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Oncologia","A Coruña","15006",{"type":59,"coordinates":2093},[2094,2095],-8.396,43.37135,{"lat":2095,"lon":2094},{"facility":2098,"status":402,"city":2059,"state":28,"zip":2099,"country":2061,"countryCode":2062,"cosmosGeoPoint":2100,"geoPoint":2104,"contacts":28},"Hospital Universitari Dexeus Grupo Quironsalud | Oncologia","08028",{"type":59,"coordinates":2101},[2102,2103],2.15899,41.38879,{"lat":2103,"lon":2102},{"facility":2106,"status":402,"city":2059,"state":28,"zip":2107,"country":2061,"countryCode":2062,"cosmosGeoPoint":2108,"geoPoint":2110,"contacts":28},"Hospital Universitari Vall D Hebron | Oncologia","08035",{"type":59,"coordinates":2109},[2102,2103],{"lat":2103,"lon":2102},{"facility":2112,"status":52,"city":2059,"state":28,"zip":2113,"country":2061,"countryCode":2062,"cosmosGeoPoint":2114,"geoPoint":2116,"contacts":28},"Hospital Clinic De Barcelona | Oncologia","08036",{"type":59,"coordinates":2115},[2102,2103],{"lat":2103,"lon":2102},{"facility":2118,"status":114,"city":2071,"state":28,"zip":2119,"country":2061,"countryCode":2062,"cosmosGeoPoint":2120,"geoPoint":2124,"contacts":28},"Hospital General Universitario Gregorio Maranon | Oncologia","28009",{"type":59,"coordinates":2121},[2122,2123],-3.70256,40.4165,{"lat":2123,"lon":2122},{"facility":2126,"status":52,"city":2071,"state":28,"zip":2127,"country":2061,"countryCode":2062,"cosmosGeoPoint":2128,"geoPoint":2130,"contacts":28},"Hospital Universitario Ramon Y Cajal | Oncologia","28034",{"type":59,"coordinates":2129},[2122,2123],{"lat":2123,"lon":2122},{"facility":2132,"status":52,"city":2071,"state":28,"zip":2133,"country":2061,"countryCode":2062,"cosmosGeoPoint":2134,"geoPoint":2136,"contacts":28},"Hospital Universitario Fundacion Jimenez Diaz | Oncologia","28040",{"type":59,"coordinates":2135},[2122,2123],{"lat":2123,"lon":2122},{"facility":2138,"status":114,"city":2139,"state":28,"zip":2140,"country":2061,"countryCode":2062,"cosmosGeoPoint":2141,"geoPoint":2145,"contacts":28},"Fundacion Instituto Valenciano De Oncologia | Oncologia","Valencia","46009",{"type":59,"coordinates":2142},[2143,2144],-0.37966,39.47391,{"lat":2144,"lon":2143},{"facility":2147,"status":402,"city":2139,"state":28,"zip":2148,"country":2061,"countryCode":2062,"cosmosGeoPoint":2149,"geoPoint":2151,"contacts":28},"Hospital Universitario Y Politecnico La Fe | Oncologia","46026",{"type":59,"coordinates":2150},[2143,2144],{"lat":2144,"lon":2143},{"facility":2153,"status":104,"city":2154,"state":2155,"zip":2156,"country":2157,"countryCode":2158,"cosmosGeoPoint":2159,"geoPoint":2163,"contacts":28},"Norrlands Universitetssjukhus Umeå - Cancercentrum","Umeå","Västerbotten County","901 85","Sweden","SE",{"type":59,"coordinates":2160},[2161,2162],20.25972,63.82842,{"lat":2162,"lon":2161},{"facility":2165,"status":402,"city":2166,"state":28,"zip":2167,"country":2157,"countryCode":2158,"cosmosGeoPoint":2168,"geoPoint":2172,"contacts":28},"Skånes Universitetssjukhus - Lund - Lungmedicin","Lund","221 85",{"type":59,"coordinates":2169},[2170,2171],13.19321,55.70584,{"lat":2171,"lon":2170},{"facility":2174,"status":75,"city":2175,"state":2176,"zip":2177,"country":2178,"countryCode":2179,"cosmosGeoPoint":2180,"geoPoint":2184,"contacts":28},"Kantonsspital Baden","Baden","Canton of Aargau","5404","Switzerland","CH",{"type":59,"coordinates":2181},[2182,2183],8.30592,47.47333,{"lat":2183,"lon":2182},{"facility":2186,"status":114,"city":2187,"state":28,"zip":2188,"country":2178,"countryCode":2179,"cosmosGeoPoint":2189,"geoPoint":2193,"contacts":28},"HFR Freiburg - Kantonsspital","Fribourg","1708",{"type":59,"coordinates":2190},[2191,2192],7.15128,46.80237,{"lat":2192,"lon":2191},{"facility":2195,"status":75,"city":2196,"state":28,"zip":2197,"country":2198,"countryCode":2199,"cosmosGeoPoint":2200,"geoPoint":2204,"contacts":28},"Kaohsiung Medical University Chung-Ho Memorial Hospital","Kaohsiung City","807377","Taiwan","TW",{"type":59,"coordinates":2201},[2202,2203],120.31333,22.61626,{"lat":2203,"lon":2202},{"facility":2206,"status":75,"city":2207,"state":28,"zip":2208,"country":2198,"countryCode":2199,"cosmosGeoPoint":2209,"geoPoint":2213,"contacts":28},"Chung Shan Medical University Hospital","Taichung","402306",{"type":59,"coordinates":2210},[2211,2212],120.6839,24.1469,{"lat":2212,"lon":2211},{"facility":2215,"status":75,"city":2207,"state":28,"zip":2216,"country":2198,"countryCode":2199,"cosmosGeoPoint":2217,"geoPoint":2219,"contacts":28},"Taichung Veterans General Hospital","40705",{"type":59,"coordinates":2218},[2211,2212],{"lat":2212,"lon":2211},{"facility":2221,"status":75,"city":2222,"state":28,"zip":2223,"country":2198,"countryCode":2199,"cosmosGeoPoint":2224,"geoPoint":2228,"contacts":28},"National Cheng Kung University Hospital","Tainan","704",{"type":59,"coordinates":2225},[2226,2227],120.21333,22.99083,{"lat":2227,"lon":2226},{"facility":2230,"status":104,"city":2222,"state":28,"zip":2231,"country":2198,"countryCode":2199,"cosmosGeoPoint":2232,"geoPoint":2234,"contacts":28},"Chi-Mei Medical Center, Liouyine","73657",{"type":59,"coordinates":2233},[2226,2227],{"lat":2227,"lon":2226},{"facility":2236,"status":75,"city":2237,"state":28,"zip":2238,"country":2198,"countryCode":2199,"cosmosGeoPoint":2239,"geoPoint":2243,"contacts":28},"National Taiwan University Hospital (NTUH) - Cancer Research Center","Taipei","100225",{"type":59,"coordinates":2240},[2241,2242],121.52639,25.05306,{"lat":2242,"lon":2241},{"facility":2245,"status":75,"city":2237,"state":28,"zip":2246,"country":2198,"countryCode":2199,"cosmosGeoPoint":2247,"geoPoint":2249,"contacts":28},"National Taiwan University Hospital","100",{"type":59,"coordinates":2248},[2241,2242],{"lat":2242,"lon":2241},{"facility":2251,"status":75,"city":2237,"state":28,"zip":2252,"country":2198,"countryCode":2199,"cosmosGeoPoint":2253,"geoPoint":2255,"contacts":28},"Taipei Veterans General Hospital","11217",{"type":59,"coordinates":2254},[2241,2242],{"lat":2242,"lon":2241},{"facility":2257,"status":402,"city":2258,"state":2259,"zip":2260,"country":2261,"countryCode":28,"cosmosGeoPoint":28,"geoPoint":28,"contacts":28},"Ankara Bilkent Sehir Hastanesi","Bilkent Çankaya","Ankara","6800","Turkey (Türkiye)",{"facility":2263,"status":402,"city":2264,"state":2265,"zip":2266,"country":2261,"countryCode":28,"cosmosGeoPoint":2267,"geoPoint":2271,"contacts":28},"İstanbul Medeniyet Üniversitesi Göztepe Süleyman Yalçın Şehir Hastanesi","Kadıköy","Istanbul","34722",{"type":59,"coordinates":2268},[2269,2270],28.36417,41.13658,{"lat":2270,"lon":2269},{"facility":2273,"status":104,"city":2265,"state":28,"zip":2274,"country":2261,"countryCode":28,"cosmosGeoPoint":2275,"geoPoint":2279,"contacts":28},"Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi","34899",{"type":59,"coordinates":2276},[2277,2278],28.94966,41.01384,{"lat":2278,"lon":2277},{"facility":2281,"status":402,"city":2282,"state":28,"zip":2283,"country":2261,"countryCode":28,"cosmosGeoPoint":2284,"geoPoint":2288,"contacts":28},"Ege Universitesi Tip Fakultesi Hastanesi","Izmir","35100",{"type":59,"coordinates":2285},[2286,2287],27.13838,38.41273,{"lat":2287,"lon":2286},{"facility":2290,"status":114,"city":2291,"state":28,"zip":2292,"country":2261,"countryCode":28,"cosmosGeoPoint":2293,"geoPoint":2297,"contacts":28},"İ.A.Ü. VM Medical Park Florya Hastanesi","Küçükçekmece","34295",{"type":59,"coordinates":2294},[2295,2296],28.77123,40.99104,{"lat":2296,"lon":2295},{"facility":2299,"status":114,"city":2300,"state":28,"zip":2301,"country":2261,"countryCode":28,"cosmosGeoPoint":2302,"geoPoint":2306,"contacts":28},"Sakarya Universitesi Egitim ve Arastirma Hastanesi","Sakarya","54100",{"type":59,"coordinates":2303},[2304,2305],32.07583,39.50333,{"lat":2305,"lon":2304},{"facility":2308,"status":114,"city":2309,"state":28,"zip":2310,"country":2261,"countryCode":28,"cosmosGeoPoint":2311,"geoPoint":2315,"contacts":28},"Ankara Etlik Sehir Hastanesi","Yenimahalle","6170",{"type":59,"coordinates":2312},[2313,2314],27.4238,40.22627,{"lat":2314,"lon":2313},{"facility":2317,"status":104,"city":2318,"state":28,"zip":2319,"country":2261,"countryCode":28,"cosmosGeoPoint":2320,"geoPoint":2324,"contacts":28},"Adana Sehir Egitim ve Arastirma Hastanesi","Yüreğir","1370",{"type":59,"coordinates":2321},[2322,2323],35.35916,36.97439,{"lat":2323,"lon":2322},{"facility":2326,"status":114,"city":2327,"state":28,"zip":2328,"country":2329,"countryCode":2330,"cosmosGeoPoint":2331,"geoPoint":2335,"contacts":28},"LLC \"RDP Ukraine\" - Medical Department","Dnipro","49102","Ukraine","UA",{"type":59,"coordinates":2332},[2333,2334],35.04066,48.46664,{"lat":2334,"lon":2333},{"facility":2337,"status":114,"city":2338,"state":28,"zip":2339,"country":2329,"countryCode":2330,"cosmosGeoPoint":2340,"geoPoint":2344,"contacts":28},"Private Enterprise Private Production Company \"Acinus\", Treatment and Diagnostic Center","Kropyvnytskyi","25006",{"type":59,"coordinates":2341},[2342,2343],32.26618,48.50834,{"lat":2343,"lon":2342},{"facility":2346,"status":114,"city":2347,"state":28,"zip":2348,"country":2329,"countryCode":2330,"cosmosGeoPoint":2349,"geoPoint":2353,"contacts":28},"Kyiv City Clinical Oncology Center - Department of Chemotherapy #1","Kyiv","03115",{"type":59,"coordinates":2350},[2351,2352],30.5238,50.45466,{"lat":2352,"lon":2351},{"facility":2355,"status":75,"city":2347,"state":28,"zip":2356,"country":2329,"countryCode":2330,"cosmosGeoPoint":2357,"geoPoint":2359,"contacts":28},"Limited Liability Company \"MedOffice Group Medical Center\"","03189",{"type":59,"coordinates":2358},[2351,2352],{"lat":2352,"lon":2351},{"facility":2361,"status":114,"city":2347,"state":28,"zip":2362,"country":2329,"countryCode":2330,"cosmosGeoPoint":2363,"geoPoint":2365,"contacts":28},"Medical Center LLC \"Verum Expert Clinic\"","3039",{"type":59,"coordinates":2364},[2351,2352],{"lat":2352,"lon":2351},{"facility":2367,"status":114,"city":2368,"state":28,"zip":2369,"country":2329,"countryCode":2330,"cosmosGeoPoint":2370,"geoPoint":2374,"contacts":28},"Regional Medical Oncology Centre_Oncology Chemotherapy Department","Lutsk","43018",{"type":59,"coordinates":2371},[2372,2373],25.35024,50.75784,{"lat":2373,"lon":2372},{"facility":2376,"status":75,"city":2377,"state":28,"zip":2378,"country":2329,"countryCode":2330,"cosmosGeoPoint":2379,"geoPoint":2383,"contacts":28},"Municipal Enterprise Rivne Regional Antitumor Center of the Rivne Regional Council, Abdominal department","Rivne","33010",{"type":59,"coordinates":2380},[2381,2382],26.23695,50.62036,{"lat":2382,"lon":2381},{"facility":2385,"status":114,"city":2386,"state":28,"zip":2387,"country":2329,"countryCode":2330,"cosmosGeoPoint":2388,"geoPoint":2392,"contacts":28},"MNCE \"Uzhhorod City Multidisciplinary Clinical Hospital\" -Oncology Department","Uzhhorod","88000",{"type":59,"coordinates":2389},[2390,2391],22.2947,48.6242,{"lat":2391,"lon":2390},{"facility":2394,"status":75,"city":2395,"state":2396,"zip":2397,"country":2398,"countryCode":2399,"cosmosGeoPoint":2400,"geoPoint":2404,"contacts":28},"Torbay Hospital | Oncology","Torquay","Devon","TQ2 7AA","United Kingdom","UK",{"type":59,"coordinates":2401},[2402,2403],-3.52522,50.46198,{"lat":2403,"lon":2402},{"facility":2406,"status":52,"city":2407,"state":2408,"zip":2409,"country":2398,"countryCode":2399,"cosmosGeoPoint":2410,"geoPoint":2414,"contacts":28},"Belfast City Hospital | Oncology","Belfast","Northern Ireland","BT12 7AB",{"type":59,"coordinates":2411},[2412,2413],-5.92541,54.59682,{"lat":2413,"lon":2412},{"facility":2416,"status":75,"city":2417,"state":2418,"zip":2419,"country":2398,"countryCode":2399,"cosmosGeoPoint":2420,"geoPoint":2424,"contacts":28},"Royal Surrey County Hospital | Cancer Centre","Guildford","Surrey","GU2 7XX",{"type":59,"coordinates":2421},[2422,2423],-0.57427,51.23536,{"lat":2423,"lon":2422},{"facility":2426,"status":114,"city":2427,"state":2428,"zip":2429,"country":2398,"countryCode":2399,"cosmosGeoPoint":2430,"geoPoint":2434,"contacts":28},"Velindre Cancer Centre | Clinical Trials Unit","Cardiff","Wales","CF14 2TL",{"type":59,"coordinates":2431},[2432,2433],-3.18,51.48,{"lat":2433,"lon":2432},{"type":2436,"investigatorFullName":28,"investigatorTitle":28,"investigatorAffiliation":28,"oldNameTitle":28,"oldOrganization":28},"SPONSOR","100550838","phase-3-a-study-to-learn-more-about-how-well-sevabertinib-works-and-how-safe-it-is-compared-with-standard-treatment-in-participants-who-have-advanced-non-small-cell-lung-cancer-nsclc-with-mutations-of-the-human-epidermal-growth-factor-receptor-2-her2-100550838",false,"NCT06452277","A Study to Learn More About How Well Sevabertinib Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)","A Phase 3 Open-label, Randomized, Active-controlled, Multicenter Trial to Evaluate the Efficacy and Safety of Orally Administered BAY 2927088 Compared With Standard of Care as a First-line Therapy in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) With HER2-activating Mutations","SOHO-02","Inclusion Criteria:\n\n* Participant must be ≥18 years of age or over the legal age of consent in countries where that is greater than 18 years at the time of signing the informed consent.\n* Documented histologically or cytologically confirmed locally advanced non-squamous NSCLC, not suitable for definitive therapy or metastatic non-squamous NSCLC at screening (small cell or mixed histologies are excluded) (Stage III-IV NSCLC).\n* Documented activating HER2 mutation in the tyrosine kinase domain (TKD) assessed by tissue molecular test in a CLIA-certified (US sites) or an equally accredited (outside of the US) local laboratory. However, participants may be included at the discretion of the investigator if the laboratory performing the assay is not CLIA or similar certified but the laboratory is locally accredited.\n* No prior systemic therapy for locally advanced or metastatic disease. No prior treatment with a HER2 ex20ins-targeted therapy (e.g. poziotinib, trastuzumab deruxtecan). Participants who received adjuvant or neoadjuvant therapy are eligible if the adjuvant\u002Fneoadjuvant therapy was completed at least 12 months prior to the start of screening.\n* Eligible to receive treatment with the selected platinum-based doublet-chemotherapy (i.e. cisplatin\u002Fpemetrexed or carboplatin\u002Fpemetrexed) and pembrolizumab in accordance with the SmPC\u002FProduct Information.\n\nExclusion Criteria:\n\n* Known history of prior malignancy except if the participant has undergone potentially curative therapy with no evidence of that disease recurrence for five years since initiation of that therapy. Exception: the following cancer types are acceptable within five years if curatively treated or under surveillance:\n\n  * a. in situ cancers of cervix, breast, or skin,\n  * b. superficial bladder cancer (Ta, Tis and T1),\n  * c. limited-stage prostate cancer,\n  * d. basal or squamous cancers of the skin.\n* Tumors with targetable alterations with approved available therapy, with the exception of HER2 mutation in the TKD.\n* Inability to discontinue treatment with chronic systemic corticosteroids. Participants who require intermittent use of bronchodilators, inhaled steroids, or local steroid injections would not be excluded from the study. Replacement therapy (e.g., physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is acceptable, provided that the dose is stable for \\>4 weeks prior to planned start of study intervention.\n* Pre-existing peripheral neuropathy that is Grade ≥2 by CTCAE (v5.0).\n* History of severe hypersensitivity reaction to treatment with a monoclonal antibody.\n* Prior radiotherapy outside of the brain within 21 days before of planned start of study intervention. Participants must have recovered from all radiation-related toxicities and not require corticosteroids.","ALL","18 Years",{"count":2448,"type":2449},444,"ESTIMATED","INTERVENTIONAL",[2452],"PHASE3","Researchers are looking for a better way to treat people who have advanced non-small cell lung cancer (NSCLC) with specific genetic changes called human epidermal growth factor receptor 2 (HER2) mutations. Advanced NSCLC means lung cancer that has spread nearby or to other parts of the body or is unlikely to be controlled with current treatments. HER2 is a protein that helps cells to grow and divide. Sometimes, cancer cells have a damaged HER2 gene. This is called a mutation. This mutation can lead to an abnormal HER2 protein which may cause cancer cells to grow and divide too quickly.\n\nThe study treatment, sevabertinib, is designed to block the mutated HER2 protein and may help slow or stop the cancer from growing.\n\nThe main purpose of this study is to find out how well sevabertinib works and how safe it is, compared with standard treatment in participants with advanced NSCLC with a HER2 mutation.\n\nThe study participants will receive one of the study treatments:\n\n* Sevabertinib as a tablet taken by mouth twice a day\n* Standard approved treatment for this condition given by infusion into a vein every 21 days Participants will continue their assigned treatment for as long as they benefit from it and do not experience severe side effects, or until they or their doctor decide to stop treatment. When a participant assigned to the standard treatment has their cancer gets worse, they may have the opportunity to switch to receive sevabertinib. This switch is called a crossover.\n\nParticipants who switch to sevabertinib will continue this treatment until their disease gets worse again, they have side effects that are too severe, or they or their doctor decide to stop treatment.\n\nDuring the study, the research team will:\n\n* do scans such as CT, PET, MRI, or X-rays to check the cancer\n* Check the overall health of the participants by performing tests such as blood and urine tests and checking heart health using an electrocardiogram and echocardiogram.\n* do pregnancy tests when needed\n* ask how the participants are feeling and whether they have had any adverse events or other health problems An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events, irrespective if they think it is related or not to the study treatment.",[2455],"Advanced Non-small Cell Lung Cancer, HER2 Mutation",[2457,2458,2459],"NSCLC","ERBB2 mutation","HER2 mutation","2026-08-18",{"date":2462,"type":2463},"2026-08-19","ACTUAL",{"date":2465,"type":2463},"2024-08-28",{"date":2467,"type":2449},"2029-06-27",{"name":5,"class":6},270]