[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100635688":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":51,"centralContacts":55,"locations":63,"responsibleParty":431,"collaborators":30,"id":433,"slug":434,"hasResults":435,"nctId":436,"briefTitle":437,"officialTitle":438,"acronym":439,"eligibilityCriteria":440,"healthyVolunteers":435,"sex":441,"minAge":442,"maxAge":30,"enrollmentInfo":443,"targetDuration":30,"studyType":446,"phases":447,"briefSummary":449,"conditions":450,"keywords":30,"overallStatus":66,"whyStopped":30,"lastUpdateSubmitDate":452,"lastUpdatePostDateStruct":453,"startDateStruct":456,"completionDateStruct":458,"leadSponsor":460,"locationsCount":461},{"fullName":5,"class":6},"Hoffmann-La Roche","INDUSTRY",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Cevostamab + Pomalidomide + Dexamethasone","EXPERIMENTAL","Cevostamab will be administered intravenously on a 21-day cycle in cycle 1 and on a 28-day cycle from cycle 2 onwards.\n\nPomalidomide will be administered orally (PO) on a 28-day cycle from cycle 2 onwards.\n\nDexamethasone will be administered as a premedication prior to cevostamab.",[13,14,15],"Drug: Cevostamab","Drug: Pomalidomide","Drug: Dexamethasone",{"label":17,"type":18,"description":19,"interventionNames":20},"Standard of Care (SOC)","ACTIVE_COMPARATOR","Participants will receive investigator's choice of one SOC regimen.",[14,15,21,22,23],"Drug: Daratumumab","Drug: Elotuzumab","Drug: Carfilzomib",[25,31,35,39,43,47],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DRUG","Cevostamab","Participants will receive cevostamab IV as per the schedule given in the protocol.",[9],null,{"type":26,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"Pomalidomide","Participants will receive pomalidomide tablet orally PO as per the schedule given in the protocol.",[9,17],{"type":26,"name":36,"description":37,"armGroupLabels":38,"otherNames":30},"Dexamethasone","Participants will receive dexamethasone tablet orally PO or IV as per the schedule given in the protocol.",[9,17],{"type":26,"name":40,"description":41,"armGroupLabels":42,"otherNames":30},"Daratumumab","Participants will receive daratumumab SC as per the schedule given in the protocol.",[17],{"type":26,"name":44,"description":45,"armGroupLabels":46,"otherNames":30},"Elotuzumab","Participants will receive elotuzumab IV as per the schedule given in the protocol.",[17],{"type":26,"name":48,"description":49,"armGroupLabels":50,"otherNames":30},"Carfilzomib","Participants will receive carfilzomib IV as per the schedule given in the protocol.",[17],[52],{"name":53,"affiliation":5,"role":54},"Clinical Trials","STUDY_DIRECTOR",[56,61],{"name":57,"role":58,"phone":59,"phoneExt":30,"email":60},"Reference Study ID Number: CO46096 https:\u002F\u002Fforpatients.roche.com\u002F No attachments to email below.","CONTACT","888-662-6728","global-roche-genentech-trials@gene.com",{"name":62,"role":58,"phone":30,"phoneExt":30,"email":30},"Fastest response: use the inquiry form. https:\u002F\u002Fwww.gene.com\u002Fcontact-us\u002Fsubmit-medical-inquiry",[64,78,87,97,107,117,126,136,148,159,168,177,188,194,203,214,223,235,245,254,266,275,279,288,297,306,315,324,333,345,349,360,365,374,380,386,392,404,413,422],{"facility":65,"status":66,"city":67,"state":68,"zip":69,"country":70,"countryCode":71,"cosmosGeoPoint":72,"geoPoint":77,"contacts":30},"City of Hope National Medical Center","RECRUITING","Duarte","California","91010-3012","United States","US",{"type":73,"coordinates":74},"Point",[75,76],-117.97729,34.13945,{"lat":76,"lon":75},{"facility":79,"status":66,"city":80,"state":68,"zip":81,"country":70,"countryCode":71,"cosmosGeoPoint":82,"geoPoint":86,"contacts":30},"City of Hope - Lennar Foundation Cancer 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Carolina","28204",{"type":73,"coordinates":113},[114,115],-80.84313,35.22709,{"lat":115,"lon":114},{"facility":118,"status":66,"city":119,"state":110,"zip":120,"country":70,"countryCode":71,"cosmosGeoPoint":121,"geoPoint":125,"contacts":30},"Forsythe Memorial Hospital Inc., dba Novant Health Oncology Specialists","Winston-Salem","27103",{"type":73,"coordinates":122},[123,124],-80.24422,36.09986,{"lat":124,"lon":123},{"facility":127,"status":66,"city":128,"state":129,"zip":130,"country":70,"countryCode":71,"cosmosGeoPoint":131,"geoPoint":135,"contacts":30},"TriHealth Cancer and Blood Institute","Cincinnati","Ohio","45220",{"type":73,"coordinates":132},[133,134],-84.51439,39.12711,{"lat":134,"lon":133},{"facility":137,"status":66,"city":138,"state":139,"zip":140,"country":141,"countryCode":142,"cosmosGeoPoint":143,"geoPoint":147,"contacts":30},"Hamilton Health Sciences - Juravinski Cancer Centre","Hamilton","Ontario","L8V 1C3","Canada","CA",{"type":73,"coordinates":144},[145,146],-79.84963,43.25011,{"lat":146,"lon":145},{"facility":149,"status":66,"city":150,"state":30,"zip":151,"country":152,"countryCode":153,"cosmosGeoPoint":154,"geoPoint":158,"contacts":30},"HELIOS Klinikum Bad Saarow","Bad Saarow","15526","Germany","DE",{"type":73,"coordinates":155},[156,157],14.06667,52.28333,{"lat":157,"lon":156},{"facility":160,"status":66,"city":161,"state":30,"zip":162,"country":152,"countryCode":153,"cosmosGeoPoint":163,"geoPoint":167,"contacts":30},"Charite Universitaetsmedizin Berlin - Campus Benjamin Franklin","Berlin","12200",{"type":73,"coordinates":164},[165,166],13.41053,52.52437,{"lat":166,"lon":165},{"facility":169,"status":66,"city":170,"state":30,"zip":171,"country":152,"countryCode":153,"cosmosGeoPoint":172,"geoPoint":176,"contacts":30},"UKSH, Campus Kiel","Kiel","24105",{"type":73,"coordinates":173},[174,175],10.13489,54.32133,{"lat":175,"lon":174},{"facility":178,"status":66,"city":179,"state":30,"zip":180,"country":181,"countryCode":182,"cosmosGeoPoint":183,"geoPoint":187,"contacts":30},"Evangelismos General Hospital of Athens","Athens","106 76","Greece","GR",{"type":73,"coordinates":184},[185,186],23.72784,37.98376,{"lat":186,"lon":185},{"facility":189,"status":66,"city":179,"state":30,"zip":190,"country":181,"countryCode":182,"cosmosGeoPoint":191,"geoPoint":193,"contacts":30},"Alexandras General Hospital of Athens","11528",{"type":73,"coordinates":192},[185,186],{"lat":186,"lon":185},{"facility":195,"status":66,"city":196,"state":30,"zip":197,"country":181,"countryCode":182,"cosmosGeoPoint":198,"geoPoint":202,"contacts":30},"Anticancer Hospital of Thessaloniki \" Theagenio\"","Thessaloniki","540 07",{"type":73,"coordinates":199},[200,201],22.93493,40.64072,{"lat":201,"lon":200},{"facility":204,"status":66,"city":205,"state":30,"zip":206,"country":207,"countryCode":208,"cosmosGeoPoint":209,"geoPoint":213,"contacts":30},"Rambam Health Care Campus","Haifa","31096","Israel","IL",{"type":73,"coordinates":210},[211,212],34.99928,32.81303,{"lat":212,"lon":211},{"facility":215,"status":66,"city":216,"state":30,"zip":217,"country":207,"countryCode":208,"cosmosGeoPoint":218,"geoPoint":222,"contacts":30},"Chaim Sheba Medical Center","Ramat Gan","5266200",{"type":73,"coordinates":219},[220,221],34.81065,32.08227,{"lat":221,"lon":220},{"facility":224,"status":66,"city":225,"state":226,"zip":227,"country":228,"countryCode":229,"cosmosGeoPoint":230,"geoPoint":234,"contacts":30},"IRCCS Istituto Romagnolo per lo studio dei tumori \"Dino 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Hospital","Toyohashi","Aichi-ken","441-8570","Japan","JP",{"type":73,"coordinates":262},[263,264],137.38333,34.76667,{"lat":264,"lon":263},{"facility":267,"status":66,"city":268,"state":30,"zip":269,"country":259,"countryCode":260,"cosmosGeoPoint":270,"geoPoint":274,"contacts":30},"Nagoya City University Hospital","Aichi","467-8602",{"type":73,"coordinates":271},[272,273],130.62158,32.51879,{"lat":273,"lon":272},{"facility":276,"status":66,"city":277,"state":30,"zip":278,"country":259,"countryCode":260,"cosmosGeoPoint":30,"geoPoint":30,"contacts":30},"Gunma University Hospital","Gunma","371-8511",{"facility":280,"status":66,"city":281,"state":30,"zip":282,"country":259,"countryCode":260,"cosmosGeoPoint":283,"geoPoint":287,"contacts":30},"Hyogo Medical University Hospital","Hyōgo","663-8501",{"type":73,"coordinates":284},[285,286],144.43333,43.36667,{"lat":286,"lon":285},{"facility":289,"status":66,"city":290,"state":30,"zip":291,"country":259,"countryCode":260,"cosmosGeoPoint":292,"geoPoint":296,"contacts":30},"University Hospital Kyoto Prefectural University of Medicine","Kyoto","602-8566",{"type":73,"coordinates":293},[294,295],135.75385,35.02107,{"lat":295,"lon":294},{"facility":298,"status":66,"city":299,"state":30,"zip":300,"country":259,"countryCode":260,"cosmosGeoPoint":301,"geoPoint":305,"contacts":30},"National Hospital Organization Okayama Medical Center","Okayama","701-1192",{"type":73,"coordinates":302},[303,304],133.93333,34.65,{"lat":304,"lon":303},{"facility":307,"status":66,"city":308,"state":30,"zip":309,"country":259,"countryCode":260,"cosmosGeoPoint":310,"geoPoint":314,"contacts":30},"Dokkyo Medical University Saitama Medical Center","Saitama","343-8555",{"type":73,"coordinates":311},[312,313],139.65657,35.90807,{"lat":313,"lon":312},{"facility":316,"status":66,"city":317,"state":30,"zip":318,"country":259,"countryCode":260,"cosmosGeoPoint":319,"geoPoint":323,"contacts":30},"The Cancer Institute Hospital of JFCR","Tokyo","135-8550",{"type":73,"coordinates":320},[321,322],139.69171,35.6895,{"lat":322,"lon":321},{"facility":325,"status":66,"city":326,"state":30,"zip":327,"country":259,"countryCode":260,"cosmosGeoPoint":328,"geoPoint":332,"contacts":30},"Yamagata University Hospital","Yamagata","990-9585",{"type":73,"coordinates":329},[330,331],140.36667,38.23333,{"lat":331,"lon":330},{"facility":334,"status":66,"city":335,"state":336,"zip":337,"country":338,"countryCode":339,"cosmosGeoPoint":340,"geoPoint":344,"contacts":30},"SP ZOZ Szpital Uniwersytecki w Krakowie-Jakubowskiego 2;Oddzial Kliniczny Hematologii","Krakow","Lesser Poland Voivodeship","30-688","Poland","PL",{"type":73,"coordinates":341},[342,343],19.93658,50.06143,{"lat":343,"lon":342},{"facility":346,"status":66,"city":347,"state":30,"zip":348,"country":338,"countryCode":339,"cosmosGeoPoint":30,"geoPoint":30,"contacts":30},"Uniwersyteckie Centrum Kliniczne","Gda?sk","80-214",{"facility":350,"status":66,"city":351,"state":30,"zip":352,"country":353,"countryCode":354,"cosmosGeoPoint":355,"geoPoint":359,"contacts":30},"Auxilio Mutuo Cancer Center","San Juan","917","Puerto Rico","PR",{"type":73,"coordinates":356},[357,358],-66.10572,18.46633,{"lat":358,"lon":357},{"facility":361,"status":66,"city":362,"state":30,"zip":363,"country":364,"countryCode":30,"cosmosGeoPoint":30,"geoPoint":30,"contacts":30},"Chonnam National University Hwasun Hospital","Jeollanam-do","58128","South Korea",{"facility":366,"status":66,"city":367,"state":30,"zip":368,"country":364,"countryCode":30,"cosmosGeoPoint":369,"geoPoint":373,"contacts":30},"Seoul National University Hospital","Seoul","03080",{"type":73,"coordinates":370},[371,372],126.9784,37.566,{"lat":372,"lon":371},{"facility":375,"status":66,"city":367,"state":30,"zip":376,"country":364,"countryCode":30,"cosmosGeoPoint":377,"geoPoint":379,"contacts":30},"Asan Medical Center","05505",{"type":73,"coordinates":378},[371,372],{"lat":372,"lon":371},{"facility":381,"status":66,"city":367,"state":30,"zip":382,"country":364,"countryCode":30,"cosmosGeoPoint":383,"geoPoint":385,"contacts":30},"Samsung Medical Center","06351",{"type":73,"coordinates":384},[371,372],{"lat":372,"lon":371},{"facility":387,"status":66,"city":367,"state":30,"zip":388,"country":364,"countryCode":30,"cosmosGeoPoint":389,"geoPoint":391,"contacts":30},"Seoul St Mary's Hospital","06591",{"type":73,"coordinates":390},[371,372],{"lat":372,"lon":371},{"facility":393,"status":66,"city":394,"state":395,"zip":396,"country":397,"countryCode":398,"cosmosGeoPoint":399,"geoPoint":403,"contacts":30},"Clinica Universitaria de Navarra","Pamplona","Navarre","31008","Spain","ES",{"type":73,"coordinates":400},[401,402],-1.64323,42.81687,{"lat":402,"lon":401},{"facility":405,"status":66,"city":406,"state":30,"zip":407,"country":397,"countryCode":398,"cosmosGeoPoint":408,"geoPoint":412,"contacts":30},"Hospital Clinic i Provincial de Barcelona","Barcelona","08036",{"type":73,"coordinates":409},[410,411],2.15899,41.38879,{"lat":411,"lon":410},{"facility":414,"status":66,"city":415,"state":30,"zip":416,"country":397,"countryCode":398,"cosmosGeoPoint":417,"geoPoint":421,"contacts":30},"Hospital General Universitario Gregorio Marañon","Madrid","28009",{"type":73,"coordinates":418},[419,420],-3.70256,40.4165,{"lat":420,"lon":419},{"facility":423,"status":66,"city":424,"state":30,"zip":425,"country":397,"countryCode":398,"cosmosGeoPoint":426,"geoPoint":430,"contacts":30},"Hospital Clinico Universitario de Salamanca","Salamanca","37007",{"type":73,"coordinates":427},[428,429],-5.66388,40.96882,{"lat":429,"lon":428},{"type":432,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR","100635688","phase-3-cevostamab-in-combination-with-pomalidomide-and-dexamethasone-versus-standard-of-care-in-participants-with-previously-treated-multiple-myeloma-100635688",false,"NCT07555938","Cevostamab in Combination With Pomalidomide and Dexamethasone Versus Standard of Care in Participants With Previously Treated Multiple Myeloma","A Phase III, Randomized, Open-Label, Multicenter Study Evaluating the Efficacy and Safety of Cevostamab in Combination With Pomalidomide and Dexamethasone Versus Standard of Care in Patients With Multiple Myeloma Who Have Received One to Three Prior Lines of Therapy","CEVOLUTION","Inclusion Criteria:\n\n* Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1 at screening and immediately prior to start of administration of study treatment.\n* Individuals with ECOG Performance Status of 2 solely due to local symptoms of myeloma (e.g., pain) are eligible\n* MM diagnosis according to the International Myeloma Working Group (IMWG) diagnostic criteria\n* Received one to three lines of prior therapy that included at least two consecutive cycles of either of the following: A regimen containing an anti-CD38 therapy, a regimen containing lenalidomide\n* Participants must have measurable disease during screening\n\nExclusion Criteria:\n\n* Known history of amyloidosis (e.g., positive Congo Red stain or equivalent in tissue biopsy or documented within serum amyloid P component scan)\n* Plasma cell leukemia or circulating plasma cell count exceeding 500 cells\u002Fliter (L) or 5% of the peripheral blood white cells\n* GI disease that might significantly alter absorption of oral drugs\n* Participants must not have any ongoing CNS disease or non-secretory myeloma","ALL","18 Years",{"count":444,"type":445},380,"ESTIMATED","INTERVENTIONAL",[448],"PHASE3","The purpose of this study is to assess the efficacy and safety of cevostamab in combination with pomalidomide and dexamethasone (CevosPd) versus standard of care (SOC) in participants with multiple myeloma (MM) who have received one to three prior lines of therapy and have been exposed to an anti-CD38 monoclonal antibody (mAb) and lenalidomide.",[451],"Multiple Myeloma","2026-08-13",{"date":454,"type":455},"2026-08-14","ACTUAL",{"date":457,"type":455},"2026-06-23",{"date":459,"type":445},"2033-01-31",{"name":5,"class":6},40]