[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100517030":3},{"organization":4,"outcomesModule":7,"designInfo":65,"detailedDescription":64,"studyPopulation":64,"armGroups":76,"interventions":163,"overallOfficials":175,"centralContacts":179,"locations":185,"responsibleParty":2657,"collaborators":64,"id":2659,"slug":2660,"hasResults":2661,"nctId":2662,"briefTitle":2663,"officialTitle":2664,"acronym":2665,"eligibilityCriteria":2666,"healthyVolunteers":2661,"sex":2667,"minAge":2668,"maxAge":2669,"enrollmentInfo":2670,"targetDuration":64,"studyType":2673,"phases":2674,"briefSummary":2676,"conditions":2677,"keywords":2679,"overallStatus":248,"whyStopped":64,"lastUpdateSubmitDate":2680,"lastUpdatePostDateStruct":2681,"startDateStruct":2684,"completionDateStruct":2686,"leadSponsor":2688,"locationsCount":2689},{"fullName":5,"class":6},"AbbVie","INDUSTRY",{"primaryOutcomes":8,"secondaryOutcomes":17,"otherOutcomes":64},[9,13],{"measure":10,"description":11,"timeFrame":12},"Percentage of Participants with the Achievement of Severity of Alopecia Tool (SALT) Score \u003C= 20","The SALT is a global AA severity score based on the combination of extent and density of scalp hair loss. The score is determined by visually defining the amount of terminal hair loss in each of the 4 views of the scalp (left and right side each accounting for 18% of scalp area, the top for 40%, and the back for 24%) and adding these together with a maximum score of 100%.","Week 24",{"measure":14,"description":15,"timeFrame":16},"Number of Participants with Adverse Events (AEs)","An AE is defined as any untoward medical occurrence in a patient or clinical investigation in which a participant is administered a pharmaceutical product which does not necessarily have a causal relationship with this treatment.","Up to approximately 164 weeks",[18,20,23,26,30,33,36,39,41,44,47,50,53,56,59,62],{"measure":19,"description":11,"timeFrame":12},"Achievement of SALT score \u003C= 20 for the Comparison of Upadacitinib Dose A QD Versus Placebo",{"measure":21,"description":11,"timeFrame":22},"Percentage of Participants with the Achievement of SALT Score \u003C= 10","Up to Week 24",{"measure":24,"description":11,"timeFrame":25},"Percentage of Participants with the Achievement of SALT Score \u003C= 20","Up to Week 12",{"measure":27,"description":28,"timeFrame":29},"Percentage of Participants with the Achievement of Clinician-Reported Outcome (ClinRO) Measure for Eyebrow Hair Loss of 0 or 1","The ClinRO for Eyebrow Hair Loss is a 4-point response scale where 0 = The eyebrows have full coverage and no areas of hair loss and 3 = No notable eyebrows. Responses should have a ≥ 2-point improvement from Baseline among participants with Baseline score ≥ 2.","Baseline to Week 24",{"measure":31,"description":32,"timeFrame":29},"Percentage of Participants with the Achievement of ClinRO Measure for Eyelash Hair Loss of 0 or 1","The ClinRO for Eyelash Hair Loss is a 4-point response scale where 0 = The eyelashes form a continuous line along the eyelids on both eyes and 3 = No notable eyelashes. Responses should have a ≥ 2-point improvement from Baseline among participants with Baseline score ≥ 2.",{"measure":34,"description":35,"timeFrame":29},"Percentage of Participants with the Achievement of SALT 75","SALT 75 is defined as at least a 75% improvement \\[decrease\\] from Baseline in SALT score.",{"measure":37,"description":38,"timeFrame":29},"Percentage of Participants with the Achievement of SALT 90","SALT 90 is defined as at least a 90% improvement \\[decrease\\] from Baseline in SALT score.",{"measure":40,"description":11,"timeFrame":29},"Percent Change from Baseline in SALT Score",{"measure":42,"description":43,"timeFrame":22},"Percentage of Participants with the Achievement of Patients' Global Impression of Change of Alopecia Areata (PaGIC-AA) Score of 1 \"Much Better\" or 2 \"Moderately Better\"","The PaGIC-AA is a single-item measure that asks participants to rate how their alopecia condition has changed overall since the start of the study using a 7-point scale. Responses range from \"much better\" to \"much worse.\"",{"measure":45,"description":46,"timeFrame":29},"Percentage of Participants with the Achievement of Patient-Reported Outcome (PRO) for Scalp Hair Assessment 0\u002F1 with ≥ 2-Point Improvement (Reduction)","The PRO for Scalp Hair Assessment is single item, five-point, categorical response scale that asks respondents to look in the mirror and assess the total area of the scalp with missing hair. Response items range from \"No missing hair\" to \"Nearly all or all\" and includes percentage ranges for each category (0%, 1 to 20%, 21 to 49%, 50 to 94%, and 95 to 100%). Responses among participants with baseline score \\>=3.",{"measure":48,"description":49,"timeFrame":12},"Change from Baseline in Alopecia Areata Symptom Impact Scale (AASIS) Interference Subscale Score","The AASIS Interference Subscale is a 6-item assessment with scores ranging from 0 = 'did not interfere' to 10 = 'interfered completely' with higher scores indicating greater symptom interference.",{"measure":51,"description":52,"timeFrame":12},"Change from Baseline in AASIS Symptoms Subscale Score","The AASIS Symptom Subscale is a 7-item assessment with scores ranging from 0 = 'not present' to 10 = 'as bad as you can imagine' with higher scores indicating greater symptom severity.",{"measure":54,"description":55,"timeFrame":12},"Change from Baseline in Skindex-16 AA Emotions Domain Scores","The Skindex-16 AA Emotions Domain is a 7-item assessment ranging from 0 = never bothered to 6 = always bothered that measures the effects of AA on a subject's health-related quality of life. Higher scores indicate greater impact on health-related quality of life.",{"measure":57,"description":58,"timeFrame":12},"Change from Baseline in Skindex-16 AA Functioning Domain Scores","The Skindex-16 AA Emotions Domain is a 5-item assessment ranging from 0 = never bothered to 6 = always bothered, that measures the effects of AA on a subject's health-related quality of life. Higher scores indicate greater impact on health-related quality of life.",{"measure":60,"description":61,"timeFrame":29},"Achievement of Hospital Anxiety and Depression Scale (HADS)-Anxiety \u003C 8 and HADS-Depression \u003C 8 at Week 24 Among Participants with HADS-A >= 8 or HADS-D >= 8 at Baseline","The HADS is a self-administered scale which measures anxiety and depression. It contains 14 items and is comprised of anxiety (7 items) and depression (7 items) subscales, which are scored separately and summed to give a total score. Item scores range from 0 (best) to 3 (worst), and total scores are categorized as normal (0 to 7), borderline abnormal (8 to 10), and abnormal (11 to 21).",{"measure":63,"description":11,"timeFrame":12},"Percentage of Participants with the Achievement of SALT Score 0",null,{"allocation":66,"interventionModel":67,"interventionModelDescription":64,"primaryPurpose":68,"observationalModel":64,"timePerspective":64,"maskingInfo":69},"RANDOMIZED","SEQUENTIAL","TREATMENT",{"masking":70,"maskingDescription":64,"whoMasked":71},"QUADRUPLE",[72,73,74,75],"PARTICIPANT","CARE_PROVIDER","INVESTIGATOR","OUTCOMES_ASSESSOR",[77,83,87,92,96,100,104,107,110,113,116,119,122,126,130,134,138,142,146,150,154,157,160],{"label":78,"type":79,"description":80,"interventionNames":81},"Study 1: Group 1 Upadacitinib Dose A","EXPERIMENTAL","Participants will receive upadacitinib Dose A once daily for 52 weeks in Period A and Period B.",[82],"Drug: Upadacitinib",{"label":84,"type":79,"description":85,"interventionNames":86},"Study 1: Group 2 Upadacitinib Dose B","Participants will receive upadacitinib Dose B once daily for 52 weeks in Period A and Period B.",[82],{"label":88,"type":79,"description":89,"interventionNames":90},"Study 1: Group 3 Placebo","Participants will receive matching placebo once daily for 24 weeks in Period A.",[91],"Drug: Placebo",{"label":93,"type":79,"description":94,"interventionNames":95},"Study 1: Group 4 Upadacitinib Dose A","Participants initially randomized to placebo (Period A) with a SALT score \\> 20 at Week 24 will be re-randomized to receive upadacitinib Dose A once daily for 28 weeks in Period B.",[82,91],{"label":97,"type":79,"description":98,"interventionNames":99},"Study 1: Group 5 Upadacitinib Dose B","Participants initially randomized to placebo (Period A) with a SALT score \\> 20 at Week 24 will be re-randomized to receive upadacitinib Dose B once daily for 28 weeks in Period B.",[82,91],{"label":101,"type":79,"description":102,"interventionNames":103},"Study 1: Group 6 Placebo","Participants initially randomized to placebo with a SALT score ≤ 20 at Week 24 will continue on placebo through Week 160.",[91],{"label":105,"type":79,"description":80,"interventionNames":106},"Study 2: Group 1 Upadacitinib Dose A",[82],{"label":108,"type":79,"description":85,"interventionNames":109},"Study 2: Group 2 Upadacitinib Dose B",[82],{"label":111,"type":79,"description":89,"interventionNames":112},"Study 2: Group 3 Placebo",[91],{"label":114,"type":79,"description":94,"interventionNames":115},"Study 2: Group 4 Upadacitinib Dose A",[82,91],{"label":117,"type":79,"description":98,"interventionNames":118},"Study 2: Group 5 Upadacitinib Dose B",[82,91],{"label":120,"type":79,"description":102,"interventionNames":121},"Study 2: Group 6 Placebo",[91],{"label":123,"type":79,"description":124,"interventionNames":125},"Study 3: Group 1 Upadacitinib Dose B (SALT > 20)","Participants receiving upadacitinib Dose A with a SALT score \\> 20 at Week 52 (end of Period B) of Study 1 or Study 2 will dose escalate to upadacitinib Dose B once daily for 108 weeks.",[82],{"label":127,"type":79,"description":128,"interventionNames":129},"Study 3: Group 2 Upadacitinib Dose A (SALT ≤ 20)","Participants receiving upadacitinib Dose A with a SALT score ≤ 20 at Week 52 (end of Period B) of Study 1 or Study 2 will remain on upadacitinib Dose A once daily for 108 weeks.",[82],{"label":131,"type":79,"description":132,"interventionNames":133},"Study 3: Group 3 Upadacitinib Dose B (Non-Sustained)","Participants who end Period B on upadacitinib Dose B with a with a SALT score \\> 20 at Week 40 or Week 52 of Study 1 or Study 2 will remain on upadacitinib Dose B once daily for 108 weeks.",[82],{"label":135,"type":79,"description":136,"interventionNames":137},"Study 3: Group 4 Upadacitinib Dose B (Sustained)","Participants who end Period B on upadacitinib Dose B with a with a SALT score ≤ 20 at Week 40 and Week 52 of Study 1 or Study 2 will be re-randomized to receive upadacitinib Dose B once daily for 108 weeks.",[82],{"label":139,"type":79,"description":140,"interventionNames":141},"Study 3: Group 5 Upadacitinib Dose A (Sustained)","Participants who end Period B on upadacitinib Dose B with a with a SALT score ≤ 20 at Week 40 and Week 52 of Study 1 or Study 2 will be re-randomized to receive upadacitinib Dose A once daily for 108 weeks.",[82],{"label":143,"type":79,"description":144,"interventionNames":145},"Study 4: Group 1 Upadacitinib Dose A","US only adolescent participants will receive upadacitinib Dose A once daily for 52 weeks in Period A and Period B.",[82],{"label":147,"type":79,"description":148,"interventionNames":149},"Study 4: Group 2 Upadacitinib Dose B","US only adolescent participants will receive upadacitinib Dose B once daily for 52 weeks in Period A and Period B.",[82],{"label":151,"type":79,"description":152,"interventionNames":153},"Study 4: Group 3 Placebo","US only adolescent participants will receive matching placebo once daily for 24 weeks in Period A.",[91],{"label":155,"type":79,"description":94,"interventionNames":156},"Study 4: Group 4 Upadacitinib Dose A",[82],{"label":158,"type":79,"description":98,"interventionNames":159},"Study 4: Group 5 Upadacitinib Dose B",[82],{"label":161,"type":79,"description":102,"interventionNames":162},"Study 4: Group 6 Placebo",[91],[164,172],{"type":165,"name":166,"description":167,"armGroupLabels":168,"otherNames":169},"DRUG","Upadacitinib","Oral Tablets",[78,84,93,97,105,108,114,117,123,127,131,135,139,143,147,155,158],[170,171],"Rinvoq","ABT-494",{"type":165,"name":173,"description":167,"armGroupLabels":174,"otherNames":64},"Placebo",[88,93,97,101,111,114,117,120,151,161],[176],{"name":177,"affiliation":5,"role":178},"ABBVIE INC.","STUDY_DIRECTOR",[180],{"name":181,"role":182,"phone":183,"phoneExt":64,"email":184},"ABBVIE CALL CENTER","CONTACT","844-663-3742","abbvieclinicaltrials@abbvie.com",[186,200,211,220,226,236,246,256,265,274,283,292,302,311,324,333,342,348,357,368,377,382,391,400,409,421,427,437,446,456,465,475,485,498,508,518,527,537,549,558,567,576,585,595,604,614,624,636,649,661,671,679,684,690,696,702,712,722,731,743,752,762,768,778,788,800,810,820,830,839,851,860,866,872,881,890,899,909,919,926,929,931,940,949,961,970,980,989,999,1008,1017,1027,1039,1048,1057,1067,1077,1086,1098,1108,1117,1126,1134,1141,1144,1147,1156,1164,1173,1185,1191,1200,1210,1220,1230,1239,1248,1257,1266,1275,1284,1293,1303,1312,1321,1333,1342,1351,1361,1376,1382,1391,1397,1407,1417,1423,1429,1435,1444,1450,1463,1469,1479,1489,1499,1512,1522,1532,1542,1548,1558,1568,1574,1583,1595,1600,1605,1615,1625,1637,1647,1657,1667,1677,1687,1697,1706,1715,1724,1736,1746,1756,1768,1778,1790,1802,1807,1816,1822,1834,1843,1848,1858,1868,1874,1886,1895,1905,1913,1922,1934,1944,1954,1964,1970,1980,1986,1992,2001,2010,2019,2028,2035,2040,2049,2058,2068,2073,2077,2082,2094,2102,2110,2119,2131,2140,2150,2160,2170,2176,2186,2196,2206,2213,2225,2234,2243,2254,2263,2272,2278,2284,2296,2302,2312,2321,2332,2342,2352,2362,2372,2382,2392,2398,2404,2410,2416,2428,2438,2446,2454,2462,2471,2483,2492,2502,2513,2522,2531,2537,2546,2552,2560,2569,2578,2587,2599,2609,2619,2629,2639,2648],{"facility":187,"status":188,"city":189,"state":190,"zip":191,"country":192,"countryCode":193,"cosmosGeoPoint":194,"geoPoint":199,"contacts":64},"Total Skin and Beauty Dermatology Center \u002FID# 259539","ACTIVE_NOT_RECRUITING","Birmingham","Alabama","35205","United States","US",{"type":195,"coordinates":196},"Point",[197,198],-86.80249,33.52066,{"lat":198,"lon":197},{"facility":201,"status":202,"city":203,"state":204,"zip":205,"country":192,"countryCode":193,"cosmosGeoPoint":206,"geoPoint":210,"contacts":64},"Duplicate_Advanced Research Associates - Glendale \u002FID# 259108","COMPLETED","Glendale","Arizona","85308",{"type":195,"coordinates":207},[208,209],-112.18599,33.53865,{"lat":209,"lon":208},{"facility":212,"status":202,"city":213,"state":204,"zip":214,"country":192,"countryCode":193,"cosmosGeoPoint":215,"geoPoint":219,"contacts":64},"Southwest Skin Specialists \u002FID# 258234","Phoenix","85018-3953",{"type":195,"coordinates":216},[217,218],-112.07404,33.44838,{"lat":218,"lon":217},{"facility":221,"status":188,"city":213,"state":204,"zip":222,"country":192,"countryCode":193,"cosmosGeoPoint":223,"geoPoint":225,"contacts":64},"Alliance Dermatology and Mohs Center \u002FID# 258111","85032",{"type":195,"coordinates":224},[217,218],{"lat":218,"lon":217},{"facility":227,"status":188,"city":228,"state":229,"zip":230,"country":192,"countryCode":193,"cosmosGeoPoint":231,"geoPoint":235,"contacts":64},"Johnson Dermatology Clinic \u002FID# 259103","Fort Smith","Arkansas","72916-6103",{"type":195,"coordinates":232},[233,234],-94.39855,35.38592,{"lat":234,"lon":233},{"facility":237,"status":202,"city":238,"state":239,"zip":240,"country":192,"countryCode":193,"cosmosGeoPoint":241,"geoPoint":245,"contacts":64},"Duplicate_JOSEPH RAOOF MD,INC \u002FID# 258031","Encino","California","91436",{"type":195,"coordinates":242},[243,244],-118.50119,34.15917,{"lat":244,"lon":243},{"facility":247,"status":248,"city":249,"state":239,"zip":250,"country":192,"countryCode":193,"cosmosGeoPoint":251,"geoPoint":255,"contacts":64},"First Oc Dermatology \u002FID# 259220","RECRUITING","Fountain Valley","92708",{"type":195,"coordinates":252},[253,254],-117.95367,33.70918,{"lat":254,"lon":253},{"facility":257,"status":188,"city":258,"state":239,"zip":259,"country":192,"countryCode":193,"cosmosGeoPoint":260,"geoPoint":264,"contacts":64},"University of California Irvine \u002FID# 259096","Irvine","92697-1385",{"type":195,"coordinates":261},[262,263],-117.82311,33.66946,{"lat":263,"lon":262},{"facility":266,"status":248,"city":267,"state":239,"zip":268,"country":192,"countryCode":193,"cosmosGeoPoint":269,"geoPoint":273,"contacts":64},"Dermatology Research Associates \u002FID# 258033","Los Angeles","90045",{"type":195,"coordinates":270},[271,272],-118.24368,34.05223,{"lat":272,"lon":271},{"facility":275,"status":202,"city":276,"state":239,"zip":277,"country":192,"countryCode":193,"cosmosGeoPoint":278,"geoPoint":282,"contacts":64},"Stanford University School of Medicine - Redwood City \u002FID# 259542","Redwood City","94063",{"type":195,"coordinates":279},[280,281],-122.23635,37.48522,{"lat":281,"lon":280},{"facility":284,"status":248,"city":285,"state":239,"zip":286,"country":192,"countryCode":193,"cosmosGeoPoint":287,"geoPoint":291,"contacts":64},"Integrative Skin Science and Research \u002FID# 258114","Sacramento","95815",{"type":195,"coordinates":288},[289,290],-121.4944,38.58157,{"lat":290,"lon":289},{"facility":293,"status":248,"city":285,"state":239,"zip":294,"country":192,"countryCode":193,"cosmosGeoPoint":295,"geoPoint":297,"contacts":298},"University of California Davis Health \u002FID# 258112","95817",{"type":195,"coordinates":296},[289,290],{"lat":290,"lon":289},[299],{"name":300,"role":182,"phone":301,"phoneExt":64,"email":64},"Site Coordinator","916-551-2635",{"facility":303,"status":248,"city":304,"state":239,"zip":305,"country":192,"countryCode":193,"cosmosGeoPoint":306,"geoPoint":310,"contacts":64},"Clinical Trials Research Institute \u002FID# 258021","Thousand Oaks","91320-2130",{"type":195,"coordinates":307},[308,309],-118.83759,34.17056,{"lat":309,"lon":308},{"facility":312,"status":248,"city":313,"state":314,"zip":315,"country":192,"countryCode":193,"cosmosGeoPoint":316,"geoPoint":320,"contacts":321},"Skin Care Research Boca Raton \u002FID# 258012","Boca Raton","Florida","33486-2269",{"type":195,"coordinates":317},[318,319],-80.0831,26.35869,{"lat":319,"lon":318},[322],{"name":300,"role":182,"phone":323,"phoneExt":64,"email":64},"+1-561-948-3116",{"facility":325,"status":188,"city":326,"state":314,"zip":327,"country":192,"countryCode":193,"cosmosGeoPoint":328,"geoPoint":332,"contacts":64},"Apex Clinical Trials \u002FID# 259205","Brandon","33511",{"type":195,"coordinates":329},[330,331],-82.28592,27.9378,{"lat":331,"lon":330},{"facility":334,"status":188,"city":335,"state":314,"zip":336,"country":192,"countryCode":193,"cosmosGeoPoint":337,"geoPoint":341,"contacts":64},"Florida Academic Dermatology Center \u002FID# 259353","Coral Gables","33134-5755",{"type":195,"coordinates":338},[339,340],-80.26838,25.72149,{"lat":340,"lon":339},{"facility":343,"status":202,"city":335,"state":314,"zip":344,"country":192,"countryCode":193,"cosmosGeoPoint":345,"geoPoint":347,"contacts":64},"Skin Research Institute LLC \u002FID# 259207","33146-1837",{"type":195,"coordinates":346},[339,340],{"lat":340,"lon":339},{"facility":349,"status":202,"city":350,"state":314,"zip":351,"country":192,"countryCode":193,"cosmosGeoPoint":352,"geoPoint":356,"contacts":64},"Revival Research \u002FID# 259213","Doral","33122-1902",{"type":195,"coordinates":353},[354,355],-80.35533,25.81954,{"lat":355,"lon":354},{"facility":358,"status":248,"city":359,"state":314,"zip":360,"country":192,"countryCode":193,"cosmosGeoPoint":361,"geoPoint":365,"contacts":366},"Skin Care Research - Hollywood \u002FID# 259210","Hollywood","33021-6748",{"type":195,"coordinates":362},[363,364],-80.14949,26.0112,{"lat":364,"lon":363},[367],{"name":300,"role":182,"phone":323,"phoneExt":64,"email":64},{"facility":369,"status":248,"city":370,"state":314,"zip":371,"country":192,"countryCode":193,"cosmosGeoPoint":372,"geoPoint":376,"contacts":64},"GSI Clinical Research, LLC \u002FID# 259352","Margate","33063",{"type":195,"coordinates":373},[374,375],-80.20644,26.24453,{"lat":375,"lon":374},{"facility":378,"status":188,"city":370,"state":314,"zip":371,"country":192,"countryCode":193,"cosmosGeoPoint":379,"geoPoint":381,"contacts":64},"Life Clinical Trials - N State Rd - Margate \u002FID# 259358",{"type":195,"coordinates":380},[374,375],{"lat":375,"lon":374},{"facility":383,"status":248,"city":384,"state":314,"zip":385,"country":192,"countryCode":193,"cosmosGeoPoint":386,"geoPoint":390,"contacts":64},"Lenus Research and Medical Group \u002FID# 259356","Miami","33172",{"type":195,"coordinates":387},[388,389],-80.19366,25.77427,{"lat":389,"lon":388},{"facility":392,"status":202,"city":393,"state":314,"zip":394,"country":192,"countryCode":193,"cosmosGeoPoint":395,"geoPoint":399,"contacts":64},"International Clinical Research - Sanford \u002FID# 259547","Sanford","32771",{"type":195,"coordinates":396},[397,398],-81.27312,28.80055,{"lat":398,"lon":397},{"facility":401,"status":202,"city":402,"state":314,"zip":403,"country":192,"countryCode":193,"cosmosGeoPoint":404,"geoPoint":408,"contacts":64},"FWD Clinical Research \u002FID# 266687","Tamarac","33321-2931",{"type":195,"coordinates":405},[406,407],-80.24977,26.21286,{"lat":407,"lon":406},{"facility":410,"status":248,"city":411,"state":314,"zip":412,"country":192,"countryCode":193,"cosmosGeoPoint":413,"geoPoint":417,"contacts":418},"Advanced Clinical Research Institute - Tampa \u002FID# 259204","Tampa","33607",{"type":195,"coordinates":414},[415,416],-82.45843,27.94752,{"lat":416,"lon":415},[419],{"name":300,"role":182,"phone":420,"phoneExt":64,"email":64},"1-813-362-1037",{"facility":422,"status":202,"city":411,"state":314,"zip":423,"country":192,"countryCode":193,"cosmosGeoPoint":424,"geoPoint":426,"contacts":64},"Avita Clinical Research \u002FID# 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(Türkiye)",{"facility":2553,"status":188,"city":2548,"state":64,"zip":2554,"country":2551,"countryCode":64,"cosmosGeoPoint":2555,"geoPoint":2559,"contacts":64},"Ankara City Hospital \u002FID# 257417","06800",{"type":195,"coordinates":2556},[2557,2558],32.85427,39.91987,{"lat":2558,"lon":2557},{"facility":2561,"status":188,"city":2562,"state":64,"zip":2563,"country":2551,"countryCode":64,"cosmosGeoPoint":2564,"geoPoint":2568,"contacts":64},"Gaziantep Universitesi \u002FID# 257418","Gaziantep","27310",{"type":195,"coordinates":2565},[2566,2567],37.3825,37.05944,{"lat":2567,"lon":2566},{"facility":2570,"status":188,"city":2571,"state":64,"zip":2572,"country":2551,"countryCode":64,"cosmosGeoPoint":2573,"geoPoint":2577,"contacts":64},"Bagcilar Medipol Mega Universite Hastanesi \u002FID# 257449","Istanbul","34214",{"type":195,"coordinates":2574},[2575,2576],28.94966,41.01384,{"lat":2576,"lon":2575},{"facility":2579,"status":188,"city":2580,"state":64,"zip":2581,"country":2551,"countryCode":64,"cosmosGeoPoint":2582,"geoPoint":2586,"contacts":64},"Erciyes University Medical Faculty \u002FID# 259034","Kayseri","38039",{"type":195,"coordinates":2583},[2584,2585],35.48528,38.73222,{"lat":2585,"lon":2584},{"facility":2588,"status":188,"city":2589,"state":2590,"zip":2591,"country":2592,"countryCode":2593,"cosmosGeoPoint":2594,"geoPoint":2598,"contacts":64},"Velocity Clinical Research Ltd \u002FID# 257925","High Wycombe","Buckinghamshire","HP11 2QW","United Kingdom","UK",{"type":195,"coordinates":2595},[2596,2597],-0.74934,51.62907,{"lat":2597,"lon":2596},{"facility":2600,"status":188,"city":2601,"state":2602,"zip":2603,"country":2592,"countryCode":2593,"cosmosGeoPoint":2604,"geoPoint":2608,"contacts":64},"Royal Sussex County Hospital \u002FID# 257912","Brighton","East Sussex","BN2 5BE",{"type":195,"coordinates":2605},[2606,2607],-0.13947,50.82838,{"lat":2607,"lon":2606},{"facility":2610,"status":188,"city":2611,"state":2612,"zip":2613,"country":2592,"countryCode":2593,"cosmosGeoPoint":2614,"geoPoint":2618,"contacts":64},"Gloucestershire Royal Hospital \u002FID# 257953","Gloucester","Gloucestershire","GL1 3NN",{"type":195,"coordinates":2615},[2616,2617],-2.2431,51.86568,{"lat":2617,"lon":2616},{"facility":2620,"status":188,"city":2621,"state":2622,"zip":2623,"country":2592,"countryCode":2593,"cosmosGeoPoint":2624,"geoPoint":2628,"contacts":64},"Chelsea and Westminster Hospital \u002FID# 259128","London","Greater London","SW10 9NH",{"type":195,"coordinates":2625},[2626,2627],-0.12574,51.50853,{"lat":2627,"lon":2626},{"facility":2630,"status":188,"city":2631,"state":2632,"zip":2633,"country":2592,"countryCode":2593,"cosmosGeoPoint":2634,"geoPoint":2638,"contacts":64},"Oxford University Hospitals NHS Foundation Trust \u002FID# 257948","Oxford","Oxfordshire","OX3 9DU",{"type":195,"coordinates":2635},[2636,2637],-1.25596,51.75222,{"lat":2637,"lon":2636},{"facility":2640,"status":188,"city":2641,"state":64,"zip":2642,"country":2592,"countryCode":2593,"cosmosGeoPoint":2643,"geoPoint":2647,"contacts":64},"London North West University Healthcare NHS Trust \u002FID# 257914","Harrow","HA1 3UJ",{"type":195,"coordinates":2644},[2645,2646],-0.33208,51.57835,{"lat":2646,"lon":2645},{"facility":2649,"status":188,"city":2650,"state":64,"zip":2651,"country":2592,"countryCode":2593,"cosmosGeoPoint":2652,"geoPoint":2656,"contacts":64},"Northern Care Alliance NHS Group \u002FID# 257952","Salford","M6 8HD",{"type":195,"coordinates":2653},[2654,2655],-2.29042,53.48771,{"lat":2655,"lon":2654},{"type":2658,"investigatorFullName":64,"investigatorTitle":64,"investigatorAffiliation":64,"oldNameTitle":64,"oldOrganization":64},"SPONSOR","100517030","phase-3-a-study-to-evaluate-the-safety-and-effectiveness-of-upadacitinib-tablets-in-adult-and-adolescent-participants-with-severe-alopecia-areata-100517030",false,"NCT06012240","A Study to Evaluate the Safety and Effectiveness of Upadacitinib Tablets in Adult and Adolescent Participants With Severe Alopecia Areata","A Phase 3 Randomized, Placebo-controlled, Double-blind Program to Evaluate Efficacy and Safety of Upadacitinib in Adult and Adolescent Subjects With Severe Alopecia Areata","Up-AA","Inclusion Criteria:\n\n* Adult individuals must be \\\u003C 64 years old at Baseline Visit. Where permitted outside United States (US)\u002FEuropean Union (EU), adolescent individuals who are at least 12 years old at Screening may participate in Study 1 and Study 2. Adolescent individuals in the US who are at least 12 years old at Screening may participate in Study 4.\n* Diagnosis of severe alopecia areata (AA) with Severity of Alopecia Tool (SALT) score \\>= 50 scalp hair loss at Screening and Baseline.\n* Severe AA with no spontaneous scalp hair regrowth over the past 6 months.\n* Current episode of AA of less than 8 years.\n\nExclusion Criteria:\n\n* Current diagnosis of primarily diffuse type of AA.\n* Current diagnosis of other types of alopecia that would interfere with evaluation of AA, including but not limited to female pattern hair loss, male pattern hair loss (androgenetic alopecia) Stage III or greater based on Hamilton-Norwood classification, traction alopecia, lichen planopilaris (LPP), discoid lupus, frontal fibrosing alopecia (FFA), central centrifugal cicatricial alopecia (CCCA), folliculitis decalvans, trichotillomania, and telogen effluvium.\n* Diagnosis of other types of inflammatory scalp, eyebrow, or eyelash disorders that would interfere with evaluation of AA as determined by the investigator, including but not limited to seborrheic dermatitis, scalp psoriasis, atopic dermatitis (AD), and tinea capitis.","ALL","12 Years","63 Years",{"count":2671,"type":2672},1500,"ESTIMATED","INTERVENTIONAL",[2675],"PHASE3","Alopecia areata (AA) is a disease that happens when the immune system attacks hair follicles and causes hair loss. AA usually affects the head and face, but hair loss can happen on any part of the body. The purpose of this study is to assess how safe, effective, and tolerable upadacitinib is in adolescent and adult participants with severe AA.\n\nUpadacitinib is an approved drug being investigated for the treatment of AA. In Study 1 and Study 2 and Study 4 Period A, participants are placed in 1 of 3 groups, called treatment arms. Each group receives a different treatment. There is a 1 in 5 chance that participants will be assigned to placebo. In Study 1 and Study 2 and Study 4 Period B, participants originally randomized to upadacitinib dose group in Period A will continue their same treatment in Period B. Participants originally randomized to Placebo in Period A will either remain on placebo in Period B, or be randomized in 1 of 2 groups, based off of their Severity of Alopecia Tool (SALT) score. Participants who complete Study 1, Study 2 or Study 4, can join Study 3 and may be re-randomized to receive 1 of 2 doses of upadacitinib for up to 108 weeks. Around 1500 participants with severe AA will be enrolled in the study at approximately 280 sites worldwide.\n\nParticipants will receive oral tablets of either upadacitinib or placebo once daily for up to 160 weeks with the potential of being re-randomized into a different treatment group at Weeks 24 and 52. Participants will be followed up for up to 30 days after last study drug dose.\n\nThere may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.",[2678],"Alopecia Areata",[2678,166,170,171],"2026-10-07",{"date":2682,"type":2683},"2026-10-13","ACTUAL",{"date":2685,"type":2683},"2023-10-11",{"date":2687,"type":2672},"2030-04",{"name":5,"class":6},272]