[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630354":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":41,"responsibleParty":58,"collaborators":26,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":26,"eligibilityCriteria":68,"healthyVolunteers":64,"sex":69,"minAge":70,"maxAge":26,"enrollmentInfo":71,"targetDuration":26,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":86,"whyStopped":26,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Cairo University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"AWBT plus antihistamines","EXPERIMENTAL","All patients will take desloratadine 10 mg at four-fold dose daily The AWBT test group patients will receive 8 doses of autologous whole blood therapy (AWBT) once weekly. The first dose will be 2.5ml and subsequent doses will be 5ml of venous blood, which will be drawn from any accessible vein under aseptic precautions. The blood will be re-injected immediately by deep intramuscular injection (IM) on alternate gluteal regions.",[13,14],"Biological: Autologous whole blood therapy","Drug: Desloratadine",{"label":16,"type":17,"description":18,"interventionNames":19},"antihistamines alone","ACTIVE_COMPARATOR","All patients will take desloratadine 10 mg at four-fold dose daily",[14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BIOLOGICAL","Autologous whole blood therapy","The AWBT test group patients will receive 8 doses of autologous whole blood therapy (AWBT) once weekly. The first dose will be 2.5ml and subsequent doses will be 5ml of venous blood, which will be drawn from any accessible vein under aseptic precautions. The blood will be re-injected immediately by deep intramuscular injection (IM) on alternate gluteal regions.",[9],null,{"type":28,"name":29,"description":18,"armGroupLabels":30,"otherNames":26},"DRUG","Desloratadine",[9,16],[32,37],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Sarah Elsayed, MSc, MBBCh","CONTACT","00201094077370","sarahelsaid651@gmail.com",{"name":38,"role":34,"phone":39,"phoneExt":26,"email":40},"Ahmed Mourad, MD","00201021534245","ahmedmourad@kasralainy.edu.eg",[42],{"facility":43,"status":26,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Faculty of Medicine, Cairo university","Cairo","Cairo Governorate","11553","Egypt","EG",{"type":50,"coordinates":51},"Point",[52,53],31.24967,30.06263,{"lat":53,"lon":52},[56,57],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},{"name":38,"role":34,"phone":26,"phoneExt":26,"email":40},{"type":59,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Sarah Elsayed Mahmoud Awad","Assistent lecturer","100630354","phase-3-autologous-whole-blood-therapy-in-chronic-idiopathic-urticaria-patients-100630354",false,"NCT07486583","Autologous Whole Blood Therapy in Chronic Idiopathic Urticaria Patients.","Autologous Whole Blood Therapy in Autologous Serum Skin Test (ASST) Positive and Negative Chronic Idiopathic Urticaria Patients, a Clinical and Biochemical Randomized Controlled Trial.","Inclusion Criteria:\n\nChronic idiopathic urticaria patients of both sexes aging 18 years of age or older who are unresponsive to four-fold of antihistamines.\n\nExclusion Criteria:\n\n1. other types of chronic urticaria\n2. Pregnancy\n3. Lactation\n4. Immunocompromised patients\n5. Patients on Systemic corticosteroid or immunosuppressive drugs used in the past 6 weeks\n6. History of Bronchial Asthma\n7. Patients on anticoagulants\n8. Patients on non-steroidal anti-inflammatory drugs","ALL","18 Years",{"count":72,"type":73},40,"ESTIMATED","INTERVENTIONAL",[76],"PHASE3","To evaluate the efficacy of Autologous Whole Blood Therapy versus conventional treatment using fourfold dose of antihistamines in Autologus serum skin test (ASST) positive and negative Chronic Idiopathic Urticaria (CIU) patients and suggest its possible mechanism of action.",[79],"Chronic Idiopathic Urticaria",[81,82,83,84,85],"chronic idiopathic urticaria","antihistamines","desloratadine","autologous serum skin test","autologous whole blood therpy","NOT_YET_RECRUITING","2026-03-18",{"date":89,"type":90},"2026-03-20","ACTUAL",{"date":92,"type":73},"2026-04-30",{"date":94,"type":73},"2026-11-30",{"name":5,"class":6},1]