[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652006":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":28,"centralContacts":32,"locations":37,"responsibleParty":51,"collaborators":27,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":27,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":61,"maxAge":27,"enrollmentInfo":62,"targetDuration":27,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":27,"overallStatus":71,"whyStopped":27,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"Pfizer","INDUSTRY",[8,14,17,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Group 1","EXPERIMENTAL","RSVpreF Vaccine",[13],"Biological: RSVpreF Vaccine",{"label":15,"type":10,"description":11,"interventionNames":16},"Group 2",[13],{"label":18,"type":10,"description":11,"interventionNames":19},"Group 3",[13],{"label":21,"type":10,"description":11,"interventionNames":22},"Group 4",[13],[24],{"type":25,"name":11,"description":11,"armGroupLabels":26,"otherNames":27},"BIOLOGICAL",[9,15,18,21],null,[29],{"name":30,"affiliation":5,"role":31},"Pfizer CT.gov Call Center","STUDY_DIRECTOR",[33],{"name":30,"role":34,"phone":35,"phoneExt":27,"email":36},"CONTACT","1-800-718-1021","ClinicalTrials.gov_Inquiries@pfizer.com",[38],{"facility":39,"status":27,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":27},"Rochester Clinical Research","Rochester","New York","14609","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-77.61556,43.15478,{"lat":49,"lon":48},{"type":52,"investigatorFullName":27,"investigatorTitle":27,"investigatorAffiliation":27,"oldNameTitle":27,"oldOrganization":27},"SPONSOR","100652006","phase-3-a-study-to-learn-about-revaccination-with-a-vaccine-called-rsvpref-in-immunocompromised-adults-100652006",false,"NCT07768345","A Study to Learn About Revaccination With a Vaccine Called RSVpreF in Immunocompromised Adults","A PHASE 3, OPEN-LABEL STUDY TO EVALUATE THE SAFETY, TOLERABILITY, AND IMMUNOGENICITY OF REVACCINATION WITH RESPIRATORY SYNCYTIAL VIRUS STABILIZED PREFUSION F SUBUNIT VACCINE (RSVPREF) IN IMMUNOCOMPROMISED ADULTS","Key Inclusion Criteria:\n\n* Participants ≥18 years of age who are\u002Fwere immunocompromised at the time of initial RSVpreF vaccination, per study protocol, and will be grouped based on prior RSV vaccination history:\n* Group 1 will include participants naïve to any RSV vaccine.\n* Group 2 will include participants who received a single prior dose of RSVpreF (Abrysvo) approximately 1 year (9 to 15 months) prior to enrollment.\n* Group 3 will include participants who received a single prior dose of RSVpreF (Abrysvo) approximately 2 years (21 to 27 months) prior to enrollment.\n* Group 4 will include participants who previously received 2 doses of RSVpreF in Study C3671023 Substudy B approximately 3 years (36 to 42 months) prior to enrollment.\n* Participants should have a life expectancy ≥12 months (365 days) in the opinion of the investigator at enrollment.\n\nKey Exclusion Criteria:\n\n* Prior history of any subtype of Guillain-Barré Syndrome (GBS) of any etiology.\n* History of severe adverse reaction associated with a vaccine and\u002For severe allergic reaction (eg, anaphylaxis) to any components of the study intervention(s).\n* Participants with a history of transplant rejection, or PTLD, or participants who have had treatment for these conditions, within 90 days prior to study enrollment or suspected chronic humoral or cellular rejection.\n* Receipt of B-cell depleting therapies within 180 days prior to initial study vaccination.\n\nRefer to the study contact for further eligibility details.","ALL","18 Years",{"count":63,"type":64},440,"ESTIMATED","INTERVENTIONAL",[67],"PHASE3","The purpose of this phase 3 study is to learn the safety, tolerability and immunogenicity of revaccination with RSVpreF at approximately 1-, 2-, and 3-year intervals to inform the revaccination interval in immunocompromised adults.\n\nThis study is seeking participants who are 18 years of age and older and will be grouped based on prior RSV vaccination history. Participants are required to be immunocompromised per study protocol.\n\nAll participants in this study will receive 1 shot to their arm of a RSVPreF vaccine.\n\nParticipants will take part in this study for about 12 months and will need to visit the clinical study site at least 4 times.",[70],"Respiratory Syncytial Virus (RSV)","NOT_YET_RECRUITING","2026-08-12",{"date":74,"type":75},"2026-08-17","ACTUAL",{"date":77,"type":64},"2026-08-31",{"date":79,"type":64},"2028-02-02",{"name":5,"class":6},1]