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Participants will then be assessed at scheduled study visits, with Dose Regimen Adjustment (DRA) decisions beginning at Week 16 based on predefined disease-activity criteria. Injections will be administered at protocol-defined intervals ranging from every 4 to 16 weeks through the end of the study.",[13],"Drug: ABP 938 8 mg",{"label":15,"type":16,"description":17,"interventionNames":18},"Aflibercept (US) 8 mg","ACTIVE_COMPARATOR","Participants will receive intravitreal Aflibercept (US) 8 mg injections at Baseline, Week 4, and Week 8. Participants will then be assessed at scheduled study visits, with DRA decisions beginning at Week 16 based on predefined disease-activity criteria. Injections will be administered at protocol-defined intervals ranging from every 4 to 16 weeks through the end of the study.",[19],"Drug: Aflibercept (US) 8 mg",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","IVT injection",[9],null,{"type":22,"name":15,"description":23,"armGroupLabels":27,"otherNames":28},[15],[29],"EYLEA HD",[31],{"name":32,"affiliation":5,"role":33},"MD","STUDY_DIRECTOR",[35],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Amgen Call Center","CONTACT","866-572-6436","medinfo@amgen.com",[41,55,64,73,82,91,100,110,116,125,135,145,154,163,173,183,193,202,211,221,231,241,251,261,271,281,290,300,309,319,329,339,348,357,366,375,383,393,403,412,421,430,439,447,456,465,474,484,494,504,513],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":25},"Retina Consultants of Orange County","RECRUITING","Fullerton","California","92835-3432","United States","US",{"type":50,"coordinates":51},"Point",[52,53],-117.92534,33.87029,{"lat":53,"lon":52},{"facility":56,"status":43,"city":57,"state":45,"zip":58,"country":47,"countryCode":48,"cosmosGeoPoint":59,"geoPoint":63,"contacts":25},"South Coast Retina Center - 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Research","Oceanside","11572",{"type":50,"coordinates":286},[287,288],-73.64013,40.63871,{"lat":288,"lon":287},{"facility":291,"status":43,"city":292,"state":293,"zip":294,"country":47,"countryCode":48,"cosmosGeoPoint":295,"geoPoint":299,"contacts":25},"North Carolina Retina Associates","Raleigh","North Carolina","27607-7514",{"type":50,"coordinates":296},[297,298],-78.63861,35.7721,{"lat":298,"lon":297},{"facility":301,"status":43,"city":302,"state":293,"zip":303,"country":47,"countryCode":48,"cosmosGeoPoint":304,"geoPoint":308,"contacts":25},"NC Retina Associates-RCA","Wake Forest","27587",{"type":50,"coordinates":305},[306,307],-78.50972,35.97987,{"lat":307,"lon":306},{"facility":310,"status":43,"city":311,"state":312,"zip":313,"country":47,"countryCode":48,"cosmosGeoPoint":314,"geoPoint":318,"contacts":25},"Midwest Retina - Main Office","Dublin","Ohio","43016",{"type":50,"coordinates":315},[316,317],-83.11408,40.09923,{"lat":317,"lon":316},{"facility":320,"status":43,"city":321,"state":322,"zip":323,"country":47,"countryCode":48,"cosmosGeoPoint":324,"geoPoint":328,"contacts":25},"Eye Care Specialists - 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Pleasant","29464",{"type":50,"coordinates":371},[372,373],-79.86259,32.79407,{"lat":373,"lon":372},{"facility":376,"status":43,"city":377,"state":332,"zip":351,"country":47,"countryCode":48,"cosmosGeoPoint":378,"geoPoint":382,"contacts":25},"Palmetto Retina Center, Florence (RCA)","West Columbia",{"type":50,"coordinates":379},[380,381],-81.07398,33.99349,{"lat":381,"lon":380},{"facility":384,"status":43,"city":385,"state":386,"zip":387,"country":47,"countryCode":48,"cosmosGeoPoint":388,"geoPoint":392,"contacts":25},"Tennessee Retina PC","Nashville","Tennessee","37203",{"type":50,"coordinates":389},[390,391],-86.78444,36.16589,{"lat":391,"lon":390},{"facility":394,"status":43,"city":395,"state":396,"zip":397,"country":47,"countryCode":48,"cosmosGeoPoint":398,"geoPoint":402,"contacts":25},"Texas Retina Associates (TRA) - Arlington","Arlington","Texas","76012",{"type":50,"coordinates":399},[400,401],-97.10807,32.73569,{"lat":401,"lon":400},{"facility":404,"status":43,"city":405,"state":396,"zip":406,"country":47,"countryCode":48,"cosmosGeoPoint":407,"geoPoint":411,"contacts":25},"Austin Retina Associates - Ophthalmology\u002FRetina","Austin","78705",{"type":50,"coordinates":408},[409,410],-97.74306,30.26715,{"lat":410,"lon":409},{"facility":413,"status":43,"city":414,"state":396,"zip":415,"country":47,"countryCode":48,"cosmosGeoPoint":416,"geoPoint":420,"contacts":25},"Retina Consultants of Texas - Bellaire","Bellaire","77401",{"type":50,"coordinates":417},[418,419],-95.45883,29.70579,{"lat":419,"lon":418},{"facility":422,"status":43,"city":423,"state":396,"zip":424,"country":47,"countryCode":48,"cosmosGeoPoint":425,"geoPoint":429,"contacts":25},"Texas Retina Associates (TRA) - Dallas Main","Dallas","75231",{"type":50,"coordinates":426},[427,428],-96.80667,32.78306,{"lat":428,"lon":427},{"facility":431,"status":43,"city":432,"state":396,"zip":433,"country":47,"countryCode":48,"cosmosGeoPoint":434,"geoPoint":438,"contacts":25},"Texas Retina Associates - Fort Worth","Fort Worth","76104",{"type":50,"coordinates":435},[436,437],-97.32085,32.72541,{"lat":437,"lon":436},{"facility":440,"status":43,"city":441,"state":396,"zip":415,"country":47,"countryCode":48,"cosmosGeoPoint":442,"geoPoint":446,"contacts":25},"Retina Consultants of Texas - Katy Retina Center","Houston",{"type":50,"coordinates":443},[444,445],-95.36327,29.76328,{"lat":445,"lon":444},{"facility":448,"status":43,"city":449,"state":396,"zip":450,"country":47,"countryCode":48,"cosmosGeoPoint":451,"geoPoint":455,"contacts":25},"Retinal Consultants of Texas- San Antonio","San Antonio","78240",{"type":50,"coordinates":452},[453,454],-98.49363,29.42412,{"lat":454,"lon":453},{"facility":457,"status":43,"city":458,"state":396,"zip":459,"country":47,"countryCode":48,"cosmosGeoPoint":460,"geoPoint":464,"contacts":25},"Retina Consultants of Texas - Schertz","Schertz","78154",{"type":50,"coordinates":461},[462,463],-98.26973,29.55217,{"lat":463,"lon":462},{"facility":466,"status":43,"city":467,"state":396,"zip":468,"country":47,"countryCode":48,"cosmosGeoPoint":469,"geoPoint":473,"contacts":25},"Strategic Clinical Research Group, LLC","Willow Park","76087",{"type":50,"coordinates":470},[471,472],-97.65058,32.76263,{"lat":472,"lon":471},{"facility":475,"status":43,"city":476,"state":477,"zip":478,"country":47,"countryCode":48,"cosmosGeoPoint":479,"geoPoint":483,"contacts":25},"Retina Associates of Utah - Retina Specialist","Salt Lake City","Utah","84107",{"type":50,"coordinates":480},[481,482],-111.89105,40.76078,{"lat":482,"lon":481},{"facility":485,"status":43,"city":486,"state":487,"zip":488,"country":47,"countryCode":48,"cosmosGeoPoint":489,"geoPoint":493,"contacts":25},"Emerson Clinical Research- Virginia Retina Specialists","Falls Church","Virginia","22042-2349",{"type":50,"coordinates":490},[491,492],-77.17109,38.88233,{"lat":492,"lon":491},{"facility":495,"status":43,"city":496,"state":497,"zip":498,"country":47,"countryCode":48,"cosmosGeoPoint":499,"geoPoint":503,"contacts":25},"Vitreoretinal Associates of Washington","Bellevue","Washington","98004-3779",{"type":50,"coordinates":500},[501,502],-122.20068,47.61038,{"lat":502,"lon":501},{"facility":505,"status":43,"city":506,"state":497,"zip":507,"country":47,"countryCode":48,"cosmosGeoPoint":508,"geoPoint":512,"contacts":25},"Retina Center NW PLLC","Silverdale","98383",{"type":50,"coordinates":509},[510,511],-122.69487,47.64454,{"lat":511,"lon":510},{"facility":514,"status":43,"city":515,"state":497,"zip":516,"country":47,"countryCode":48,"cosmosGeoPoint":517,"geoPoint":521,"contacts":25},"Spokane Eye Clinic (OCT and optical exam","Spokane","99204-2509",{"type":50,"coordinates":518},[519,520],-117.42908,47.65966,{"lat":520,"lon":519},{"type":523,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100642316","phase-3-a-study-to-evaluate-efficacy-safety-and-immunogenicity-with-abp-938-8-mg-versus-eylea-hd-aflibercept-in-participants-with-neovascular-age-related-macular-degeneration-100642316",false,"NCT07614776","A Study to Evaluate Efficacy, Safety, and Immunogenicity With ABP 938 8 mg Versus EYLEA® HD (Aflibercept) in Participants With Neovascular Age-related Macular Degeneration","A Randomized, Double-masked, Comparative Clinical Study Evaluating the Efficacy, Safety, and Immunogenicity of ABP 938 8 mg Versus EYLEA® HD (Aflibercept) Delivered Via Intravitreal Injection in Participants With Neovascular Age-related Macular Degeneration","Inclusion Criteria:\n\n* Men or women ≥ 50 years old, capable of giving signed informed consent\n* Active, treatment-naïve subfoveal CNV lesions secondary to nAMD including juxtafoveal lesions that affect the fovea as confirmed by SD-OCT and FA in the study eye (SE)\n* Total area of CNV (including both classic and occult components) \\> 50% of the total lesion area in the SE\n* The BCVA letter score ≥ 24 and ≤ 78 letters, in the SE\n* Presence of intra and\u002For subretinal fluid affecting the central subfield of the SE as identified by SD-OCT attributable to active CNV. The central subfield is defined as a circle with a diameter of 1 mm, centered on the fovea\n\nExclusion Criteria:\n\nParticipants are excluded from the study if any of the following criteria apply at either screening or baseline, unless otherwise indicated per protocol:\n\n* Total lesion size \\> 12 disc areas (30.5 mm2) including blood, scars, and neovascularization, in the study eye\n* Scar, fibrosis, or atrophy involving the central subfield in the study eye\n* Scar or fibrosis involving \\> 50% of the total lesion in the study eye\n* Presence of retinal pigment epithelium tears or rips involving the macula in the study eye\n* History of any vitreous hemorrhage ≤ 4 weeks (28 days) before randomization in the study\n* Presence of other causes of CNV, including pathologic myopia (spherical equivalent ≥ 8 diopters negative or axial length ≥ 25 mm), ocular histoplasmosis syndrome, angioid streaks, choroidal rupture, or multifocal choroiditis in the study\n* Uncontrolled glaucoma (defined as IOP \\>25 mmHg despite treatment with anti-glaucoma medication) in the study eye\n* History or clinical evidence of DR, DME, idiopathic autoimmune uveitis, or any other vascular disease affecting the retina, other than nAMD in either eye\n* Evidence of active extraocular or periocular infection or inflammation (including infectious blepharitis, keratitis, scleritis, or conjunctivitis) in either eye at the time of screening or randomization\n* Uncontrolled blood pressure (defined as systolic \\>160 mmHg or diastolic \\>95 mmHg). Blood pressure needs to be stable for at least 12 weeks (84 days) prior to screening\n* Any prior or concomitant ocular or systemic treatment (with an investigational or approved, anti VEGF or anti-VEGF\u002Fanti-angiopoietin agent) in the SE, or surgery for nAMD in the SE, except dietary supplements or vitamins\n* History or evidence of any other clinically significant disorder, condition, disease or clinical laboratory abnormality that, in the opinion of the investigator or study medical monitor, if consulted, would pose a risk to participant safety or interfere with the study evaluation or results interpretation\n* Other protocol-specified exclusion criteria","ALL","50 Years",{"count":534,"type":535},304,"ESTIMATED","INTERVENTIONAL",[538],"PHASE3","The aim of this trial is to demonstrate similarity in efficacy between ABP 938 8 mg and aflibercept (US) 8 mg by evaluating the change in best corrected visual acuity (BCVA) in participants with neovascular age-related macular degeneration (nAMD)",[541,542],"Neovascular Age-related Macular Degeneration","nAMD",[544,545,546,547,548,549],"ABP 938","Aflibercept","neovascular age-related macular degeneration","Intravitreal","Randomized Controlled Trial","Double-masked","2026-08-14",{"date":552,"type":553},"2026-08-17","ACTUAL",{"date":555,"type":553},"2026-05-27",{"date":557,"type":535},"2028-01-12",{"name":5,"class":6},51]