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DOR analysis will only include responders.",{"measure":45,"description":46,"timeFrame":12},"Time to Next Treatment (TTNT)","TTNT is defined as the time from randomization to the start of the next treatment for CLL.",{"measure":48,"description":49,"timeFrame":50},"Change from Baseline in Score on European Organization for Research and Treatment of Cancer (EORTC) Item Library (IL)-409 Questionnaire","Patient-reported symptoms of global health status (GHS), role functioning, and physical functioning, symptom burden and physical condition\u002Ffatigue will be measured using the European Organization for Research and Treatment of Cancer quality of life questionnaire EORTC IL-409 (an itemized version of \\[EORTC\\] quality of life questionnaire core 30 \\[QLQ-C30\\] and its CLL module CLL17). The EORTC-IL-409 consists of 17 questions answered on a 4-point scale where 1 = Not at all (best) to 4 = Very Much (worst) and 2 global health questions answered on a 7-point scale where 1 = Very poor (worst) to 7 = Excellent (best). Higher scores in GHS and functional scales and lower scores in symptom scales indicate better quality of life.","At baseline and up to approximately 70 months",null,{"allocation":53,"interventionModel":54,"interventionModelDescription":51,"primaryPurpose":55,"observationalModel":51,"timePerspective":51,"maskingInfo":56},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":57,"maskingDescription":51,"whoMasked":51},"NONE",[59,66],{"label":60,"type":61,"description":62,"interventionNames":63},"Arm A: Sonrotoclax plus Zanubrutinib","EXPERIMENTAL","Participants will receive sonrotoclax and zanubrutinib for a fixed duration followed by observation.",[64,65],"Drug: Sonrotoclax","Drug: Zanubrutinib",{"label":67,"type":68,"description":69,"interventionNames":70},"Arm B: Venetoclax plus Acalabrutinib","ACTIVE_COMPARATOR","Participants will receive venetoclax and acalabrutinib for a fixed duration followed by observation.",[71,72],"Drug: Acalabrutinib","Drug: 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Usor","Aurora","Colorado","80012-5405",{"type":117,"coordinates":146},[147,148],-104.83192,39.72943,{"lat":148,"lon":147},{"facility":151,"status":110,"city":152,"state":153,"zip":154,"country":114,"countryCode":115,"cosmosGeoPoint":155,"geoPoint":159,"contacts":51},"Mayo Clinic Jacksonville","Jacksonville","Florida","32224-1865",{"type":117,"coordinates":156},[157,158],-81.65565,30.33218,{"lat":158,"lon":157},{"facility":161,"status":110,"city":162,"state":153,"zip":163,"country":114,"countryCode":115,"cosmosGeoPoint":164,"geoPoint":168,"contacts":51},"Mount Sinai Medical Center Braman Comprehensive Cancer Center","Miami","33140",{"type":117,"coordinates":165},[166,167],-80.19366,25.77427,{"lat":167,"lon":166},{"facility":170,"status":110,"city":171,"state":153,"zip":172,"country":114,"countryCode":115,"cosmosGeoPoint":173,"geoPoint":177,"contacts":51},"Moffitt Cancer 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City","Utah","84112-5550",{"type":117,"coordinates":292},[293,294],-111.89105,40.76078,{"lat":294,"lon":293},{"facility":297,"status":110,"city":298,"state":299,"zip":300,"country":114,"countryCode":115,"cosmosGeoPoint":301,"geoPoint":305,"contacts":51},"Fred Hutchinson Cancer Research Center","Seattle","Washington","98109-4433",{"type":117,"coordinates":302},[303,304],-122.33207,47.60621,{"lat":304,"lon":303},{"facility":307,"status":110,"city":308,"state":309,"zip":310,"country":114,"countryCode":115,"cosmosGeoPoint":311,"geoPoint":315,"contacts":51},"Medical College of Wisconsin","Milwaukee","Wisconsin","53226-3522",{"type":117,"coordinates":312},[313,314],-87.90647,43.0389,{"lat":314,"lon":313},{"facility":317,"status":110,"city":318,"state":319,"zip":320,"country":321,"countryCode":322,"cosmosGeoPoint":323,"geoPoint":327,"contacts":51},"Blacktown Cancer and Haematology Centre","Blacktown","New South Wales","NSW 2148","Australia","AU",{"type":117,"coordinates":324},[325,326],150.91667,-33.76667,{"lat":326,"lon":325},{"facility":329,"status":110,"city":330,"state":319,"zip":331,"country":321,"countryCode":322,"cosmosGeoPoint":332,"geoPoint":336,"contacts":51},"Concord Repatriation General Hospital","Concord","NSW 2139",{"type":117,"coordinates":333},[334,335],151.10381,-33.84722,{"lat":335,"lon":334},{"facility":338,"status":110,"city":339,"state":319,"zip":340,"country":321,"countryCode":322,"cosmosGeoPoint":341,"geoPoint":345,"contacts":51},"Genesiscare North Shore","St Leonards","NSW 2065",{"type":117,"coordinates":342},[343,344],151.19836,-33.82344,{"lat":344,"lon":343},{"facility":347,"status":110,"city":348,"state":349,"zip":350,"country":321,"countryCode":322,"cosmosGeoPoint":351,"geoPoint":355,"contacts":51},"Princess Alexandra Hospital","Woolloongabba","Queensland","QLD 4102",{"type":117,"coordinates":352},[353,354],153.03655,-27.48855,{"lat":354,"lon":353},{"facility":357,"status":110,"city":358,"state":359,"zip":360,"country":321,"countryCode":322,"cosmosGeoPoint":361,"geoPoint":365,"contacts":51},"Monash Health","Clayton","Victoria","VIC 3168",{"type":117,"coordinates":362},[363,364],145.11667,-37.91667,{"lat":364,"lon":363},{"facility":367,"status":110,"city":368,"state":359,"zip":369,"country":321,"countryCode":322,"cosmosGeoPoint":370,"geoPoint":374,"contacts":51},"Austin Health","Heidelberg","VIC 3084",{"type":117,"coordinates":371},[372,373],145.06667,-37.75,{"lat":373,"lon":372},{"facility":376,"status":110,"city":377,"state":359,"zip":378,"country":321,"countryCode":322,"cosmosGeoPoint":379,"geoPoint":383,"contacts":51},"Cabrini Hospital Malvern","Malvern","VIC 3144",{"type":117,"coordinates":380},[381,382],145.02811,-37.86259,{"lat":382,"lon":381},{"facility":385,"status":110,"city":386,"state":359,"zip":387,"country":321,"countryCode":322,"cosmosGeoPoint":388,"geoPoint":392,"contacts":51},"The Alfred Hospital","Melbourne","VIC 3004",{"type":117,"coordinates":389},[390,391],144.96332,-37.814,{"lat":391,"lon":390},{"facility":394,"status":110,"city":395,"state":51,"zip":396,"country":397,"countryCode":398,"cosmosGeoPoint":399,"geoPoint":403,"contacts":51},"Instituto Dor de Pesquisa E Ensino Distrito Federal","Brasília","70390140","Brazil","BR",{"type":117,"coordinates":400},[401,402],-47.92972,-15.77972,{"lat":402,"lon":401},{"facility":405,"status":110,"city":406,"state":51,"zip":407,"country":397,"countryCode":398,"cosmosGeoPoint":408,"geoPoint":412,"contacts":51},"Centro Gaucho Integrado de Oncologia Hospital Mae de Deus","Porto Alegre","90110-270",{"type":117,"coordinates":409},[410,411],-51.23019,-30.03283,{"lat":411,"lon":410},{"facility":414,"status":110,"city":415,"state":51,"zip":416,"country":397,"countryCode":398,"cosmosGeoPoint":417,"geoPoint":421,"contacts":51},"Ensino E Terapia de Inovacao Clinica Amo Etica","Salvador","41950-640",{"type":117,"coordinates":418},[419,420],-38.49096,-12.97563,{"lat":420,"lon":419},{"facility":423,"status":110,"city":424,"state":51,"zip":425,"country":397,"countryCode":398,"cosmosGeoPoint":426,"geoPoint":430,"contacts":51},"Instituto Dor de Pesquisa E Ensino Sao Paulo","São Paulo","01401-004",{"type":117,"coordinates":427},[428,429],-46.63611,-23.5475,{"lat":429,"lon":428},{"facility":432,"status":110,"city":424,"state":51,"zip":433,"country":397,"countryCode":398,"cosmosGeoPoint":434,"geoPoint":436,"contacts":51},"Sociedade Beneficente Israelita Brasileira Hospital Albert 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