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Schertz","Schertz","78154",{"type":107,"coordinates":541},[542,543],-98.26973,29.55217,{"lat":543,"lon":542},{"facility":546,"status":100,"city":547,"state":462,"zip":548,"country":104,"countryCode":105,"cosmosGeoPoint":549,"geoPoint":553,"contacts":11},"Strategic Clinical Research Group, LLC","Willow Park","76087",{"type":107,"coordinates":550},[551,552],-97.65058,32.76263,{"lat":552,"lon":551},{"facility":555,"status":100,"city":556,"state":557,"zip":558,"country":104,"countryCode":105,"cosmosGeoPoint":559,"geoPoint":563,"contacts":11},"Retina Associates of Utah - Retina Specialist","Salt Lake City","Utah","84107",{"type":107,"coordinates":560},[561,562],-111.89105,40.76078,{"lat":562,"lon":561},{"facility":565,"status":100,"city":566,"state":567,"zip":568,"country":104,"countryCode":105,"cosmosGeoPoint":569,"geoPoint":573,"contacts":11},"Emerson Clinical Research- Virginia Retina Specialists","Falls Church","Virginia","22042-2349",{"type":107,"coordinates":570},[571,572],-77.17109,38.88233,{"lat":572,"lon":571},{"facility":575,"status":100,"city":576,"state":577,"zip":578,"country":104,"countryCode":105,"cosmosGeoPoint":579,"geoPoint":583,"contacts":11},"Vitreoretinal Associates of Washington","Bellevue","Washington","98004-3779",{"type":107,"coordinates":580},[581,582],-122.20068,47.61038,{"lat":582,"lon":581},{"facility":585,"status":100,"city":586,"state":577,"zip":587,"country":104,"countryCode":105,"cosmosGeoPoint":588,"geoPoint":592,"contacts":11},"Retina Center NW PLLC","Silverdale","98383",{"type":107,"coordinates":589},[590,591],-122.69487,47.64454,{"lat":591,"lon":590},{"facility":594,"status":100,"city":595,"state":577,"zip":596,"country":104,"countryCode":105,"cosmosGeoPoint":597,"geoPoint":601,"contacts":11},"Spokane Eye Clinic (OCT and optical exam","Spokane","99204-2509",{"type":107,"coordinates":598},[599,600],-117.42908,47.65966,{"lat":600,"lon":599},{"facility":603,"status":100,"city":604,"state":605,"zip":606,"country":607,"countryCode":11,"cosmosGeoPoint":608,"geoPoint":612,"contacts":11},"Visus, spol. s r.o. - Nachod","Náchod","Hradec Králové Region","547 01","Czechia",{"type":107,"coordinates":609},[610,611],16.16289,50.4167,{"lat":611,"lon":610},{"facility":614,"status":100,"city":615,"state":615,"zip":616,"country":607,"countryCode":11,"cosmosGeoPoint":617,"geoPoint":621,"contacts":11},"AXON clinical","Prague","150 00",{"type":107,"coordinates":618},[619,620],14.42076,50.08804,{"lat":620,"lon":619},{"facility":623,"status":100,"city":624,"state":625,"zip":626,"country":607,"countryCode":11,"cosmosGeoPoint":627,"geoPoint":631,"contacts":11},"Oblastni nemocnice Mlada Boleslav, a.s., nemocnice Stredoceskeho kraje - Klaudianova nemocnice","Mladá Boleslav","Stredoceský Kraj","293 01",{"type":107,"coordinates":628},[629,630],14.90318,50.41135,{"lat":630,"lon":629},{"facility":633,"status":100,"city":634,"state":635,"zip":636,"country":637,"countryCode":638,"cosmosGeoPoint":11,"geoPoint":11,"contacts":11},"Tokyo Medical Center - Ophthalmology","Meguro-ku","Tokyo","152-8902","Japan","JP",{"facility":640,"status":100,"city":641,"state":641,"zip":642,"country":643,"countryCode":644,"cosmosGeoPoint":645,"geoPoint":649,"contacts":11},"Latvian American Eye Center","Riga","LV-1009","Latvia","LV",{"type":107,"coordinates":646},[647,648],24.10589,56.946,{"lat":648,"lon":647},{"facility":651,"status":100,"city":652,"state":653,"zip":654,"country":655,"countryCode":656,"cosmosGeoPoint":11,"geoPoint":11,"contacts":11},"Szpital sw. Rozy Sp. z o.o.","Kraków","Masovian Voivodeship","30-363","Poland","PL",{"facility":658,"status":100,"city":659,"state":660,"zip":661,"country":655,"countryCode":656,"cosmosGeoPoint":662,"geoPoint":666,"contacts":11},"Centrum Diagnostyki i Mikrochirurgii Oka-Lens Sp. z o.o.","Olsztyn","Warmian-Masurian Voivodeship","10-424",{"type":107,"coordinates":663},[664,665],20.49272,53.78376,{"lat":665,"lon":664},{"facility":668,"status":100,"city":669,"state":670,"zip":671,"country":672,"countryCode":673,"cosmosGeoPoint":674,"geoPoint":678,"contacts":11},"NsP Trebisov, a.s. - Ocne oddelenie","Trebišov","Košice Region","075 01","Slovakia","SK",{"type":107,"coordinates":675},[676,677],21.71954,48.62858,{"lat":677,"lon":676},{"facility":680,"status":100,"city":681,"state":682,"zip":683,"country":672,"countryCode":673,"cosmosGeoPoint":684,"geoPoint":688,"contacts":11},"Fakultna nemocnica Trencin - Ocna klinika","Trenčín","Trenčín Region","911 71",{"type":107,"coordinates":685},[686,687],18.04436,48.89452,{"lat":687,"lon":686},{"facility":690,"status":100,"city":691,"state":692,"zip":693,"country":672,"countryCode":673,"cosmosGeoPoint":694,"geoPoint":698,"contacts":11},"Fakultna nemocnica s poliklinikou Zilina - Ocne oddelenie","Žilina","Žilina Region","012 07",{"type":107,"coordinates":695},[696,697],18.73941,49.22315,{"lat":697,"lon":696},{"type":700,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100642316","phase-3-a-study-to-evaluate-efficacy-safety-and-immunogenicity-with-abp-938-8-mg-versus-eylea-hd-aflibercept-in-participants-with-neovascular-age-related-macular-degeneration-100642316",false,"NCT07614776","A Study to Evaluate Efficacy, Safety, and Immunogenicity With ABP 938 8 mg Versus EYLEA® HD (Aflibercept) in Participants With Neovascular Age-related Macular Degeneration","A Randomized, Double-masked, Comparative Clinical Study Evaluating the Efficacy, Safety, and Immunogenicity of ABP 938 8 mg Versus EYLEA® HD (Aflibercept) Delivered Via Intravitreal Injection in Participants With Neovascular Age-related Macular Degeneration","Inclusion Criteria:\n\n* Men or women ≥ 50 years old, capable of giving signed informed consent\n* Active, treatment-naïve subfoveal CNV lesions secondary to nAMD including juxtafoveal lesions that affect the fovea as confirmed by SD-OCT and FA in the study eye (SE)\n* Total area of CNV (including both classic and occult components) \\> 50% of the total lesion area in the SE\n* The BCVA letter score ≥ 24 and ≤ 78 letters, in the SE\n* Presence of intra and\u002For subretinal fluid affecting the central subfield of the SE as identified by SD-OCT attributable to active CNV. The central subfield is defined as a circle with a diameter of 1 mm, centered on the fovea\n\nExclusion Criteria:\n\nParticipants are excluded from the study if any of the following criteria apply at either screening or baseline, unless otherwise indicated per protocol:\n\n* Total lesion size \\> 12 disc areas (30.5 mm2) including blood, scars, and neovascularization, in the study eye\n* Scar, fibrosis, or atrophy involving the central subfield in the study eye\n* Scar or fibrosis involving \\> 50% of the total lesion in the study eye\n* Presence of retinal pigment epithelium tears or rips involving the macula in the study eye\n* History of any vitreous hemorrhage ≤ 4 weeks (28 days) before randomization in the study\n* Presence of other causes of CNV, including pathologic myopia (spherical equivalent ≥ 8 diopters negative or axial length ≥ 25 mm), ocular histoplasmosis syndrome, angioid streaks, choroidal rupture, or multifocal choroiditis in the study\n* Uncontrolled glaucoma (defined as IOP \\>25 mmHg despite treatment with anti-glaucoma medication) in the study eye\n* History or clinical evidence of DR, DME, idiopathic autoimmune uveitis, or any other vascular disease affecting the retina, other than nAMD in either eye\n* Evidence of active extraocular or periocular infection or inflammation (including infectious blepharitis, keratitis, scleritis, or conjunctivitis) in either eye at the time of screening or randomization\n* Uncontrolled blood pressure (defined as systolic \\>160 mmHg or diastolic \\>95 mmHg). Blood pressure needs to be stable for at least 12 weeks (84 days) prior to screening\n* Any prior or concomitant ocular or systemic treatment (with an investigational or approved, anti VEGF or anti-VEGF\u002Fanti-angiopoietin agent) in the SE, or surgery for nAMD in the SE, except dietary supplements or vitamins\n* History or evidence of any other clinically significant disorder, condition, disease or clinical laboratory abnormality that, in the opinion of the investigator or study medical monitor, if consulted, would pose a risk to participant safety or interfere with the study evaluation or results interpretation\n* Other protocol-specified exclusion criteria","ALL","50 Years",{"count":711,"type":712},304,"ESTIMATED","INTERVENTIONAL",[715],"PHASE3","The aim of this trial is to demonstrate similarity in efficacy between ABP 938 8 mg and aflibercept (US) 8 mg by evaluating the change in best corrected visual acuity (BCVA) in participants with neovascular age-related macular degeneration (nAMD)",[718,719],"Neovascular Age-related Macular Degeneration","nAMD",[721,722,723,724,725,726],"ABP 938","Aflibercept","neovascular age-related macular degeneration","Intravitreal","Randomized Controlled Trial","Double-masked","2026-09-16",{"date":729,"type":730},"2026-09-17","ACTUAL",{"date":732,"type":730},"2026-05-27",{"date":734,"type":712},"2028-01-12",{"name":5,"class":6},64]