[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621024":3},{"organization":4,"outcomesModule":7,"designInfo":37,"detailedDescription":36,"studyPopulation":36,"armGroups":43,"interventions":58,"overallOfficials":76,"centralContacts":80,"locations":86,"responsibleParty":671,"collaborators":36,"id":673,"slug":674,"hasResults":675,"nctId":676,"briefTitle":677,"officialTitle":678,"acronym":36,"eligibilityCriteria":679,"healthyVolunteers":675,"sex":680,"minAge":681,"maxAge":36,"enrollmentInfo":682,"targetDuration":36,"studyType":685,"phases":686,"briefSummary":688,"conditions":689,"keywords":691,"overallStatus":89,"whyStopped":36,"lastUpdateSubmitDate":694,"lastUpdatePostDateStruct":695,"startDateStruct":698,"completionDateStruct":700,"leadSponsor":702,"locationsCount":703},{"fullName":5,"class":6},"AbbVie","INDUSTRY",{"primaryOutcomes":8,"secondaryOutcomes":17,"otherOutcomes":36},[9,13],{"measure":10,"description":11,"timeFrame":12},"Objective Response (OR) as Measured by Overall Response Rate (ORR) Based on Blinded Independent Central Review (BICR)","OR is defined as participants achieving a best overall response (BOR) of confirmed complete response (CR)\u002Fpartial response (PR) per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 as determined by BICR assessment prior to initiation of subsequent anti-cancer therapy. OR will be summarized by ORR, defined as the percentage of participants achieving OR and will be summarized for each arm with its associated 95% confidence interval (CI).","Up to approximately 24 months",{"measure":14,"description":15,"timeFrame":16},"Overall Survival (OS)","OS is defined as the time from the date of randomization to the date of death of any cause.","Up to approximately 28 months",[18,22,25,29,32],{"measure":19,"description":20,"timeFrame":21},"Progression-free survival (PFS) based on BICR assessment per RECIST v1.1.","PFS is defined as the time from the date of randomization to the first documentation of radiographic disease progression per RECIST v1.1 based on BICR assessment or death from any cause, whichever occurs first.","Up to Approximately 24 Months",{"measure":23,"description":24,"timeFrame":21},"Duration of response (DoR) based on BICR assessment per RECIST v1.1.","DoR is defined as the time from the initial response of confirmed CR or PR per RECIST v1.1 based on BICR assessment to radiographic disease progression per RECIST v1.1 based on BICR assessment, or death of any cause, whichever occurs first.",{"measure":26,"description":27,"timeFrame":28},"Change from baseline at Week 12 in physical functioning as measured by the physical functioning domain of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30).","Health-related quality-of-life (HRQoL) and symptoms will be assessed with the EORTC QLQ-C30, version 3.0. The EORTC QLQ-C30 is a 30-item patient-reported questionnaire composed of both multi-item and single scales including 5 functional scales (physical, role, emotional, social, and cognitive), 3 symptom scales (fatigue, nausea and vomiting, and pain), a global health status (GHS)\u002FQoL scale, and 6 single items (dyspnea, insomnia, appetite loss, constipation, diarrhea, and financial difficulties). Participants rate items on a 4 point scale ranging from 1 to 4 (1 = Not at All, 2 = A Little, 3 = Quite a Bit, and 4 = Very Much).","Week 12",{"measure":30,"description":31,"timeFrame":28},"Change from baseline at Week 12 in Global Health Status (GHS)\u002FQuality of life (QoL) as measured by the EORTC QLQ-C30 GHS\u002FQoL scale","Health-related quality-of-life and symptoms will be assessed with the EORTC QLQ-C30, version 3.0. The EORTC QLQ-C30 is a 30-item patient-reported questionnaire composed of both multi-item and single scales including 5 functional scales (physical, role, emotional, social, and cognitive), 3 symptom scales (fatigue, nausea and vomiting, and pain), a GHS\u002FQoL scale, and 6 single items (dyspnea, insomnia, appetite loss, constipation, diarrhea, and financial difficulties). Participants rate items on a 4 point scale ranging from 1 to 4 (1 = Not at All, 2 = A Little, 3 = Quite a Bit, and 4 = Very Much).",{"measure":33,"description":34,"timeFrame":35},"Number of Participants with Adverse Events (AEs)","An AE is defined as any untoward medical occurrence in a patient or clinical investigation in which a participant is administered a pharmaceutical product which does not necessarily have a causal relationship with this treatment.","Up to Approximately 53 Months",null,{"allocation":38,"interventionModel":39,"interventionModelDescription":36,"primaryPurpose":40,"observationalModel":36,"timePerspective":36,"maskingInfo":41},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":42,"maskingDescription":36,"whoMasked":36},"NONE",[44,50],{"label":45,"type":46,"description":47,"interventionNames":48},"ABBV-706","EXPERIMENTAL","Participants will receive ABBV-706 as part of the 53 month study duration.",[49],"Drug: ABBV-706",{"label":51,"type":52,"description":53,"interventionNames":54},"Stand of Care (SOC)","ACTIVE_COMPARATOR","Participants will receive SOC (topotecan, lurbinectedin, and amrubicin) as part of the 53 month study duration.",[55,56,57],"Drug: Topotecan","Drug: Lurbinectedin","Drug: Amrubicin",[59,63,67,70,73],{"type":60,"name":45,"description":61,"armGroupLabels":62,"otherNames":36},"DRUG","Intravenous (IV) Infusion",[45],{"type":60,"name":64,"description":65,"armGroupLabels":66,"otherNames":36},"Topotecan","IV Infusion",[51],{"type":60,"name":64,"description":68,"armGroupLabels":69,"otherNames":36},"Oral",[51],{"type":60,"name":71,"description":65,"armGroupLabels":72,"otherNames":36},"Lurbinectedin",[51],{"type":60,"name":74,"description":65,"armGroupLabels":75,"otherNames":36},"Amrubicin",[51],[77],{"name":78,"affiliation":5,"role":79},"ABBVIE INC.","STUDY_DIRECTOR",[81],{"name":82,"role":83,"phone":84,"phoneExt":36,"email":85},"ABBVIE CALL CENTER","CONTACT","844-663-3742","abbvieclinicaltrials@abbvie.com",[87,101,110,120,130,139,149,158,167,177,187,196,205,215,225,235,245,255,265,275,285,295,301,310,319,325,335,344,354,363,372,382,392,404,414,426,438,450,460,472,481,490,502,512,521,531,541,546,556,565,575,580,588,592,602,607,612,615,623,634,641,651,661],{"facility":88,"status":89,"city":90,"state":91,"zip":92,"country":93,"countryCode":94,"cosmosGeoPoint":95,"geoPoint":100,"contacts":36},"Birmingham Hematology and Oncology Associates d\u002Fb\u002Fa Alabama Oncology \u002FID# 280063","RECRUITING","Birmingham","Alabama","35243","United States","US",{"type":96,"coordinates":97},"Point",[98,99],-86.80249,33.52066,{"lat":99,"lon":98},{"facility":102,"status":89,"city":103,"state":91,"zip":104,"country":93,"countryCode":94,"cosmosGeoPoint":105,"geoPoint":109,"contacts":36},"Usa Mitchell Cancer Institute \u002FID# 280198","Mobile","36604",{"type":96,"coordinates":106},[107,108],-88.04305,30.69436,{"lat":108,"lon":107},{"facility":111,"status":89,"city":112,"state":113,"zip":114,"country":93,"countryCode":94,"cosmosGeoPoint":115,"geoPoint":119,"contacts":36},"City Of Hope - Phoenix \u002FID# 281323","Goodyear","Arizona","85338",{"type":96,"coordinates":116},[117,118],-112.35821,33.43532,{"lat":118,"lon":117},{"facility":121,"status":89,"city":122,"state":123,"zip":124,"country":93,"countryCode":94,"cosmosGeoPoint":125,"geoPoint":129,"contacts":36},"City of Hope National Medical Center \u002FID# 281322","Duarte","California","91010",{"type":96,"coordinates":126},[127,128],-117.97729,34.13945,{"lat":128,"lon":127},{"facility":131,"status":89,"city":132,"state":123,"zip":133,"country":93,"countryCode":94,"cosmosGeoPoint":134,"geoPoint":138,"contacts":36},"City of Hope - Orange County Lennar Foundation Cancer Center \u002FID# 281396","Irvine","92618",{"type":96,"coordinates":135},[136,137],-117.82311,33.66946,{"lat":137,"lon":136},{"facility":140,"status":89,"city":141,"state":142,"zip":143,"country":93,"countryCode":94,"cosmosGeoPoint":144,"geoPoint":148,"contacts":36},"Florida Cancer Specialists & Research Institute - South \u002FID# 281387","Fort Myers","Florida","33901",{"type":96,"coordinates":145},[146,147],-81.84059,26.62168,{"lat":147,"lon":146},{"facility":150,"status":89,"city":151,"state":142,"zip":152,"country":93,"countryCode":94,"cosmosGeoPoint":153,"geoPoint":157,"contacts":36},"Orlando Health Cancer Institute \u002FID# 280418","Orlando","32806",{"type":96,"coordinates":154},[155,156],-81.37924,28.53834,{"lat":156,"lon":155},{"facility":159,"status":89,"city":160,"state":142,"zip":161,"country":93,"countryCode":94,"cosmosGeoPoint":162,"geoPoint":166,"contacts":36},"Moffitt Cancer Center \u002FID# 279732","Tampa","33612",{"type":96,"coordinates":163},[164,165],-82.45843,27.94752,{"lat":165,"lon":164},{"facility":168,"status":89,"city":169,"state":170,"zip":171,"country":93,"countryCode":94,"cosmosGeoPoint":172,"geoPoint":176,"contacts":36},"City Of Hope - Atlanta \u002FID# 279929","Newnan","Georgia","30265",{"type":96,"coordinates":173},[174,175],-84.79966,33.38067,{"lat":175,"lon":174},{"facility":178,"status":89,"city":179,"state":180,"zip":181,"country":93,"countryCode":94,"cosmosGeoPoint":182,"geoPoint":186,"contacts":36},"OSF St. Francis Medical Center \u002FID# 279930","Peoria","Illinois","61637-0001",{"type":96,"coordinates":183},[184,185],-89.58899,40.69365,{"lat":185,"lon":184},{"facility":188,"status":89,"city":189,"state":180,"zip":190,"country":93,"countryCode":94,"cosmosGeoPoint":191,"geoPoint":195,"contacts":36},"Springfield Clinic - First \u002FID# 281309","Springfield","62702",{"type":96,"coordinates":192},[193,194],-89.64371,39.80172,{"lat":194,"lon":193},{"facility":197,"status":89,"city":198,"state":180,"zip":199,"country":93,"countryCode":94,"cosmosGeoPoint":200,"geoPoint":204,"contacts":36},"City Of Hope - Chicago \u002FID# 281335","Zion","60099",{"type":96,"coordinates":201},[202,203],-87.83285,42.44613,{"lat":203,"lon":202},{"facility":206,"status":89,"city":207,"state":208,"zip":209,"country":93,"countryCode":94,"cosmosGeoPoint":210,"geoPoint":214,"contacts":36},"Franciscan St. Francis Health \u002FID# 279788","Indianapolis","Indiana","46237",{"type":96,"coordinates":211},[212,213],-86.15804,39.76838,{"lat":213,"lon":212},{"facility":216,"status":89,"city":217,"state":218,"zip":219,"country":93,"countryCode":94,"cosmosGeoPoint":220,"geoPoint":224,"contacts":36},"Dana-Farber Cancer Institute \u002FID# 279690","Boston","Massachusetts","02215",{"type":96,"coordinates":221},[222,223],-71.05977,42.35843,{"lat":223,"lon":222},{"facility":226,"status":89,"city":227,"state":228,"zip":229,"country":93,"countryCode":94,"cosmosGeoPoint":230,"geoPoint":234,"contacts":36},"Cancer And Hematology Centers Of Western Michigan - Grand Rapids \u002FID# 279955","Grand Rapids","Michigan","49503",{"type":96,"coordinates":231},[232,233],-85.66809,42.96336,{"lat":233,"lon":232},{"facility":236,"status":89,"city":237,"state":238,"zip":239,"country":93,"countryCode":94,"cosmosGeoPoint":240,"geoPoint":244,"contacts":36},"Minnesota Oncology - Edina Clinic \u002FID# 280698","Edina","Minnesota","55435",{"type":96,"coordinates":241},[242,243],-93.34995,44.88969,{"lat":243,"lon":242},{"facility":246,"status":89,"city":247,"state":248,"zip":249,"country":93,"countryCode":94,"cosmosGeoPoint":250,"geoPoint":254,"contacts":36},"FirstHealth of the Carolinas- Speciality Center \u002FID# 279857","Pinehurst","North Carolina","28374",{"type":96,"coordinates":251},[252,253],-79.46948,35.19543,{"lat":253,"lon":252},{"facility":256,"status":89,"city":257,"state":258,"zip":259,"country":93,"countryCode":94,"cosmosGeoPoint":260,"geoPoint":264,"contacts":36},"Oncology Hematology Care - Fairfield \u002FID# 280641","Fairfield","Ohio","45014",{"type":96,"coordinates":261},[262,263],-84.5605,39.34589,{"lat":263,"lon":262},{"facility":266,"status":89,"city":267,"state":268,"zip":269,"country":93,"countryCode":94,"cosmosGeoPoint":270,"geoPoint":274,"contacts":36},"Willamette Valley Cancer Institute and Research Center \u002FID# 280617","Eugene","Oregon","97401",{"type":96,"coordinates":271},[272,273],-123.08675,44.05207,{"lat":273,"lon":272},{"facility":276,"status":89,"city":277,"state":278,"zip":279,"country":93,"countryCode":94,"cosmosGeoPoint":280,"geoPoint":284,"contacts":36},"St. Lukes University Hospital \u002FID# 280204","Bethlehem","Pennsylvania","18015",{"type":96,"coordinates":281},[282,283],-75.37046,40.62593,{"lat":283,"lon":282},{"facility":286,"status":89,"city":287,"state":288,"zip":289,"country":93,"countryCode":94,"cosmosGeoPoint":290,"geoPoint":294,"contacts":36},"Tennessee Cancer Specialists - Knoxville - Old Weisgarber Road \u002FID# 280619","Knoxville","Tennessee","37909",{"type":96,"coordinates":291},[292,293],-83.92074,35.96064,{"lat":293,"lon":292},{"facility":296,"status":89,"city":287,"state":288,"zip":297,"country":93,"countryCode":94,"cosmosGeoPoint":298,"geoPoint":300,"contacts":36},"University Of Tennessee Medical Center \u002FID# 279896","37920",{"type":96,"coordinates":299},[292,293],{"lat":293,"lon":292},{"facility":302,"status":89,"city":303,"state":288,"zip":304,"country":93,"countryCode":94,"cosmosGeoPoint":305,"geoPoint":309,"contacts":36},"Baptist Memorial Hospital \u002FID# 281405","Memphis","38120",{"type":96,"coordinates":306},[307,308],-90.04898,35.14953,{"lat":308,"lon":307},{"facility":311,"status":89,"city":312,"state":288,"zip":313,"country":93,"countryCode":94,"cosmosGeoPoint":314,"geoPoint":318,"contacts":36},"SCRI Oncology Partners \u002FID# 279779","Nashville","37203",{"type":96,"coordinates":315},[316,317],-86.78444,36.16589,{"lat":317,"lon":316},{"facility":320,"status":89,"city":312,"state":288,"zip":321,"country":93,"countryCode":94,"cosmosGeoPoint":322,"geoPoint":324,"contacts":36},"Vanderbilt University Medical Center \u002FID# 280169","37232",{"type":96,"coordinates":323},[316,317],{"lat":317,"lon":316},{"facility":326,"status":89,"city":327,"state":328,"zip":329,"country":93,"countryCode":94,"cosmosGeoPoint":330,"geoPoint":334,"contacts":36},"The University of Texas MD Anderson Cancer Center \u002FID# 280070","Houston","Texas","77030",{"type":96,"coordinates":331},[332,333],-95.36327,29.76328,{"lat":333,"lon":332},{"facility":336,"status":89,"city":337,"state":328,"zip":338,"country":93,"countryCode":94,"cosmosGeoPoint":339,"geoPoint":343,"contacts":36},"Texas Oncology - Northeast Texas \u002FID# 280642","Tyler","75702",{"type":96,"coordinates":340},[341,342],-95.30106,32.35126,{"lat":342,"lon":341},{"facility":345,"status":89,"city":346,"state":347,"zip":348,"country":93,"countryCode":94,"cosmosGeoPoint":349,"geoPoint":353,"contacts":36},"Blue Ridge Cancer Care - Blacksburg \u002FID# 281583","Blacksburg","Virginia","24060",{"type":96,"coordinates":350},[351,352],-80.41394,37.22957,{"lat":352,"lon":351},{"facility":355,"status":89,"city":356,"state":347,"zip":357,"country":93,"countryCode":94,"cosmosGeoPoint":358,"geoPoint":362,"contacts":36},"Virginia Cancer Specialists - Fairfax \u002FID# 280710","Fairfax","22031",{"type":96,"coordinates":359},[360,361],-77.30637,38.84622,{"lat":361,"lon":360},{"facility":364,"status":89,"city":365,"state":347,"zip":366,"country":93,"countryCode":94,"cosmosGeoPoint":367,"geoPoint":371,"contacts":36},"Shenandoah Oncology \u002FID# 280699","Winchester","22601",{"type":96,"coordinates":368},[369,370],-78.16333,39.18566,{"lat":370,"lon":369},{"facility":373,"status":89,"city":374,"state":375,"zip":376,"country":93,"countryCode":94,"cosmosGeoPoint":377,"geoPoint":381,"contacts":36},"West Virginia University Hospitals \u002FID# 279883","Morgantown","West Virginia","26506",{"type":96,"coordinates":378},[379,380],-79.9559,39.62953,{"lat":380,"lon":379},{"facility":383,"status":89,"city":384,"state":385,"zip":386,"country":93,"countryCode":94,"cosmosGeoPoint":387,"geoPoint":391,"contacts":36},"University of Wisconsin \u002FID# 279909","Madison","Wisconsin","53792-0001",{"type":96,"coordinates":388},[389,390],-89.40123,43.07305,{"lat":390,"lon":389},{"facility":393,"status":89,"city":394,"state":395,"zip":396,"country":397,"countryCode":398,"cosmosGeoPoint":399,"geoPoint":403,"contacts":36},"Universitaetsklinikum Krems \u002FID# 280608","Krems","Lower Austria","3500","Austria","AT",{"type":96,"coordinates":400},[401,402],15.61415,48.40921,{"lat":402,"lon":401},{"facility":405,"status":89,"city":406,"state":407,"zip":408,"country":397,"countryCode":398,"cosmosGeoPoint":409,"geoPoint":413,"contacts":36},"Ordensklinikum Linz Elisabethinen \u002FID# 281314","Linz","Upper Austria","4010",{"type":96,"coordinates":410},[411,412],14.28611,48.30639,{"lat":412,"lon":411},{"facility":415,"status":89,"city":416,"state":417,"zip":418,"country":419,"countryCode":420,"cosmosGeoPoint":421,"geoPoint":425,"contacts":36},"AZ-Delta. \u002FID# 280341","Roeselare","West-Vlaanderen","8800","Belgium","BE",{"type":96,"coordinates":422},[423,424],3.12269,50.94653,{"lat":424,"lon":423},{"facility":427,"status":89,"city":428,"state":429,"zip":430,"country":431,"countryCode":432,"cosmosGeoPoint":433,"geoPoint":437,"contacts":36},"Assistance Publique Hopitaux de Marseille - Hopital Nord \u002FID# 280600","Marseille","Bouches-du-Rhone","13915","France","FR",{"type":96,"coordinates":434},[435,436],5.38107,43.29695,{"lat":436,"lon":435},{"facility":439,"status":89,"city":440,"state":441,"zip":442,"country":443,"countryCode":444,"cosmosGeoPoint":445,"geoPoint":449,"contacts":36},"Klinikum Kassel \u002FID# 280427","Kassel","Hesse","34125","Germany","DE",{"type":96,"coordinates":446},[447,448],9.5,51.31667,{"lat":448,"lon":447},{"facility":451,"status":89,"city":452,"state":453,"zip":454,"country":443,"countryCode":444,"cosmosGeoPoint":455,"geoPoint":459,"contacts":36},"Universitaetsklinikum Koeln \u002FID# 280867","Cologne","North Rhine-Westphalia","50937",{"type":96,"coordinates":456},[457,458],6.95,50.93333,{"lat":458,"lon":457},{"facility":461,"status":89,"city":462,"state":463,"zip":464,"country":465,"countryCode":466,"cosmosGeoPoint":467,"geoPoint":471,"contacts":36},"Henry Dunnant Hospital Center \u002FID# 280369","Athens","Attica","11526","Greece","GR",{"type":96,"coordinates":468},[469,470],23.72784,37.98376,{"lat":470,"lon":469},{"facility":473,"status":89,"city":474,"state":463,"zip":475,"country":465,"countryCode":466,"cosmosGeoPoint":476,"geoPoint":480,"contacts":36},"Metropolitan Hospital \u002FID# 280359","Piraeus","18547",{"type":96,"coordinates":477},[478,479],23.64619,37.94203,{"lat":479,"lon":478},{"facility":482,"status":89,"city":483,"state":36,"zip":484,"country":465,"countryCode":466,"cosmosGeoPoint":485,"geoPoint":489,"contacts":36},"Interbalkan Medical Center Of Thessaloniki \u002FID# 280361","Thessaloniki","57001",{"type":96,"coordinates":486},[487,488],22.93493,40.64072,{"lat":488,"lon":487},{"facility":491,"status":89,"city":492,"state":493,"zip":494,"country":495,"countryCode":496,"cosmosGeoPoint":497,"geoPoint":501,"contacts":36},"Fujita Health University Hospital \u002FID# 279969","Toyoake","Aichi-ken","470-1192","Japan","JP",{"type":96,"coordinates":498},[499,500],136.99931,35.038,{"lat":500,"lon":499},{"facility":503,"status":89,"city":504,"state":505,"zip":506,"country":495,"countryCode":496,"cosmosGeoPoint":507,"geoPoint":511,"contacts":36},"Hirosaki University Hospital \u002FID# 279926","Hirosaki","Aomori","036-8563",{"type":96,"coordinates":508},[509,510],140.4725,40.59306,{"lat":510,"lon":509},{"facility":513,"status":89,"city":514,"state":514,"zip":515,"country":495,"countryCode":496,"cosmosGeoPoint":516,"geoPoint":520,"contacts":36},"Kyushu University Hospital \u002FID# 279964","Fukuoka","812-8582",{"type":96,"coordinates":517},[518,519],130.41667,33.6,{"lat":519,"lon":518},{"facility":522,"status":89,"city":523,"state":524,"zip":525,"country":495,"countryCode":496,"cosmosGeoPoint":526,"geoPoint":530,"contacts":36},"Hokkaido Cancer Center \u002FID# 280024","Sapporo","Hokkaido","003-0804",{"type":96,"coordinates":527},[528,529],141.35,43.06667,{"lat":529,"lon":528},{"facility":532,"status":89,"city":533,"state":534,"zip":535,"country":495,"countryCode":496,"cosmosGeoPoint":536,"geoPoint":540,"contacts":36},"Kobe University Hospital \u002FID# 280290","Kobe","Hyōgo","650-0017",{"type":96,"coordinates":537},[538,539],135.183,34.6913,{"lat":539,"lon":538},{"facility":542,"status":89,"city":543,"state":544,"zip":545,"country":495,"countryCode":496,"cosmosGeoPoint":36,"geoPoint":36,"contacts":36},"Kitasato University Hospital \u002FID# 280033","Sagamihara-shi","Kanagawa","252-0375",{"facility":547,"status":89,"city":548,"state":549,"zip":550,"country":495,"countryCode":496,"cosmosGeoPoint":551,"geoPoint":555,"contacts":36},"Sendai Kousei Hospital \u002FID# 279790","Sendai","Miyagi","981-0914",{"type":96,"coordinates":552},[553,554],140.86667,38.26667,{"lat":554,"lon":553},{"facility":557,"status":89,"city":558,"state":558,"zip":559,"country":495,"countryCode":496,"cosmosGeoPoint":560,"geoPoint":564,"contacts":36},"Niigata University Medical and Dental Hospital \u002FID# 280027","Niigata","951-8520",{"type":96,"coordinates":561},[562,563],139.04125,37.92259,{"lat":563,"lon":562},{"facility":566,"status":89,"city":567,"state":568,"zip":569,"country":495,"countryCode":496,"cosmosGeoPoint":570,"geoPoint":574,"contacts":36},"Okayama University Hospital \u002FID# 280023","Okayama","Okayama-ken","700-8558",{"type":96,"coordinates":571},[572,573],133.93333,34.65,{"lat":573,"lon":572},{"facility":576,"status":89,"city":577,"state":578,"zip":579,"country":495,"countryCode":496,"cosmosGeoPoint":36,"geoPoint":36,"contacts":36},"Kansai Medical University Hospital \u002FID# 279925","Hirakata-shi","Osaka","573-1191",{"facility":581,"status":89,"city":578,"state":578,"zip":582,"country":495,"countryCode":496,"cosmosGeoPoint":583,"geoPoint":587,"contacts":36},"Osaka International Cancer Institute \u002FID# 280026","5418567",{"type":96,"coordinates":584},[585,586],135.50107,34.69379,{"lat":586,"lon":585},{"facility":589,"status":89,"city":590,"state":578,"zip":591,"country":495,"countryCode":496,"cosmosGeoPoint":36,"geoPoint":36,"contacts":36},"Kindai University Hospital \u002FID# 280034","Sakai-shi","590-0197",{"facility":593,"status":89,"city":594,"state":595,"zip":596,"country":495,"countryCode":496,"cosmosGeoPoint":597,"geoPoint":601,"contacts":36},"Saitama Medical University International Medical Center \u002FID# 279962","Hidaka","Saitama","350-1298",{"type":96,"coordinates":598},[599,600],139.36233,35.91664,{"lat":600,"lon":599},{"facility":603,"status":89,"city":604,"state":605,"zip":606,"country":495,"countryCode":496,"cosmosGeoPoint":36,"geoPoint":36,"contacts":36},"Shizuoka Cancer Center \u002FID# 279924","Sunto-gun","Shizuoka","411-8777",{"facility":608,"status":89,"city":609,"state":610,"zip":611,"country":495,"countryCode":496,"cosmosGeoPoint":36,"geoPoint":36,"contacts":36},"Juntendo University Hospital \u002FID# 280095","Bunkyo-ku","Tokyo","113-8431",{"facility":613,"status":89,"city":609,"state":610,"zip":614,"country":495,"countryCode":496,"cosmosGeoPoint":36,"geoPoint":36,"contacts":36},"Nippon Medical School Hospital \u002FID# 280687","113-8603",{"facility":616,"status":89,"city":610,"state":36,"zip":617,"country":495,"countryCode":496,"cosmosGeoPoint":618,"geoPoint":622,"contacts":36},"Teikyo University Hospital \u002FID# 280307","173-8605",{"type":96,"coordinates":619},[620,621],139.69171,35.6895,{"lat":621,"lon":620},{"facility":624,"status":89,"city":625,"state":36,"zip":626,"country":627,"countryCode":628,"cosmosGeoPoint":629,"geoPoint":633,"contacts":36},"Hospital Clinic de Barcelona \u002FID# 281271","Barcelona","08036","Spain","ES",{"type":96,"coordinates":630},[631,632],2.15899,41.38879,{"lat":632,"lon":631},{"facility":635,"status":89,"city":636,"state":637,"zip":638,"country":639,"countryCode":640,"cosmosGeoPoint":36,"geoPoint":36,"contacts":36},"University Hospital Basel \u002FID# 280787","Basel Town","Canton of Basel-City","4031","Switzerland","CH",{"facility":642,"status":89,"city":643,"state":644,"zip":645,"country":639,"countryCode":640,"cosmosGeoPoint":646,"geoPoint":650,"contacts":36},"Hopitaux Universitaires de Geneve \u002FID# 280748","Geneva","Canton of Geneva","1205",{"type":96,"coordinates":647},[648,649],6.14569,46.20222,{"lat":649,"lon":648},{"facility":652,"status":89,"city":653,"state":654,"zip":655,"country":639,"countryCode":640,"cosmosGeoPoint":656,"geoPoint":660,"contacts":36},"Centre Hospitalier Universitaire Vaudois \u002FID# 280847","Lausanne","Canton of Vaud","1011",{"type":96,"coordinates":657},[658,659],6.63282,46.516,{"lat":659,"lon":658},{"facility":662,"status":89,"city":663,"state":664,"zip":665,"country":639,"countryCode":640,"cosmosGeoPoint":666,"geoPoint":670,"contacts":36},"EOC Ospedale Regionale Lugano \u002FID# 280583","Lugano","Canton Ticino","6900",{"type":96,"coordinates":667},[668,669],8.96004,46.01008,{"lat":669,"lon":668},{"type":672,"investigatorFullName":36,"investigatorTitle":36,"investigatorAffiliation":36,"oldNameTitle":36,"oldOrganization":36},"SPONSOR","100621024","phase-3-a-study-to-evaluate-adverse-events-and-change-in-disease-activity-of-intravenous-abbv-706-versus-standard-of-care-in-adult-participants-with-relapsedrefractory-small-cell-lung-cancer-100621024",false,"NCT07365241","A Study to Evaluate Adverse Events and Change in Disease Activity of Intravenous ABBV-706 Versus Standard of Care in Adult Participants With Relapsed\u002FRefractory Small Cell Lung Cancer","A Phase 3 Randomized, Open Label, Multicenter Study to Evaluate the Safety and Efficacy of ABBV-706 Versus Standard of Care in Subjects With Relapsed\u002FRefractory Small Cell Lung Cancer (SCLC)","Inclusion Criteria:\n\n* Diagnosis of histologically or cytologically confirmed Relapsed\u002FRefractory (R\u002FR) Small Cell Lung Cancer (SCLC).\n* Participants must have progressed on prior systemic therapy, with CPI (if eligible) and prior tarlatamab, defined as:\n\n  * In the 1L and 2L setting respectively, platinum-based chemotherapy (i.e., carboplatin or cisplatin and etoposide with CPI, if eligible for CPI) and 2L tarlatamab; or\n  * In the 1L and 2L setting, platinum-based chemotherapy (i.e., carboplatin and etoposide with atezolizumab and lurbinectedin in combination with atezolizumab maintenance and 2L tarlatamab; or\n  * In the 1L setting, platinum-based chemotherapy (i.e., carboplatin or cisplatin and etoposide with CPI if eligible) in combination with tarlatamab in frontline induction and\u002For maintenance\n* Participants must be considered suitable to receive SOC comparator (topotecan, lurbinectedin, or amrubicin).\n* Participants must have an Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 to 1 during the screening period prior to the first dose of study treatment.\n* Participants must have measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1. Target lesions situated in a previously irradiated area are considered measurable if progression has been demonstrated in such lesions.\n* Participants with brain metastasis from an extracranial solid tumor are eligible if the brain metastases are:\n\n  * Previously treated and not requiring anticonvulsants and steroids for at least 7 days prior to first dose of study treatment. If required for management, subjects on a steroid equivalent of prednisone dose of ≤ 10 mg\u002Fday are eligible or;\n  * Untreated and asymptomatic not requiring anticonvulsants and steroids for at least 7 days prior to the first dose of study treatment. If required for management, subjects on a steroid equivalent of prednisone of ≤ 10 mg\u002Fday are eligible.\n\nExclusion Criteria:\n\n* Participants with known active\u002Fsymptomatic central nervous system metastases.\n* Participants with a history of interstitial lung disease (ILD) or pneumonitis that previously required treatment with systemic steroids, or any evidence of active ILD\u002Fpneumonitis on screening chest computed tomography (CT) scan.\n* Participants with any clinically significant conditions that would adversely affect the participation in the study, and the subject should have a life expectancy of at least 3 months.\n* Participants who have received prior treatment with a seizure-related 6 homolog (SEZ6) targeted Antibody drug conjugate (ADC), other targeted ADCs, or any other investigational agent not including tarlatamab in 1L.\n* Participants who have received prior treatment with any Top1i such as topotecan, irinotecan, belotecan, camptothecin, rubitecan, exatecan or locally approved topoisomerase I inhibitor (Top1i) payload.","ALL","18 Years",{"count":683,"type":684},531,"ESTIMATED","INTERVENTIONAL",[687],"PHASE3","Small cell lung cancer (SCLC) is characterized by aggressive and rapid growth and a tendency to develop early spread to distant sites including mediastinal lymph nodes, liver, bones, adrenal glands, and brain. The purpose of this study is to assess safety, tolerability, and change in disease activity of ABBV-706 compared to standard of care (SOC) treatment (topotecan, lurbinectedin, or amrubicin).\n\nABBV-706 is an investigational drug being developed for the treatment of SCLC. There are two treatment arms in this study. Participants will either receive ABBV-706 or SOC. Approximately 531 adult participants will be enrolled in the study across 175 sites worldwide.\n\nParticipants with SCLC will receive intravenous (IV) ABBV-706 or SOC \\[topotecan (IV or orally), or lubinectedin (IV), or amrubicin (IV)\\]. The estimated duration of the study is approximately 53 months.\n\nThere may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic and may require frequent medical assessments, blood tests, questionnaires, and scans.",[690],"Small Cell Lung Cancer",[690,692,45,64,71,74,693],"SCLC","Cancer","2026-09-11",{"date":696,"type":697},"2026-09-15","ACTUAL",{"date":699,"type":697},"2026-07-02",{"date":701,"type":684},"2030-09",{"name":5,"class":6},63]