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M.Kopernika w Lodzi","Lodz","93-513",{"type":72,"coordinates":685},[686,687],19.47395,51.77058,{"lat":687,"lon":686},{"facility":690,"status":33,"city":691,"state":33,"zip":692,"country":673,"countryCode":674,"cosmosGeoPoint":693,"geoPoint":697,"contacts":33},"Uniwersytecki Szpital Kliniczny W Poznaniu","Poznan","60-569",{"type":72,"coordinates":694},[695,696],16.92993,52.40692,{"lat":696,"lon":695},{"facility":699,"status":33,"city":700,"state":33,"zip":701,"country":673,"countryCode":674,"cosmosGeoPoint":702,"geoPoint":706,"contacts":33},"Instytut Hematologii i Transfuzjologii","Warsaw","02-776",{"type":72,"coordinates":703},[704,705],21.01178,52.22977,{"lat":705,"lon":704},{"facility":708,"status":33,"city":709,"state":710,"zip":711,"country":712,"countryCode":713,"cosmosGeoPoint":33,"geoPoint":33,"contacts":33},"Charlotte Maxeke Johannesburg Academic Hospital","Parktown, Johannesburg","Gauteng","2193","South Africa","ZA",{"facility":715,"status":33,"city":716,"state":717,"zip":718,"country":719,"countryCode":720,"cosmosGeoPoint":721,"geoPoint":725,"contacts":33},"Hospital Virgen de la Arrixaca - Hematología","El Palmar","Murcia","30120","Spain","ES",{"type":72,"coordinates":722},[723,724],-1.16095,37.93939,{"lat":724,"lon":723},{"facility":727,"status":33,"city":728,"state":33,"zip":729,"country":719,"countryCode":720,"cosmosGeoPoint":730,"geoPoint":734,"contacts":33},"Hospital Vall d'Hebron","Barcelona","08035",{"type":72,"coordinates":731},[732,733],2.15899,41.38879,{"lat":733,"lon":732},{"facility":736,"status":33,"city":737,"state":33,"zip":738,"country":719,"countryCode":720,"cosmosGeoPoint":739,"geoPoint":743,"contacts":33},"Hospital Universitario La Paz","Madrid","28046",{"type":72,"coordinates":740},[741,742],-3.70256,40.4165,{"lat":742,"lon":741},{"facility":745,"status":33,"city":746,"state":33,"zip":747,"country":719,"countryCode":720,"cosmosGeoPoint":748,"geoPoint":752,"contacts":33},"Hospital Universitario Virgen del Rocío","Seville","41013",{"type":72,"coordinates":749},[750,751],-5.97317,37.38283,{"lat":751,"lon":750},{"facility":754,"status":33,"city":755,"state":33,"zip":756,"country":719,"countryCode":720,"cosmosGeoPoint":757,"geoPoint":761,"contacts":33},"Hospital La Fe_Hemostasia y Trombosis","Valencia","46026",{"type":72,"coordinates":758},[759,760],-0.37966,39.47391,{"lat":760,"lon":759},{"facility":763,"status":33,"city":764,"state":33,"zip":765,"country":766,"countryCode":33,"cosmosGeoPoint":767,"geoPoint":771,"contacts":33},"Ankara Bilkent Şehir Hastanesi","Ankara","06800","Turkey (Türkiye)",{"type":72,"coordinates":768},[769,770],32.85427,39.91987,{"lat":770,"lon":769},{"facility":773,"status":33,"city":774,"state":33,"zip":775,"country":766,"countryCode":33,"cosmosGeoPoint":776,"geoPoint":780,"contacts":33},"İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Hastanesi","Istanbul","34098",{"type":72,"coordinates":777},[778,779],28.94966,41.01384,{"lat":779,"lon":778},{"facility":782,"status":33,"city":783,"state":33,"zip":784,"country":766,"countryCode":33,"cosmosGeoPoint":785,"geoPoint":789,"contacts":33},"Ege Üniversitesi Hastanesi- Hematoloji","Izmir","35100",{"type":72,"coordinates":786},[787,788],27.13838,38.41273,{"lat":788,"lon":787},{"facility":791,"status":33,"city":792,"state":33,"zip":793,"country":794,"countryCode":795,"cosmosGeoPoint":796,"geoPoint":800,"contacts":33},"Queen Elizabeth Hospital, Birmingham - Haemophilia","Birmingham","B15 2TH","United Kingdom","UK",{"type":72,"coordinates":797},[798,799],-1.89983,52.48142,{"lat":799,"lon":798},{"facility":802,"status":33,"city":803,"state":33,"zip":804,"country":794,"countryCode":795,"cosmosGeoPoint":805,"geoPoint":809,"contacts":33},"University Hospital of Wales - Haemophilia","Cardiff","CF14 4XW",{"type":72,"coordinates":806},[807,808],-3.18,51.48,{"lat":808,"lon":807},{"facility":811,"status":33,"city":812,"state":33,"zip":813,"country":794,"countryCode":795,"cosmosGeoPoint":814,"geoPoint":818,"contacts":33},"Royal Free Hospital - Haemophilia","London","NW3 2QG",{"type":72,"coordinates":815},[816,817],-0.12574,51.50853,{"lat":817,"lon":816},{"facility":820,"status":33,"city":812,"state":33,"zip":821,"country":794,"countryCode":795,"cosmosGeoPoint":822,"geoPoint":824,"contacts":33},"St Thomas' Hospital - Haemostasis and Thrombosis Centre","SE1 7EH",{"type":72,"coordinates":823},[816,817],{"lat":817,"lon":816},{"facility":826,"status":33,"city":827,"state":33,"zip":828,"country":794,"countryCode":795,"cosmosGeoPoint":829,"geoPoint":833,"contacts":33},"Nuffield Orthopaedic Centre - Oxford Haemophilia and Thrombosis Centre","Oxford","OX3 7HE",{"type":72,"coordinates":830},[831,832],-1.25596,51.75222,{"lat":832,"lon":831},{"facility":835,"status":33,"city":836,"state":33,"zip":837,"country":794,"countryCode":795,"cosmosGeoPoint":838,"geoPoint":842,"contacts":33},"Royal Hallamshire Hospital","Sheffield","S10 2JF",{"type":72,"coordinates":839},[840,841],-1.4659,53.38297,{"lat":841,"lon":840},{"type":844,"investigatorFullName":33,"investigatorTitle":33,"investigatorAffiliation":33,"oldNameTitle":33,"oldOrganization":33},"SPONSOR","100656820","phase-3-a-research-study-investigating-denecimig-mim8-in-adults-with-acquired-haemophilia-a-100656820",false,"NCT07830732","A Research Study Investigating Denecimig (Mim8) in Adults With Acquired Haemophilia A","A Multinational, Open-label Study to Investigate Efficacy and Safety of Denecimig (Mim8) in Adults With Acquired Haemophilia A","FRONTIERAHA","Inclusion Criteria:\n\n* Informed consent obtained before any study-related activities. Study-related activities are any procedures that are carried out as part of the study, including activities to determine suitability for the study.\n* Male or female participants (sex assigned at birth, inclusive of all gender identities) newly diagnosed with acquired haemophilia A (AHA) prior to signing the informed consent form, with AHA diagnosis (FVIII activity lesser than (\\\u003C) 50 percentage (%) and FVIII inhibitors greater than (\\>) 0.6 Bethesda units \\[BU\\]) confirmed at screening.\n* Treatment-requiring bleed(s) due to AHA from diagnosis and until screening.\n* The participant is capable of following study procedures and able to seek medical attention when needed.\n\nExclusion Criteria:\n\n* Female who is pregnant, breast-feeding or intends to become pregnant or is of childbearing potential and not using an adequate and highly effective contraceptive method.\n* Previous or current thromboembolic disease or eventsa (with the exception of previous catheter associated thrombosis for which anti-thrombotic treatment is not currently ongoing) or risk of thromboembolic disease.\n* Life expectancy \\\u003C3 months at the time of screening, as evaluated by the investigator.\n* Therapy with immunosuppressive or immune modulating drugs for treatment of AHA (other than less than or equal to (≤) 2 days of prednisolone (or equivalent) for AHA at a dose ≤100 mg per day) prior to screening.\n* Immunosuppressive therapy (IST) initiated prior to AHA diagnosis for other medical conditions (e.g., other autoimmune disorders) is permitted, provided it was initiated greater than or equal to (≥) 6 months prior to screening, has been maintained at a stable dose and regimen since initiation, and is expected to remain at a stable dose and regimen at least during the main treatment period (Weeks 0-12).","ALL","18 Years",{"count":856,"type":857},84,"ESTIMATED","INTERVENTIONAL",[860],"PHASE3","The purpose of this study is to find out if denecimig is safe and effective for treating people who have acquired haemophilia A. Participants will be in this study for up to around 1 year and 5 months (73 week).",[863],"Haemophilia A","NOT_YET_RECRUITING","2026-09-15",{"date":867,"type":868},"2026-09-21","ACTUAL",{"date":870,"type":857},"2026-10-09",{"date":872,"type":857},"2029-03-23",{"name":5,"class":6},83]