[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100436801":3},{"organization":4,"armGroups":7,"interventions":28,"overallOfficials":39,"centralContacts":49,"locations":54,"responsibleParty":514,"collaborators":517,"id":522,"slug":523,"hasResults":524,"nctId":525,"briefTitle":526,"officialTitle":526,"acronym":527,"eligibilityCriteria":528,"healthyVolunteers":524,"sex":529,"minAge":530,"maxAge":34,"enrollmentInfo":531,"targetDuration":34,"studyType":534,"phases":535,"briefSummary":537,"conditions":538,"keywords":540,"overallStatus":57,"whyStopped":34,"lastUpdateSubmitDate":544,"lastUpdatePostDateStruct":545,"startDateStruct":548,"completionDateStruct":550,"leadSponsor":552,"locationsCount":553},{"fullName":5,"class":6},"University of Pittsburgh","OTHER",[8,14,20,24],{"label":9,"type":10,"description":11,"interventionNames":12},"Trial 1: Initial standard energy SLT","ACTIVE_COMPARATOR","Standard energy SLT is performed as follows: beginning at 0.8 mJ, energy will be titrated up or down within the first 5-10 spots until champagne bubbles are visualized with every 2nd or 3rd spot. Energy can be titrated throughout the procedure, in response to variations in pigmentation, to ensure the appearance of champagne bubbles with every 2nd or 3rd spot throughout the full 360° treatment. Energy should be increased if no bubbles are seen with 5 consecutive spots and decreased if bubbles are seen with 5 consecutive spots.",[13],"Procedure: Standard Energy SLT",{"label":15,"type":16,"description":17,"interventionNames":18},"Trial 2: Month 12 Randomization: Annual Low Energy Repeat SLT","EXPERIMENTAL","At month 12, eligible subjects will be randomized to undergo repeat SLT either annually at low energy or as needed at standard energy.\n\nLow energy SLT will consist of 100 treatment spots delivered at 0.4 mJ per spot throughout the full 360° treatment, with the exception that energy can be reduced to 0.3 mJ if bubbles are seen with 5 consecutive spots and can be increased back to a maximum of 0.4mJ is no bubbles are seen with 5 consecutive spots.",[19],"Procedure: Low Energy SLT",{"label":21,"type":10,"description":22,"interventionNames":23},"Trial 2: Month 12 Randomization: As-Needed Repeat SLT at Standard Energy","At month 12, eligible subjects will be randomized to undergo repeat SLT either annually at low energy or as needed at standard energy.\n\nStandard SLT will be performed as follows: beginning at 0.8 mJ, energy will be titrated up or down within the first 5-10 spots until champagne bubbles are visualized with every 2nd or 3rd spot. Energy can be titrated throughout the procedure, in response to variations in pigmentation, to ensure the appearance of champagne bubbles with every 2nd or 3rd spot throughout the full 360° treatment. Energy should be increased if no bubbles are seen with 5 consecutive spots and decreased if bubbles are seen with 5 consecutive spots.",[13],{"label":25,"type":16,"description":26,"interventionNames":27},"Trial 1: Initial Low Energy SLT","Note: This arm was discontinued following a planned interim analysis.\n\nLow energy SLT will consist of 100 treatment spots delivered at 0.4 mJ per spot throughout the full 360° treatment, with the exception that energy can be reduced to 0.3 mJ if bubbles are seen with 5 consecutive spots and can be increased back to a maximum of 0.4mJ if no bubbles are seen with 5 consecutive spots.",[19],[29,35],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"PROCEDURE","Low Energy SLT","SLT performed at low energy",[25,15],null,{"type":30,"name":36,"description":37,"armGroupLabels":38,"otherNames":34},"Standard Energy SLT","SLT performed at standard energy",[9,21],[40,44,47],{"name":41,"affiliation":42,"role":43},"Tony Realini, MD, MPH","West Virginia University","STUDY_CHAIR",{"name":45,"affiliation":5,"role":46},"Goundappa K Balasubramani, PhD","PRINCIPAL_INVESTIGATOR",{"name":48,"affiliation":5,"role":46},"Stephen Wisniewski, PhD",[50],{"name":41,"role":51,"phone":52,"phoneExt":34,"email":53},"CONTACT","3045986926","hypotonywvu@gmail.com",[55,76,93,109,125,143,155,172,188,204,221,237,250,266,283,299,316,333,346,363,380,396,409,419,436,453,470,485,502],{"facility":56,"status":57,"city":58,"state":59,"zip":60,"country":61,"countryCode":62,"cosmosGeoPoint":63,"geoPoint":68,"contacts":69},"Harvard Eye Associates","RECRUITING","Laguna Hills","California","92653","United States","US",{"type":64,"coordinates":65},"Point",[66,67],-117.71283,33.61252,{"lat":67,"lon":66},[70,74],{"name":71,"role":51,"phone":72,"phoneExt":34,"email":73},"Ashwini Ravichandran","949-951-2020","aravichandran@harvardeye.com",{"name":75,"role":46,"phone":34,"phoneExt":34,"email":34},"Ye Elaine Wang, MD",{"facility":77,"status":57,"city":78,"state":59,"zip":79,"country":61,"countryCode":62,"cosmosGeoPoint":80,"geoPoint":84,"contacts":85},"Doheny Eye Center UCLA","Pasadena","91105",{"type":64,"coordinates":81},[82,83],-118.14452,34.14778,{"lat":83,"lon":82},[86,91],{"name":87,"role":51,"phone":88,"phoneExt":89,"email":90},"Mayra Raygoza","(626) 817-4747","19093","MRaygoza@mednet.ucla.edu",{"name":92,"role":46,"phone":34,"phoneExt":34,"email":34},"Judy L Chen, MD",{"facility":94,"status":57,"city":95,"state":59,"zip":96,"country":61,"countryCode":62,"cosmosGeoPoint":97,"geoPoint":101,"contacts":102},"University of California, Davis","Sacramento","95817",{"type":64,"coordinates":98},[99,100],-121.4944,38.58157,{"lat":100,"lon":99},[103,107],{"name":104,"role":51,"phone":105,"phoneExt":34,"email":106},"Leslie Valverde","916-734-6302","ldlopez@ucdavis.edu",{"name":108,"role":46,"phone":34,"phoneExt":34,"email":34},"James Brandt, MD",{"facility":110,"status":57,"city":111,"state":59,"zip":112,"country":61,"countryCode":62,"cosmosGeoPoint":113,"geoPoint":117,"contacts":118},"University of California, San Francisco","San Francisco","94158",{"type":64,"coordinates":114},[115,116],-122.41942,37.77493,{"lat":116,"lon":115},[119,123],{"name":120,"role":51,"phone":121,"phoneExt":34,"email":122},"Ethan Liang","(415) 525-9890","Ethan.Liang@ucsf.edu",{"name":124,"role":46,"phone":34,"phoneExt":34,"email":34},"Ying Han, MD",{"facility":126,"status":57,"city":127,"state":128,"zip":129,"country":61,"countryCode":62,"cosmosGeoPoint":130,"geoPoint":134,"contacts":135},"Mile High Eye Institute","Sheridan","Colorado","80110",{"type":64,"coordinates":131},[132,133],-105.02526,39.64693,{"lat":133,"lon":132},[136,141],{"name":137,"role":51,"phone":138,"phoneExt":139,"email":140},"Michelle Lopez Galindo","(303) 482-1300","106","Michelle@mhei.com",{"name":142,"role":46,"phone":34,"phoneExt":34,"email":34},"Zachary Vest, MD",{"facility":144,"status":57,"city":145,"state":146,"zip":147,"country":61,"countryCode":62,"cosmosGeoPoint":34,"geoPoint":34,"contacts":148},"Clear Vue Laser Eye Center","Lakeworth","Florida","33467",[149,153],{"name":150,"role":51,"phone":151,"phoneExt":34,"email":152},"Michelle Hill","561-432-4141","michelle@clearvuenow.com",{"name":154,"role":46,"phone":34,"phoneExt":34,"email":34},"Monique Barbour, MD",{"facility":156,"status":57,"city":157,"state":158,"zip":159,"country":61,"countryCode":62,"cosmosGeoPoint":160,"geoPoint":164,"contacts":165},"Northwestern Medical Group","Chicago","Illinois","60615",{"type":64,"coordinates":161},[162,163],-87.65005,41.85003,{"lat":163,"lon":162},[166,170],{"name":167,"role":51,"phone":168,"phoneExt":34,"email":169},"Madison Wood","(312) 695-0252","madison.wood@northwestern.edu",{"name":171,"role":46,"phone":34,"phoneExt":34,"email":34},"Angelo Tanna, MD",{"facility":173,"status":57,"city":174,"state":158,"zip":175,"country":61,"countryCode":62,"cosmosGeoPoint":176,"geoPoint":180,"contacts":181},"Chicago Arbor Eye Institute","Orland Park","60467",{"type":64,"coordinates":177},[178,179],-87.85394,41.63031,{"lat":179,"lon":178},[182,186],{"name":183,"role":51,"phone":184,"phoneExt":34,"email":185},"Lorene Rafol","708-249-1026","lorenerafol@arboreyecare.com",{"name":187,"role":46,"phone":34,"phoneExt":34,"email":34},"Richard Quinones, MD",{"facility":189,"status":57,"city":190,"state":158,"zip":191,"country":61,"countryCode":62,"cosmosGeoPoint":192,"geoPoint":196,"contacts":197},"Illinois Eye Center","Peoria","61615",{"type":64,"coordinates":193},[194,195],-89.58899,40.69365,{"lat":195,"lon":194},[198,202],{"name":199,"role":51,"phone":200,"phoneExt":34,"email":201},"Lori Hendershott","309-213-0664","lhendershott@illinoiseyecenter.com",{"name":203,"role":46,"phone":34,"phoneExt":34,"email":34},"Sachin Kalarn, MD",{"facility":205,"status":57,"city":206,"state":207,"zip":208,"country":61,"countryCode":62,"cosmosGeoPoint":209,"geoPoint":213,"contacts":214},"Wilmer Eye Institute Johns Hopkins","Baltimore","Maryland","21287",{"type":64,"coordinates":210},[211,212],-76.61219,39.29038,{"lat":212,"lon":211},[215,219],{"name":216,"role":51,"phone":217,"phoneExt":34,"email":218},"Rucha Thaker","908- 616-1807","rthaker2@jh.edu",{"name":220,"role":46,"phone":34,"phoneExt":34,"email":34},"Pradeep Ramulu, MD",{"facility":222,"status":57,"city":223,"state":224,"zip":225,"country":61,"countryCode":62,"cosmosGeoPoint":226,"geoPoint":230,"contacts":231},"Massachusetts Eye and Ear","Boston","Massachusetts","02114",{"type":64,"coordinates":227},[228,229],-71.05977,42.35843,{"lat":229,"lon":228},[232,235],{"name":233,"role":51,"phone":34,"phoneExt":34,"email":234},"Michael Cheung","mcheung0@meei.harvard.edu",{"name":236,"role":46,"phone":34,"phoneExt":34,"email":34},"Michael Lin, MD",{"facility":238,"status":57,"city":223,"state":224,"zip":239,"country":61,"countryCode":62,"cosmosGeoPoint":240,"geoPoint":242,"contacts":243},"Ophthalmic Consultants of Boston","02451",{"type":64,"coordinates":241},[228,229],{"lat":229,"lon":228},[244,248],{"name":245,"role":51,"phone":246,"phoneExt":34,"email":247},"Jessica Placher","(617) 314-2734","jplacher@eyeboston.com",{"name":249,"role":46,"phone":34,"phoneExt":34,"email":34},"Theodor Sauer, MD",{"facility":251,"status":57,"city":252,"state":224,"zip":253,"country":61,"countryCode":62,"cosmosGeoPoint":254,"geoPoint":258,"contacts":259},"Mark Latina, LLC","Reading","01867",{"type":64,"coordinates":255},[256,257],-71.09533,42.52565,{"lat":257,"lon":256},[260,264],{"name":261,"role":51,"phone":262,"phoneExt":34,"email":263},"Ann Gardikas","781-942-9876","anngardikas76@gmail.com",{"name":265,"role":46,"phone":34,"phoneExt":34,"email":34},"Mark Latina, MD",{"facility":267,"status":57,"city":268,"state":269,"zip":270,"country":61,"countryCode":62,"cosmosGeoPoint":271,"geoPoint":275,"contacts":276},"University of Michigan Kellogg Eye Center","Ann Arbor","Michigan","48105",{"type":64,"coordinates":272},[273,274],-83.74088,42.27756,{"lat":274,"lon":273},[277,281],{"name":278,"role":51,"phone":279,"phoneExt":34,"email":280},"Lindsay Rudberg","734-647-9196","rulindsa@med.umich.edu",{"name":282,"role":46,"phone":34,"phoneExt":34,"email":34},"Amanda Bicket, MD",{"facility":284,"status":57,"city":285,"state":269,"zip":286,"country":61,"countryCode":62,"cosmosGeoPoint":287,"geoPoint":291,"contacts":292},"Kresge Eye Institute Wayne State University","Detroit","48201",{"type":64,"coordinates":288},[289,290],-83.04575,42.33143,{"lat":290,"lon":289},[293,297],{"name":294,"role":51,"phone":295,"phoneExt":34,"email":296},"Bayan El-Haik","313-515-5487","bayan.el-haik@wayne.edu",{"name":298,"role":46,"phone":34,"phoneExt":34,"email":34},"Bret Hughes, MD",{"facility":300,"status":57,"city":301,"state":302,"zip":303,"country":61,"countryCode":62,"cosmosGeoPoint":304,"geoPoint":308,"contacts":309},"New York Eye Surgery Associates","The Bronx","New York","10469",{"type":64,"coordinates":305},[306,307],-73.86641,40.84985,{"lat":307,"lon":306},[310,314],{"name":311,"role":51,"phone":312,"phoneExt":34,"email":313},"Krystina Tavarez-Feliciano","347-860-4474","kfeliciano@nyeye.com",{"name":315,"role":46,"phone":34,"phoneExt":34,"email":34},"Nathan Radcliffe, MD",{"facility":317,"status":57,"city":318,"state":319,"zip":320,"country":61,"countryCode":62,"cosmosGeoPoint":321,"geoPoint":325,"contacts":326},"University Hospitals Eye Institute","Cleveland","Ohio","44106",{"type":64,"coordinates":322},[323,324],-81.69541,41.4995,{"lat":324,"lon":323},[327,331],{"name":328,"role":51,"phone":329,"phoneExt":34,"email":330},"Sangeetha Raghupathy","216-844-8552","Sangeetha.Raghupathy@uhhospitals.org",{"name":332,"role":46,"phone":34,"phoneExt":34,"email":34},"Douglas Rhee, MD",{"facility":334,"status":57,"city":318,"state":319,"zip":335,"country":61,"countryCode":62,"cosmosGeoPoint":336,"geoPoint":338,"contacts":339},"Cleveland Clinic Cole Eye Institute","44195",{"type":64,"coordinates":337},[323,324],{"lat":324,"lon":323},[340,344],{"name":341,"role":51,"phone":342,"phoneExt":34,"email":343},"Dusica Vasic","216-445-3840","vasicd@ccf.org",{"name":345,"role":46,"phone":34,"phoneExt":34,"email":34},"Ang Li, MD",{"facility":347,"status":57,"city":348,"state":349,"zip":350,"country":61,"countryCode":62,"cosmosGeoPoint":351,"geoPoint":355,"contacts":356},"Devers Eye Institute","Portland","Oregon","97210",{"type":64,"coordinates":352},[353,354],-122.67621,45.52345,{"lat":354,"lon":353},[357,361],{"name":358,"role":51,"phone":359,"phoneExt":34,"email":360},"Jack Rees","503-413-8495","jrees@deverseye.org",{"name":362,"role":46,"phone":34,"phoneExt":34,"email":34},"Robert Kinast, MD",{"facility":364,"status":57,"city":365,"state":366,"zip":367,"country":61,"countryCode":62,"cosmosGeoPoint":368,"geoPoint":372,"contacts":373},"Eye Care Specialists","Kingston","Pennsylvania","18704",{"type":64,"coordinates":369},[370,371],-75.89686,41.26175,{"lat":371,"lon":370},[374,378],{"name":375,"role":51,"phone":376,"phoneExt":34,"email":377},"Cheryl Bayley","570-714-5915","cheryl.bayley@vipeyes.com",{"name":379,"role":46,"phone":34,"phoneExt":34,"email":34},"Daniel Lutz, MD",{"facility":381,"status":57,"city":382,"state":366,"zip":383,"country":61,"countryCode":62,"cosmosGeoPoint":384,"geoPoint":388,"contacts":389},"Scheie Eye Institute","Philadelphia","19104",{"type":64,"coordinates":385},[386,387],-75.16362,39.95238,{"lat":387,"lon":386},[390,394],{"name":391,"role":51,"phone":392,"phoneExt":34,"email":393},"Criston Young","856-519-8295","Criston.Young@pennmedicine.upenn.edu",{"name":395,"role":46,"phone":34,"phoneExt":34,"email":34},"Ahmara Ross, MD",{"facility":397,"status":57,"city":382,"state":366,"zip":398,"country":61,"countryCode":62,"cosmosGeoPoint":399,"geoPoint":401,"contacts":402},"Wills Eye Hospital","19107",{"type":64,"coordinates":400},[386,387],{"lat":387,"lon":386},[403,407],{"name":404,"role":51,"phone":405,"phoneExt":34,"email":406},"Meskerem Divers","215-825-4712","MDivers@willseye.org",{"name":408,"role":46,"phone":34,"phoneExt":34,"email":34},"Lauren Hock, MD",{"facility":410,"status":411,"city":412,"state":366,"zip":413,"country":61,"countryCode":62,"cosmosGeoPoint":414,"geoPoint":418,"contacts":34},"UPMC Eye Center","ACTIVE_NOT_RECRUITING","Pittsburgh","15213",{"type":64,"coordinates":415},[416,417],-79.99589,40.44062,{"lat":417,"lon":416},{"facility":420,"status":57,"city":421,"state":422,"zip":423,"country":61,"countryCode":62,"cosmosGeoPoint":424,"geoPoint":428,"contacts":429},"Vanderbilt Eye Institute","Nashville","Tennessee","37232",{"type":64,"coordinates":425},[426,427],-86.78444,36.16589,{"lat":427,"lon":426},[430,434],{"name":431,"role":51,"phone":432,"phoneExt":34,"email":433},"Marybeth Carter","616-936-1639","marybeth.l.carter@vumc.org",{"name":435,"role":46,"phone":34,"phoneExt":34,"email":34},"Rachel Kuchtey, MD",{"facility":437,"status":57,"city":438,"state":439,"zip":440,"country":61,"countryCode":62,"cosmosGeoPoint":441,"geoPoint":445,"contacts":446},"Ophthalmology Associates","Fort Worth","Texas","76102",{"type":64,"coordinates":442},[443,444],-97.32085,32.72541,{"lat":444,"lon":443},[447,451],{"name":448,"role":51,"phone":449,"phoneExt":34,"email":450},"Kaitlin Sinclair","940-452-1173","ksinclair@oafw2020.com",{"name":452,"role":46,"phone":34,"phoneExt":34,"email":34},"Brian Flowers, MD",{"facility":454,"status":57,"city":455,"state":456,"zip":457,"country":61,"countryCode":62,"cosmosGeoPoint":458,"geoPoint":462,"contacts":463},"Spokane Eye Clinical Research","Spokane","Washington","99204",{"type":64,"coordinates":459},[460,461],-117.42908,47.65966,{"lat":461,"lon":460},[464,468],{"name":465,"role":51,"phone":466,"phoneExt":34,"email":467},"Dylan Waidelich","509-623-9768","dwaidelich@spokaneeye.com",{"name":469,"role":46,"phone":34,"phoneExt":34,"email":34},"Rory Allar, MD",{"facility":42,"status":57,"city":471,"state":472,"zip":473,"country":61,"countryCode":62,"cosmosGeoPoint":474,"geoPoint":478,"contacts":479},"Morgantown","West Virginia","26505",{"type":64,"coordinates":475},[476,477],-79.9559,39.62953,{"lat":477,"lon":476},[480,484],{"name":481,"role":51,"phone":482,"phoneExt":34,"email":483},"Athena Echols, LPN","304-598-6977","athena.sparks@wvumedicine.org",{"name":41,"role":46,"phone":34,"phoneExt":34,"email":34},{"facility":486,"status":57,"city":487,"state":488,"zip":489,"country":61,"countryCode":62,"cosmosGeoPoint":490,"geoPoint":494,"contacts":495},"University of Wisconsin-Madison","Madison","Wisconsin","53705",{"type":64,"coordinates":491},[492,493],-89.40123,43.07305,{"lat":493,"lon":492},[496,500],{"name":497,"role":51,"phone":498,"phoneExt":34,"email":499},"Kelly Boyd","608-265-4589","kmboyd@wisc.edu",{"name":501,"role":46,"phone":34,"phoneExt":34,"email":34},"Yao Liu, MD",{"facility":503,"status":411,"city":504,"state":505,"zip":506,"country":507,"countryCode":508,"cosmosGeoPoint":509,"geoPoint":513,"contacts":34},"Ocular Health Centre","Kitchener","Ontario","N2A0K5","Canada","CA",{"type":64,"coordinates":510},[511,512],-80.5112,43.42537,{"lat":512,"lon":511},{"type":46,"investigatorFullName":515,"investigatorTitle":516,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"Balasubramani Goundappa","Research Associate Professor",[518,521],{"name":519,"class":520},"National Eye Institute (NEI)","NIH",{"name":42,"class":6},"100436801","phase-3-clarifying-the-optimal-application-of-slt-therapy-trial-100436801",false,"NCT04967989","Clarifying the Optimal Application of SLT Therapy Trial","COAST","Inclusion Criteria:\n\n1. Age 18 or older and in good health\n2. Each eye with one of the following qualifying diagnoses (diagnoses may differ between eyes):\n\n   1. High-risk ocular hypertension (OHT): IOP \\> 21 mmHg without glaucomatous optic neuropathy (excavation, diffuse or focal thinning or notching of the neuroretinal rim, visible nerve fiber layer defects, or asymmetry of the vertical cup-to-disc ratio of \\>0.2 between eyes)\n   2. Mild primary open-angle glaucoma: glaucomatous optic neuropathy, visual field mean deviation better than -6.0 dB with no points in the central 5° \\\u003C15 dB (see figure on next page)\n   3. Moderate primary open-angle glaucoma: glaucomatous optic neuropathy, visual field mean deviation equal to or worse than -6.0 dB but no worse than -12.0 dB and no central 5° points \\\u003C15 dB or mean deviation -12.0 dB or better with 1 central 5° points \\\u003C15 dB (see figure on next page).\n3. Each eye with BCVA 20\u002F200 (UK 6\u002F60) or better\n\nExclusion Criteria:\n\n1. Use of topical IOP-lowering medications for more than 6 cumulative months at any time in the past 5 years (this is a modification implemented during active enrollment)\n2. Any history of IOP-lowering laser (prophylactic iridotomy not included) or surgical procedure\n3. Advanced POAG in either eye (worse than moderate POAG as defined above)\n4. Glaucoma other than POAG (including pigmentary and pseudoexfoliation glaucoma) in either eye\n5. Mean IOP \\> 35 mmHg at either the screening or baseline visit in either eye\n6. Narrow or closed angle (Shaffer Grade 0, 1, or 2) in either eye\n7. Contraindications to SLT or any other study intervention\n8. Any corneal pathology that would preclude accurate assessment of IOP by Goldmann tonometry in either eye\n9. Any intraocular surgical procedure within the past 6 months in either eye\n10. Inability to attend all scheduled study visits\n11. Pregnant or planning to become pregnant in the next 4 years","ALL","18 Years",{"count":532,"type":533},790,"ESTIMATED","INTERVENTIONAL",[536],"PHASE3","The goal of this study is to understand if SLT performed at low energy is as effective as SLT performed at standard energy, and also to see if repeating SLT at low energy once a year will prevent or delay the need for daily eye drop medications better than waiting for SLT to wear off before repeating it.",[539],"Glaucoma and Ocular Hypertension",[541,542,543],"glaucoma","selective laser trabeculoplasty","clinical trial","2026-08-12",{"date":546,"type":547},"2026-08-14","ACTUAL",{"date":549,"type":547},"2021-09-07",{"date":551,"type":533},"2027-08-31",{"name":5,"class":6},29]