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279788","Indianapolis","Indiana","46237",{"type":61,"coordinates":158},[159,160],-86.15804,39.76838,{"lat":160,"lon":159},{"facility":163,"status":54,"city":164,"state":165,"zip":166,"country":58,"countryCode":59,"cosmosGeoPoint":167,"geoPoint":171,"contacts":27},"Cancer And Hematology Centers Of Western Michigan - Grand Rapids \u002FID# 279955","Grand Rapids","Michigan","49503",{"type":61,"coordinates":168},[169,170],-85.66809,42.96336,{"lat":170,"lon":169},{"facility":173,"status":54,"city":174,"state":175,"zip":176,"country":58,"countryCode":59,"cosmosGeoPoint":177,"geoPoint":181,"contacts":27},"Minnesota Oncology - Edina Clinic \u002FID# 280698","Edina","Minnesota","55435",{"type":61,"coordinates":178},[179,180],-93.34995,44.88969,{"lat":180,"lon":179},{"facility":183,"status":54,"city":184,"state":185,"zip":186,"country":58,"countryCode":59,"cosmosGeoPoint":187,"geoPoint":191,"contacts":27},"FirstHealth of the Carolinas- Speciality Center \u002FID# 279857","Pinehurst","North 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279779","Nashville","37203",{"type":61,"coordinates":242},[243,244],-86.78444,36.16589,{"lat":244,"lon":243},{"facility":247,"status":54,"city":239,"state":215,"zip":248,"country":58,"countryCode":59,"cosmosGeoPoint":249,"geoPoint":251,"contacts":27},"Vanderbilt University Medical Center \u002FID# 280169","37232",{"type":61,"coordinates":250},[243,244],{"lat":244,"lon":243},{"facility":253,"status":54,"city":254,"state":255,"zip":256,"country":58,"countryCode":59,"cosmosGeoPoint":257,"geoPoint":261,"contacts":27},"The University of Texas MD Anderson Cancer Center \u002FID# 280070","Houston","Texas","77030",{"type":61,"coordinates":258},[259,260],-95.36327,29.76328,{"lat":260,"lon":259},{"facility":263,"status":54,"city":264,"state":255,"zip":265,"country":58,"countryCode":59,"cosmosGeoPoint":266,"geoPoint":270,"contacts":27},"Texas Oncology - Northeast Texas \u002FID# 280642","Tyler","75702",{"type":61,"coordinates":267},[268,269],-95.30106,32.35126,{"lat":269,"lon":268},{"facility":272,"status":54,"city":273,"state":274,"zip":275,"country":58,"countryCode":59,"cosmosGeoPoint":276,"geoPoint":280,"contacts":27},"Blue Ridge Cancer Care - Blacksburg \u002FID# 281583","Blacksburg","Virginia","24060",{"type":61,"coordinates":277},[278,279],-80.41394,37.22957,{"lat":279,"lon":278},{"facility":282,"status":54,"city":283,"state":274,"zip":284,"country":58,"countryCode":59,"cosmosGeoPoint":285,"geoPoint":289,"contacts":27},"Shenandoah Oncology \u002FID# 280699","Winchester","22601",{"type":61,"coordinates":286},[287,288],-78.16333,39.18566,{"lat":288,"lon":287},{"facility":291,"status":54,"city":292,"state":293,"zip":294,"country":58,"countryCode":59,"cosmosGeoPoint":295,"geoPoint":299,"contacts":27},"West Virginia University Hospitals \u002FID# 279883","Morgantown","West 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280427","Kassel","Hesse","34125","Germany","DE",{"type":61,"coordinates":330},[331,332],9.5,51.31667,{"lat":332,"lon":331},{"facility":335,"status":54,"city":336,"state":337,"zip":338,"country":339,"countryCode":340,"cosmosGeoPoint":341,"geoPoint":345,"contacts":27},"Metropolitan Hospital \u002FID# 280359","Piraeus","Attica","18547","Greece","GR",{"type":61,"coordinates":342},[343,344],23.64619,37.94203,{"lat":344,"lon":343},{"facility":347,"status":54,"city":348,"state":349,"zip":350,"country":351,"countryCode":352,"cosmosGeoPoint":353,"geoPoint":357,"contacts":27},"Fujita Health University Hospital \u002FID# 279969","Toyoake","Aichi-ken","470-1192","Japan","JP",{"type":61,"coordinates":354},[355,356],136.99931,35.038,{"lat":356,"lon":355},{"facility":359,"status":54,"city":360,"state":361,"zip":362,"country":351,"countryCode":352,"cosmosGeoPoint":363,"geoPoint":367,"contacts":27},"Hirosaki University Hospital \u002FID# 279926","Hirosaki","Aomori","036-8563",{"type":61,"coordinates":364},[365,366],140.4725,40.59306,{"lat":366,"lon":365},{"facility":369,"status":54,"city":370,"state":370,"zip":371,"country":351,"countryCode":352,"cosmosGeoPoint":372,"geoPoint":376,"contacts":27},"Kyushu University Hospital \u002FID# 279964","Fukuoka","812-8582",{"type":61,"coordinates":373},[374,375],130.41667,33.6,{"lat":375,"lon":374},{"facility":378,"status":54,"city":379,"state":380,"zip":381,"country":351,"countryCode":352,"cosmosGeoPoint":382,"geoPoint":386,"contacts":27},"Hokkaido Cancer Center \u002FID# 280024","Sapporo","Hokkaido","003-0804",{"type":61,"coordinates":383},[384,385],141.35,43.06667,{"lat":385,"lon":384},{"facility":388,"status":54,"city":389,"state":390,"zip":391,"country":351,"countryCode":352,"cosmosGeoPoint":392,"geoPoint":396,"contacts":27},"Kobe University Hospital \u002FID# 280290","Kobe","Hyōgo","650-0017",{"type":61,"coordinates":393},[394,395],135.183,34.6913,{"lat":395,"lon":394},{"facility":398,"status":54,"city":399,"state":400,"zip":401,"country":351,"countryCode":352,"cosmosGeoPoint":27,"geoPoint":27,"contacts":27},"Kitasato University Hospital \u002FID# 280033","Sagamihara-shi","Kanagawa","252-0375",{"facility":403,"status":54,"city":404,"state":405,"zip":406,"country":351,"countryCode":352,"cosmosGeoPoint":407,"geoPoint":411,"contacts":27},"Sendai Kousei Hospital \u002FID# 279790","Sendai","Miyagi","981-0914",{"type":61,"coordinates":408},[409,410],140.86667,38.26667,{"lat":410,"lon":409},{"facility":413,"status":54,"city":414,"state":414,"zip":415,"country":351,"countryCode":352,"cosmosGeoPoint":416,"geoPoint":420,"contacts":27},"Niigata University Medical and Dental Hospital \u002FID# 280027","Niigata","951-8520",{"type":61,"coordinates":417},[418,419],139.04125,37.92259,{"lat":419,"lon":418},{"facility":422,"status":54,"city":423,"state":424,"zip":425,"country":351,"countryCode":352,"cosmosGeoPoint":27,"geoPoint":27,"contacts":27},"Kansai Medical University Hospital \u002FID# 279925","Hirakata-shi","Osaka","573-1191",{"facility":427,"status":54,"city":424,"state":424,"zip":428,"country":351,"countryCode":352,"cosmosGeoPoint":429,"geoPoint":433,"contacts":27},"Osaka International Cancer Institute \u002FID# 280026","5418567",{"type":61,"coordinates":430},[431,432],135.50107,34.69379,{"lat":432,"lon":431},{"facility":435,"status":54,"city":436,"state":424,"zip":437,"country":351,"countryCode":352,"cosmosGeoPoint":27,"geoPoint":27,"contacts":27},"Kindai University Hospital \u002FID# 280034","Sakai-shi","590-0197",{"facility":439,"status":54,"city":440,"state":441,"zip":442,"country":351,"countryCode":352,"cosmosGeoPoint":443,"geoPoint":447,"contacts":27},"Saitama Medical University International Medical Center \u002FID# 279962","Hidaka","Saitama","350-1298",{"type":61,"coordinates":444},[445,446],139.36233,35.91664,{"lat":446,"lon":445},{"facility":449,"status":54,"city":450,"state":451,"zip":452,"country":351,"countryCode":352,"cosmosGeoPoint":27,"geoPoint":27,"contacts":27},"Shizuoka Cancer Center \u002FID# 279924","Sunto-gun","Shizuoka","411-8777",{"facility":454,"status":54,"city":455,"state":456,"zip":457,"country":351,"countryCode":352,"cosmosGeoPoint":27,"geoPoint":27,"contacts":27},"Juntendo University Hospital \u002FID# 280095","Bunkyo-ku","Tokyo","113-8431",{"facility":459,"status":54,"city":455,"state":456,"zip":460,"country":351,"countryCode":352,"cosmosGeoPoint":27,"geoPoint":27,"contacts":27},"Nippon Medical School Hospital \u002FID# 280687","113-8603",{"facility":462,"status":54,"city":456,"state":27,"zip":463,"country":351,"countryCode":352,"cosmosGeoPoint":464,"geoPoint":468,"contacts":27},"Teikyo University Hospital \u002FID# 280307","173-8605",{"type":61,"coordinates":465},[466,467],139.69171,35.6895,{"lat":467,"lon":466},{"facility":470,"status":54,"city":471,"state":27,"zip":472,"country":473,"countryCode":474,"cosmosGeoPoint":475,"geoPoint":479,"contacts":27},"Hospital Clinic de Barcelona \u002FID# 281271","Barcelona","08036","Spain","ES",{"type":61,"coordinates":476},[477,478],2.15899,41.38879,{"lat":478,"lon":477},{"facility":481,"status":54,"city":482,"state":483,"zip":484,"country":485,"countryCode":486,"cosmosGeoPoint":487,"geoPoint":491,"contacts":27},"Hopitaux Universitaires de Geneve \u002FID# 280748","Geneva","Canton of Geneva","1205","Switzerland","CH",{"type":61,"coordinates":488},[489,490],6.14569,46.20222,{"lat":490,"lon":489},{"facility":493,"status":54,"city":494,"state":495,"zip":496,"country":485,"countryCode":486,"cosmosGeoPoint":497,"geoPoint":501,"contacts":27},"Centre Hospitalier Universitaire Vaudois \u002FID# 280847","Lausanne","Canton of Vaud","1011",{"type":61,"coordinates":498},[499,500],6.63282,46.516,{"lat":500,"lon":499},{"type":503,"investigatorFullName":27,"investigatorTitle":27,"investigatorAffiliation":27,"oldNameTitle":27,"oldOrganization":27},"SPONSOR","100621024","phase-3-a-study-to-evaluate-adverse-events-and-change-in-disease-activity-of-intravenous-abbv-706-versus-standard-of-care-in-adult-participants-with-relapsedrefractory-small-cell-lung-cancer-100621024",false,"NCT07365241","A Study to Evaluate Adverse Events and Change in Disease Activity of Intravenous ABBV-706 Versus Standard of Care in Adult Participants With Relapsed\u002FRefractory Small Cell Lung Cancer","A Phase 3 Randomized, Open Label, Multicenter Study to Evaluate the Safety and Efficacy of ABBV-706 Versus Standard of Care in Subjects With Relapsed\u002FRefractory Small Cell Lung Cancer (SCLC)","Inclusion Criteria:\n\n* Diagnosis of histologically or cytologically confirmed Relapsed\u002FRefractory (R\u002FR) Small Cell Lung Cancer (SCLC).\n* Participants must have progressed on prior systemic therapy, with CPI (if eligible) and prior tarlatamab, defined as:\n\n  * In the 1L and 2L setting respectively, platinum-based chemotherapy (i.e., carboplatin or cisplatin and etoposide with CPI, if eligible for CPI) and 2L tarlatamab; or\n  * In the 1L and 2L setting, platinum-based chemotherapy (i.e., carboplatin and etoposide with atezolizumab and lurbinectedin in combination with atezolizumab maintenance and 2L tarlatamab; or\n  * In the 1L setting, platinum-based chemotherapy (i.e., carboplatin or cisplatin and etoposide with CPI if eligible) in combination with tarlatamab in frontline induction and\u002For maintenance\n* Participants must be considered suitable to receive SOC comparator (topotecan, lurbinectedin, or amrubicin).\n* Participants must have an Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 to 1 during the screening period prior to the first dose of study treatment.\n* Participants must have measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1. Target lesions situated in a previously irradiated area are considered measurable if progression has been demonstrated in such lesions.\n* Participants with brain metastasis from an extracranial solid tumor are eligible if the brain metastases are:\n\n  * Previously treated and not requiring anticonvulsants and steroids for at least 7 days prior to first dose of study treatment. If required for management, subjects on a steroid equivalent of prednisone dose of ≤ 10 mg\u002Fday are eligible or;\n  * Untreated and asymptomatic not requiring anticonvulsants and steroids for at least 7 days prior to the first dose of study treatment. If required for management, subjects on a steroid equivalent of prednisone of ≤ 10 mg\u002Fday are eligible.\n\nExclusion Criteria:\n\n* Participants with known active\u002Fsymptomatic central nervous system metastases.\n* Participants with a history of interstitial lung disease (ILD) or pneumonitis that previously required treatment with systemic steroids, or any evidence of active ILD\u002Fpneumonitis on screening chest computed tomography (CT) scan.\n* Participants with any clinically significant conditions that would adversely affect the participation in the study, and the subject should have a life expectancy of at least 3 months.\n* Participants who have received prior treatment with a seizure-related 6 homolog (SEZ6) targeted Antibody drug conjugate (ADC), other targeted ADCs, or any other investigational agent not including tarlatamab in 1L.\n* Participants who have received prior treatment with any Top1i such as topotecan, irinotecan, belotecan, camptothecin, rubitecan, exatecan or locally approved topoisomerase I inhibitor (Top1i) payload.","ALL","18 Years",{"count":514,"type":515},531,"ESTIMATED","INTERVENTIONAL",[518],"PHASE3","Small cell lung cancer (SCLC) is characterized by aggressive and rapid growth and a tendency to develop early spread to distant sites including mediastinal lymph nodes, liver, bones, adrenal glands, and brain. The purpose of this study is to assess safety, tolerability, and change in disease activity of ABBV-706 compared to standard of care (SOC) treatment (topotecan, lurbinectedin, or amrubicin).\n\nABBV-706 is an investigational drug being developed for the treatment of SCLC. There are two treatment arms in this study. Participants will either receive ABBV-706 or SOC. Approximately 531 adult participants will be enrolled in the study across 175 sites worldwide.\n\nParticipants with SCLC will receive intravenous (IV) ABBV-706 or SOC \\[topotecan (IV or orally), or lubinectedin (IV), or amrubicin (IV)\\]. The estimated duration of the study is approximately 53 months.\n\nThere may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic and may require frequent medical assessments, blood tests, questionnaires, and scans.",[521],"Small Cell Lung Cancer",[521,523,9,29,36,39,524],"SCLC","Cancer","2026-08-19",{"date":527,"type":528},"2026-08-21","ACTUAL",{"date":530,"type":528},"2026-07-02",{"date":532,"type":515},"2030-09",{"name":5,"class":6},49]