[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636847":3},{"organization":4,"outcomesModule":7,"designInfo":99,"detailedDescription":98,"studyPopulation":98,"armGroups":111,"interventions":124,"overallOfficials":133,"centralContacts":137,"locations":143,"responsibleParty":843,"collaborators":98,"id":845,"slug":846,"hasResults":847,"nctId":848,"briefTitle":849,"officialTitle":850,"acronym":851,"eligibilityCriteria":852,"healthyVolunteers":847,"sex":853,"minAge":854,"maxAge":98,"enrollmentInfo":855,"targetDuration":98,"studyType":858,"phases":859,"briefSummary":861,"conditions":862,"keywords":98,"overallStatus":146,"whyStopped":98,"lastUpdateSubmitDate":866,"lastUpdatePostDateStruct":867,"startDateStruct":870,"completionDateStruct":872,"leadSponsor":874,"locationsCount":875},{"fullName":5,"class":6},"Novo Nordisk A\u002FS","INDUSTRY",{"primaryOutcomes":8,"secondaryOutcomes":16,"otherOutcomes":98},[9,13],{"measure":10,"description":11,"timeFrame":12},"Relative change in body weight","Measured as percentage (%) change in body weight.","From baseline (week 0) to (week 80)",{"measure":14,"description":15,"timeFrame":12},"Change in apnoea-hypopnoea index (AHI)","Measured as events\u002Fhour.",[17,20,23,26,29,32,35,38,41,44,47,49,51,53,55,58,61,64,67,70,73,75,77,79,81,83,86,89,93,96],{"measure":18,"description":19,"timeFrame":12},"Relative change in AHI","Measured as percentage change in AHI.",{"measure":21,"description":22,"timeFrame":12},"Achievement of 50% reduction in AHI (Yes\u002FNo)","Measured as number of participant.",{"measure":24,"description":25,"timeFrame":12},"Achievement of: AHI less than (\u003C) 5","Measured as number of participants.",{"measure":27,"description":28,"timeFrame":12},"Achievement of: AHI 5-14 with Epworth Sleepiness Scale (ESS) ≤ 10 (Yes\u002FNo)","Measures as number of participants",{"measure":30,"description":31,"timeFrame":12},"Change in sleep apnoea specific hypoxic burden (SASHB)","Measured as percentage minutes per hour (%min\u002Fh).",{"measure":33,"description":34,"timeFrame":12},"Change in ESS score","Measured as score on a scale. ESS measures the level of daytime sleepiness or average sleep propensity. The measure consists of 8 items yielding one total score. Total score ranges from 0-24. Higher scores indicate higher sleepiness or average sleep propensity in daily life.",{"measure":36,"description":37,"timeFrame":12},"Change in Patient-Reported Outcomes Measurement Information System (PROMIS) Short Form v1.0 Sleep-Related Impairment 8a score","Measured as score on a scale. PROMIS-SRI measures perceptions of alertness, sleepiness, and tiredness during usual waking hours, and the perceived functional impairments during wakefulness associated with sleep problems or impaired alertness. The measure consists of 8 items each rated on a 5-point scale ranging from \"not at all\" to \"very much\". Individual item scores will be combined and converted to a T-score using a response pattern scoring approach. The T-score standardises the raw score to a distribution with a mean of 50 and standard deviation of 10. Total score (T-score range): Sleep-related impairment (ranging approximately from 30-80.1). Higher scores indicate more sleep-related impairment.",{"measure":39,"description":40,"timeFrame":12},"Change in PROMIS Short Form v1.0 Sleep Disturbance 8b score","Measured as score on a scale. PROMIS-SD measures perceptions of sleep quality, sleep depth, and restoration associated with sleep. The measure consists of 8 items each rated on a 5-point scale ranging from \"not at all\" to \"very much,\" \"never\" to \"always,\" or \"very poor\" to \"very good\". Individual item scores will be combined and converted to a T-score using a response pattern scoring approach. The T-score standardises the raw score to a distribution with a mean of 50 and standard deviation of 10. Total score (T-score range): Sleep disturbance (ranging approximately from 30-80.1).\n\nHigher scores indicate more sleep disturbance.",{"measure":42,"description":43,"timeFrame":12},"Change in body weight","Measured as kilogram (Kg).",{"measure":45,"description":46,"timeFrame":12},"Change in body mass index (BMI)","Measured as kilograms per meter square (kg\u002Fm\\^2).",{"measure":48,"description":25,"timeFrame":12},"Improvement in obstructive sleep apnoea (OSA) severity category: AHI \u003C 5\u002Fhour = normal (Yes\u002FNo)",{"measure":50,"description":25,"timeFrame":12},"Improvement in obstructive sleep apnoea (OSA) severity category: ≥ 5 and \u003C 15\u002Fhour = mild (Yes\u002FNo)",{"measure":52,"description":25,"timeFrame":12},"Improvement in obstructive sleep apnoea (OSA) severity category: ≥ 15 and \u003C 30\u002Fhour = moderate (Yes\u002FNo)",{"measure":54,"description":25,"timeFrame":12},"Improvement in obstructive sleep apnoea (OSA) severity category: ≥ 30\u002Fhour = 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reduced-calorie diet and increased physical activity.",[123],"Drug: Placebo (matched to NNC0487-0111)",[125,129],{"type":126,"name":113,"description":127,"armGroupLabels":128,"otherNames":98},"DRUG","NNC0487-0111 will be administered subcutaneously using PDS290 pre-filled pen-injectors to one of the body parts: thigh, abdomen or upper arm.",[113],{"type":126,"name":130,"description":131,"armGroupLabels":132,"otherNames":98},"Placebo (matched to NNC0487-0111)","Placebo matched to NNC0487-0111 will be administered subcutaneously using PDS290 pre-filled pen-injectors to one of the body parts: thigh, abdomen or upper arm.",[119],[134],{"name":135,"affiliation":5,"role":136},"Clinical Transparency dept. 2834","STUDY_DIRECTOR",[138],{"name":139,"role":140,"phone":141,"phoneExt":98,"email":142},"Novo Nordisk","CONTACT","(+1) 866-867-7178","clinicaltrials@novonordisk.com",[144,158,168,178,187,197,206,216,225,235,245,255,264,269,278,287,296,306,318,328,337,347,357,369,379,388,397,407,418,427,438,447,456,465,474,483,496,505,515,525,535,544,554,564,574,584,594,603,610,622,631,637,646,652,661,670,676,682,688,700,710,719,728,737,746,754,760,769,780,789,795,801,810,815,819,823,827,831,835,839],{"facility":145,"status":146,"city":147,"state":148,"zip":149,"country":150,"countryCode":151,"cosmosGeoPoint":152,"geoPoint":157,"contacts":98},"Artemis Insitute for Clin Res","RECRUITING","San Diego","California","92123","United States","US",{"type":153,"coordinates":154},"Point",[155,156],-117.16472,32.71571,{"lat":156,"lon":155},{"facility":159,"status":146,"city":160,"state":161,"zip":162,"country":150,"countryCode":151,"cosmosGeoPoint":163,"geoPoint":167,"contacts":98},"PharmaDev Clinical Research Institute LLC","Miami","Florida","33176",{"type":153,"coordinates":164},[165,166],-80.19366,25.77427,{"lat":166,"lon":165},{"facility":169,"status":170,"city":171,"state":161,"zip":172,"country":150,"countryCode":151,"cosmosGeoPoint":173,"geoPoint":177,"contacts":98},"Essence MD Research","NOT_YET_RECRUITING","Naples","34102",{"type":153,"coordinates":174},[175,176],-81.79596,26.14234,{"lat":176,"lon":175},{"facility":179,"status":146,"city":180,"state":161,"zip":181,"country":150,"countryCode":151,"cosmosGeoPoint":182,"geoPoint":186,"contacts":98},"Renstar Medical Research","Ocala","34470",{"type":153,"coordinates":183},[184,185],-82.14009,29.1872,{"lat":185,"lon":184},{"facility":188,"status":146,"city":189,"state":190,"zip":191,"country":150,"countryCode":151,"cosmosGeoPoint":192,"geoPoint":196,"contacts":98},"Conquest Research","Atlanta","Georgia","30328",{"type":153,"coordinates":193},[194,195],-84.38798,33.749,{"lat":195,"lon":194},{"facility":198,"status":146,"city":199,"state":190,"zip":200,"country":150,"countryCode":151,"cosmosGeoPoint":201,"geoPoint":205,"contacts":98},"Physicians Research Associates","Lawrenceville","30046",{"type":153,"coordinates":202},[203,204],-83.98796,33.95621,{"lat":204,"lon":203},{"facility":207,"status":146,"city":208,"state":209,"zip":210,"country":150,"countryCode":151,"cosmosGeoPoint":211,"geoPoint":215,"contacts":98},"University Of Chicago","Chicago","Illinois","60637",{"type":153,"coordinates":212},[213,214],-87.65005,41.85003,{"lat":214,"lon":213},{"facility":217,"status":146,"city":218,"state":218,"zip":219,"country":150,"countryCode":151,"cosmosGeoPoint":220,"geoPoint":224,"contacts":98},"Weil Cornell Medicine","New York","10021",{"type":153,"coordinates":221},[222,223],-74.00597,40.71427,{"lat":223,"lon":222},{"facility":226,"status":146,"city":227,"state":228,"zip":229,"country":150,"countryCode":151,"cosmosGeoPoint":230,"geoPoint":234,"contacts":98},"CTI Clinical Research Center","Cincinnati","Ohio","45212",{"type":153,"coordinates":231},[232,233],-84.51439,39.12711,{"lat":233,"lon":232},{"facility":236,"status":170,"city":237,"state":238,"zip":239,"country":150,"countryCode":151,"cosmosGeoPoint":240,"geoPoint":244,"contacts":98},"Clinical Research Associates of Central PA, LLC","DuBois","Pennsylvania","15801",{"type":153,"coordinates":241},[242,243],-78.76003,41.11923,{"lat":243,"lon":242},{"facility":246,"status":146,"city":247,"state":248,"zip":249,"country":150,"countryCode":151,"cosmosGeoPoint":250,"geoPoint":254,"contacts":98},"Epic Medical Research","DeSoto","Texas","75115",{"type":153,"coordinates":251},[252,253],-96.85695,32.58986,{"lat":253,"lon":252},{"facility":256,"status":146,"city":257,"state":248,"zip":258,"country":150,"countryCode":151,"cosmosGeoPoint":259,"geoPoint":263,"contacts":98},"Advanced Neurology Epilepsy and Sleep Center ANESC","El Paso","79912",{"type":153,"coordinates":260},[261,262],-106.48693,31.75872,{"lat":262,"lon":261},{"facility":265,"status":146,"city":257,"state":248,"zip":258,"country":150,"countryCode":151,"cosmosGeoPoint":266,"geoPoint":268,"contacts":98},"Biorhythms Center for Integrative Sleep Medicine",{"type":153,"coordinates":267},[261,262],{"lat":262,"lon":261},{"facility":270,"status":146,"city":271,"state":248,"zip":272,"country":150,"countryCode":151,"cosmosGeoPoint":273,"geoPoint":277,"contacts":98},"Houston Pulm Med Res Network","Houston","77089",{"type":153,"coordinates":274},[275,276],-95.36327,29.76328,{"lat":276,"lon":275},{"facility":279,"status":146,"city":280,"state":248,"zip":281,"country":150,"countryCode":151,"cosmosGeoPoint":282,"geoPoint":286,"contacts":98},"Sleep Therapy Research Center","San Antonio","78229",{"type":153,"coordinates":283},[284,285],-98.49363,29.42412,{"lat":285,"lon":284},{"facility":288,"status":146,"city":289,"state":248,"zip":290,"country":150,"countryCode":151,"cosmosGeoPoint":291,"geoPoint":295,"contacts":98},"Tricoastal Sleep Center","Sugar Land","77478",{"type":153,"coordinates":292},[293,294],-95.63495,29.61968,{"lat":294,"lon":293},{"facility":297,"status":146,"city":298,"state":299,"zip":300,"country":150,"countryCode":151,"cosmosGeoPoint":301,"geoPoint":305,"contacts":98},"Rainier Clin Res Ctr Inc","Renton","Washington","98057",{"type":153,"coordinates":302},[303,304],-122.21707,47.48288,{"lat":304,"lon":303},{"facility":307,"status":146,"city":308,"state":309,"zip":310,"country":311,"countryCode":312,"cosmosGeoPoint":313,"geoPoint":317,"contacts":98},"Woolcock Institute","Macquarie Park","New South Wales","2113","Australia","AU",{"type":153,"coordinates":314},[315,316],151.12757,-33.78105,{"lat":316,"lon":315},{"facility":319,"status":146,"city":320,"state":321,"zip":322,"country":311,"countryCode":312,"cosmosGeoPoint":323,"geoPoint":327,"contacts":98},"University of Sunshine Coast - Vitality Village","Birtinya","Queensland","4575",{"type":153,"coordinates":324},[325,326],153.11913,-26.74322,{"lat":326,"lon":325},{"facility":329,"status":170,"city":330,"state":321,"zip":331,"country":311,"countryCode":312,"cosmosGeoPoint":332,"geoPoint":336,"contacts":98},"Mater Research - RIO Clinical Trials Unit","South Brisbane","4101",{"type":153,"coordinates":333},[334,335],153.02049,-27.48034,{"lat":335,"lon":334},{"facility":338,"status":146,"city":339,"state":340,"zip":341,"country":311,"countryCode":312,"cosmosGeoPoint":342,"geoPoint":346,"contacts":98},"Nightingale Research Adelaide","Adelaide","South Australia","5000",{"type":153,"coordinates":343},[344,345],138.59863,-34.92866,{"lat":345,"lon":344},{"facility":348,"status":146,"city":349,"state":350,"zip":351,"country":311,"countryCode":312,"cosmosGeoPoint":352,"geoPoint":356,"contacts":98},"University of Western Australia - Centre for Sleep Science","Crawley","Western Australia","6009",{"type":153,"coordinates":353},[354,355],115.81603,-31.98418,{"lat":355,"lon":354},{"facility":358,"status":146,"city":359,"state":360,"zip":361,"country":362,"countryCode":363,"cosmosGeoPoint":364,"geoPoint":368,"contacts":98},"Peking University People's Hospital-Endocrinology","Beijing","Beijing Municipality","100044","China","CN",{"type":153,"coordinates":365},[366,367],116.39723,39.9075,{"lat":367,"lon":366},{"facility":370,"status":146,"city":371,"state":372,"zip":373,"country":362,"countryCode":363,"cosmosGeoPoint":374,"geoPoint":378,"contacts":98},"The Second Affiliated Hospital of Nanjing Medical University-Endocrinology","Nanjing","Jiangsu","210011",{"type":153,"coordinates":375},[376,377],118.77778,32.06167,{"lat":377,"lon":376},{"facility":380,"status":146,"city":381,"state":372,"zip":382,"country":362,"countryCode":363,"cosmosGeoPoint":383,"geoPoint":387,"contacts":98},"The First Affiliated Hospital of Soochow University-Endocrinology","Suzhou","215006",{"type":153,"coordinates":384},[385,386],120.59538,31.30408,{"lat":386,"lon":385},{"facility":389,"status":146,"city":390,"state":372,"zip":391,"country":362,"countryCode":363,"cosmosGeoPoint":392,"geoPoint":396,"contacts":98},"The Affiliated Hospital of Jiangsu University-Endocrinology","Zhenjiang","212001",{"type":153,"coordinates":393},[394,395],119.45508,32.21086,{"lat":395,"lon":394},{"facility":398,"status":146,"city":399,"state":400,"zip":401,"country":362,"countryCode":363,"cosmosGeoPoint":402,"geoPoint":406,"contacts":98},"Huzhou Central Hospital-Endocrinology","Huzhou","Zhejiang","313000",{"type":153,"coordinates":403},[404,405],120.0933,30.8703,{"lat":405,"lon":404},{"facility":408,"status":146,"city":409,"state":98,"zip":410,"country":411,"countryCode":412,"cosmosGeoPoint":413,"geoPoint":417,"contacts":98},"Regionshospitalet Gødstrup, Øre-næse-hals-kirurgisk","Herning","7400","Denmark","DK",{"type":153,"coordinates":414},[415,416],8.97662,56.13615,{"lat":416,"lon":415},{"facility":419,"status":146,"city":420,"state":98,"zip":421,"country":411,"countryCode":412,"cosmosGeoPoint":422,"geoPoint":426,"contacts":98},"Sjællands Universitetshospital, Køge - Øre-Næse-Hals afdeling","Køge","4600",{"type":153,"coordinates":423},[424,425],12.18214,55.45802,{"lat":425,"lon":424},{"facility":428,"status":146,"city":429,"state":98,"zip":430,"country":431,"countryCode":432,"cosmosGeoPoint":433,"geoPoint":437,"contacts":98},"Siteworks GmbH Bochum","Bochum","44787","Germany","DE",{"type":153,"coordinates":434},[435,436],7.21648,51.48165,{"lat":436,"lon":435},{"facility":439,"status":146,"city":440,"state":98,"zip":441,"country":431,"countryCode":432,"cosmosGeoPoint":442,"geoPoint":446,"contacts":98},"Wendisch - Dahl Hamburg - DZHW","Hamburg","22607",{"type":153,"coordinates":443},[444,445],9.99302,53.55073,{"lat":445,"lon":444},{"facility":448,"status":146,"city":449,"state":98,"zip":450,"country":431,"countryCode":432,"cosmosGeoPoint":451,"geoPoint":455,"contacts":98},"Siteworks GmbH 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Rose","Münster","48145",{"type":153,"coordinates":470},[471,472],7.62571,51.96236,{"lat":472,"lon":471},{"facility":475,"status":146,"city":476,"state":98,"zip":477,"country":431,"countryCode":432,"cosmosGeoPoint":478,"geoPoint":482,"contacts":98},"Siteworks GmbH - Prüfzentrum Schleswig | RespiRatio","Schleswig","24837",{"type":153,"coordinates":479},[480,481],9.56829,54.52021,{"lat":481,"lon":480},{"facility":484,"status":485,"city":486,"state":487,"zip":488,"country":489,"countryCode":490,"cosmosGeoPoint":491,"geoPoint":495,"contacts":98},"Guntur Government medical College","COMPLETED","Guntur","Andhra Pradesh","522004,","India","IN",{"type":153,"coordinates":492},[493,494],80.45729,16.29974,{"lat":494,"lon":493},{"facility":497,"status":146,"city":498,"state":487,"zip":499,"country":489,"countryCode":490,"cosmosGeoPoint":500,"geoPoint":504,"contacts":98},"Government Siddhartha Medical College & Government General Hospital, Vijayawada","Vijayawada","520008",{"type":153,"coordinates":501},[502,503],80.6466,16.50745,{"lat":503,"lon":502},{"facility":506,"status":146,"city":507,"state":508,"zip":509,"country":489,"countryCode":490,"cosmosGeoPoint":510,"geoPoint":514,"contacts":98},"Rajarajeswari Medical College and Hospital","Bengaluru","Karnataka","560074",{"type":153,"coordinates":511},[512,513],77.59369,12.97194,{"lat":513,"lon":512},{"facility":516,"status":146,"city":517,"state":518,"zip":519,"country":489,"countryCode":490,"cosmosGeoPoint":520,"geoPoint":524,"contacts":98},"Amrita Institute Of Medical Sciences & Research Centre","Kochi","Kerala","682041",{"type":153,"coordinates":521},[522,523],76.26022,9.93988,{"lat":523,"lon":522},{"facility":526,"status":146,"city":527,"state":528,"zip":529,"country":489,"countryCode":490,"cosmosGeoPoint":530,"geoPoint":534,"contacts":98},"Bhaktivedanta Hospital & Research 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Bhubaneswar","Bhubaneswar","Odisha","751019",{"type":153,"coordinates":560},[561,562],85.83385,20.27241,{"lat":562,"lon":561},{"facility":565,"status":485,"city":566,"state":567,"zip":568,"country":489,"countryCode":490,"cosmosGeoPoint":569,"geoPoint":573,"contacts":98},"Yashoda Hospital","Hyderabad","Telangana","500084",{"type":153,"coordinates":570},[571,572],78.45636,17.38405,{"lat":572,"lon":571},{"facility":575,"status":146,"city":576,"state":577,"zip":578,"country":489,"countryCode":490,"cosmosGeoPoint":579,"geoPoint":583,"contacts":98},"Midland Healthcare & Research Center","Lucknow","Uttar Pradesh","226006",{"type":153,"coordinates":580},[581,582],80.92313,26.83928,{"lat":582,"lon":581},{"facility":585,"status":146,"city":586,"state":587,"zip":588,"country":489,"countryCode":490,"cosmosGeoPoint":589,"geoPoint":593,"contacts":98},"Apollo Multispeciality Hospital, Kolkata","Kolkata","West 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Once-weekly in Participants With Overweight or Obesity, and Obstructive Sleep Apnoea Not Treated With Positive Airway Pressure (AMAZE 3)","AMAZE 3","Key Inclusion Criteria:\n\n* Male or female (sex at birth)\n* Age 18 years or above at the time of signing informed consent\n* Previously diagnosed moderate-to-severe OSA with an AHI ≥ 15, as diagnosed with polysomnography (PSG), home sleep apnoea test (HSAT), or other method that meets local guidelines prior to screening\n\nKey Exclusion Criteria:\n\n* Glycated haemoglobin (HbA1c) ≥ 6.5% (48 mmol\u002Fmol) as measured by the central laboratory at screening\n* History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records\n* Any planned or previous surgery within 90 days prior to screening for sleep apnoea, including septoplasty, turbinoplasty, or other ear, nose, and throat surgeries, including tonsillectomy and adenoidectomy\n* Significant craniofacial abnormalities that may affect breathing at baseline, for example Treacher Collins syndrome and Pierre Robin Sequence\n* Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonist (RA), dual GLP-1\u002Fgastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues before screening","ALL","18 Years",{"count":856,"type":857},300,"ESTIMATED","INTERVENTIONAL",[860],"PHASE3","This study is being done to look at the efficacy and safety of NNC0487-0111 in participants with excess body weight and obstructive sleep apnoea not treated with positive airway pressure lose weight and improve sleep apnoea. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111, (the treatment being tested) or Placebo (a treatment that has no active medicine in it) and which treatment participants get is decided by chance.",[863,864,865],"Obesity","Overweight","Obstructive Sleep Apnoea","2026-09-10",{"date":868,"type":869},"2026-09-11","ACTUAL",{"date":871,"type":869},"2026-05-05",{"date":873,"type":857},"2028-10-04",{"name":5,"class":6},80]