[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100578128":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":44,"responsibleParty":455,"collaborators":30,"id":457,"slug":458,"hasResults":459,"nctId":460,"briefTitle":461,"officialTitle":462,"acronym":30,"eligibilityCriteria":463,"healthyVolunteers":459,"sex":464,"minAge":465,"maxAge":466,"enrollmentInfo":467,"targetDuration":30,"studyType":470,"phases":471,"briefSummary":473,"conditions":474,"keywords":476,"overallStatus":47,"whyStopped":30,"lastUpdateSubmitDate":478,"lastUpdatePostDateStruct":479,"startDateStruct":482,"completionDateStruct":484,"leadSponsor":486,"locationsCount":487},{"fullName":5,"class":6},"Pfizer","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Abrocitinib","EXPERIMENTAL","Abrocitinib administered as liquid oral suspension.",[13],"Drug: Abrocitinib",{"label":15,"type":16,"description":17,"interventionNames":18},"Matching Placebo","PLACEBO_COMPARATOR","Placebo administered as liquid oral suspension.",[19],"Other: Placebo",[21,26],{"type":22,"name":9,"description":11,"armGroupLabels":23,"otherNames":24},"DRUG",[9],[25],"PF-04965842",{"type":27,"name":28,"description":17,"armGroupLabels":29,"otherNames":30},"OTHER","Placebo",[15],null,[32],{"name":33,"affiliation":5,"role":34},"Pfizer CT.gov Call Center","STUDY_DIRECTOR",[36,40],{"name":33,"role":37,"phone":38,"phoneExt":30,"email":39},"CONTACT","1-800-718-1021","ClinicalTrials.gov_Inquiries@pfizer.com",{"name":41,"role":37,"phone":42,"phoneExt":30,"email":43},"Nancy A Sherman, BA","2127332323","Nancy.Sherman@Pfizer.com",[45,59,69,79,84,94,104,114,124,134,143,153,165,175,185,195,205,215,220,226,238,248,260,270,275,281,293,303,308,317,323,335,345,354,363,375,385,395,404,414,424,436,446],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":30},"Cahaba Dermatology & Skin Health Center, LLC","RECRUITING","Birmingham","Alabama","35244","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-86.80249,33.52066,{"lat":57,"lon":56},{"facility":60,"status":47,"city":61,"state":62,"zip":63,"country":51,"countryCode":52,"cosmosGeoPoint":64,"geoPoint":68,"contacts":30},"Arkansas Research Trials","North Little Rock","Arkansas","72117",{"type":54,"coordinates":65},[66,67],-92.26709,34.76954,{"lat":67,"lon":66},{"facility":70,"status":47,"city":71,"state":72,"zip":73,"country":51,"countryCode":52,"cosmosGeoPoint":74,"geoPoint":78,"contacts":30},"Investigational Drug Service - Rady Childrens Hospital-San Diego","San Diego","California","92123",{"type":54,"coordinates":75},[76,77],-117.16472,32.71571,{"lat":77,"lon":76},{"facility":80,"status":47,"city":71,"state":72,"zip":73,"country":51,"countryCode":52,"cosmosGeoPoint":81,"geoPoint":83,"contacts":30},"University of California, San Diego\u002FRady Children's Hospital-San Diego; Pediatric & Adolescent Derm",{"type":54,"coordinates":82},[76,77],{"lat":77,"lon":76},{"facility":85,"status":47,"city":86,"state":87,"zip":88,"country":51,"countryCode":52,"cosmosGeoPoint":89,"geoPoint":93,"contacts":30},"Solutions Through Advanced Research","Jacksonville","Florida","32256",{"type":54,"coordinates":90},[91,92],-81.65565,30.33218,{"lat":92,"lon":91},{"facility":95,"status":47,"city":96,"state":97,"zip":98,"country":51,"countryCode":52,"cosmosGeoPoint":99,"geoPoint":103,"contacts":30},"Ada West Research","Meridian","Idaho","83646",{"type":54,"coordinates":100},[101,102],-116.39151,43.61211,{"lat":102,"lon":101},{"facility":105,"status":47,"city":106,"state":107,"zip":108,"country":51,"countryCode":52,"cosmosGeoPoint":109,"geoPoint":113,"contacts":30},"Dawes Fretzin Clinical Research Group, LLC","Indianapolis","Indiana","46250",{"type":54,"coordinates":110},[111,112],-86.15804,39.76838,{"lat":112,"lon":111},{"facility":115,"status":47,"city":116,"state":117,"zip":118,"country":51,"countryCode":52,"cosmosGeoPoint":119,"geoPoint":123,"contacts":30},"Saint Louis University - Department of Dermatology","St Louis","Missouri","63104",{"type":54,"coordinates":120},[121,122],-90.19789,38.62727,{"lat":122,"lon":121},{"facility":125,"status":47,"city":126,"state":127,"zip":128,"country":51,"countryCode":52,"cosmosGeoPoint":129,"geoPoint":133,"contacts":30},"Medical University of South Carolina","Charleston","South Carolina","29425",{"type":54,"coordinates":130},[131,132],-79.93275,32.77632,{"lat":132,"lon":131},{"facility":135,"status":47,"city":136,"state":127,"zip":137,"country":51,"countryCode":52,"cosmosGeoPoint":138,"geoPoint":142,"contacts":30},"Tribe Clinical Research, LLC","Greenville","29607",{"type":54,"coordinates":139},[140,141],-82.39401,34.85262,{"lat":141,"lon":140},{"facility":144,"status":47,"city":145,"state":146,"zip":147,"country":51,"countryCode":52,"cosmosGeoPoint":148,"geoPoint":152,"contacts":30},"Texas Dermatology and Laser Specialists","San Antonio","Texas","78235",{"type":54,"coordinates":149},[150,151],-98.49363,29.42412,{"lat":151,"lon":150},{"facility":154,"status":47,"city":155,"state":156,"zip":157,"country":158,"countryCode":159,"cosmosGeoPoint":160,"geoPoint":164,"contacts":30},"Beijing Children's hospital, Capital Medical University","Beijing","Beijing Municipality","100045","China","CN",{"type":54,"coordinates":161},[162,163],116.39723,39.9075,{"lat":163,"lon":162},{"facility":166,"status":47,"city":167,"state":168,"zip":169,"country":158,"countryCode":159,"cosmosGeoPoint":170,"geoPoint":174,"contacts":30},"Shenzhen Children's Hospital","Shenzhen","Guangdong","518026",{"type":54,"coordinates":171},[172,173],114.0683,22.54554,{"lat":173,"lon":172},{"facility":176,"status":47,"city":177,"state":178,"zip":179,"country":158,"countryCode":159,"cosmosGeoPoint":180,"geoPoint":184,"contacts":30},"Hunan Children's Hospital","Changsha","Hunan","410007",{"type":54,"coordinates":181},[182,183],112.97087,28.19874,{"lat":183,"lon":182},{"facility":186,"status":47,"city":187,"state":188,"zip":189,"country":158,"countryCode":159,"cosmosGeoPoint":190,"geoPoint":194,"contacts":30},"Dermatology Hospital of Jiangxi Province","Nanchang","Jiangxi","330000",{"type":54,"coordinates":191},[192,193],115.85306,28.68396,{"lat":193,"lon":192},{"facility":196,"status":47,"city":197,"state":198,"zip":199,"country":158,"countryCode":159,"cosmosGeoPoint":200,"geoPoint":204,"contacts":30},"Shanghai Children's Hospital","Shanghai","Shanghai Municipality","200040",{"type":54,"coordinates":201},[202,203],121.45806,31.22222,{"lat":203,"lon":202},{"facility":206,"status":47,"city":207,"state":208,"zip":209,"country":158,"countryCode":159,"cosmosGeoPoint":210,"geoPoint":214,"contacts":30},"Hangzhou Third People's Hospital","Hangzhou","Zhejiang","310009",{"type":54,"coordinates":211},[212,213],120.16142,30.29365,{"lat":213,"lon":212},{"facility":196,"status":47,"city":197,"state":30,"zip":216,"country":158,"countryCode":159,"cosmosGeoPoint":217,"geoPoint":219,"contacts":30},"200062",{"type":54,"coordinates":218},[202,203],{"lat":203,"lon":202},{"facility":221,"status":47,"city":197,"state":30,"zip":222,"country":158,"countryCode":159,"cosmosGeoPoint":223,"geoPoint":225,"contacts":30},"Xinhua Hospital Affiliated to Shanghai JiaoTong University School of Medicine","200092",{"type":54,"coordinates":224},[202,203],{"lat":203,"lon":202},{"facility":227,"status":47,"city":228,"state":229,"zip":230,"country":231,"countryCode":232,"cosmosGeoPoint":233,"geoPoint":237,"contacts":30},"Universitätsklinikum Münster","Münster","North Rhine-Westphalia","48149","Germany","DE",{"type":54,"coordinates":234},[235,236],7.62571,51.96236,{"lat":236,"lon":235},{"facility":239,"status":47,"city":240,"state":241,"zip":242,"country":231,"countryCode":232,"cosmosGeoPoint":243,"geoPoint":247,"contacts":30},"Universitaetsklinikum Carl Gustav Carus, Technischen Universitaet Dresden","Dresden","Saxony","01307",{"type":54,"coordinates":244},[245,246],13.73832,51.05089,{"lat":246,"lon":245},{"facility":249,"status":47,"city":250,"state":251,"zip":252,"country":253,"countryCode":254,"cosmosGeoPoint":255,"geoPoint":259,"contacts":30},"Pécsi Tudományegyetem Klinikai Központ","Pécs","Baranya","7632","Hungary","HU",{"type":54,"coordinates":256},[257,258],18.22814,46.07617,{"lat":258,"lon":257},{"facility":261,"status":47,"city":262,"state":263,"zip":264,"country":253,"countryCode":254,"cosmosGeoPoint":265,"geoPoint":269,"contacts":30},"Trial Pharma Kft.","Békéscsaba","Bekes County","5600",{"type":54,"coordinates":266},[267,268],21.1,46.68333,{"lat":268,"lon":267},{"facility":271,"status":47,"city":272,"state":273,"zip":274,"country":253,"countryCode":254,"cosmosGeoPoint":30,"geoPoint":30,"contacts":30},"Clinexpert Kft.","Budapest","Pest County","1033",{"facility":276,"status":47,"city":250,"state":30,"zip":277,"country":253,"countryCode":254,"cosmosGeoPoint":278,"geoPoint":280,"contacts":30},"University of Pecs","7622",{"type":54,"coordinates":279},[257,258],{"lat":258,"lon":257},{"facility":282,"status":47,"city":283,"state":284,"zip":285,"country":286,"countryCode":287,"cosmosGeoPoint":288,"geoPoint":292,"contacts":30},"Queen's square Medical Facilities Queen's square Dermatology and Allergology","Yokohama","Kanagawa","220-6208","Japan","JP",{"type":54,"coordinates":289},[290,291],139.65,35.43333,{"lat":291,"lon":290},{"facility":294,"status":47,"city":295,"state":296,"zip":297,"country":286,"countryCode":287,"cosmosGeoPoint":298,"geoPoint":302,"contacts":30},"Dermatology and Ophthalmology Kume Clinic","Sakai","Osaka","593-8324",{"type":54,"coordinates":299},[300,301],135.46653,34.58216,{"lat":301,"lon":300},{"facility":304,"status":47,"city":305,"state":306,"zip":307,"country":286,"countryCode":287,"cosmosGeoPoint":30,"geoPoint":30,"contacts":30},"Sasamoto Children's Clinic","Setagaya-ku","Tokyo","157-0066",{"facility":309,"status":47,"city":310,"state":30,"zip":311,"country":286,"countryCode":287,"cosmosGeoPoint":312,"geoPoint":316,"contacts":30},"Fukuoka National Hospital","Fukuoka","811-1394",{"type":54,"coordinates":313},[314,315],130.41667,33.6,{"lat":315,"lon":314},{"facility":318,"status":47,"city":310,"state":30,"zip":319,"country":286,"countryCode":287,"cosmosGeoPoint":320,"geoPoint":322,"contacts":30},"Saruta Dermatology Clinic","819-0042",{"type":54,"coordinates":321},[314,315],{"lat":315,"lon":314},{"facility":324,"status":325,"city":326,"state":326,"zip":327,"country":328,"countryCode":329,"cosmosGeoPoint":330,"geoPoint":334,"contacts":30},"Hospital Infantil de México Federico Gómez","NOT_YET_RECRUITING","Mexico City","06720","Mexico","MX",{"type":54,"coordinates":331},[332,333],-99.12766,19.42847,{"lat":333,"lon":332},{"facility":336,"status":47,"city":337,"state":338,"zip":339,"country":328,"countryCode":329,"cosmosGeoPoint":340,"geoPoint":344,"contacts":30},"Eukarya Pharmasite S.C.","Monterrey","Nuevo León","64718",{"type":54,"coordinates":341},[342,343],-100.31721,25.68435,{"lat":343,"lon":342},{"facility":346,"status":47,"city":347,"state":347,"zip":348,"country":328,"countryCode":329,"cosmosGeoPoint":349,"geoPoint":353,"contacts":30},"Arke SMO S.A. de C.V.","Veracruz","91900",{"type":54,"coordinates":350},[351,352],-96.1429,19.18095,{"lat":352,"lon":351},{"facility":355,"status":47,"city":356,"state":30,"zip":357,"country":328,"countryCode":329,"cosmosGeoPoint":358,"geoPoint":362,"contacts":30},"Servicios Hospitalarios de México S.A. de C.V. (Hospital Angeles Chihuahua)","Chihuahua City","31238",{"type":54,"coordinates":359},[360,361],-106.08889,28.63528,{"lat":361,"lon":360},{"facility":364,"status":47,"city":365,"state":366,"zip":367,"country":368,"countryCode":369,"cosmosGeoPoint":370,"geoPoint":374,"contacts":30},"LUXDERM Specjalistyczny Gabinet Dermatologiczny prof. dr hab. n. med. Dorota Krasowska","Lublin","Lublin Voivodeship","20-573","Poland","PL",{"type":54,"coordinates":371},[372,373],22.57009,51.25058,{"lat":373,"lon":372},{"facility":376,"status":47,"city":377,"state":378,"zip":379,"country":368,"countryCode":369,"cosmosGeoPoint":380,"geoPoint":384,"contacts":30},"Centrum Medyczne Evimed","Warsaw","Masovian Voivodeship","02-625",{"type":54,"coordinates":381},[382,383],21.01178,52.22977,{"lat":383,"lon":382},{"facility":386,"status":47,"city":387,"state":388,"zip":389,"country":368,"countryCode":369,"cosmosGeoPoint":390,"geoPoint":394,"contacts":30},"DERMAPOLIS Medical Dermatology Center dr n. med. Edyta Gebska","Chorzów","Silesian Voivodeship","41-500",{"type":54,"coordinates":391},[392,393],18.9742,50.30582,{"lat":393,"lon":392},{"facility":396,"status":47,"city":397,"state":388,"zip":398,"country":368,"countryCode":369,"cosmosGeoPoint":399,"geoPoint":403,"contacts":30},"Centrum Medyczne Angelius Provita","Katowice","40-611",{"type":54,"coordinates":400},[401,402],19.02173,50.2597,{"lat":402,"lon":401},{"facility":405,"status":47,"city":406,"state":407,"zip":408,"country":368,"countryCode":369,"cosmosGeoPoint":409,"geoPoint":413,"contacts":30},"Dermoklinika - Centrum Medyczne spółka cywilna M. Kierstan, J. Narbutt, A. Lesiak","Lodz","Łódź Voivodeship","90-436",{"type":54,"coordinates":410},[411,412],19.47395,51.77058,{"lat":412,"lon":411},{"facility":415,"status":47,"city":416,"state":417,"zip":418,"country":368,"countryCode":369,"cosmosGeoPoint":419,"geoPoint":423,"contacts":30},"Dermedic Jacek Zdybski","Ostrowiec Świętokrzyski","Świętokrzyskie Voivodeship","27-400",{"type":54,"coordinates":420},[421,422],21.38525,50.92936,{"lat":422,"lon":421},{"facility":425,"status":47,"city":426,"state":427,"zip":428,"country":429,"countryCode":430,"cosmosGeoPoint":431,"geoPoint":435,"contacts":30},"CHUS - Hospital Clinico Universitario","Santiago de Compostela","A Coruña [LA Coruña]","15706","Spain","ES",{"type":54,"coordinates":432},[433,434],-8.54569,42.88052,{"lat":434,"lon":433},{"facility":437,"status":47,"city":438,"state":439,"zip":440,"country":429,"countryCode":430,"cosmosGeoPoint":441,"geoPoint":445,"contacts":30},"Hospital General de Granollers","Granollers","Barcelona [barcelona]","08402",{"type":54,"coordinates":442},[443,444],2.28773,41.60797,{"lat":444,"lon":443},{"facility":447,"status":47,"city":448,"state":30,"zip":449,"country":429,"countryCode":430,"cosmosGeoPoint":450,"geoPoint":454,"contacts":30},"Hospital Universitario Miguel Servet","Zaragoza","50009",{"type":54,"coordinates":451},[452,453],-0.87734,41.65606,{"lat":453,"lon":452},{"type":456,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR","100578128","phase-3-a-study-of-the-medicine-called-abrocitinib-in-children-6-to-less-than-12-years-of-age-with-moderate-to-severe-eczema-100578128",false,"NCT06807268","A Study of the Medicine Called Abrocitinib in Children 6 to Less Than 12 Years of Age With Moderate-to-Severe Eczema","A 16-WEEK, MULTICENTER, INTERVENTIONAL, PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL GROUP STUDY TO INVESTIGATE EFFICACY AND SAFETY OF ABROCITINIB IN CHILDREN 6 TO LESS THAN 12 YEARS OF AGE WITH MODERATE-TO-SEVERE ATOPIC DERMATITIS","Inclusion Criteria Children aged 6 to \\\u003C12 years at the time of informed consent\u002Fassent.\n\n• No contraception methods are required for male participants. Refer to Appendix 4 for reproductive criteria for male (Section 10.4.1) and female (Section 10.4.2) participants.\n\nDisease Characteristics:\n\nParticipants who meet all of the following AD criteria:\n\n* A documented diagnosis of chronic AD for at least 1 year prior to screening and confirmed at screening and baseline visits according to the Hanifin and Rajka criteria\\[19\\]; and\n* A diagnosis of moderate-to-severe AD at the baseline visit (must fulfill all of the following criteria: BSA ≥10%, vIGA ≥3, EASI ≥16, and WI-NRS ≥4); and\n* Documented history (within 6 months of the screening visit) of inadequate response to treatment with topical medical therapy for AD (eg, TCS and TCI), for at least 4 weeks and are candidates for systemic therapy\n\nOther Inclusion Criteria:\n\nBody weight ≥15 kg\n\nExclusion Criteria\n\nParticipants are excluded from the study if any of the following criteria apply:\n\nMedical Conditions:\n\nAny medical or psychiatric condition including any active suicidal ideation in the past year or suicidal behavior in the past 5 years or laboratory abnormality that may increase the risk of study participation or, in the investigator's judgment, make the participant inappropriate for the study.\n\nIf the participant has SDQ total score ≥17, the investigator should exclude them or refer the child to a pediatric MHP to determine if it is safe to participate in the study. A copy or summary of the evaluation should be placed in the site source documents.\n\nHave any of the following medical conditions:\n\n* Infections:\n\n  * Skin infections that require treatment with systemic antimicrobials within 2 weeks prior to Day 1 (Baseline) or have superficial skin infections within 1 week of Day 1.\n  * History of systemic infection requiring hospitalization or parenteral antimicrobial therapy or as otherwise judged clinically significant by the investigator within 1 month prior to Day 1.\n  * Have a history (single episode) of disseminated herpes zoster or disseminated herpes simplex, or a recurrent localized, dermatomal herpes zoster.\n  * Infection with HIV, hepatitis B, and\u002For hepatitis C\n  * Evidence of active TB or inadequately treated latent TB.\n* Skin Conditions:\n\n  \\- Including but not limited to psoriasis, seborrheic dermatitis or lupus on Day 1 that would interfere with evaluation of AD or response to treatment.\n* Other Conditions:\n\n  * Documented history of skeletal dysplasia.\n  * Documented history of retinal detachment.\n  * History of or conditions associated with thrombocytopenia, coagulopathy or platelet dysfunction.\n  * Prior history of leukemia, lymphoma, sarcoma or any other malignancy.\n  * Immunodeficiency disorder or a first-degree relative with a hereditary immunodeficiency.\n  * Any other medical conditions that in the investigator's judgment make the participant inappropriate for the study.\n\nPrior\u002FConcomitant Therapy:\n\nPrior treatment with a systemic JAK inhibitor for AD. Live attenuated vaccination within 6 weeks prior to Day 1 or require vaccination with live attenuated vaccines during treatment or within 6 weeks after the last dose of study intervention.\n\nConcomitant use of strong inhibitors and inducers of CYP2C19 enzymes, strong inducers of CYP2C9 enzymes, P-gp substrates with narrow therapeutic index and sensitive CYP2C19 substrates is not allowed in the study.\n\nPrior\u002FConcurrent Clinical Study Experience:\n\nPrevious administration of an investigational drug within 30 days or 5 half lives, whichever is longer, of Day 1.","ALL","6 Years","11 Years",{"count":468,"type":469},150,"ESTIMATED","INTERVENTIONAL",[472],"PHASE3","This research study is being conducted to find out if the test medicine, abrocitinib, improves eczema and is safe for children 6 to \\\u003C12 years of age who have moderate-to-severe eczema. Research study participants who meet the study criteria will be assigned by chance (like the flip of a coin) to receive either abrocitinib test medicine or placebo (pretend medicine that looks just like the test medicine) for 16 weeks. The study will last for about 24 weeks in total.",[475],"Eczema",[477],"Dermatitis","2026-08-14",{"date":480,"type":481},"2026-08-17","ACTUAL",{"date":483,"type":481},"2025-07-24",{"date":485,"type":469},"2027-05-02",{"name":5,"class":6},43]