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283530","Porto","4200-319",{"type":70,"coordinates":614},[615,616],-8.61097,41.1485,{"lat":616,"lon":615},{"facility":619,"status":33,"city":620,"state":621,"zip":622,"country":623,"countryCode":624,"cosmosGeoPoint":625,"geoPoint":629,"contacts":33},"Hospital Universitario Marques de Valdecilla \u002FID# 283344","Santander","Cantabria","39008","Spain","ES",{"type":70,"coordinates":626},[627,628],-3.80493,43.46589,{"lat":628,"lon":627},{"facility":631,"status":33,"city":632,"state":633,"zip":634,"country":623,"countryCode":624,"cosmosGeoPoint":635,"geoPoint":639,"contacts":33},"Clinica Universidad de Navarra - Pamplona \u002FID# 283290","Pamplona","Navarre","31008",{"type":70,"coordinates":636},[637,638],-1.64323,42.81687,{"lat":638,"lon":637},{"facility":641,"status":33,"city":642,"state":33,"zip":643,"country":623,"countryCode":624,"cosmosGeoPoint":644,"geoPoint":648,"contacts":33},"Hospital General Universitario Gregorio Maranon \u002FID# 283342","Madrid","28007",{"type":70,"coordinates":645},[646,647],-3.70256,40.4165,{"lat":647,"lon":646},{"facility":650,"status":33,"city":651,"state":33,"zip":652,"country":653,"countryCode":654,"cosmosGeoPoint":655,"geoPoint":659,"contacts":33},"Kaohsiung Chang Gung Memorial Hospital \u002FID# 282970","Kaohsiung City","833","Taiwan","TW",{"type":70,"coordinates":656},[657,658],120.31333,22.61626,{"lat":658,"lon":657},{"facility":661,"status":33,"city":662,"state":663,"zip":664,"country":665,"countryCode":666,"cosmosGeoPoint":667,"geoPoint":671,"contacts":33},"University Hospitals Plymouth NHS Trust \u002FID# 283108","Plymouth","Devon","PL6 8DH","United Kingdom","UK",{"type":70,"coordinates":668},[669,670],-4.14305,50.37153,{"lat":670,"lon":669},{"facility":673,"status":33,"city":674,"state":675,"zip":676,"country":665,"countryCode":666,"cosmosGeoPoint":677,"geoPoint":681,"contacts":33},"Western General Hospital - NHS Lothian \u002FID# 281838","Edinburgh","Edinburgh, City of","EH4 2XU",{"type":70,"coordinates":678},[679,680],-3.19648,55.95206,{"lat":680,"lon":679},{"facility":683,"status":33,"city":373,"state":684,"zip":685,"country":665,"countryCode":666,"cosmosGeoPoint":686,"geoPoint":690,"contacts":33},"St Bartholomews Hospital - Barts Health \u002FID# 283714","Greater London","EC1A 7BE",{"type":70,"coordinates":687},[688,689],-0.12574,51.50853,{"lat":689,"lon":688},{"facility":692,"status":33,"city":693,"state":694,"zip":695,"country":665,"countryCode":666,"cosmosGeoPoint":696,"geoPoint":700,"contacts":33},"Queen Alexandra Hospital \u002FID# 281839","Portsmouth","Hampshire","PO6 3LY",{"type":70,"coordinates":697},[698,699],-1.09125,50.79899,{"lat":699,"lon":698},{"facility":702,"status":33,"city":703,"state":704,"zip":705,"country":665,"countryCode":666,"cosmosGeoPoint":706,"geoPoint":710,"contacts":33},"NHS Lanarkshire \u002FID# 282021","Airdrie","North Lanarkshire","ML6 0JS",{"type":70,"coordinates":707},[708,709],-3.98025,55.86602,{"lat":709,"lon":708},{"facility":712,"status":33,"city":713,"state":714,"zip":715,"country":665,"countryCode":666,"cosmosGeoPoint":716,"geoPoint":720,"contacts":33},"Nottingham City Hospital \u002FID# 282748","Nottingham","Nottinghamshire","NG5 1PB",{"type":70,"coordinates":717},[718,719],-1.15047,52.9536,{"lat":719,"lon":718},{"type":722,"investigatorFullName":33,"investigatorTitle":33,"investigatorAffiliation":33,"oldNameTitle":33,"oldOrganization":33},"SPONSOR","100648859","phase-3-a-study-to-evaluate-adverse-events-and-change-in-disease-activity-with-injected-etentamig-plus-oral-pomalidomide-versus-standard-therapies-in-adults-with-relapsed-or-refractory-multiple-myeloma-100648859",false,"NCT07728188","A Study to Evaluate Adverse Events and Change in Disease Activity With Injected Etentamig Plus Oral Pomalidomide Versus Standard Therapies in Adults With Relapsed or Refractory Multiple Myeloma","A Phase 3, Multicenter, Randomized, Open Label Study to Evaluate the Safety and Efficacy of Etentamig in Combination With Pomalidomide Compared With Standard Available Therapies in Subjects With Relapsed or Refractory Multiple Myeloma (2L+ RRMM)","Inclusion Criteria:\n\n* Diagnosis of relapsed or refractory (RR) multiple myeloma (MM).\n* Prior treatment with at least one and no more than three prior lines of therapy, including lenalidomide.\n* Adequate organ function and performance status\n\nExclusion Criteria:\n\n* Prior B-cell maturation antigen (BCMA) directed T-cell engager therapy (bispecific or trispecific)\n* Known central nervous system involvement of MM\n* Known history of other active malignancies within the past 3 years (with specific exceptions)\n* Clinically significant conditions (renal, neurologic, psychiatric, endocrine, metabolic, immunologic, cardiovascular, pulmonary, or hepatic disease within the last 6 months)","ALL","18 Years",{"count":733,"type":734},520,"ESTIMATED","INTERVENTIONAL",[737],"PHASE3","Multiple myeloma (MM) is a plasma cell malignancy characterized by the proliferation of clonal plasma cells in the bone marrow. The disease primarily localizes to the bones and bone marrow, with resultant cytopenias, bone pain, fractures, infections, hypercalcemia, and renal failure. This study aims to evaluate the safety and change in disease activity of etentamig in combination with pomalidomide compared with standard available therapies in participants with relapsed or refractory multiple myeloma who have received 1-3 prior lines of treatment, including lenalidomide.\n\nEtentamig is an investigational drug being developed for the treatment of relapsed or refractory multiple myeloma. This is a randomized, open-label study. The study will include a safety run-in portion and a randomized portion. The safety run-in participants will receive etentamig in combination with pomalidomide. The randomized portion of the study participants will receive either etentamig with pomalidomide or Standard Available Therapies (SATs). Approximately 520 participants will be enrolled in the study at approximately 200 sites worldwide.\n\nPrior to initiation of the randomized portion of the study, the safety run-in will be conducted in which participants will receive etentamig injections plus oral pomalidomide. Following review of the safety run-in data and per protocol-defined criteria, the study will advance to the randomized portion where participants will be randomized to receive either etentamig injections plus oral pomalidomide or investigator's choice of SAT: SC daratumumab, oral pomalidomide, and oral\u002F IV dexamethasone (DPd); SC daratumumab, IV carfilzomib, and oral\u002FIV dexamethasone (DKd); or SC teclistamab monotherapy. The total study duration is approximately 75 months\n\nThere may be higher treatment burden for participants in this trial compared to their standard of care due to study procedures. Participants will attend regular visits during the study at a hospital or clinic. The effects of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.",[740],"Relapsed or Refractory Multiple Myeloma",[740,30,35,742],"Cancer","NOT_YET_RECRUITING","2026-07-22",{"date":746,"type":747},"2026-07-27","ACTUAL",{"date":749,"type":734},"2026-11-30",{"date":751,"type":734},"2033-02",{"name":5,"class":6},66]