[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100605586":3},{"organization":4,"outcomesModule":7,"designInfo":42,"detailedDescription":41,"studyPopulation":41,"armGroups":51,"interventions":78,"overallOfficials":100,"centralContacts":104,"locations":110,"responsibleParty":1660,"collaborators":41,"id":1662,"slug":1663,"hasResults":1664,"nctId":1665,"briefTitle":1666,"officialTitle":1667,"acronym":1668,"eligibilityCriteria":1669,"healthyVolunteers":1664,"sex":1670,"minAge":1671,"maxAge":41,"enrollmentInfo":1672,"targetDuration":41,"studyType":1675,"phases":1676,"briefSummary":1678,"conditions":1679,"keywords":41,"overallStatus":113,"whyStopped":41,"lastUpdateSubmitDate":1681,"lastUpdatePostDateStruct":1682,"startDateStruct":1685,"completionDateStruct":1687,"leadSponsor":1689,"locationsCount":1690},{"fullName":5,"class":6},"Janssen Research & Development, LLC","INDUSTRY",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":41},[9],{"measure":10,"description":11,"timeFrame":12},"Overall Survival (OS)","OS is defined as the time from randomization to date of death due to any cause.","Up to 2 years and 8 months",[14,17,20,23,26,29,32,35,38],{"measure":15,"description":16,"timeFrame":12},"Radiographic Progression-free Survival (rPFS)","rPFS assessed by investigator defined as the time from the date of randomization until the date of radiographic disease progression (based on response evaluation criteria in solid tumors \\[RECIST\\] version (v) 1.1 and prostate cancer working group 3 \\[PCWG3\\] criteria) or death, whichever comes first.",{"measure":18,"description":19,"timeFrame":12},"Time to Symptomatic Progression","Time to symptomatic progression is defined as time from the date of randomization to the date of any of the following (whichever occurs first): (a) the use of external beam radiation therapy to relieve cancer-related symptoms; (b) the need for tumor-related orthopedic surgical intervention; (c) other cancer-related procedures; (d) cancer-related morbid events; (e) initiation of a new systemic anti-cancer therapy because of cancer symptoms.",{"measure":21,"description":22,"timeFrame":12},"Time to Skeletal-Related Event","Time to skeletal-related event is defined as the time from the date of randomization to the date of first occurrence of any of the following (whichever occurs first): (a) the use of external beam radiation for skeletal or pelvic symptoms; b) the need for tumor-related orthopedic surgical intervention; (c) the occurrence of new bone fractures (cancer-related); (d) the occurrence of tumor-related spinal cord compression.",{"measure":24,"description":25,"timeFrame":12},"Progression-Free Survival (PFS)","PFS is defined as the date of randomization to the date of first evidence of radiographic progression, clinical progression, or death from any cause, whichever occurs first.",{"measure":27,"description":28,"timeFrame":12},"Time to Prostate Specific Antigen (PSA) Progression","Time to PSA progression, defined as the time from randomization to the first date of documented PSA progression per PCWG3 criteria. PSA progression is defined as: after a decline from baseline, PSA increases \\>= 25 percentage (%) and \\>= 2 nanograms per milliliter (ng\u002FmL) above the nadir, confirmed by a second value \\>= 3 weeks later (that is, a confirmed rising trend), or If there is no decline from baseline, PSA increases \\>= 25 % and \\>= 2 ng\u002FmL from baseline after 12 weeks.",{"measure":30,"description":31,"timeFrame":12},"Time to Pain Progression (TTPP) as Assessed by the Brief Pain Inventory-Short Form (BPI-SF) Item 3 Worst Pain in 24 Hours","TTPP is defined as the time from the date of randomization to the date of the first observation of pain progression. Pain progression is defined as an increase of at least 2 points from baseline in the BPI-SF worst pain intensity (item 3) observed at 2 consecutive evaluations \\>= 3 weeks apart. BPI-SF is an 11-item questionnaire, designed to assess severity and impact of pain on daily functions. Total score range from 0 to 10 with 0 representing \"no pain\" and 10 representing\" pain as bad as you can imagine\".",{"measure":33,"description":34,"timeFrame":12},"Time to Deterioration in Fatigue as Assessed by the European Organisation For Research And Treatment of Cancer Quality of Life Questionnaire-Core-30 (EORTC QLQ-C30) Fatigue Scale Score","Time to deterioration is defined as the time from randomization to the date of the first observation of deterioration in Fatigue. Deterioration in Fatigue is defined as an increase of 10 points on the EORTC QLQ-C30 FA scale observed at 2 consecutive evaluations \\>= 3 weeks apart. The EORTC QLQ-C30 is a widely used tool for assessing the quality of life of cancer patients in clinical trials. Responses to items 1-28 are rated on a 4-point Likert response scale ranging from 1 \"Not at all\" to 4 \"Very much\". Two global health status items are rated on a 7-point numeric rating scale from 1 \"Very Poor\" to 7 \"Excellent\". Each subscale of the EORTC QLQ-C30 is scored on a range from 0 to 100. Higher scores indicate worse symptoms or problems.",{"measure":36,"description":37,"timeFrame":12},"Number of Participants with Adverse Events (AEs)","An AE is any untoward medical occurrence in a participant participating in a clinical study that does not necessarily have a causal relationship with the pharmaceutical\u002Fbiological agent under study.",{"measure":39,"description":40,"timeFrame":12},"Number of Participants with Abnormalities in Clinical Laboratory Assessments","Participants with abnormalities in clinical laboratory parameters (hematology, clinical chemistry etc.) will be assessed.",null,{"allocation":43,"interventionModel":44,"interventionModelDescription":41,"primaryPurpose":45,"observationalModel":41,"timePerspective":41,"maskingInfo":46},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":47,"maskingDescription":41,"whoMasked":48},"DOUBLE",[49,50],"PARTICIPANT","INVESTIGATOR",[52,59,65,69,74],{"label":53,"type":54,"description":55,"interventionNames":56},"Part 1: Pasritamig+Best Supportive Care (BSC)","EXPERIMENTAL","Participants in Part 1 will receive 2 step-up doses of pasritamig intravenously (IV) followed by the target dose. Participants will receive study treatment until confirmed progressive disease, death, intolerable toxicity, withdrawal of consent, or end of the study, whichever occurs first. All participants may receive BSC (defined as palliative external beam radiation, low dose steroids, pain medication, bone sparing agents, and needed palliative procedures) at the discretion of the physician.",[57,58],"Biological: Pasritamig","Drug: Best Supportive Care (BSC)",{"label":60,"type":61,"description":62,"interventionNames":63},"Part 1: Placebo+BSC","PLACEBO_COMPARATOR","Participants in Part 1 will receive 2 step-up doses of placebo IV followed by the target dose. Participants will receive study treatment until confirmed progressive disease, death, intolerable toxicity, withdrawal of consent, or end of the study, whichever occurs first. All participants may receive BSC (defined as palliative external beam radiation, low dose steroids, pain medication, bone sparing agents, and needed palliative procedures) at the discretion of the physician.",[64,58],"Other: Placebo",{"label":66,"type":54,"description":67,"interventionNames":68},"Part 2: Pasritamig+BSC","Participants in Part 2 will receive 2 step-up doses of pasritamig IV followed by the target dose. Participants will receive study treatment until confirmed progressive disease, death, intolerable toxicity, withdrawal of consent, or end of the study, whichever occurs first. All participants may receive BSC (defined as palliative external beam radiation, low dose steroids, pain medication, bone sparing agents, and needed palliative procedures) at the discretion of the physician.",[57,58],{"label":70,"type":54,"description":71,"interventionNames":72},"Part 2: Pasritamig+JNJ-87189401+BSC","Participants in Part 2 will receive 2 step-up doses of pasritamig IV followed by the target dose. JNJ-87189401 will be administered with the first target dose of pasritamig. Participants will receive study treatment until confirmed progressive disease, death, intolerable toxicity, withdrawal of consent, or end of the study, whichever occurs first. All participants may receive BSC (defined as palliative external beam radiation, low dose steroids, pain medication, bone sparing agents, and needed palliative procedures) at the discretion of the physician.",[57,58,73],"Biological: JNJ-87189401",{"label":75,"type":61,"description":76,"interventionNames":77},"Part 2: Placebo +BSC","Participants in Part 2 will receive 2 step-up doses of placebo IV followed by the target dose. Participants will receive study treatment until confirmed progressive disease, death, intolerable toxicity, withdrawal of consent, or end of the study, whichever occurs first. All participants may receive BSC (defined as palliative external beam radiation, low dose steroids, pain medication, bone sparing agents, and needed palliative procedures) at the discretion of the physician.",[64,58],[79,86,91,96],{"type":80,"name":81,"description":82,"armGroupLabels":83,"otherNames":84},"BIOLOGICAL","Pasritamig","Pasritamig will be administrated through IV infusion.",[53,66,70],[85],"JNJ-78278343",{"type":87,"name":88,"description":89,"armGroupLabels":90,"otherNames":41},"OTHER","Placebo","Placebo will be administrated through IV infusion.",[60,75],{"type":92,"name":93,"description":94,"armGroupLabels":95,"otherNames":41},"DRUG","Best Supportive Care (BSC)","BSC will be administered at the discretion of the treating physician.",[53,60,66,70,75],{"type":80,"name":97,"description":98,"armGroupLabels":99,"otherNames":41},"JNJ-87189401","JNJ-87189401 will be administered.",[70],[101],{"name":102,"affiliation":5,"role":103},"Janssen Research & Development, LLC Clinical Trial","STUDY_DIRECTOR",[105],{"name":106,"role":107,"phone":108,"phoneExt":41,"email":109},"Study Contact","CONTACT","844-434-4210","Participate-In-This-Study1@its.jnj.com",[111,125,134,140,149,159,165,174,184,194,204,213,222,232,241,251,261,271,281,290,300,310,320,329,337,343,353,362,372,381,392,398,407,417,426,435,444,454,463,472,481,491,500,510,516,525,530,539,549,559,568,577,587,593,599,610,619,628,637,646,657,666,675,680,689,698,707,716,725,736,745,754,763,772,784,794,804,813,819,829,840,849,858,864,873,882,891,900,909,918,927,936,945,954,963,974,983,992,1001,1010,1019,1028,1037,1046,1055,1064,1075,1084,1093,1102,1111,1120,1128,1137,1146,1155,1164,1175,1184,1193,1202,1211,1220,1229,1238,1249,1258,1267,1276,1285,1294,1303,1307,1316,1325,1331,1340,1351,1360,1369,1378,1387,1396,1405,1414,1425,1434,1443,1452,1458,1469,1478,1488,1497,1501,1510,1516,1522,1528,1539,1548,1557,1563,1572,1583,1592,1598,1607,1613,1622,1633,1642,1651],{"facility":112,"status":113,"city":114,"state":115,"zip":116,"country":117,"countryCode":118,"cosmosGeoPoint":119,"geoPoint":124,"contacts":41},"University of California at San Diego","RECRUITING","La Jolla","California","92093","United States","US",{"type":120,"coordinates":121},"Point",[122,123],-117.2742,32.84727,{"lat":123,"lon":122},{"facility":126,"status":113,"city":127,"state":115,"zip":128,"country":117,"countryCode":118,"cosmosGeoPoint":129,"geoPoint":133,"contacts":41},"Cedars Sinai Medical Center","Los Angeles","90048",{"type":120,"coordinates":130},[131,132],-118.24368,34.05223,{"lat":132,"lon":131},{"facility":135,"status":113,"city":127,"state":115,"zip":136,"country":117,"countryCode":118,"cosmosGeoPoint":137,"geoPoint":139,"contacts":41},"Ronald Reagan UCLA Medical Center","90095",{"type":120,"coordinates":138},[131,132],{"lat":132,"lon":131},{"facility":141,"status":113,"city":142,"state":115,"zip":143,"country":117,"countryCode":118,"cosmosGeoPoint":144,"geoPoint":148,"contacts":41},"San Francisco VA Medical Center","San Francisco","94121",{"type":120,"coordinates":145},[146,147],-122.41942,37.77493,{"lat":147,"lon":146},{"facility":150,"status":113,"city":151,"state":152,"zip":153,"country":117,"countryCode":118,"cosmosGeoPoint":154,"geoPoint":158,"contacts":41},"Rocky Mountain Cancer Centers","Aurora","Colorado","80012",{"type":120,"coordinates":155},[156,157],-104.83192,39.72943,{"lat":157,"lon":156},{"facility":160,"status":113,"city":151,"state":152,"zip":161,"country":117,"countryCode":118,"cosmosGeoPoint":162,"geoPoint":164,"contacts":41},"University of Colorado Cancer Center","80045",{"type":120,"coordinates":163},[156,157],{"lat":157,"lon":156},{"facility":166,"status":113,"city":167,"state":152,"zip":168,"country":117,"countryCode":118,"cosmosGeoPoint":169,"geoPoint":173,"contacts":41},"Colorado Clinical Research","Lakewood","80228",{"type":120,"coordinates":170},[171,172],-105.08137,39.70471,{"lat":172,"lon":171},{"facility":175,"status":113,"city":176,"state":177,"zip":178,"country":117,"countryCode":118,"cosmosGeoPoint":179,"geoPoint":183,"contacts":41},"Hartford Hospital","Hartford","Connecticut","06102",{"type":120,"coordinates":180},[181,182],-72.68509,41.76371,{"lat":182,"lon":181},{"facility":185,"status":113,"city":186,"state":187,"zip":188,"country":117,"countryCode":118,"cosmosGeoPoint":189,"geoPoint":193,"contacts":41},"Johns Hopkins Office of Capital Region Research - Sibley Memorial Hospital","Washington D.C.","District of Columbia","20016",{"type":120,"coordinates":190},[191,192],-77.03637,38.89511,{"lat":192,"lon":191},{"facility":195,"status":113,"city":196,"state":197,"zip":198,"country":117,"countryCode":118,"cosmosGeoPoint":199,"geoPoint":203,"contacts":41},"Bay Pines VA Healthcare System","Bay Pines","Florida","33744",{"type":120,"coordinates":200},[201,202],-82.77816,27.81419,{"lat":202,"lon":201},{"facility":205,"status":113,"city":206,"state":197,"zip":207,"country":117,"countryCode":118,"cosmosGeoPoint":208,"geoPoint":212,"contacts":41},"Florida Cancer Specialists & Research Institute","Fort Myers","33901",{"type":120,"coordinates":209},[210,211],-81.84059,26.62168,{"lat":211,"lon":210},{"facility":214,"status":113,"city":215,"state":197,"zip":216,"country":117,"countryCode":118,"cosmosGeoPoint":217,"geoPoint":221,"contacts":41},"Moffitt Cancer Center","Tampa","33612",{"type":120,"coordinates":218},[219,220],-82.45843,27.94752,{"lat":220,"lon":219},{"facility":223,"status":113,"city":224,"state":225,"zip":226,"country":117,"countryCode":118,"cosmosGeoPoint":227,"geoPoint":231,"contacts":41},"University of Iowa Hospital and Clinics","Iowa City","Iowa","52242",{"type":120,"coordinates":228},[229,230],-91.53017,41.66113,{"lat":230,"lon":229},{"facility":233,"status":113,"city":234,"state":225,"zip":235,"country":117,"countryCode":118,"cosmosGeoPoint":236,"geoPoint":240,"contacts":41},"Mission Cancer Blood","Waukee","50263",{"type":120,"coordinates":237},[238,239],-93.88523,41.61166,{"lat":239,"lon":238},{"facility":242,"status":113,"city":243,"state":244,"zip":245,"country":117,"countryCode":118,"cosmosGeoPoint":246,"geoPoint":250,"contacts":41},"East Jefferson General Hospital","Metairie","Louisiana","70006",{"type":120,"coordinates":247},[248,249],-90.15285,29.98409,{"lat":249,"lon":248},{"facility":252,"status":113,"city":253,"state":254,"zip":255,"country":117,"countryCode":118,"cosmosGeoPoint":256,"geoPoint":260,"contacts":41},"Johns Hopkins University","Baltimore","Maryland","21287",{"type":120,"coordinates":257},[258,259],-76.61219,39.29038,{"lat":259,"lon":258},{"facility":262,"status":113,"city":263,"state":264,"zip":265,"country":117,"countryCode":118,"cosmosGeoPoint":266,"geoPoint":270,"contacts":41},"Dana Farber Cancer Institute","Boston","Massachusetts","02115",{"type":120,"coordinates":267},[268,269],-71.05977,42.35843,{"lat":269,"lon":268},{"facility":272,"status":113,"city":273,"state":274,"zip":275,"country":117,"countryCode":118,"cosmosGeoPoint":276,"geoPoint":280,"contacts":41},"University of Michigan Health System","Ann Arbor","Michigan","48109",{"type":120,"coordinates":277},[278,279],-83.74088,42.27756,{"lat":279,"lon":278},{"facility":282,"status":113,"city":283,"state":274,"zip":284,"country":117,"countryCode":118,"cosmosGeoPoint":285,"geoPoint":289,"contacts":41},"Henry Ford Cancer Detroit","Detroit","48202",{"type":120,"coordinates":286},[287,288],-83.04575,42.33143,{"lat":288,"lon":287},{"facility":291,"status":113,"city":292,"state":293,"zip":294,"country":117,"countryCode":118,"cosmosGeoPoint":295,"geoPoint":299,"contacts":41},"University Of Minnesota Medical Center","Minneapolis","Minnesota","55455",{"type":120,"coordinates":296},[297,298],-93.26384,44.97997,{"lat":298,"lon":297},{"facility":301,"status":113,"city":302,"state":303,"zip":304,"country":117,"countryCode":118,"cosmosGeoPoint":305,"geoPoint":309,"contacts":41},"XCancer Omaha \u002F Urology Cancer Center","Omaha","Nebraska","68130",{"type":120,"coordinates":306},[307,308],-95.94043,41.25626,{"lat":308,"lon":307},{"facility":311,"status":113,"city":312,"state":313,"zip":314,"country":117,"countryCode":118,"cosmosGeoPoint":315,"geoPoint":319,"contacts":41},"NYU Langone Hospitals","Brooklyn","New York","11220",{"type":120,"coordinates":316},[317,318],-73.94958,40.6501,{"lat":318,"lon":317},{"facility":321,"status":113,"city":322,"state":313,"zip":323,"country":117,"countryCode":118,"cosmosGeoPoint":324,"geoPoint":328,"contacts":41},"NYU Langone Hospital Long Island","Mineola","11501",{"type":120,"coordinates":325},[326,327],-73.64068,40.74927,{"lat":327,"lon":326},{"facility":330,"status":113,"city":313,"state":313,"zip":331,"country":117,"countryCode":118,"cosmosGeoPoint":332,"geoPoint":336,"contacts":41},"NYU Langone Health Laura and Isaac Perlmutter Cancer Center","10016",{"type":120,"coordinates":333},[334,335],-74.00597,40.71427,{"lat":335,"lon":334},{"facility":338,"status":113,"city":313,"state":313,"zip":339,"country":117,"countryCode":118,"cosmosGeoPoint":340,"geoPoint":342,"contacts":41},"Columbia University Medical Center","10032",{"type":120,"coordinates":341},[334,335],{"lat":335,"lon":334},{"facility":344,"status":113,"city":345,"state":346,"zip":347,"country":117,"countryCode":118,"cosmosGeoPoint":348,"geoPoint":352,"contacts":41},"Levine Cancer Institute","Charlotte","North Carolina","28204",{"type":120,"coordinates":349},[350,351],-80.84313,35.22709,{"lat":351,"lon":350},{"facility":354,"status":113,"city":355,"state":346,"zip":356,"country":117,"countryCode":118,"cosmosGeoPoint":357,"geoPoint":361,"contacts":41},"Atrium Health Wake Forest Baptist Comprehensive Cancer Center","Winston-Salem","27157",{"type":120,"coordinates":358},[359,360],-80.24422,36.09986,{"lat":360,"lon":359},{"facility":363,"status":113,"city":364,"state":365,"zip":366,"country":117,"countryCode":118,"cosmosGeoPoint":367,"geoPoint":371,"contacts":41},"University of Cincinnati","Cincinnati","Ohio","45219",{"type":120,"coordinates":368},[369,370],-84.51439,39.12711,{"lat":370,"lon":369},{"facility":373,"status":113,"city":374,"state":365,"zip":375,"country":117,"countryCode":118,"cosmosGeoPoint":376,"geoPoint":380,"contacts":41},"University Hospital of Cleveland","Cleveland","44106",{"type":120,"coordinates":377},[378,379],-81.69541,41.4995,{"lat":379,"lon":378},{"facility":382,"status":383,"city":384,"state":385,"zip":386,"country":117,"countryCode":118,"cosmosGeoPoint":387,"geoPoint":391,"contacts":41},"Compass Oncology","COMPLETED","Portland","Oregon","97227",{"type":120,"coordinates":388},[389,390],-122.67621,45.52345,{"lat":390,"lon":389},{"facility":393,"status":113,"city":384,"state":385,"zip":394,"country":117,"countryCode":118,"cosmosGeoPoint":395,"geoPoint":397,"contacts":41},"VA Portland Health Care System","97239",{"type":120,"coordinates":396},[389,390],{"lat":390,"lon":389},{"facility":399,"status":113,"city":400,"state":385,"zip":401,"country":117,"countryCode":118,"cosmosGeoPoint":402,"geoPoint":406,"contacts":41},"Oregon Urology Institute","Springfield","97477",{"type":120,"coordinates":403},[404,405],-123.02203,44.04624,{"lat":405,"lon":404},{"facility":408,"status":113,"city":409,"state":410,"zip":411,"country":117,"countryCode":118,"cosmosGeoPoint":412,"geoPoint":416,"contacts":41},"MidLantic Urology","Bala-Cynwyd","Pennsylvania","19004",{"type":120,"coordinates":413},[414,415],-75.23407,40.00761,{"lat":415,"lon":414},{"facility":418,"status":113,"city":419,"state":410,"zip":420,"country":117,"countryCode":118,"cosmosGeoPoint":421,"geoPoint":425,"contacts":41},"Keystone Urology Specialists","Lancaster","17601",{"type":120,"coordinates":422},[423,424],-76.30551,40.03788,{"lat":424,"lon":423},{"facility":427,"status":113,"city":428,"state":410,"zip":429,"country":117,"countryCode":118,"cosmosGeoPoint":430,"geoPoint":434,"contacts":41},"Penn Medicine Abramson Cancer Center","Philadelphia","19104",{"type":120,"coordinates":431},[432,433],-75.16362,39.95238,{"lat":433,"lon":432},{"facility":436,"status":113,"city":437,"state":410,"zip":438,"country":117,"countryCode":118,"cosmosGeoPoint":439,"geoPoint":443,"contacts":41},"UPMC Cancer Centers","Pittsburgh","15232",{"type":120,"coordinates":440},[441,442],-79.99589,40.44062,{"lat":442,"lon":441},{"facility":445,"status":113,"city":446,"state":447,"zip":448,"country":117,"countryCode":118,"cosmosGeoPoint":449,"geoPoint":453,"contacts":41},"Ralph H Johnson Veterans Hospital","Charleston","South Carolina","29401",{"type":120,"coordinates":450},[451,452],-79.93275,32.77632,{"lat":452,"lon":451},{"facility":455,"status":113,"city":456,"state":447,"zip":457,"country":117,"countryCode":118,"cosmosGeoPoint":458,"geoPoint":462,"contacts":41},"Gibbs Cancer Center and Research Institute Pelham","Greer","29650",{"type":120,"coordinates":459},[460,461],-82.22706,34.93873,{"lat":461,"lon":460},{"facility":464,"status":113,"city":465,"state":447,"zip":466,"country":117,"countryCode":118,"cosmosGeoPoint":467,"geoPoint":471,"contacts":41},"Carolina Urologic Research Center","Myrtle Beach","29572",{"type":120,"coordinates":468},[469,470],-78.88669,33.68906,{"lat":470,"lon":469},{"facility":473,"status":113,"city":474,"state":447,"zip":475,"country":117,"countryCode":118,"cosmosGeoPoint":476,"geoPoint":480,"contacts":41},"Gibbs Cancer Center","Spartanburg","29303",{"type":120,"coordinates":477},[478,479],-81.93205,34.94957,{"lat":479,"lon":478},{"facility":482,"status":113,"city":483,"state":484,"zip":485,"country":117,"countryCode":118,"cosmosGeoPoint":486,"geoPoint":490,"contacts":41},"Tennessee Oncology - Chattanooga","Chattanooga","Tennessee","37404",{"type":120,"coordinates":487},[488,489],-85.30968,35.04563,{"lat":489,"lon":488},{"facility":492,"status":113,"city":493,"state":484,"zip":494,"country":117,"countryCode":118,"cosmosGeoPoint":495,"geoPoint":499,"contacts":41},"Tennessee Oncology Nashville","Nashville","37203",{"type":120,"coordinates":496},[497,498],-86.78444,36.16589,{"lat":498,"lon":497},{"facility":501,"status":383,"city":502,"state":503,"zip":504,"country":117,"countryCode":118,"cosmosGeoPoint":505,"geoPoint":509,"contacts":41},"Urology Clinics of North Texas","Dallas","Texas","75231",{"type":120,"coordinates":506},[507,508],-96.80667,32.78306,{"lat":508,"lon":507},{"facility":511,"status":113,"city":502,"state":503,"zip":512,"country":117,"countryCode":118,"cosmosGeoPoint":513,"geoPoint":515,"contacts":41},"UT Southwestern Medical Center","75390",{"type":120,"coordinates":514},[507,508],{"lat":508,"lon":507},{"facility":517,"status":113,"city":518,"state":503,"zip":519,"country":117,"countryCode":118,"cosmosGeoPoint":520,"geoPoint":524,"contacts":41},"MD Anderson Cancer Center","Houston","77030",{"type":120,"coordinates":521},[522,523],-95.36327,29.76328,{"lat":523,"lon":522},{"facility":526,"status":113,"city":518,"state":503,"zip":519,"country":117,"countryCode":118,"cosmosGeoPoint":527,"geoPoint":529,"contacts":41},"Michael E DeBakey VA Medical 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Visceral disease is not allowed\n* PSA greater than or equal to (≥) 2 nanogram per milliliter (ng\u002FmL) at screening\n* In the opinion of the investigator, the next best treatment option is a clinical trial\n* Participants are required to have had all life-prolonging therapies for which they are clinically eligible in the opinion of the investigator and to which they have access. Prior therapies could have been given in any disease setting (not limited to mCRPC). In particular, prior treatment specifications include receipt of the following:\n\nAndrogen-receptor pathway inhibitor (ARPI): Must have progressed on at least 1 ARPI and unlikely to benefit from retreatment with another ARPI\n\nTaxanes: Required to have received at least 2 previous taxane-based regimens. If a participant has received only 1 taxane regimen, the participant is eligible if:\n\n1. Cabazitaxel is not available\n2. The participant's physician deems the participant unsuitable to receive a second taxane regimen due to toxicity risk or prior intolerance Note: a taxane-based regimen consists of at least 2 cycles of a taxane (either as a single agent or in combination with other therapies) administered within the same 2-month period\n\nRadioligand therapy: Required to have been previously treated with at least 1 dose of Prostate-specific membrane antigen (PSMA)-targeted lutetium radioligand therapy (eg, lutetium Lu-177 vipivotide tetraxetan), unless one of the following applies:\n\n1. PSMA-targeted lutetium radioligand therapy is unavailable, not accessible, or not clinically indicated.\n2. The participant's physician deems the participant unsuitable to receive PSMA-targeted lutetium radioligand therapy.\n\nPolyadenosine diphosphate-ribose polymerase inhibitors (PARPi): Required to have been previously treated with PARPi, if the participant has a known germline or somatic BRCA mutation and treatment is available\n\n* Prior orchiectomy or medical castration (receiving ongoing ADT with a GnRH analog \\[agonist or antagonist\\]) prior to the first dose of study treatment and must continue this therapy throughout the treatment phase\n* Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2\n* Participants are eligible if they have the following values:\n\nA) eGFR ≥ 40 milliliters per minute (mL\u002Fmin) B) Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) less than or equal to (≤) 3 times the Upper Limit of Normal (ULN) C) Total bilirubin \\\u003C1.5 times ULN D) Absolute neutrophil count (ANC) ≥ 1.0x10\\^9\u002Fper liter (L) E) Hemoglobin ≥ 8.0 grams per deciliter (g\u002FdL) F) Platelet count ≥ 75x10\\^9\u002FL\n\nExclusion Criteria\n\n* Venous thromboembolic events within 1 month prior to the first dose of study treatment; uncomplicated (Grade ≤ 2) deep vein thrombosis is not exclusionary\n* Active autoimmune disease within the past 12 months that requires systemic immunosuppressive medications (eg, chronic corticosteroid, methotrexate, or tacrolimus)\n* Participants with Grade 1 or higher fever (≥38ºC) or active infection requiring systemic treatment within 7 days prior to randomization are ineligible. Participants must be afebrile (\\\u003C38ºC) at the time of study treatment dosing unless approved by medical monitor\n* Clinically significant pulmonary compromise, particularly a requirement for supplemental oxygen use (\\>2 liters per minute (L\u002Fmin) by nasal cannula) to maintain adequate oxygenation\n* Prior or concurrent second malignancy (other than the disease under study) for which natural history or treatment could likely interfere with any study endpoints of safety or the efficacy of the study treatment(s)\n* Any of the following within 6 months prior to first dose of study treatment:\n\nA) Myocardial infarction B) Severe or unstable angina C) Clinically significant ventricular arrhythmias D) Congestive heart failure (New York Heart Association class II to IV) E) Transient ischemic attack F) Cerebrovascular accident\n\n\\- Prior treatment with any CD3-directed therapy","MALE","18 Years",{"count":1673,"type":1674},1203,"ESTIMATED","INTERVENTIONAL",[1677],"PHASE3","The purpose of this study is to evaluate the overall survival (length of time from the start of study to date of death from any cause) for pasritamig (JNJ-78278343) in Part 1 in combination with best supportive care (BSC) and in Part 2 with JNJ-87189401+BSC as compared to placebo with BSC in participants with metastatic castration-resistant prostate cancer (mCRPC; a stage of cancer that has spread beyond the prostate gland and is no longer responding to hormone therapies).",[1680],"Metastatic Castration-resistant Prostatic Neoplasms","2026-08-21",{"date":1683,"type":1684},"2026-08-25","ACTUAL",{"date":1686,"type":1684},"2025-09-02",{"date":1688,"type":1674},"2028-08-18",{"name":5,"class":6},173]