183,"status":46,"city":184,"state":175,"zip":185,"country":50,"countryCode":51,"cosmosGeoPoint":186,"geoPoint":190,"contacts":37},"Retina Consultants, PC","Manchester","06042",{"type":53,"coordinates":187},[188,189],-72.52148,41.77593,{"lat":189,"lon":188},{"facility":192,"status":46,"city":193,"state":175,"zip":194,"country":50,"countryCode":51,"cosmosGeoPoint":195,"geoPoint":199,"contacts":37},"Retina Group of New England, PC","Waterford","06385",{"type":53,"coordinates":196},[197,198],-72.13597,41.3417,{"lat":198,"lon":197},{"facility":201,"status":115,"city":202,"state":203,"zip":204,"country":50,"countryCode":51,"cosmosGeoPoint":205,"geoPoint":209,"contacts":37},"Florida Eye Clinic","Altamonte Springs","Florida","32701",{"type":53,"coordinates":206},[207,208],-81.36562,28.66111,{"lat":208,"lon":207},{"facility":211,"status":46,"city":212,"state":203,"zip":213,"country":50,"countryCode":51,"cosmosGeoPoint":214,"geoPoint":218,"contacts":37},"Retina Group of Florida (Ft. Lauderdale)","Fort Lauderdale","33308",{"type":53,"coordinates":215},[216,217],-80.14338,26.12231,{"lat":217,"lon":216},{"facility":220,"status":46,"city":221,"state":203,"zip":222,"country":50,"countryCode":51,"cosmosGeoPoint":223,"geoPoint":227,"contacts":37},"Retina Vitreous Associates of Florida (St. Petersburg)","St. Petersburg","33711",{"type":53,"coordinates":224},[225,226],-82.67927,27.77086,{"lat":226,"lon":225},{"facility":229,"status":46,"city":230,"state":231,"zip":232,"country":50,"countryCode":51,"cosmosGeoPoint":233,"geoPoint":237,"contacts":37},"Retina Associates, LTD","Elmhurst","Illinois","60126",{"type":53,"coordinates":234},[235,236],-87.94034,41.89947,{"lat":236,"lon":235},{"facility":239,"status":46,"city":240,"state":241,"zip":242,"country":50,"countryCode":51,"cosmosGeoPoint":243,"geoPoint":247,"contacts":37},"Associated Vitreoretinal and Uveitis Consultants LLC","Carmel","Indiana","46032",{"type":53,"coordinates":244},[245,246],-86.11804,39.97837,{"lat":246,"lon":245},{"facility":249,"status":46,"city":240,"state":241,"zip":242,"country":50,"countryCode":51,"cosmosGeoPoint":250,"geoPoint":252,"contacts":37},"Midwest Eye Institute",{"type":53,"coordinates":251},[245,246],{"lat":246,"lon":245},{"facility":254,"status":46,"city":255,"state":256,"zip":257,"country":50,"countryCode":51,"cosmosGeoPoint":258,"geoPoint":262,"contacts":37},"Cumberland Valley Retina Consultants","Hagerstown","Maryland","21740",{"type":53,"coordinates":259},[260,261],-77.71999,39.64176,{"lat":261,"lon":260},{"facility":264,"status":46,"city":265,"state":266,"zip":267,"country":50,"countryCode":51,"cosmosGeoPoint":268,"geoPoint":272,"contacts":37},"Ophthalmic Consultants of Boston","Boston","Massachusetts","02114",{"type":53,"coordinates":269},[270,271],-71.05977,42.35843,{"lat":271,"lon":270},{"facility":274,"status":46,"city":275,"state":276,"zip":277,"country":50,"countryCode":51,"cosmosGeoPoint":278,"geoPoint":282,"contacts":37},"Retina Consultants of Minnesota","Saint Louis Park","Minnesota","55416",{"type":53,"coordinates":279},[280,281],-93.34801,44.9483,{"lat":281,"lon":280},{"facility":284,"status":46,"city":285,"state":286,"zip":287,"country":50,"countryCode":51,"cosmosGeoPoint":288,"geoPoint":292,"contacts":37},"The Retina Institute","St Louis","Missouri","63128",{"type":53,"coordinates":289},[290,291],-90.19789,38.62727,{"lat":291,"lon":290},{"facility":294,"status":46,"city":295,"state":296,"zip":297,"country":50,"countryCode":51,"cosmosGeoPoint":298,"geoPoint":302,"contacts":37},"St. Mary's Eye Surgery Center (Metropolitan Eye Research and Surgery Institute)","Palisades Park","New Jersey","07650",{"type":53,"coordinates":299},[300,301],-73.99764,40.84816,{"lat":301,"lon":300},{"facility":304,"status":115,"city":305,"state":306,"zip":307,"country":50,"countryCode":51,"cosmosGeoPoint":308,"geoPoint":312,"contacts":37},"Eye Associates of New Mexico, Vision Research Center","Albuquerque","New Mexico","87109",{"type":53,"coordinates":309},[310,311],-106.65114,35.08449,{"lat":311,"lon":310},{"facility":314,"status":46,"city":315,"state":315,"zip":316,"country":50,"countryCode":51,"cosmosGeoPoint":317,"geoPoint":321,"contacts":37},"Retina Associates of New York, P.C.","New York","10075",{"type":53,"coordinates":318},[319,320],-74.00597,40.71427,{"lat":320,"lon":319},{"facility":323,"status":46,"city":324,"state":325,"zip":326,"country":50,"countryCode":51,"cosmosGeoPoint":327,"geoPoint":331,"contacts":37},"North Carolina Retina Associates (Cary)","Cary","North Carolina","27511",{"type":53,"coordinates":328},[329,330],-78.78112,35.79154,{"lat":330,"lon":329},{"facility":333,"status":46,"city":334,"state":325,"zip":335,"country":50,"countryCode":51,"cosmosGeoPoint":336,"geoPoint":340,"contacts":37},"North Carolina Retina Associates (Wake Forest)","Wake Forest","27587",{"type":53,"coordinates":337},[338,339],-78.50972,35.97987,{"lat":339,"lon":338},{"facility":342,"status":115,"city":343,"state":344,"zip":345,"country":50,"countryCode":51,"cosmosGeoPoint":346,"geoPoint":350,"contacts":37},"Cleveland Clinic","Cleveland","Ohio","44195",{"type":53,"coordinates":347},[348,349],-81.69541,41.4995,{"lat":349,"lon":348},{"facility":352,"status":46,"city":353,"state":344,"zip":354,"country":50,"countryCode":51,"cosmosGeoPoint":355,"geoPoint":359,"contacts":37},"Ohio State University","Columbus","43212",{"type":53,"coordinates":356},[357,358],-82.99879,39.96118,{"lat":358,"lon":357},{"facility":361,"status":46,"city":362,"state":363,"zip":364,"country":50,"countryCode":51,"cosmosGeoPoint":365,"geoPoint":369,"contacts":37},"Cascade Medical Research Institute","Springfield","Oregon","97477",{"type":53,"coordinates":366},[367,368],-123.02203,44.04624,{"lat":368,"lon":367},{"facility":371,"status":46,"city":372,"state":373,"zip":374,"country":50,"countryCode":51,"cosmosGeoPoint":375,"geoPoint":379,"contacts":37},"Erie Retina Research","Erie","Pennsylvania","16507",{"type":53,"coordinates":376},[377,378],-80.08506,42.12922,{"lat":378,"lon":377},{"facility":381,"status":157,"city":382,"state":373,"zip":383,"country":50,"countryCode":51,"cosmosGeoPoint":384,"geoPoint":388,"contacts":37},"Vision Research Solutions","Philadelphia","19141",{"type":53,"coordinates":385},[386,387],-75.16362,39.95238,{"lat":387,"lon":386},{"facility":390,"status":46,"city":391,"state":392,"zip":393,"country":50,"countryCode":51,"cosmosGeoPoint":394,"geoPoint":398,"contacts":37},"Charleston Neuroscience Institute, LLC (Charleston)","Charleston","South Carolina","29414",{"type":53,"coordinates":395},[396,397],-79.93275,32.77632,{"lat":397,"lon":396},{"facility":400,"status":46,"city":401,"state":392,"zip":402,"country":50,"countryCode":51,"cosmosGeoPoint":403,"geoPoint":407,"contacts":37},"Palmetto Retina Center (West Columbia)","West Columbia","29169",{"type":53,"coordinates":404},[405,406],-81.07398,33.99349,{"lat":406,"lon":405},{"facility":409,"status":46,"city":410,"state":411,"zip":412,"country":50,"countryCode":51,"cosmosGeoPoint":413,"geoPoint":417,"contacts":37},"Ophthalmology Ltd","Sioux Falls","South Dakota","57108",{"type":53,"coordinates":414},[415,416],-96.72796,43.54369,{"lat":416,"lon":415},{"facility":419,"status":46,"city":420,"state":421,"zip":422,"country":50,"countryCode":51,"cosmosGeoPoint":423,"geoPoint":427,"contacts":37},"Tennessee Retina PC","Nashville","Tennessee","37203",{"type":53,"coordinates":424},[425,426],-86.78444,36.16589,{"lat":426,"lon":425},{"facility":429,"status":46,"city":420,"state":421,"zip":430,"country":50,"countryCode":51,"cosmosGeoPoint":431,"geoPoint":433,"contacts":37},"Vanderbilt Eye Institute","37232",{"type":53,"coordinates":432},[425,426],{"lat":426,"lon":425},{"facility":435,"status":46,"city":436,"state":437,"zip":438,"country":50,"countryCode":51,"cosmosGeoPoint":439,"geoPoint":443,"contacts":37},"Retina Research Institute of Texas","Abilene","Texas","79606",{"type":53,"coordinates":440},[441,442],-99.73314,32.44874,{"lat":442,"lon":441},{"facility":445,"status":46,"city":446,"state":437,"zip":447,"country":50,"countryCode":51,"cosmosGeoPoint":448,"geoPoint":452,"contacts":37},"Austin Retina Associates, PLLC (Austin)","Austin","78705",{"type":53,"coordinates":449},[450,451],-97.74306,30.26715,{"lat":451,"lon":450},{"facility":454,"status":115,"city":446,"state":437,"zip":455,"country":50,"countryCode":51,"cosmosGeoPoint":456,"geoPoint":458,"contacts":37},"UT Austin","78712",{"type":53,"coordinates":457},[450,451],{"lat":451,"lon":450},{"facility":460,"status":46,"city":461,"state":437,"zip":462,"country":50,"countryCode":51,"cosmosGeoPoint":463,"geoPoint":467,"contacts":37},"Retina Consultants of Texas (Bellaire)","Bellaire","77401",{"type":53,"coordinates":464},[465,466],-95.45883,29.70579,{"lat":466,"lon":465},{"facility":469,"status":46,"city":470,"state":437,"zip":471,"country":50,"countryCode":51,"cosmosGeoPoint":472,"geoPoint":476,"contacts":37},"Texas Retina Center","Houston","77030",{"type":53,"coordinates":473},[474,475],-95.36327,29.76328,{"lat":475,"lon":474},{"facility":478,"status":46,"city":479,"state":437,"zip":480,"country":50,"countryCode":51,"cosmosGeoPoint":481,"geoPoint":485,"contacts":37},"Retina Consultants of Texas (Katy)","Katy","77494",{"type":53,"coordinates":482},[483,484],-95.8244,29.78579,{"lat":484,"lon":483},{"facility":487,"status":46,"city":488,"state":437,"zip":489,"country":50,"countryCode":51,"cosmosGeoPoint":490,"geoPoint":494,"contacts":37},"Texas Retina Associates (Plano)","Plano","75075",{"type":53,"coordinates":491},[492,493],-96.69889,33.01984,{"lat":493,"lon":492},{"facility":496,"status":46,"city":497,"state":437,"zip":498,"country":50,"countryCode":51,"cosmosGeoPoint":499,"geoPoint":503,"contacts":37},"Austin Retina Associates, PLLC (Round Rock)","Round Rock","78681",{"type":53,"coordinates":500},[501,502],-97.6789,30.50826,{"lat":502,"lon":501},{"facility":505,"status":46,"city":506,"state":437,"zip":507,"country":50,"countryCode":51,"cosmosGeoPoint":508,"geoPoint":512,"contacts":37},"Retina Consultants of Texas (San Antonio)","San Antonio","78240",{"type":53,"coordinates":509},[510,511],-98.49363,29.42412,{"lat":511,"lon":510},{"facility":514,"status":46,"city":515,"state":437,"zip":516,"country":50,"countryCode":51,"cosmosGeoPoint":517,"geoPoint":521,"contacts":37},"Retina Consultants of Texas (Woodlands)","The Woodlands","77384",{"type":53,"coordinates":518},[519,520],-95.48938,30.15799,{"lat":520,"lon":519},{"facility":523,"status":46,"city":524,"state":525,"zip":526,"country":50,"countryCode":51,"cosmosGeoPoint":527,"geoPoint":531,"contacts":37},"Pacific Northwest Retina (Bellevue)","Bellevue","Washington","98004",{"type":53,"coordinates":528},[529,530],-122.20068,47.61038,{"lat":530,"lon":529},{"facility":533,"status":46,"city":534,"state":525,"zip":535,"country":50,"countryCode":51,"cosmosGeoPoint":536,"geoPoint":540,"contacts":37},"Pacific Northwest Retina (Silverdale)","Silverdale","98383",{"type":53,"coordinates":537},[538,539],-122.69487,47.64454,{"lat":539,"lon":538},{"facility":542,"status":46,"city":543,"state":544,"zip":545,"country":50,"countryCode":51,"cosmosGeoPoint":546,"geoPoint":550,"contacts":37},"Eye Clinic of Wisconsin","Wausau","Wisconsin","54403",{"type":53,"coordinates":547},[548,549],-89.63012,44.95914,{"lat":549,"lon":548},{"facility":552,"status":46,"city":553,"state":37,"zip":554,"country":555,"countryCode":556,"cosmosGeoPoint":557,"geoPoint":561,"contacts":37},"Centro Oftalmologico Metropolitano","San Juan","00921","Puerto Rico","PR",{"type":53,"coordinates":558},[559,560],-66.10572,18.46633,{"lat":560,"lon":559},{"type":563,"investigatorFullName":37,"investigatorTitle":37,"investigatorAffiliation":37,"oldNameTitle":37,"oldOrganization":37},"SPONSOR","100592642","phase-3-a-phase-3-study-to-evaluate-the-efficacy-and-safety-of-intravitreal-ksi-101-in-participants-with-macular-edema-secondary-to-inflammation-mesi---pinnacle-100592642",false,"NCT06996080","A Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal KSI-101 in Participants With Macular Edema Secondary to Inflammation (MESI) - PINNACLE","A Randomized, Double-masked, Sham-controlled, Multicenter, Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal Tabirafusp Alfa (KSI-101) in Participants With Macular Edema Secondary to Inflammation (MESI) - PINNACLE","PINNACLE","Inclusion Criteria:\n\n* Macular Edema Secondary to Inflammation (MESI) with a central subfield thickness (CST) of ≥320 and \\\u003C400 microns on SD-OCT and a BCVA score of ≥25 and ≤78 ETDRS letters (between \\~20\u002F25 and 20\u002F320 Snellen equivalent) in the Study Eye.\n* Definitive presence of Intraretinal Fluid and\u002For Subretinal Fluid on SD-OCT in the Study Eye.\n* Diagnosis of active or inactive non-infectious intraocular inflammation, acute or chronic in the Study Eye.\n\nExclusion Criteria:\n\n* ME in the Study Eye secondary to diabetes, RVO, or wAMD.\n* Active or suspected ocular or periocular infection in either eye.\n* Any history of or active occlusive retinal vasculitis in either eye.","ALL","18 Years",{"count":575,"type":576},300,"ESTIMATED","INTERVENTIONAL",[579],"PHASE3","A Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal KSI-101 in Participants with Macular Edema Secondary to Inflammation (MESI)",[582],"Macular Edema Secondary to Inflammation",[584,585,586,587],"MESI","macular edema","inflammatory macular edema","macular edema associated with inflammation","2026-05-14",{"date":590,"type":591},"2026-05-18","ACTUAL",{"date":593,"type":591},"2025-07-16",{"date":595,"type":576},"2027-08",{"name":5,"class":6},56]