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Criteria:\n\n* age between 18 - 80 years' old\n* female\\* and male\n\n  * ≥ 1 risk factor of aspiration of gastric contents defined as\n  * preoperative fasting period of less than 6 hours,\n  * occlusive syndrome, functional ileus, vomiting episode within the last 12 hours,\n  * orthopaedic trauma within the last 12 hours,\n  * medical history of symptomatic gastroesophageal reflux or hiatus, hernia or gastroparesis or dysautonomia or gastroesophageal surgery with sphincter dysfunction)\n* patient requiring orotracheal intubation during general anaesthesia in the operating room.\n* patient or his\u002Fher next of kin written informed consent or emergency procedure\n* failure to discontinue GLP1 analogue as recommended (exenatide, liraglutide, albiglutide, taspoglutide, lixisenatide)\n\nExclusion Criteria:\n\n* predicted impossible tracheal intubation (≥ 1 of the following criteria: patient with known intubation complications, Mallampati score IV, Thyromental Distance ≤ 4.0 cm, Mouth Opening \\\u003C 3 cm, Sternomental Distance \\\u003C 12.5 cm, significant modification of the airway due to congenital, cancer, trauma or burning lesions (non-exhaustive list)) \\[30\\]\n* preoperative arterial hypotension (MAP \\\u003C 65 mmHg or under catecholamine)\n* preoperative respiratory distress syndrome (SpO2 \\\u003C 90% in room air)\n* contraindications to the use of ketamine and\u002For propofol and\u002For NMB:\n\n  * allergy to the active substance or to one of the excipients or to soy or peanuts,\n  * porphyria\n  * intracranial hypertension\n  * uncontrolled arterial hypertension (systolic arterial pressure \\> 180 mmHg)\n  * personal or family history of known malignant hyperthermia, congenital muscular dystrophy, myasthenia, a known congenital deficit in plasma pseudocholinesterase\n* pregnancy or breast-feeding woman\n* patients under court protection or guardianship\n* absence of insurance covering health costs","ALL","18 Years","80 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So, we designed the HyPnotiKs randomized controlled study to investigate the efficacy of these hypnotic drugs in patients undergoing RSI in the operating theatre. The primary endpoint will be the successful tracheal intubation at the first attempt without major arterial hypotension event.",[332],"Rapid Sequence Induction",[334,335,336,337,338,339,340],"Rapid sequence induction","Full stomach patient","hypotension","propofol","ketamine","ketofol","general anesthesia","2025-11-24",{"date":343,"type":344},"2025-12-02","ACTUAL",{"date":346,"type":344},"2025-04-14",{"date":348,"type":326},"2027-04-30",{"name":5,"class":6},20]