[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638486":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":35,"locations":44,"responsibleParty":66,"collaborators":26,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":26,"eligibilityCriteria":74,"healthyVolunteers":71,"sex":75,"minAge":76,"maxAge":26,"enrollmentInfo":77,"targetDuration":26,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":89,"whyStopped":26,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"King George's Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Role of Vonoprazan in prevention of post EVL ulcer","EXPERIMENTAL","Patients who are diagnosed to have esophageal varices and requiring EVL will be enrolled Patients who are willing to participate in the study will be randomized into two arms in 1:1 ratio. The experimental arm will receive Vonoprazan 20 mg once a day for 2 weeks. Patients will also be advised to take nonselective beta blockers (NSBB) as per standard of care.\n\nPatients will undergo upper GI endoscopy after 2 weeks to evaluate varices and ulcers, ulcer will be classified according to Jamwal \\& Sarin classification system.",[13],"Drug: Vonoprazan",{"label":15,"type":16,"description":17,"interventionNames":18},"Role of Rabeprazole in prevention of post EVL ulcer","ACTIVE_COMPARATOR","Patients who are diagnosed to have esophageal varices and requiring EVL will be enrolled Patients who are willing to participate in the study will be randomized into two arms in 1:1 ratio. The comparator arm will receive Rabeprazole 20 mg once a day for 2 weeks. Patients will also be advised to take nonselective beta blockers (NSBB) as per standard of care.\n\nPatients will undergo upper GI endoscopy after 2 weeks to evaluate varices and ulcers, ulcer will be classified according to Jamwal \\& Sarin classification system.",[19],"Drug: Rabeprazol",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Vonoprazan","Patients who are willing to participate in the study will be randomized into two arms in 1:1 ratio. One arm is Vonoprazan 20 mg once a day group and second arm will be rabeprazole 20 mg once a day. Duration of therapy will be 2 weeks. Patients will also be advised to take nonselective beta blockers (NSBB) as per standard of care.\n\nPatients will undergo upper GI endoscopy after 2 weeks to evaluate varices and ulcers, ulcer will be classified according to Jamwal \\& Sarin classification system.",[9],null,{"type":22,"name":28,"description":24,"armGroupLabels":29,"otherNames":26},"Rabeprazol",[15],[31],{"name":32,"affiliation":33,"role":34},"Dr Sumit Rungta, DM- Medical Gastroenterology","King George Medical University, Lucknow, UP, India","PRINCIPAL_INVESTIGATOR",[36,40],{"name":32,"role":37,"phone":38,"phoneExt":26,"email":39},"CONTACT","+919935537944","drsumitrungta79@gmail.com",{"name":41,"role":37,"phone":42,"phoneExt":26,"email":43},"Dr Sayan Malakar, DM- Medical Gastroenterology","+919007057890","oneandonludrsayan@gmail.com",[45],{"facility":46,"status":26,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"King George Medical University","Lucknow","Uttar Pradesh","226003","India","IN",{"type":53,"coordinates":54},"Point",[55,56],80.92313,26.83928,{"lat":56,"lon":55},[59,61,64],{"name":60,"role":37,"phone":38,"phoneExt":26,"email":39},"Dr Sumit Rungta, DM-Medical Gastroenterology",{"name":62,"role":37,"phone":42,"phoneExt":26,"email":63},"Dr Sayan Malakar, DM-Medical Gastroenterology","oneandonlydrsayan@gmail.com",{"name":65,"role":34,"phone":26,"phoneExt":26,"email":26},"Dr Mayank Agarwal, MD Medicine",{"type":34,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Sumit Rungta","Professor (Doctor)","100638486","phase-3-comparison-of-rabeprazole-and-vonoprazan-in-the-prevention-of-post-endoscopic-variceal-ligation-ulcer-in-patients-with-cirrhosis-100638486",false,"NCT07608536","Comparison of Rabeprazole and Vonoprazan in the Prevention of Post-endoscopic Variceal Ligation Ulcer in Patients With Cirrhosis","Inclusion Criteria:\n\n* Age 18 years and above\n* Diagnosis of portal hypertension and esophageal varix should be established by endoscopy.\n* Who are willing to participate in the study\n\nExclusion Criteria:\n\n* Negative consent\n* Diagnosed with HCC\n* Already taking PPI\u002FVonoprazan for other indications\n* Using anticoagulants and antiplatelets","ALL","18 Years",{"count":78,"type":79},300,"ESTIMATED","INTERVENTIONAL",[82],"PHASE3","The study aims to to evaluate Vonoprazan effectiveness in prevention of post endoscopic variceal ligation (EVL) ulcer and its related bleed in comparison to Rabeprazole.\n\nAll patients who are eligible for the study will be screened from outpatient department and endoscopy lab. Patients who are diagnosed to have oesophageal varices and requiring EVL will be enrolled after fulfilling inclusion and exclusion criteria.\n\nPatient clinical and demographic data will be collected in proforma. Patients who are willing to participate in the study will be randomized into two arms in 1:1 ratio. One arm is Vonoprazan 20 mg once a day group and second arm will be rabeprazole 20 mg once a day. Duration of therapy will be 2 weeks. Patients will also be advised to take nonselective beta blockers (NSBB) as per standard of care.\n\nPatients will undergo upper GI endoscopy after 2 weeks to evaluate varices and ulcers, ulcer will be classified according to Jamwal \\& Sarin classification system.",[85],"Endoscopic Variceal Band Ligation",[87,23,88],"Post endoscopic variceal ligation (EVL) ulcer","Rabeprazole","NOT_YET_RECRUITING","2026-05-26",{"date":92,"type":93},"2026-05-27","ACTUAL",{"date":95,"type":79},"2026-05-01",{"date":97,"type":79},"2026-07-31",{"name":5,"class":6},1]