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Maria Children Emergency Clinical Hospital Iasi","Iași","700309",{"type":59,"coordinates":635},[636,637],27.6,47.16667,{"lat":637,"lon":636},[640],{"name":641,"role":92,"phone":34,"phoneExt":34,"email":34},"Ioana Grigore",{"facility":643,"status":76,"city":644,"state":34,"zip":645,"country":646,"countryCode":647,"cosmosGeoPoint":648,"geoPoint":652,"contacts":653},"Mother and Child Health Care Institute of Serbia Dr Vukan Cupic","Belgrade","11000","Serbia","RS",{"type":59,"coordinates":649},[650,651],20.46513,44.80401,{"lat":651,"lon":650},[654],{"name":655,"role":92,"phone":34,"phoneExt":34,"email":34},"Biljana Vucetic Tadic",{"facility":657,"status":76,"city":658,"state":34,"zip":659,"country":646,"countryCode":647,"cosmosGeoPoint":660,"geoPoint":664,"contacts":665},"University Clinical Center Nis","Niš","18 000",{"type":59,"coordinates":661},[662,663],21.90333,43.32472,{"lat":663,"lon":662},[666],{"name":667,"role":92,"phone":34,"phoneExt":34,"email":34},"Tatjana Tosic",{"facility":669,"status":76,"city":670,"state":34,"zip":671,"country":646,"countryCode":647,"cosmosGeoPoint":672,"geoPoint":676,"contacts":677},"Children and Youth Health Care Institute of Vojvodina","Novi Sad","21000",{"type":59,"coordinates":673},[674,675],19.83694,45.25167,{"lat":675,"lon":674},[678],{"name":679,"role":92,"phone":34,"phoneExt":34,"email":34},"Tatjana Redzek Mudrinic",{"facility":681,"status":76,"city":682,"state":34,"zip":683,"country":684,"countryCode":685,"cosmosGeoPoint":686,"geoPoint":690,"contacts":691},"Hospital de La Santa Creu i Sant Pau","Barcelona","08025","Spain","ES",{"type":59,"coordinates":687},[688,689],2.15899,41.38879,{"lat":689,"lon":688},[692],{"name":693,"role":92,"phone":34,"phoneExt":34,"email":34},"Alba Sierra-Marcos",{"facility":695,"status":76,"city":682,"state":34,"zip":696,"country":684,"countryCode":685,"cosmosGeoPoint":697,"geoPoint":699,"contacts":700},"Hospital Universitario Vall d'Hebron - PPDS","08035",{"type":59,"coordinates":698},[688,689],{"lat":689,"lon":688},[701],{"name":702,"role":92,"phone":34,"phoneExt":34,"email":34},"Manuel Toledo Argany",{"facility":704,"status":76,"city":705,"state":34,"zip":706,"country":684,"countryCode":685,"cosmosGeoPoint":707,"geoPoint":711,"contacts":712},"Hospital Infantil Universitario Niño Jesus - PIN","Madrid","28009",{"type":59,"coordinates":708},[709,710],-3.70256,40.4165,{"lat":710,"lon":709},[713],{"name":714,"role":92,"phone":34,"phoneExt":34,"email":34},"Victor Soto Insuga",{"facility":716,"status":76,"city":717,"state":34,"zip":718,"country":684,"countryCode":685,"cosmosGeoPoint":719,"geoPoint":723,"contacts":724},"Hospital Regional Universitario de Malaga - Hospital General","Málaga","29010",{"type":59,"coordinates":720},[721,722],-4.42034,36.72016,{"lat":722,"lon":721},[725],{"name":726,"role":92,"phone":34,"phoneExt":34,"email":34},"Pedro Serrano",{"facility":728,"status":76,"city":729,"state":34,"zip":730,"country":684,"countryCode":685,"cosmosGeoPoint":731,"geoPoint":735,"contacts":736},"Hospital Universitario de Navarra","Pamplona","31008",{"type":59,"coordinates":732},[733,734],-1.64323,42.81687,{"lat":734,"lon":733},[737],{"name":738,"role":92,"phone":34,"phoneExt":34,"email":34},"Sergio Aguilera Albesa",{"facility":740,"status":76,"city":741,"state":34,"zip":742,"country":684,"countryCode":685,"cosmosGeoPoint":743,"geoPoint":747,"contacts":748},"Centro de Neurologia Avanzada","Seville","41013",{"type":59,"coordinates":744},[745,746],-5.97317,37.38283,{"lat":746,"lon":745},[749],{"name":750,"role":92,"phone":34,"phoneExt":34,"email":34},"Juan Jesús Rodríguez Uranga, MD",{"type":752,"investigatorFullName":34,"investigatorTitle":34,"investigatorAffiliation":34,"oldNameTitle":34,"oldOrganization":34},"SPONSOR",[754],{"name":38,"class":6},"100444345","phase-3-an-efficacy-and-safety-study-of-clemizole-hcl-in-patients-with-lennox-gastaut-syndrome-100444345",false,"NCT05066217","An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut Syndrome","Multicenter, Randomized, Double-blind, Placebo-controlled Trial of Clemizole HCl as Adjunctive Therapy in Patients With Lennox-Gastaut Syndrome","Key Inclusion Criteria:\n\n1. Males or females, ages ≥2 to ≤55 years, at the time of Screening.\n2. Participant\u002Fparent\u002Flegal authorized representative (LAR) willing and able to give written informed consent\u002Fassent.\n3. Diagnosis of LGS, including:\n\n   * Evidence of at least one type of countable major motor seizure.\n   * History of electroencephalogram (EEG) consistent with LGS (abnormal background activity, and one of the following: 1) slow spike-wave discharges \\[\\\u003C2.5 Hz\\], or 2) paroxysmal fast activity during sleep).\n   * Abnormal cognitive development.\n   * Onset of seizures at 11 years of age or younger.\n\nKey Exclusion Criteria:\n\n1. Known sensitivity, allergy, or previous exposure to clemizole HCl.\n2. Known history of long QT syndrome or any significant history of a serious abnormality of the electrocardiogram (ECG) (e.g., recent myocardial infarction, clinically significant arrhythmia).\n3. Family history of sudden cardiac death, unexplained death, or death from a primary dysrhythmia potentially associated with QT prolongation in any family member.\n4. Seizures secondary to illicit drug or alcohol use, infection, neoplasm, demyelinating disease, degenerative neurological disease, or progressive central nervous system disease, metabolic illness, recent anoxic episode within the last 6 months requiring resuscitation, or progressive degenerative disease or any other condition, which in the opinion of the investigator, could affect seizure control.\n5. Epilepsy surgery planned during the study or epilepsy surgery within 6 months prior to Screening.\n6. Concomitant use of fenfluramine.\n7. Prior or concomitant use of lorcaserin.","ALL","2 Years","55 Years",{"count":766,"type":767},260,"ESTIMATED","INTERVENTIONAL",[770],"PHASE3","This is a multicenter, Phase 3, randomized, double-blind, placebo-controlled study designed to evaluate the efficacy and safety of clemizole HCL (EPX-100) as adjunctive therapy in children and adult participants with Lennox-Gastaut syndrome (LGS).",[773],"Lennox Gastaut Syndrome",[773,775,776,26,777],"Lennox-Gastaut Syndrome","LGS","Seizure","2026-08-19",{"date":780,"type":781},"2026-08-21","ACTUAL",{"date":783,"type":781},"2025-04-09",{"date":785,"type":767},"2029-11-01",{"name":5,"class":6},55]