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40230","Valencia",{"type":53,"coordinates":709},[710,711],-0.37966,39.47391,{"lat":711,"lon":710},{"facility":714,"status":46,"city":707,"state":41,"zip":41,"country":650,"countryCode":651,"cosmosGeoPoint":715,"geoPoint":717,"contacts":41},"Ppp001 40868",{"type":53,"coordinates":716},[710,711],{"lat":711,"lon":710},{"facility":719,"status":46,"city":135,"state":41,"zip":41,"country":720,"countryCode":721,"cosmosGeoPoint":722,"geoPoint":726,"contacts":41},"Ppp001 40113","United Kingdom","UK",{"type":53,"coordinates":723},[724,725],-0.12574,51.50853,{"lat":725,"lon":724},{"facility":728,"status":46,"city":135,"state":41,"zip":41,"country":720,"countryCode":721,"cosmosGeoPoint":729,"geoPoint":731,"contacts":41},"Ppp001 40880",{"type":53,"coordinates":730},[724,725],{"lat":725,"lon":724},{"facility":733,"status":46,"city":734,"state":41,"zip":41,"country":720,"countryCode":721,"cosmosGeoPoint":735,"geoPoint":739,"contacts":41},"Ppp001 40108","Salford",{"type":53,"coordinates":736},[737,738],-2.29042,53.48771,{"lat":738,"lon":737},{"type":741,"investigatorFullName":41,"investigatorTitle":41,"investigatorAffiliation":41,"oldNameTitle":41,"oldOrganization":41},"SPONSOR","100609810","phase-3-a-study-to-evaluate-the-efficacy-and-safety-of-bimekizumab-in-study-participants-with-palmoplantar-pustulosis-100609810",false,"NCT07219420","A Study to Evaluate the Efficacy and Safety of Bimekizumab in Study Participants With Palmoplantar Pustulosis","A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study With Open-Label Extension to Evaluate the Efficacy and Safety of Bimekizumab in Study Participants With Palmoplantar Pustulosis","BeSeen","Inclusion Criteria:\n\n* At least 18 years of age inclusive, at the time of signing the informed consent form (ICF)\n* Have a palmoplantar pustulosis (PPP) diagnosis for at least 24 weeks prior to the Screening Visit\n* Have PPPASI ≥12 at the Screening Visit and Baseline Visit\n* Have PPP-IGA ≥3 at the Screening Visit and Baseline Visit\n* Have pustules on the palms of the hands and\u002For soles of the feet at the Screening Visit and Baseline Visit, defined as pustule severity ≥2 and having more than 5 active pustules\n* Participant must be a candidate for systemic therapy or phototherapy\n\nExclusion Criteria:\n\n* Has PPP symptoms which improve significantly between the Screening Visit and Baseline Visit, defined as a reduction in the PPPASI score\n* Has the following: palmoplantar PSO (plaque PSO on palms\u002Fsoles), guttate PSO, erythrodermic PSO (EP), generalized pustular PSO (GPP), Acrodermatitis continua of Hallopeau (ACH), atopic dermatitis, dyshidrotic eczema or chronic hand eczema.\n* Has drug-induced PSO (eg, first onset or current exacerbation due to beta blockers, calcium channel inhibitors, lithium, or tumor necrosis factor \\[TNF\\] inhibitor) or drug-induced pustular PSO (eg, acute generalized exanthematous pustulosis, acute localized exanthematous pustulosis)\n* Has cutaneous lesions that may interfere with the evaluation of the affected area and\u002For evaluation of the severity of PPP\n* Is taking or has taken prohibited or restricted medications without meeting the mandatory discontinuation or stability period relative to the Baseline Visit\n* Is taking or has ever taken an interleukin (IL)-17A\u002FIL-17F inhibitor, including bimekizumab, or has participated in a bimekizumab investigational study","ALL","18 Years",{"count":753,"type":754},320,"ESTIMATED","INTERVENTIONAL",[757],"PHASE3","The purpose of this study is to evaluate the efficacy and safety of bimekizumab compared with placebo in participants with palmoplantar pustulosis (PPP).",[760],"Palmoplantar Pustulosis",[762],"Bimekizumab, PPP","2026-07-16",{"date":765,"type":766},"2026-07-17","ACTUAL",{"date":768,"type":766},"2025-11-14",{"date":770,"type":754},"2029-11-22",{"name":772,"class":6},"UCB Biopharma SRL",87]