[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100595880":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":33,"locations":41,"responsibleParty":452,"collaborators":32,"id":454,"slug":455,"hasResults":456,"nctId":457,"briefTitle":458,"officialTitle":459,"acronym":460,"eligibilityCriteria":461,"healthyVolunteers":456,"sex":462,"minAge":463,"maxAge":464,"enrollmentInfo":465,"targetDuration":32,"studyType":468,"phases":469,"briefSummary":459,"conditions":471,"keywords":489,"overallStatus":187,"whyStopped":32,"lastUpdateSubmitDate":501,"lastUpdatePostDateStruct":502,"startDateStruct":505,"completionDateStruct":507,"leadSponsor":509,"locationsCount":510},{"fullName":5,"class":6},"Avidity Biosciences, Inc.","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Del-brax","EXPERIMENTAL","Del-brax (AOC 1020) will be administered 13 times",[13],"Drug: AOC-1020",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Saline will be administered 13 times",[19],"Drug: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","AOC-1020","Del-brax will be administered by intravenous (IV) infusion.",[9],[9],{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":30},"Placebo will be administered by intravenous (IV) infusion.",[15],[31],"Saline",null,[34,39],{"name":35,"role":36,"phone":37,"phoneExt":32,"email":38},"Avidity Biosciences, Inc., A Novartis Company","CONTACT","1-888-669-6682","novartis.email@novartis.com",{"name":35,"role":36,"phone":40,"phoneExt":32,"email":38},"+41613241111",[42,56,65,75,85,95,105,115,125,135,145,155,165,175,185,197,205,214,223,234,242,252,260,268,276,286,294,302,310,320,328,336,341,351,356,364,372,382,390,400,405,413,421,431,436,444],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":32},"University of California Irvine","ACTIVE_NOT_RECRUITING","Orange","California","92868","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-117.85311,33.78779,{"lat":54,"lon":53},{"facility":57,"status":44,"city":58,"state":46,"zip":59,"country":48,"countryCode":49,"cosmosGeoPoint":60,"geoPoint":64,"contacts":32},"Stanford University","Palo Alto","94304",{"type":51,"coordinates":61},[62,63],-122.14302,37.44188,{"lat":63,"lon":62},{"facility":66,"status":44,"city":67,"state":68,"zip":69,"country":48,"countryCode":49,"cosmosGeoPoint":70,"geoPoint":74,"contacts":32},"University of Colorado","Denver","Colorado","80045",{"type":51,"coordinates":71},[72,73],-104.9847,39.73915,{"lat":73,"lon":72},{"facility":76,"status":44,"city":77,"state":78,"zip":79,"country":48,"countryCode":49,"cosmosGeoPoint":80,"geoPoint":84,"contacts":32},"University of Florida","Gainesville","Florida","32608",{"type":51,"coordinates":81},[82,83],-82.32483,29.65163,{"lat":83,"lon":82},{"facility":86,"status":44,"city":87,"state":88,"zip":89,"country":48,"countryCode":49,"cosmosGeoPoint":90,"geoPoint":94,"contacts":32},"University of Iowa","Iowa City","Iowa","52242",{"type":51,"coordinates":91},[92,93],-91.53017,41.66113,{"lat":93,"lon":92},{"facility":96,"status":44,"city":97,"state":98,"zip":99,"country":48,"countryCode":49,"cosmosGeoPoint":100,"geoPoint":104,"contacts":32},"Kansas University Medical Center","Kansas City","Kansas","66205",{"type":51,"coordinates":101},[102,103],-94.62746,39.11417,{"lat":103,"lon":102},{"facility":106,"status":44,"city":107,"state":108,"zip":109,"country":48,"countryCode":49,"cosmosGeoPoint":110,"geoPoint":114,"contacts":32},"Kennedy Krieger Institute","Baltimore","Maryland","21205",{"type":51,"coordinates":111},[112,113],-76.61219,39.29038,{"lat":113,"lon":112},{"facility":116,"status":44,"city":117,"state":118,"zip":119,"country":48,"countryCode":49,"cosmosGeoPoint":120,"geoPoint":124,"contacts":32},"University of Massachusetts","Worcester","Massachusetts","01655",{"type":51,"coordinates":121},[122,123],-71.80229,42.26259,{"lat":123,"lon":122},{"facility":126,"status":44,"city":127,"state":128,"zip":129,"country":48,"countryCode":49,"cosmosGeoPoint":130,"geoPoint":134,"contacts":32},"University of Rochester Medical Center","Rochester","New York","14642",{"type":51,"coordinates":131},[132,133],-77.61556,43.15478,{"lat":133,"lon":132},{"facility":136,"status":44,"city":137,"state":138,"zip":139,"country":48,"countryCode":49,"cosmosGeoPoint":140,"geoPoint":144,"contacts":32},"Duke University","Durham","North Carolina","27708",{"type":51,"coordinates":141},[142,143],-78.89862,35.99403,{"lat":143,"lon":142},{"facility":146,"status":44,"city":147,"state":148,"zip":149,"country":48,"countryCode":49,"cosmosGeoPoint":150,"geoPoint":154,"contacts":32},"Ohio State University","Columbus","Ohio","43221",{"type":51,"coordinates":151},[152,153],-82.99879,39.96118,{"lat":153,"lon":152},{"facility":156,"status":44,"city":157,"state":158,"zip":159,"country":48,"countryCode":49,"cosmosGeoPoint":160,"geoPoint":164,"contacts":32},"University of Pennsylvania","Philadelphia","Pennsylvania","19104",{"type":51,"coordinates":161},[162,163],-75.16362,39.95238,{"lat":163,"lon":162},{"facility":166,"status":44,"city":167,"state":168,"zip":169,"country":48,"countryCode":49,"cosmosGeoPoint":170,"geoPoint":174,"contacts":32},"University of Texas Health Science Center at San Antonio","San Antonio","Texas","78229",{"type":51,"coordinates":171},[172,173],-98.49363,29.42412,{"lat":173,"lon":172},{"facility":176,"status":44,"city":177,"state":178,"zip":179,"country":48,"countryCode":49,"cosmosGeoPoint":180,"geoPoint":184,"contacts":32},"Virginia Commonwealth University","Richmond","Virginia","23298",{"type":51,"coordinates":181},[182,183],-77.46026,37.55376,{"lat":183,"lon":182},{"facility":186,"status":187,"city":188,"state":189,"zip":32,"country":190,"countryCode":191,"cosmosGeoPoint":192,"geoPoint":196,"contacts":32},"University of Calgary - Cumming School of Medicine","RECRUITING","Calgary","Alberta","Canada","CA",{"type":51,"coordinates":193},[194,195],-114.08529,51.05011,{"lat":195,"lon":194},{"facility":198,"status":187,"city":199,"state":189,"zip":32,"country":190,"countryCode":191,"cosmosGeoPoint":200,"geoPoint":204,"contacts":32},"University of Alberta Hospital","Edmonton",{"type":51,"coordinates":201},[202,203],-113.46871,53.55014,{"lat":203,"lon":202},{"facility":206,"status":187,"city":207,"state":208,"zip":32,"country":190,"countryCode":191,"cosmosGeoPoint":209,"geoPoint":213,"contacts":32},"The Ottawa Hospital","Ottawa","Ontario",{"type":51,"coordinates":210},[211,212],-75.69812,45.41117,{"lat":212,"lon":211},{"facility":215,"status":187,"city":216,"state":217,"zip":32,"country":190,"countryCode":191,"cosmosGeoPoint":218,"geoPoint":222,"contacts":32},"Genge Partners Inc","Montreal","Quebec",{"type":51,"coordinates":219},[220,221],-73.58781,45.50884,{"lat":221,"lon":220},{"facility":224,"status":225,"city":226,"state":32,"zip":32,"country":227,"countryCode":228,"cosmosGeoPoint":229,"geoPoint":233,"contacts":32},"Aarhus University Hospital","NOT_YET_RECRUITING","Aarhus","Denmark","DK",{"type":51,"coordinates":230},[231,232],10.21076,56.15674,{"lat":232,"lon":231},{"facility":235,"status":187,"city":236,"state":32,"zip":32,"country":227,"countryCode":228,"cosmosGeoPoint":237,"geoPoint":241,"contacts":32},"Rigshospitalet","Copenhagen",{"type":51,"coordinates":238},[239,240],12.56553,55.67594,{"lat":240,"lon":239},{"facility":243,"status":225,"city":244,"state":32,"zip":32,"country":245,"countryCode":246,"cosmosGeoPoint":247,"geoPoint":251,"contacts":32},"Centre de Reference des Maladies Neuromusculaires et de la SLA - AP-HM Hopital de La Timone","Marseille","France","FR",{"type":51,"coordinates":248},[249,250],5.38107,43.29695,{"lat":250,"lon":249},{"facility":253,"status":225,"city":254,"state":32,"zip":32,"country":245,"countryCode":246,"cosmosGeoPoint":255,"geoPoint":259,"contacts":32},"CHU de Montpellier - Hopital Gui de Chauliac","Montpellier",{"type":51,"coordinates":256},[257,258],3.87635,43.61093,{"lat":258,"lon":257},{"facility":261,"status":225,"city":262,"state":32,"zip":32,"country":245,"countryCode":246,"cosmosGeoPoint":263,"geoPoint":267,"contacts":32},"CHU de Nice - Hopital Pasteur 2 - Centre de reference des Maladies Neuromusculaires","Nice",{"type":51,"coordinates":264},[265,266],7.26608,43.70313,{"lat":266,"lon":265},{"facility":269,"status":187,"city":270,"state":32,"zip":32,"country":245,"countryCode":246,"cosmosGeoPoint":271,"geoPoint":275,"contacts":32},"AP-HP Hopital Pitie-Salpetriere","Paris",{"type":51,"coordinates":272},[273,274],2.3488,48.85341,{"lat":274,"lon":273},{"facility":277,"status":187,"city":278,"state":32,"zip":32,"country":279,"countryCode":280,"cosmosGeoPoint":281,"geoPoint":285,"contacts":32},"Universitaetsklinikum Bonn","Bonn","Germany","DE",{"type":51,"coordinates":282},[283,284],7.09549,50.73438,{"lat":284,"lon":283},{"facility":287,"status":187,"city":288,"state":32,"zip":32,"country":279,"countryCode":280,"cosmosGeoPoint":289,"geoPoint":293,"contacts":32},"Georg-August-Universitaet Goettingen Stiftung oeffentlichen Rechts Universitaetsmedizin Goettingen","Göttingen",{"type":51,"coordinates":290},[291,292],9.93228,51.53443,{"lat":292,"lon":291},{"facility":295,"status":187,"city":296,"state":32,"zip":32,"country":279,"countryCode":280,"cosmosGeoPoint":297,"geoPoint":301,"contacts":32},"Klinikum der Ludwig-Maximilians-Universitaet Muenchen","München",{"type":51,"coordinates":298},[299,300],13.31243,51.60698,{"lat":300,"lon":299},{"facility":303,"status":187,"city":304,"state":32,"zip":32,"country":279,"countryCode":280,"cosmosGeoPoint":305,"geoPoint":309,"contacts":32},"Universitaetsklinikum Ulm","Ulm",{"type":51,"coordinates":306},[307,308],9.99155,48.39841,{"lat":308,"lon":307},{"facility":311,"status":187,"city":312,"state":32,"zip":32,"country":313,"countryCode":314,"cosmosGeoPoint":315,"geoPoint":319,"contacts":32},"Fondazione Serena ETS - Centro Clinico NeMO Milano","Milan","Italy","IT",{"type":51,"coordinates":316},[317,318],12.59836,42.78235,{"lat":318,"lon":317},{"facility":321,"status":187,"city":322,"state":32,"zip":32,"country":313,"countryCode":314,"cosmosGeoPoint":323,"geoPoint":327,"contacts":32},"Azienda Ospedaliero Universitaria Pisana","Pisa",{"type":51,"coordinates":324},[325,326],10.4036,43.70853,{"lat":326,"lon":325},{"facility":329,"status":187,"city":330,"state":32,"zip":32,"country":313,"countryCode":314,"cosmosGeoPoint":331,"geoPoint":335,"contacts":32},"Azienda Ospedaliero-Universitaria Sant'Andrea","Roma",{"type":51,"coordinates":332},[333,334],11.10642,44.99364,{"lat":334,"lon":333},{"facility":337,"status":187,"city":330,"state":32,"zip":32,"country":313,"countryCode":314,"cosmosGeoPoint":338,"geoPoint":340,"contacts":32},"Fondazione Policlinico Universitario A. Gemelli IRCCS - Universita Cattolica del Sacro Cuore",{"type":51,"coordinates":339},[333,334],{"lat":334,"lon":333},{"facility":342,"status":187,"city":343,"state":32,"zip":32,"country":344,"countryCode":345,"cosmosGeoPoint":346,"geoPoint":350,"contacts":32},"National Hospital Organization Osaka Toneyama Medical Center","Osaka","Japan","JP",{"type":51,"coordinates":347},[348,349],135.50107,34.69379,{"lat":349,"lon":348},{"facility":352,"status":187,"city":343,"state":32,"zip":32,"country":344,"countryCode":345,"cosmosGeoPoint":353,"geoPoint":355,"contacts":32},"The University of Osaka Hospital",{"type":51,"coordinates":354},[348,349],{"lat":349,"lon":348},{"facility":357,"status":187,"city":358,"state":32,"zip":32,"country":344,"countryCode":345,"cosmosGeoPoint":359,"geoPoint":363,"contacts":32},"National Hospital Organization Sendai Nishitaga Hospital","Sendai",{"type":51,"coordinates":360},[361,362],140.86667,38.26667,{"lat":362,"lon":361},{"facility":365,"status":187,"city":366,"state":32,"zip":32,"country":344,"countryCode":345,"cosmosGeoPoint":367,"geoPoint":371,"contacts":32},"National Center of Neurology and Psychiatry","Tokyo",{"type":51,"coordinates":368},[369,370],139.69171,35.6895,{"lat":370,"lon":369},{"facility":373,"status":187,"city":374,"state":32,"zip":32,"country":375,"countryCode":376,"cosmosGeoPoint":377,"geoPoint":381,"contacts":32},"Academisch Ziekenhuis Leiden","Leiden","Netherlands","NL",{"type":51,"coordinates":378},[379,380],4.49306,52.15833,{"lat":380,"lon":379},{"facility":383,"status":187,"city":384,"state":32,"zip":32,"country":375,"countryCode":376,"cosmosGeoPoint":385,"geoPoint":389,"contacts":32},"Stichting Radboud Universitair Medisch Centrum","Nijmegen",{"type":51,"coordinates":386},[387,388],5.85278,51.8425,{"lat":388,"lon":387},{"facility":391,"status":187,"city":392,"state":32,"zip":32,"country":393,"countryCode":394,"cosmosGeoPoint":395,"geoPoint":399,"contacts":32},"Hospital Universitari de Bellvitge","Barcelona","Spain","ES",{"type":51,"coordinates":396},[397,398],2.15899,41.38879,{"lat":398,"lon":397},{"facility":401,"status":187,"city":392,"state":32,"zip":32,"country":393,"countryCode":394,"cosmosGeoPoint":402,"geoPoint":404,"contacts":32},"Hospital Universitario Vall d'Hebron",{"type":51,"coordinates":403},[397,398],{"lat":398,"lon":397},{"facility":406,"status":187,"city":407,"state":32,"zip":32,"country":393,"countryCode":394,"cosmosGeoPoint":408,"geoPoint":412,"contacts":32},"Hospital Universitario Donostia","San Sebastián",{"type":51,"coordinates":409},[410,411],-5.9,43.56667,{"lat":411,"lon":410},{"facility":414,"status":187,"city":415,"state":32,"zip":32,"country":393,"countryCode":394,"cosmosGeoPoint":416,"geoPoint":420,"contacts":32},"Hospital Universitari i Politecnic La Fe","Valencia",{"type":51,"coordinates":417},[418,419],-0.37966,39.47391,{"lat":419,"lon":418},{"facility":422,"status":187,"city":423,"state":32,"zip":32,"country":424,"countryCode":425,"cosmosGeoPoint":426,"geoPoint":430,"contacts":32},"National Hospital for Neurology & Neurosurgery","London","United Kingdom","UK",{"type":51,"coordinates":427},[428,429],-0.12574,51.50853,{"lat":429,"lon":428},{"facility":432,"status":187,"city":423,"state":32,"zip":32,"country":424,"countryCode":425,"cosmosGeoPoint":433,"geoPoint":435,"contacts":32},"St. George's University Hospitals NHS Foundation Trust",{"type":51,"coordinates":434},[428,429],{"lat":429,"lon":428},{"facility":437,"status":187,"city":438,"state":32,"zip":32,"country":424,"countryCode":425,"cosmosGeoPoint":439,"geoPoint":443,"contacts":32},"Royal Victoria Infirmary","Newcastle upon Tyne",{"type":51,"coordinates":440},[441,442],-1.61396,54.97328,{"lat":442,"lon":441},{"facility":445,"status":187,"city":446,"state":32,"zip":32,"country":424,"countryCode":425,"cosmosGeoPoint":447,"geoPoint":451,"contacts":32},"Royal Hallamshire Hospital","Sheffield",{"type":51,"coordinates":448},[449,450],-1.4659,53.38297,{"lat":450,"lon":449},{"type":453,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR","100595880","phase-3-a-study-to-evaluate-del-brax-also-referred-to-as-aoc-1020-in-participants-with-fshd-100595880",false,"NCT07038200","A Study to Evaluate Del-brax (Also Referred to as AOC 1020) in Participants With FSHD","A Randomized, Double-blind, Placebo-controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous AOC 1020 for the Treatment of Facioscapulohumeral Muscular Dystrophy (FSHD)","FORTITUDE-3","Inclusion Criteria:\n\n* Clinical and genetic diagnosis of FSHD1 or FSHD2\n* Ability to walk independently at pre-specified walking speed (orthoses and ankle braces allowed) for at least 10 meters at screening\n* Adequate muscle strength based on QMT composite score\n\nExclusion Criteria:\n\n* Breastfeeding, pregnancy, or intent to become pregnant during the study\n* Unwilling or unable to comply with contraceptive requirements\n* Abnormal lab values, conditions or diseases that would make the participant unsuitable for the study\n* Blood Pressure \\> 140\u002F90 mmHg at Screening\n* Treatment with another investigational drug or biological agent within 1 month of Screening or 5 half-lives of the drug, whichever is longer\n* Treatment with an oligonucleotide within 9 months of Screening","ALL","16 Years","70 Years",{"count":466,"type":467},200,"ESTIMATED","INTERVENTIONAL",[470],"PHASE3",[472,473,474,475,476,477,478,479,480,481,482,483,484,485,486,487,488],"Facioscapulohumeral Muscular Dystrophy","FSHD","FSHD - Facioscapulohumeral Muscular Dystrophy","FSHD1","FSHD2","Fascioscapulohumeral Muscular Dystrophy","Fascioscapulohumeral Muscular Dystrophy Type 1","Fascioscapulohumeral Muscular Dystrophy Type 2","Facioscapulohumeral Muscular Dystrophy 1","Facioscapulohumeral Dystrophy","Facio-Scapulo-Humeral Dystrophy","Facioscapulohumeral Muscular Dystrophy 2","Facioscapulohumeral Muscular Dystrophy Type 1 (FSHD1)","FSH Muscular Dystrophy","Landouzy Dejerine Dystrophy","Landouzy-Dejerine Muscular Dystrophy","Landouzy-Dejerine Syndrome",[490,491,492,493,494,495,496,497,460,498,499,500],"Avidity","Avidity Biosciences","del-brax","del brax","delbrax","AOC1020","AOC 1020","delpacibart braxlosiran","FORTITUDE Phase 3","FORTITUDE","FORTITUDE 3","2026-07-24",{"date":503,"type":504},"2026-07-27","ACTUAL",{"date":506,"type":504},"2025-06-10",{"date":508,"type":467},"2028-07",{"name":5,"class":6},46]