[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643826":3},{"organization":4,"outcomesModule":7,"designInfo":58,"detailedDescription":57,"studyPopulation":57,"armGroups":67,"interventions":80,"overallOfficials":92,"centralContacts":96,"locations":102,"responsibleParty":2304,"collaborators":57,"id":2306,"slug":2307,"hasResults":2308,"nctId":2309,"briefTitle":2310,"officialTitle":2311,"acronym":2312,"eligibilityCriteria":2313,"healthyVolunteers":2308,"sex":2314,"minAge":2315,"maxAge":57,"enrollmentInfo":2316,"targetDuration":57,"studyType":2319,"phases":2320,"briefSummary":2322,"conditions":2323,"keywords":57,"overallStatus":105,"whyStopped":57,"lastUpdateSubmitDate":2325,"lastUpdatePostDateStruct":2326,"startDateStruct":2329,"completionDateStruct":2331,"leadSponsor":2333,"locationsCount":2334},{"fullName":5,"class":6},"Janssen Research & Development, LLC","INDUSTRY",{"primaryOutcomes":8,"secondaryOutcomes":16,"otherOutcomes":57},[9,13],{"measure":10,"description":11,"timeFrame":12},"Co-Primary: Percentage of Participants with Clinical Remission at Week 48","Clinical remission is defined as a Crohn's Disease Activity Index (CDAI) score less than (\\\u003C) 150. CDAI scores range from 0 to approximately 600. Higher score indicates higher disease activity.","At Week 48",{"measure":14,"description":15,"timeFrame":12},"Co-Primary: Percentage of Participants with Endoscopic Remission at Week 48","Endoscopic remission is defined as a Simple Endoscopic Score for Crohn's Disease (SES-CD) score of less than or equal to (\\\u003C=) 4 with at least a 2-point reduction from baseline and no subscore greater than (\\>) 1 in any individual component. The SES-CD is based on the evaluation of 4 endoscopic components (presence\u002Fsize of ulcers, proportion of mucosal surface covered by ulcers, proportion of mucosal surface affected by any lesions, and presence\u002Ftype of narrowing\u002Fstrictures) across 5 ileocolonic segments. SES-CD score can range from 0 to 56. Higher scores indicating more severe disease.",[17,20,23,26,30,33,36,39,43,46,50,53],{"measure":18,"description":19,"timeFrame":12},"Percentage of Participants with Deep Remission at Week 48","Deep remission (composite endpoint) is defined as achieving both clinical remission and endoscopic remission at Week 48 at the participant level. Clinical remission is defined as a CDAI score of \\\u003C150 and Endoscopic remission is defined as a SES-CD score of \\\u003C= 4 with at least a 2-point reduction from baseline and no subscore \\>1 in any individual component. CDAI scores range from 0 to approximately 600. Higher score indicates higher disease activity. SES-CD score can range from 0 to 56. Higher scores indicating more severe disease.",{"measure":21,"description":22,"timeFrame":12},"Percentage of Participants with Corticosteroid-Free (90-Day) Clinical Remission at Week 48","Corticosteroid-free (90-day) clinical remission at Week 48 is defined as clinical remission at Week 48 and not receiving corticosteroids for at least 90 days prior to Week 48. Clinical remission is defined as a CDAI score of \\\u003C150. CDAI scores range from 0 to approximately 600. Higher score indicates higher disease activity.",{"measure":24,"description":25,"timeFrame":12},"Percentage of Participants with Corticosteroid-Free (90-day) PRO-2 Remission at Week 48","Corticosteroid-free (90-day) patient-reported outcome(s) (PRO-2) remission at Week 48 is defined as an abdominal plan (AP) mean daily score less than or equal to (\\\u003C=) 1 and stool frequency (SF) mean daily score \\\u003C= 2.8, and no worsening of AP or SF from baseline, and not receiving corticosteroids for at least 90 days prior to Week 48.",{"measure":27,"description":28,"timeFrame":29},"Percentage of Participants with Sustained Clinical Remission","Sustained clinical remission is defined as clinical remission at Week 12 and Week 48. Clinical remission is defined as CDAI score of \\\u003C150. CDAI scores range from 0 to approximately 600. Higher score indicates higher disease activity.","At Weeks 12 and 48",{"measure":31,"description":32,"timeFrame":12},"Percentage of Participants with Histologic-Endoscopic Remission at Week 48","Composite endpoint defined as achieving both histologic remission (defined as a Robarts Histopathology Index score less than or equal to \\[\\\u003C=\\] 3, where each of the items of lamina propria neutrophils, neutrophils in epithelium, and erosions or ulcerations must be equal to 0) and endoscopic remission at the participant level.",{"measure":34,"description":35,"timeFrame":12},"Percentage of Participants with Inflammatory Bowel Disease Questionnaire (IBDQ) Response at Week 48","IBDQ response at Week 48 is defined as an improvement of at least 16 points in the IBDQ total score from baseline at Week 48. IBDQ is a validated, 32-item, self-reported questionnaire for participants with IBD that will be used to evaluate disease-specific health related quality of life (HRQoL) across 4 dimensional scores: bowel symptoms (loose stools, AP), systemic function (fatigue, altered sleep pattern), social function (work attendance, need to cancel social events), and emotional function (anger, depression, irritability). Scores range from 32 to 224, with higher scores indicating better outcomes.",{"measure":37,"description":38,"timeFrame":12},"Percentage of Participants with Patient-Reported Outcomes Measurement Information System 29 (PROMIS-29) Mental Component Summary Score (MCS) Response at Week 48","PROMIS-29 MCS response at Week 48 is defined as an improvement of at least 7 points in PROMIS-29 MCS score from baseline at Week 48. The PROMIS-29 is a collection of short forms containing 4 items for each of 7 domains (depression, anxiety, physical function, pain interference, fatigue, sleep disturbance, and ability to participate in social roles and activities). PROMIS-29 also includes an overall average pain intensity 0-10 numeric rating scale. The PROMIS-29 MCS will be assessed, which is primarily informed by domains of emotional distress (depression\u002Fanxiety) and fatigue as well as sleep disturbance where higher MCS scores reflect better mental health.",{"measure":40,"description":41,"timeFrame":42},"Percentage of Participants with Clinical Remission at Week 12","Clinical remission at Week 12 is defined as CDAI score \\\u003C150 at Week 12. CDAI scores range from 0 to approximately 600. Higher score indicates higher disease activity.","At Week 12",{"measure":44,"description":45,"timeFrame":42},"Percentage of Participants with Endoscopic Response at Week 12","Endoscopic response at Week 12 is defined as greater than (\\>) 50 percent (%) improvement from baseline in SES-CD score at Week 12 or a decrease of at least 2 points in participants with a baseline score of 4 and isolated ileal disease. SES-CD score can range from 0 to 56. Higher scores indicating more severe disease.",{"measure":47,"description":48,"timeFrame":49},"Percentage of Participants with Clinical Response at Week 4","Clinical response at week 4 is defined as \\>=100-point reduction from baseline in CDAI score at Week 4. CDAI scores range from 0 to approximately 600. Higher score indicates higher disease activity.","At Week 4",{"measure":51,"description":52,"timeFrame":49},"Percentage of Participants with Clinical Remission at Week 4","Clinical remission at Week 4 is defined as CDAI score \\\u003C150 at Week 4. CDAI scores range from 0 to approximately 600. Higher score indicates higher disease activity.",{"measure":54,"description":55,"timeFrame":56},"Number of Participants with Adverse Events (AE) and Serious AEs (SAEs)","An AE is any untoward medical occurrence in a clinical study participant administered a pharmaceutical (investigational or non investigational) product. An AE does not necessarily have a causal relationship with the intervention. An SAE is any untoward medical occurrence that at any dose: results in death, is life-threatening, requires inpatient hospitalization or prolongation of existing hospitalization, results in persistent or significant disability\u002Fincapacity, is a congenital anomaly\u002Fbirth defect, is a suspected transmission of any infectious agent via a medicinal product, and is medically important.","Up to approximately 3 years",null,{"allocation":59,"interventionModel":60,"interventionModelDescription":57,"primaryPurpose":61,"observationalModel":57,"timePerspective":57,"maskingInfo":62},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":63,"maskingDescription":57,"whoMasked":64},"DOUBLE",[65,66],"PARTICIPANT","INVESTIGATOR",[68,74],{"label":69,"type":70,"description":71,"interventionNames":72},"JNJ-78934804","EXPERIMENTAL","Participants will receive JNJ-78934804 induction dose, at Weeks 0, 4, and 8 followed by JNJ-78934804 maintenance dose, once every 4 weeks (q4w) starting at Week 12. All participants who meet the rescue criteria will receive JNJ-78934804 induction dose at Weeks 16, 20, and 24 followed by JNJ-78934804 maintenance dose q4w starting at Week 28. Participants who complete double-blind treatment phase (Week 48) and who may benefit from continued study intervention in the opinion of the investigator will have the opportunity to enter the long-term extension (LTE) phase.",[73],"Drug: JNJ-78934804",{"label":75,"type":76,"description":77,"interventionNames":78},"Guselkumab","ACTIVE_COMPARATOR","Participants will receive guselkumab induction dose at Weeks 0, 4, and 8 followed by guselkumab maintenance dose q4w starting at Week 12. All participants who meet the rescue criteria will receive JNJ-78934804 induction dose at Weeks 16, 20, and 24 followed by JNJ-78934804 maintenance dose q4w starting at Week 28. Participants who complete double-blind treatment phase (Week 48) and who may benefit from continued study intervention in the opinion of the investigator will have the opportunity to enter the LTE phase.",[73,79],"Drug: Guselkumab",[81,87],{"type":82,"name":69,"description":83,"armGroupLabels":84,"otherNames":85},"DRUG","JNJ-78934804 will be administered subcutaneously.",[75,69],[86],"JNJ-4804",{"type":82,"name":75,"description":88,"armGroupLabels":89,"otherNames":90},"Guselkumab will be administered subcutaneously.",[75],[91],"TREMFYA",[93],{"name":94,"affiliation":5,"role":95},"Janssen Research & Development, LLC Clinical Trial","STUDY_DIRECTOR",[97],{"name":98,"role":99,"phone":100,"phoneExt":57,"email":101},"Study Contact","CONTACT","844-434-4210","Participate-In-This-Study1@its.jnj.com",[103,117,126,135,144,154,164,173,182,192,202,212,221,231,241,250,260,270,280,290,300,310,320,326,335,344,353,362,371,382,391,400,409,418,421,430,439,448,459,468,477,488,497,506,515,524,533,544,553,562,571,580,589,598,604,613,622,631,637,643,652,664,670,680,690,699,709,718,727,736,746,752,763,772,781,790,799,808,817,826,835,844,853,862,871,880,889,898,908,917,921,930,936,947,956,965,974,983,992,1001,1010,1019,1028,1037,1046,1057,1063,1069,1078,1087,1096,1105,1114,1123,1132,1141,1150,1159,1168,1177,1188,1194,1205,1210,1216,1222,1231,1242,1251,1260,1269,1278,1287,1296,1302,1313,1322,1328,1337,1346,1355,1364,1373,1382,1391,1402,1408,1412,1421,1427,1433,1442,1453,1462,1471,1480,1489,1498,1507,1513,1519,1528,1537,1546,1550,1559,1565,1574,1580,1586,1595,1604,1613,1622,1633,1642,1651,1660,1669,1680,1689,1698,1709,1718,1722,1731,1740,1749,1760,1769,1775,1784,1790,1799,1808,1817,1826,1832,1841,1850,1859,1868,1874,1883,1894,1903,1912,1921,1930,1941,1947,1953,1962,1971,1982,1991,2000,2009,2018,2023,2032,2042,2051,2055,2064,2070,2076,2087,2096,2105,2114,2123,2132,2143,2154,2163,2172,2181,2191,2200,2206,2215,2224,2233,2237,2248,2257,2266,2275,2283,2289,2295],{"facility":104,"status":105,"city":106,"state":107,"zip":108,"country":109,"countryCode":110,"cosmosGeoPoint":111,"geoPoint":116,"contacts":57},"Clinnova Research","RECRUITING","Anaheim","California","92805","United States","US",{"type":112,"coordinates":113},"Point",[114,115],-117.9145,33.83529,{"lat":115,"lon":114},{"facility":118,"status":105,"city":119,"state":107,"zip":120,"country":109,"countryCode":110,"cosmosGeoPoint":121,"geoPoint":125,"contacts":57},"Gastro SB Clinic","Chula Vista","91910",{"type":112,"coordinates":122},[123,124],-117.0842,32.64005,{"lat":124,"lon":123},{"facility":127,"status":105,"city":128,"state":107,"zip":129,"country":109,"countryCode":110,"cosmosGeoPoint":130,"geoPoint":134,"contacts":57},"United Medical Doctors","Los Alamitos","90720",{"type":112,"coordinates":131},[132,133],-118.07256,33.80307,{"lat":133,"lon":132},{"facility":136,"status":105,"city":137,"state":107,"zip":138,"country":109,"countryCode":110,"cosmosGeoPoint":139,"geoPoint":143,"contacts":57},"Medical Associates Research Group, Inc.","San Diego","92123",{"type":112,"coordinates":140},[141,142],-117.16472,32.71571,{"lat":142,"lon":141},{"facility":145,"status":105,"city":146,"state":147,"zip":148,"country":109,"countryCode":110,"cosmosGeoPoint":149,"geoPoint":153,"contacts":57},"Peak Gastroenterology Associates","Colorado Springs","Colorado","80907",{"type":112,"coordinates":150},[151,152],-104.82136,38.83388,{"lat":152,"lon":151},{"facility":155,"status":105,"city":156,"state":157,"zip":158,"country":109,"countryCode":110,"cosmosGeoPoint":159,"geoPoint":163,"contacts":57},"Florida Research Center Inc.","Lakewood Rch","Florida","34211",{"type":112,"coordinates":160},[161,162],-82.4332,27.3863,{"lat":162,"lon":161},{"facility":165,"status":105,"city":166,"state":157,"zip":167,"country":109,"countryCode":110,"cosmosGeoPoint":168,"geoPoint":172,"contacts":57},"Sanchez Clinical Research, Inc","Miami","33157-6575",{"type":112,"coordinates":169},[170,171],-80.19366,25.77427,{"lat":171,"lon":170},{"facility":174,"status":105,"city":175,"state":157,"zip":176,"country":109,"countryCode":110,"cosmosGeoPoint":177,"geoPoint":181,"contacts":57},"GCP Clinical Research","Tampa","33609",{"type":112,"coordinates":178},[179,180],-82.45843,27.94752,{"lat":180,"lon":179},{"facility":183,"status":105,"city":184,"state":185,"zip":186,"country":109,"countryCode":110,"cosmosGeoPoint":187,"geoPoint":191,"contacts":57},"Atlanta Gastroenterology Specialists","Suwanee","Georgia","30024",{"type":112,"coordinates":188},[189,190],-84.0713,34.05149,{"lat":190,"lon":189},{"facility":193,"status":105,"city":194,"state":195,"zip":196,"country":109,"countryCode":110,"cosmosGeoPoint":197,"geoPoint":201,"contacts":57},"Tri-State Gastroenterology Assoc","Crestview Hills","Kentucky","41017",{"type":112,"coordinates":198},[199,200],-84.58494,39.02728,{"lat":200,"lon":199},{"facility":203,"status":105,"city":204,"state":205,"zip":206,"country":109,"countryCode":110,"cosmosGeoPoint":207,"geoPoint":211,"contacts":57},"Gastroenterology Clinic of Acadiana","Lafayette","Louisiana","70503",{"type":112,"coordinates":208},[209,210],-92.01984,30.22409,{"lat":210,"lon":209},{"facility":213,"status":105,"city":214,"state":205,"zip":215,"country":109,"countryCode":110,"cosmosGeoPoint":216,"geoPoint":220,"contacts":57},"GIA Metairie","Metairie","70006",{"type":112,"coordinates":217},[218,219],-90.15285,29.98409,{"lat":219,"lon":218},{"facility":222,"status":105,"city":223,"state":224,"zip":225,"country":109,"countryCode":110,"cosmosGeoPoint":226,"geoPoint":230,"contacts":57},"Michigan Center of Medical Research","Farmington Hills","Michigan","48334",{"type":112,"coordinates":227},[228,229],-83.37716,42.48531,{"lat":229,"lon":228},{"facility":232,"status":105,"city":233,"state":234,"zip":235,"country":109,"countryCode":110,"cosmosGeoPoint":236,"geoPoint":240,"contacts":57},"GIA Kansas City","Lee's Summit","Missouri","64086",{"type":112,"coordinates":237},[238,239],-94.38217,38.91084,{"lat":239,"lon":238},{"facility":242,"status":105,"city":243,"state":243,"zip":244,"country":109,"countryCode":110,"cosmosGeoPoint":245,"geoPoint":249,"contacts":57},"New York Gastroenterology Associates","New York","10075",{"type":112,"coordinates":246},[247,248],-74.00597,40.71427,{"lat":248,"lon":247},{"facility":251,"status":105,"city":252,"state":253,"zip":254,"country":109,"countryCode":110,"cosmosGeoPoint":255,"geoPoint":259,"contacts":57},"University of North Carolina Hospital","Chapel Hill","North Carolina","27599-7080",{"type":112,"coordinates":256},[257,258],-79.05584,35.9132,{"lat":258,"lon":257},{"facility":261,"status":105,"city":262,"state":263,"zip":264,"country":109,"countryCode":110,"cosmosGeoPoint":265,"geoPoint":269,"contacts":57},"Great Lakes Gastroenterology Research, LLC","Mentor","Ohio","44060",{"type":112,"coordinates":266},[267,268],-81.33955,41.66616,{"lat":268,"lon":267},{"facility":271,"status":105,"city":272,"state":273,"zip":274,"country":109,"countryCode":110,"cosmosGeoPoint":275,"geoPoint":279,"contacts":57},"Digestive Disease Specialists Inc","Oklahoma City","Oklahoma","73114",{"type":112,"coordinates":276},[277,278],-97.51643,35.46756,{"lat":278,"lon":277},{"facility":281,"status":105,"city":282,"state":283,"zip":284,"country":109,"countryCode":110,"cosmosGeoPoint":285,"geoPoint":289,"contacts":57},"The Oregon Clinic","Portland","Oregon","97220",{"type":112,"coordinates":286},[287,288],-122.67621,45.52345,{"lat":288,"lon":287},{"facility":291,"status":105,"city":292,"state":293,"zip":294,"country":109,"countryCode":110,"cosmosGeoPoint":295,"geoPoint":299,"contacts":57},"Gastro One","Cordova","Tennessee","38018",{"type":112,"coordinates":296},[297,298],-89.7762,35.15565,{"lat":298,"lon":297},{"facility":301,"status":105,"city":302,"state":303,"zip":304,"country":109,"countryCode":110,"cosmosGeoPoint":305,"geoPoint":309,"contacts":57},"Tyler Research Institute, LLC","Tyler","Texas","75701",{"type":112,"coordinates":306},[307,308],-95.30106,32.35126,{"lat":308,"lon":307},{"facility":311,"status":105,"city":312,"state":313,"zip":314,"country":109,"countryCode":110,"cosmosGeoPoint":315,"geoPoint":319,"contacts":57},"GI Alliance Tacoma","Tacoma","Washington","98405",{"type":112,"coordinates":316},[317,318],-122.44429,47.25288,{"lat":318,"lon":317},{"facility":321,"status":105,"city":322,"state":57,"zip":323,"country":324,"countryCode":325,"cosmosGeoPoint":57,"geoPoint":57,"contacts":57},"GEDYT","AAI","C1425BGC","Argentina","AR",{"facility":327,"status":105,"city":328,"state":57,"zip":329,"country":324,"countryCode":325,"cosmosGeoPoint":330,"geoPoint":334,"contacts":57},"Sanatorio Duarte Quiroz","Córdoba","X5002AOQ",{"type":112,"coordinates":331},[332,333],-64.18853,-31.40648,{"lat":333,"lon":332},{"facility":336,"status":105,"city":337,"state":57,"zip":338,"country":324,"countryCode":325,"cosmosGeoPoint":339,"geoPoint":343,"contacts":57},"Globalpsy","La Plata","1896",{"type":112,"coordinates":340},[341,342],-57.95442,-34.92126,{"lat":342,"lon":341},{"facility":345,"status":105,"city":346,"state":57,"zip":347,"country":324,"countryCode":325,"cosmosGeoPoint":348,"geoPoint":352,"contacts":57},"HIGEA","Mendoza","M5500DPS",{"type":112,"coordinates":349},[350,351],-68.84582,-32.88946,{"lat":351,"lon":350},{"facility":354,"status":105,"city":355,"state":57,"zip":356,"country":324,"countryCode":325,"cosmosGeoPoint":357,"geoPoint":361,"contacts":57},"Cer Instituto Medico","Quilmes","B1878DVB",{"type":112,"coordinates":358},[359,360],-58.25454,-34.72065,{"lat":360,"lon":359},{"facility":363,"status":105,"city":364,"state":57,"zip":365,"country":324,"countryCode":325,"cosmosGeoPoint":366,"geoPoint":370,"contacts":57},"Hospital Provincial del Centenario","Rosario","S2000KDS",{"type":112,"coordinates":367},[368,369],-60.63932,-32.94682,{"lat":369,"lon":368},{"facility":372,"status":105,"city":373,"state":57,"zip":374,"country":375,"countryCode":376,"cosmosGeoPoint":377,"geoPoint":381,"contacts":57},"Banksia Trials SA","Adelaide","5000","Australia","AU",{"type":112,"coordinates":378},[379,380],138.59863,-34.92866,{"lat":380,"lon":379},{"facility":383,"status":105,"city":384,"state":57,"zip":385,"country":375,"countryCode":376,"cosmosGeoPoint":386,"geoPoint":390,"contacts":57},"Royal Prince Alfred Hospital","Camperdown","2050",{"type":112,"coordinates":387},[388,389],151.17642,-33.88965,{"lat":389,"lon":388},{"facility":392,"status":105,"city":393,"state":57,"zip":394,"country":375,"countryCode":376,"cosmosGeoPoint":395,"geoPoint":399,"contacts":57},"Monash Medical Centre","Clayton","3168",{"type":112,"coordinates":396},[397,398],145.11667,-37.91667,{"lat":398,"lon":397},{"facility":401,"status":105,"city":402,"state":57,"zip":403,"country":375,"countryCode":376,"cosmosGeoPoint":404,"geoPoint":408,"contacts":57},"The Melbourne Gut Clinic Epworth Hospital","East Melbourne","3002",{"type":112,"coordinates":405},[406,407],144.9879,-37.81667,{"lat":407,"lon":406},{"facility":410,"status":105,"city":411,"state":57,"zip":412,"country":375,"countryCode":376,"cosmosGeoPoint":413,"geoPoint":417,"contacts":57},"SA Gastrointestinal Services IBD SA","Kurralta Park","5037",{"type":112,"coordinates":414},[415,416],138.56702,-34.95142,{"lat":416,"lon":415},{"facility":419,"status":105,"city":419,"state":57,"zip":420,"country":375,"countryCode":376,"cosmosGeoPoint":57,"geoPoint":57,"contacts":57},"Macquarie University","2109",{"facility":422,"status":105,"city":423,"state":57,"zip":424,"country":375,"countryCode":376,"cosmosGeoPoint":425,"geoPoint":429,"contacts":57},"Fiona Stanley Hospital","Murdoch","6150",{"type":112,"coordinates":426},[427,428],115.83757,-32.06987,{"lat":428,"lon":427},{"facility":431,"status":105,"city":432,"state":57,"zip":433,"country":375,"countryCode":376,"cosmosGeoPoint":434,"geoPoint":438,"contacts":57},"John Hunter Hospital","New Lambton Heights","2305",{"type":112,"coordinates":435},[436,437],151.69364,-32.92466,{"lat":437,"lon":436},{"facility":440,"status":105,"city":441,"state":57,"zip":442,"country":375,"countryCode":376,"cosmosGeoPoint":443,"geoPoint":447,"contacts":57},"Mater Misericordiae Hospital","South Brisbane","4101",{"type":112,"coordinates":444},[445,446],153.02049,-27.48034,{"lat":446,"lon":445},{"facility":449,"status":105,"city":450,"state":57,"zip":451,"country":452,"countryCode":453,"cosmosGeoPoint":454,"geoPoint":458,"contacts":57},"Kepler Universitatsklinikum GmbH","Linz","4021","Austria","AT",{"type":112,"coordinates":455},[456,457],14.28611,48.30639,{"lat":457,"lon":456},{"facility":460,"status":105,"city":461,"state":57,"zip":462,"country":452,"countryCode":453,"cosmosGeoPoint":463,"geoPoint":467,"contacts":57},"Krankenhaus der Barmherzigen Brüder","Vienna","1020",{"type":112,"coordinates":464},[465,466],16.37208,48.20849,{"lat":466,"lon":465},{"facility":469,"status":105,"city":470,"state":57,"zip":471,"country":452,"countryCode":453,"cosmosGeoPoint":472,"geoPoint":476,"contacts":57},"Klinikum Wels Grieskirchen","Wels","4600",{"type":112,"coordinates":473},[474,475],14.03333,48.16667,{"lat":475,"lon":474},{"facility":478,"status":105,"city":479,"state":57,"zip":480,"country":481,"countryCode":482,"cosmosGeoPoint":483,"geoPoint":487,"contacts":57},"O L V 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University Hospital of Wales","Cardiff","CF14 4XW",{"type":112,"coordinates":2253},[2254,2255],-3.18,51.48,{"lat":2255,"lon":2254},{"facility":2258,"status":105,"city":2259,"state":57,"zip":2260,"country":2241,"countryCode":2242,"cosmosGeoPoint":2261,"geoPoint":2265,"contacts":57},"Ninewells Hospital","Dundee","DD2 1GZ",{"type":112,"coordinates":2262},[2263,2264],-2.97489,56.46913,{"lat":2264,"lon":2263},{"facility":2267,"status":105,"city":2268,"state":57,"zip":2269,"country":2241,"countryCode":2242,"cosmosGeoPoint":2270,"geoPoint":2274,"contacts":57},"Glasgow Royal Infirmary","Glasgow","G31 2ER",{"type":112,"coordinates":2271},[2272,2273],-4.25763,55.86515,{"lat":2273,"lon":2272},{"facility":2276,"status":105,"city":701,"state":57,"zip":2277,"country":2241,"countryCode":2242,"cosmosGeoPoint":2278,"geoPoint":2282,"contacts":57},"Kings College Hospital","SE5 9RS",{"type":112,"coordinates":2279},[2280,2281],-0.12574,51.50853,{"lat":2281,"lon":2280},{"facility":2284,"status":105,"city":701,"state":57,"zip":2285,"country":2241,"countryCode":2242,"cosmosGeoPoint":2286,"geoPoint":2288,"contacts":57},"Chelsea And Westminster Hospital","SW10 9NH",{"type":112,"coordinates":2287},[2280,2281],{"lat":2281,"lon":2280},{"facility":2290,"status":105,"city":701,"state":57,"zip":2291,"country":2241,"countryCode":2242,"cosmosGeoPoint":2292,"geoPoint":2294,"contacts":57},"St Georges Healthcare NHS Trust","SW17 0QT",{"type":112,"coordinates":2293},[2280,2281],{"lat":2281,"lon":2280},{"facility":2296,"status":105,"city":2297,"state":57,"zip":2298,"country":2241,"countryCode":2242,"cosmosGeoPoint":2299,"geoPoint":2303,"contacts":57},"Royal Victoria Infirmary","Newcastle upon Tyne","NE1 4LP",{"type":112,"coordinates":2300},[2301,2302],-1.61396,54.97328,{"lat":2302,"lon":2301},{"type":2305,"investigatorFullName":57,"investigatorTitle":57,"investigatorAffiliation":57,"oldNameTitle":57,"oldOrganization":57},"SPONSOR","100643826","phase-3-a-study-of-jnj-78934804-in-participants-with-moderately-to-severely-active-crohns-disease-100643826",false,"NCT07577843","A Study of JNJ-78934804 in Participants With Moderately to Severely Active Crohn's Disease","A Phase 3, Randomized, Double-blind, and Active-controlled Multicenter Study to Evaluate the Efficacy and Safety of JNJ-78934804 in Participants With Moderately to Severely Active Crohn's Disease","DUET ENCORE-CD","Inclusion criteria:\n\n* Have a diagnosis of Crohn's disease (CD) or fistulizing CD established greater than or equal to (\\>=) 12 weeks before screening including both endoscopic evidence and a histopathology report consistent with a diagnosis of CD\n* Have moderately to severely active CD based on crohn's disease activity index (CDAI) criteria defined as a baseline CDAI score \\>= 220 but less than or equal to (\\\u003C=) 450 and either: a. Mean daily stool frequency (SF) count \\>= 4.0, based on the unweighted CDAI component of the number of liquid or very soft stools or b. Mean daily AP score \\>= 2.0, based on the unweighted CDAI component of abdominal pain (AP)\n* Have moderately to severely active ileal and\u002For colonic CD as assessed by central review of the screening video ileocolonoscopy based on simple endoscopic score for crohn's disease (SES-CD) criteria\n* Have had an inadequate initial response, loss of response, or intolerance to previously approved systemic therapies\n\nExclusion criteria:\n\n* Diagnosis of indeterminate colitis, microscopic colitis, ischemic colitis, ulcerative colitis (UC) or clinical findings highly suggestive of UC\n* Complications of CD such as symptomatic bowel strictures or stenoses, or any other manifestation that may require intestinal surgery while enrolled in the study\n* Presence of draining (that is, functioning) stoma or ostomy\n* Has a history of short bowel syndrome, is missing greater than (\\>) 2 of the 5 ileocolonic segments, or has any other medical condition that could preclude or confound the ability to use efficacy assessment tools (such as CDAI) to assess response to study intervention\n* Currently has or is suspected of having an abscess","ALL","18 Years",{"count":2317,"type":2318},460,"ESTIMATED","INTERVENTIONAL",[2321],"PHASE3","The purpose of this study is to assess how well JNJ-78934804 works (efficacy) and how safe it is (safety) as compared to guselkumab at Week 48 in participants with moderately to severely active Crohn's disease (a long-term, progressive \\[worsens with time\\] and life-threatening disease of the intestine).",[2324],"Crohn Disease","2026-10-08",{"date":2327,"type":2328},"2026-10-14","ACTUAL",{"date":2330,"type":2328},"2026-05-22",{"date":2332,"type":2318},"2030-07-12",{"name":5,"class":6},252]