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EORTC-IL-194 uses 0 - 4 scale (higher score is worse)",{"measure":42,"description":25,"timeFrame":26},"Proportion of patients experiencing each level of symptomatic AEs of vaginal dryness as measured by the EORTC-IL-194 item 15. EORTC-IL-194 uses 0 - 4 scale (higher score is worse)",{"measure":44,"description":25,"timeFrame":26},"Change from baseline and TTD (time to deterioration ) of health-related QoL (quality of life) as measured by the 2 global QoL items from the EORTC-QLQ-C30 items 11 and 12. 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The planned duration of treatment in either arm of the study is 60 months. The eligible patients must have intermediate or high risk of recurrence, as defined by specified clinical and biologic criteria. Prior use of CDK4\u002F6 inhibitors is permitted. The primary endpoint of the study is Invasive breast cancer-free survival (IBCFS) and main secondary endpoints include Invasive disease-free survival (IDFS), Distant relapse-free survival (DRFS), Overall survival (OS), Safety and Clinical Outcome Assessments (COAs).\n\nPatients will be followed for 10 years from randomization of the last patient.",[58,67],{"label":59,"type":60,"description":61,"interventionNames":62},"Arm A: standard endocrine therapy of investigator´s choice","ACTIVE_COMPARATOR","Continue standard endocrine therapy of investigator's choice (aromatase inhibitors \\[AI; exemestane, letrozole, anastrozole\\] or tamoxifen)",[63,64,65,66],"Drug: Tamoxifen","Drug: Anastrozole","Drug: Letrozole","Drug: Exemestane",{"label":68,"type":69,"description":70,"interventionNames":71},"Arm B: camizestrant","EXPERIMENTAL","Camizestrant",[72],"Drug: Camizestrant",[74,80,84,88,92],{"type":75,"name":70,"description":76,"armGroupLabels":77,"otherNames":78},"DRUG","Camizestrant. 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