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Participant must be at least 18 years of age, inclusive, at the time of signing the ICF.\n2. Histologically confirmed diagnosis of classic FL per WHO 2022 classification\n3. ECOG performance status of 0 to 2\n4. No prior systemic lymphoma-directed therapy\n5. Need for systemic treatment meeting at least 1 GELF criteria\n6. FDG-avid and measurable disease\n7. Stage II to IV and FLIPI 2-5 \\[Phase III only\\]\n8. Adequate liver, hematological, renal and cardiac function.\n\nThe above is a summary, other inclusion criteria details may apply\n\nExclusion Criteria:\n\n1. Follicular large B-cell lymphoma (WHO 2022 classification), formerly Follicular lymphoma Grade 3B (WHO 2016 classification) or suspicion for histologic transformation to high-grade\u002Faggressive lymphoma\n2. Contra-indication to BR, RCVP, and R-CHOP\n3. Participants with or history of CNS lymphoma\n4. 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