[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646679":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":35,"centralContacts":42,"locations":49,"responsibleParty":232,"collaborators":235,"id":238,"slug":239,"hasResults":240,"nctId":241,"briefTitle":242,"officialTitle":243,"acronym":244,"eligibilityCriteria":245,"healthyVolunteers":240,"sex":246,"minAge":247,"maxAge":34,"enrollmentInfo":248,"targetDuration":34,"studyType":251,"phases":252,"briefSummary":254,"conditions":255,"keywords":259,"overallStatus":268,"whyStopped":34,"lastUpdateSubmitDate":269,"lastUpdatePostDateStruct":270,"startDateStruct":273,"completionDateStruct":275,"leadSponsor":277,"locationsCount":278},{"fullName":5,"class":6},"University of Calgary","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Local intra-arterial (IA) thrombolysis using either tenecteplase or alteplase","ACTIVE_COMPARATOR","The intervention group will receive local intra-arterial (IA) thrombolysis using either tenecteplase at a dose of 0.0625mg\u002Fkg \"maximum dose of 6.25mg\" or alteplase \"0.225 mg\u002Fkg; maximum dose, 20mg.",[13],"Biological: Tenecteplase or Alteplase- depending upon availability at each treating centre",{"label":15,"type":16,"description":17,"interventionNames":18},"No IA thrombolysis","PLACEBO_COMPARATOR","No intra-arterial thrombolysis.",[19],"Other: Control",[21,30],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BIOLOGICAL","Tenecteplase or Alteplase- depending upon availability at each treating centre","Intra-arterial thrombolysis after endovascular therapy",[9],[27,28,29],"Thrombolytic (2 options)","tNKase, Metalyse,","tPA, Activase",{"type":6,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"Control","No intra-arterial thrombolysis after endovascular therapy",[15],null,[36,39],{"name":37,"affiliation":5,"role":38},"Bijoy K Menon, MD","PRINCIPAL_INVESTIGATOR",{"name":40,"affiliation":41,"role":38},"Craig Anderson, MD","The George Institute",[43,47],{"name":37,"role":44,"phone":45,"phoneExt":34,"email":46},"CONTACT","403-944-8107","bkmmenon@ucalgary.ca",{"name":40,"role":44,"phone":45,"phoneExt":34,"email":48},"canderson@georgeinstitute.org.au",[50,68,89,103,115,128,145,160,169,182,195,209,223],{"facility":51,"status":34,"city":52,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"The George Institute for Global Health","Sydney","Barangaroo","NSW 2000","Australia","AU",{"type":58,"coordinates":59},"Point",[60,61],151.20732,-33.86785,{"lat":61,"lon":60},[64,67],{"name":65,"role":44,"phone":34,"phoneExt":34,"email":66},"Xiaoying Chen, PHD","xchen@georgeinstitute.org.au",{"name":40,"role":38,"phone":34,"phoneExt":34,"email":34},{"facility":69,"status":34,"city":70,"state":71,"zip":72,"country":73,"countryCode":74,"cosmosGeoPoint":75,"geoPoint":79,"contacts":80},"University of Calgary- Foothills Medical Centre","Calgary","Alberta","T2N2T9","Canada","CA",{"type":58,"coordinates":76},[77,78],-114.08529,51.05011,{"lat":78,"lon":77},[81,85,88],{"name":82,"role":44,"phone":83,"phoneExt":34,"email":84},"Carol C Kenney, RN","403-944-4286","ckenney@ucalgary.ca",{"name":86,"role":44,"phone":34,"phoneExt":34,"email":87},"Mohammed Almekhlafi, MD","mohammed.almekhlafi1@ucalgary.ca",{"name":86,"role":38,"phone":34,"phoneExt":34,"email":34},{"facility":90,"status":34,"city":91,"state":71,"zip":34,"country":73,"countryCode":74,"cosmosGeoPoint":92,"geoPoint":96,"contacts":97},"University of Alberta","Edmonton",{"type":58,"coordinates":93},[94,95],-113.46871,53.55014,{"lat":95,"lon":94},[98,101],{"name":99,"role":44,"phone":34,"phoneExt":34,"email":100},"Paige Lesoway","fairall@ualberta.ca",{"name":102,"role":38,"phone":34,"phoneExt":34,"email":34},"Brian Buck, MD",{"facility":104,"status":34,"city":105,"state":106,"zip":34,"country":73,"countryCode":74,"cosmosGeoPoint":107,"geoPoint":111,"contacts":112},"Kelowna Regional Hospital","Kelowna","British Columbia",{"type":58,"coordinates":108},[109,110],-119.48568,49.88307,{"lat":110,"lon":109},[113],{"name":114,"role":38,"phone":34,"phoneExt":34,"email":34},"Aleksander Tkach, MD",{"facility":116,"status":34,"city":117,"state":106,"zip":34,"country":73,"countryCode":74,"cosmosGeoPoint":118,"geoPoint":122,"contacts":123},"Royal Columbian Hospital","New Westminster",{"type":58,"coordinates":119},[120,121],-122.91092,49.20678,{"lat":121,"lon":120},[124,126],{"name":125,"role":44,"phone":34,"phoneExt":34,"email":34},"Vishaya Naidoo",{"name":127,"role":38,"phone":34,"phoneExt":34,"email":34},"George Medvedev, MD",{"facility":129,"status":34,"city":130,"state":106,"zip":34,"country":73,"countryCode":74,"cosmosGeoPoint":131,"geoPoint":135,"contacts":136},"University of British Columbia","Vancouver",{"type":58,"coordinates":132},[133,134],-123.11934,49.24966,{"lat":134,"lon":133},[137,140,143],{"name":138,"role":44,"phone":34,"phoneExt":34,"email":139},"Geni Maclean, RN","genoveva@bcstrokecentre.ca",{"name":141,"role":44,"phone":34,"phoneExt":34,"email":142},"Carson Ma, RN","carson.ma@vch.ca",{"name":144,"role":38,"phone":34,"phoneExt":34,"email":34},"Thalia Field, MD",{"facility":146,"status":34,"city":147,"state":148,"zip":34,"country":73,"countryCode":74,"cosmosGeoPoint":149,"geoPoint":153,"contacts":154},"University of Manitoba - Winnipeg Health Science Centre","Winnipeg","Manitoba",{"type":58,"coordinates":150},[151,152],-97.14704,49.8844,{"lat":152,"lon":151},[155,158],{"name":156,"role":44,"phone":34,"phoneExt":34,"email":157},"Nishita Singh, Dr.","nishita.singh@umanitoba.ca",{"name":159,"role":38,"phone":34,"phoneExt":34,"email":34},"Nishita Singh, MD",{"facility":161,"status":34,"city":162,"state":163,"zip":34,"country":73,"countryCode":74,"cosmosGeoPoint":164,"geoPoint":168,"contacts":34},"Health Sciences North Horizon Sante-Nord","Greater Sudbury","Ontario",{"type":58,"coordinates":165},[166,167],-80.99001,46.49,{"lat":167,"lon":166},{"facility":170,"status":34,"city":171,"state":163,"zip":34,"country":73,"countryCode":74,"cosmosGeoPoint":172,"geoPoint":176,"contacts":177},"Ottawa Civic Hospital","Ottawa",{"type":58,"coordinates":173},[174,175],-75.69812,45.41117,{"lat":175,"lon":174},[178,181],{"name":179,"role":44,"phone":34,"phoneExt":34,"email":180},"Dariush Dowlatshahi, MD","ddowlatshahi@toh.ca",{"name":179,"role":38,"phone":34,"phoneExt":34,"email":34},{"facility":183,"status":34,"city":184,"state":163,"zip":34,"country":73,"countryCode":74,"cosmosGeoPoint":185,"geoPoint":189,"contacts":190},"Sunnybrook Health Science Centre","Toronto",{"type":58,"coordinates":186},[187,188],-79.39864,43.70643,{"lat":188,"lon":187},[191,194],{"name":192,"role":44,"phone":34,"phoneExt":34,"email":193},"Richard Swartz, MD","rick.swartz@sunnybrook.ca",{"name":192,"role":38,"phone":34,"phoneExt":34,"email":34},{"facility":196,"status":34,"city":197,"state":198,"zip":34,"country":73,"countryCode":74,"cosmosGeoPoint":199,"geoPoint":203,"contacts":204},"CHUM -Centre Hospitalier de l'Universite de Montreal","Montreal","Quebec",{"type":58,"coordinates":200},[201,202],-73.58781,45.50884,{"lat":202,"lon":201},[205,208],{"name":206,"role":44,"phone":34,"phoneExt":34,"email":207},"Alex Poppe, MD","alexandre.yves.poppe.med@ssss.gouv.qc.ca",{"name":206,"role":38,"phone":34,"phoneExt":34,"email":34},{"facility":210,"status":34,"city":211,"state":198,"zip":34,"country":73,"countryCode":74,"cosmosGeoPoint":212,"geoPoint":216,"contacts":217},"CIUSSS de l'Estrie - CHUS Fleurimont Hôpital (Sherbrooke)","Sherbrooke",{"type":58,"coordinates":213},[214,215],-71.89908,45.40008,{"lat":215,"lon":214},[218,221],{"name":219,"role":44,"phone":34,"phoneExt":34,"email":220},"Caroline Cayer, RN","caroline.cayer.ciussse-chus@ssss.gouv.qc.ca",{"name":222,"role":38,"phone":34,"phoneExt":34,"email":34},"Francois Moreau, MD",{"facility":224,"status":34,"city":225,"state":226,"zip":34,"country":73,"countryCode":74,"cosmosGeoPoint":227,"geoPoint":231,"contacts":34},"Royal University Hospital","Saskatoon","Saskatchewan",{"type":58,"coordinates":228},[229,230],-106.66892,52.13238,{"lat":230,"lon":229},{"type":38,"investigatorFullName":233,"investigatorTitle":234,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"Dr. Bijoy Menon","ACT GLOBAL Principal Investigator, Clinical Professor of Neurology, Section Head, MD",[236],{"name":237,"class":6},"The George Institute for Global Health, Australia","100646679","phase-3-act-global-ia-thrombolysisact-react-004domain-within-the-act-global-adaptive-platform-trial-nct06352632-100646679",false,"NCT07687056","ACT-GLOBAL IA Thrombolysis(ACT-REACT-004)Domain Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632","A Multicentre,Prospective,Randomized,Open Label,Blinded-endpoint Trial for Reperfusion Enhancement After Completing Thrombectomy Using Intraarterial Thrombolysis(REACT-IA-Thrombolysis Domain)Embedded in A Multi-faCtorial,mulTi-arm, Multi-staGe,Randomised,gLOBal Adaptive pLatform Trial for Stroke(ACT-GLOBAL) NCT06352632","ACT-REACT","Inclusion Criteria:\n\n1. Age ≥18 years\n2. Clinical diagnosis of stroke\n\nExclusion Criteria:\n\nThere are no platform level exclusion criteria.","ALL","18 Years",{"count":249,"type":250},1500,"ESTIMATED","INTERVENTIONAL",[253],"PHASE3","Study Design and Duration:\n\nThis domain will be conducted as part of ACT-GLOBAL platform trial and will have the nested domain name of REACT. It has a prospective, randomised, controlled, open-label, parallel group with blinded endpoint assessment (PROBE) design of up to 1,500 subjects with Acute Ischemic Stroke (AIS) who undergo EVT. Randomisation will be stratified by country\u002F region, and the IA thrombolytic agent (tenecteplase or alteplase). Minimal sufficient balance algorithm will operate within each stratum to preserve balance on key covariates while maintaining allocation randomness.\n\nParticipants will be followed for 90 days (or until death, if prior to 90 days). The end of the trial is defined as the date that all participants have completed their Day 90 assessment. Primary outcome data will be determined by simplified, structured method of assessment using the modified Rankin scale (mRS), conducted through centralized telephone interviews or online media performed by central trial personnel blinded to treatment assignment and received.\n\nDomain Interventions:\n\nThe intervention group will receive a single dose of local intraarterial thrombolysis using either tenecteplase (at a dose of 0.0625mg\u002Fkg; maximum dose of 6.25mg) or alteplase (0.225 mg\u002Fkg; maximum dose, 20mg) at the end of EVT procedure plus standard of care while the control group will receive standard of care alone. The selection of the thrombolytic agent will be determined according to local availability. The dose of intraarterial thrombolysis will be increased if the above dose meets prespecified posterior probabilities at the first or second interims.\n\nIn all eligible patients:\n\n1. Local intra-arterial thrombolysis using either tenecteplase at a dose of 0.0625mg\u002Fkg \"maximum dose of 6.25mg\" or alteplase \"0.225 mg\u002Fkg; maximum dose, 20mg\\*\n2. No intra-arterial thrombolysis.\n\n   * The dose of IA thrombolysis may be doubled to 0.125 mg\u002Fkg tenecteplase or 0.45 mg\u002Fkg alteplase if this dose shows futility at pre-specified interims Randomization will be stratified by country\u002F region, the IA thrombolytic agent used (tenecteplase or alteplase). IA thrombolysis will be administered as a one-time treatment.",[256,257,258],"Stroke, Acute Ischemic","Endovascular Thrombectomy","Acute Ischemic Stroke AIS",[260,261,262,263,257,264,265,266,267],"Tenecteplase","Alteplase","Intra-arterial thrombolysis","Stroke","EVT","Domain","Platform","Thrombolysis","NOT_YET_RECRUITING","2026-06-29",{"date":271,"type":272},"2026-07-07","ACTUAL",{"date":274,"type":250},"2026-06-10",{"date":276,"type":250},"2031-03-31",{"name":5,"class":6},13]