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TEAE is defined as any AE emerging or manifesting at or after the initiation of treatment in the LTE study with a trial intervention or medicinal product or any existing AE that worsens in either intensity or frequency following exposure to the trial intervention or medicinal product. SAE is any untoward medical occurrence that results in death, is life-threatening, requires inpatient hospitalization or prolongation of hospitalization, results in persistent or significant disability\u002Fincapacity, results in a congenital abnormality\u002Fbirth defect, or is an important medical event.","From start of study drug administration up to follow-up (up to Week 108)",{"measure":14,"description":15,"timeFrame":12},"Number of Participants With Adverse Events of Special Interest (AESI)","An AESI is an adverse event of scientific and medical concern specific to the compound or program, for which ongoing monitoring and rapid communication by the investigator may be appropriate.",{"measure":17,"description":18,"timeFrame":12},"Number of Participants With Clinically Significant Changes in Vital Sign Values","Vital signs will include measurement of body temperature, respiratory rate, sitting blood pressure and pulse rate. 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An ACR20 response is defined as greater than or equal to (\\>=) 20 percentage (%) improvement from baseline in both swollen joint count 66 joints (SJC66) and tender joint count 68 joints (TJC68), and \\>=20% improvement from baseline in 3 of the following 5 assessments: Patient's global assessment (PtGA) of PsA pain; PtGA of PsA; physician's global assessment of disease activity (PGA) of PsA; participant's assessment of physical function as measured by health assessment questionnaire-disability index (HAQ-DI); high-sensitivity C-reactive protein (hsCRP).","At Weeks 24, 48, and 104",{"measure":28,"description":29,"timeFrame":26},"Percentage of Participants Achieving ACR50 at Weeks 24, 48, and 104","ACR responses are the numerical measurement of improvement in multiple disease assessment criteria. It is a composite COA measure that includes both ClinROs) and PROs. An ACR50 response is defined as \\>=50% improvement from baseline in both SJC66 and TJC68, and \\>=50% improvement from baseline in 3 of the following 5 assessments: PtGA of PsA pain; PtGA of PsA; PGA of PsA; participant's assessment of physical function as measured by HAQ-DI; hsCRP.",{"measure":31,"description":32,"timeFrame":26},"Percentage of Participants Achieving ACR70 at Weeks 24, 48, and 104","ACR responses are the numerical measurement of improvement in multiple disease assessment criteria. It is a composite COA measure that includes both ClinROs) and PROs. An ACR70 response is defined as \\>=70% improvement from baseline in both SJC66 and TJC68, and \\>=70% improvement from baseline in 3 of the following 5 assessments: PtGA of PsA pain; PtGA of PsA; PGA of PsA; participant's assessment of physical function as measured by HAQ-DI; hsCRP.",{"measure":34,"description":35,"timeFrame":26},"Percentage of Participants Achieving Minimal Disease Activity (MDA) Status at Weeks 24, 48, and 104","The MDA is defined as a composite outcome measure of 7 ClinROs and PROs used in PsA. Participants are classified as achieving MDA if they fulfil 5 of 7 outcome measures: TJC68 less than or equal to (\\\u003C=) 1, SJC66 \\\u003C=1, psoriasis area and severity index (PASI) score \\\u003C=1 or body surface area (BSA) affected by psoriasis (PsO) \\\u003C=3%, PtGA of PsA Pain score \\\u003C=15, PtGA of PsA score \\\u003C=20, HAQ-DI \\\u003C=0.5, and Leeds Enthesitis Index (LEI) \\\u003C=1.",{"measure":37,"description":38,"timeFrame":26},"Percentage of Participants Achieving >=75 % Improvement From Baseline in PASI Score at Weeks 24, 48, and 104","A PASI-75 response is defined as \\>=75% improvement in the PASI score from baseline. It is a ClinRO used to measure PsO severity, combining the percentage of surface area of skin affected with the severity of erythema, induration, and desquamation across four body regions: head, upper extremities, trunk, and lower extremities. Severity is scored on a 0-4 scale, with 0 indicating a complete lack of cutaneous involvement and 4 indicating the severest possible involvement. 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The participant is aged 18 years or older at the time of signing the informed consent form (ICF). In South Korea, the age requirement for adult participants is \\>=19 years of age.\n2. The participant has completed the 52-week treatment period in one of the parent studies (TAK-279-PsA-3001 or TAK-279-PsA-3002) independent of treatment assignment, and without meeting the criteria for permanent discontinuation of trial intervention defined in the parent studies.\n3. The participant must be deemed by the investigator to benefit from continued or newly initiated (that is, for participants randomized to active comparator in parent study TAK-279-PsA-3001) zasocitinib therapy.\n\nExclusion Criteria:\n\n1. Any participant who is deemed by the investigator to be not benefiting from the trial intervention based upon lack of improvement or worsening of their symptoms in the respective parent study.\n2. Any participant who met the criteria for permanent discontinuation of trial intervention defined in the parent studies (TAK-279-PsA-3001 or TAK-279-PsA-3002).\n3. The participant has developed any disease(s) that might confound the evaluations of benefit of zasocitinib therapy since enrollment in the respective parent study, including but not limited to rheumatoid arthritis, axial spondyloarthritis (this does not include a primary diagnosis of PsA with spondylitis), systemic lupus erythematosus, Lyme disease, gout, or fibromyalgia.\n4. The participant has developed evidence of a concomitant comorbid skin condition that, in the opinion of the investigator, would interfere with the study assessments, such as evidence of non-plaque PsO (erythrodermic, pustular, predominately guttate PsO, inverse, or drug-induced PsO).","ALL","18 Years",{"count":1228,"type":1229},1182,"ESTIMATED","INTERVENTIONAL",[1232],"PHASE3","Psoriatic arthritis (PsA) is a long-term inflammatory disease that affects the joints and skin.\n\nThe purpose of this study is to check how safe zasocitinib is, how well it is tolerated and how well it works in adults with PsA over a longer period of time.\n\nAdults who completed the 1-year (52-week) treatment period in one of the parent studies (TAK-279-PsA-3001 \\[NCT06671483\\] or TAK-279-PsA-3002 \\[NCT06671496\\]) may be able to join this continuation study (also called long-term extension or LTE study). All participants in this continuation study, will receive zasocitinib (lower or higher dose), once a day (QD).\n\nEach participant can be in this study for approximately 2 years (108 weeks). This includes a treatment period of up to 2 years (104 weeks) and a 1-month (4-week) follow-up period to monitor a participant's health.",[1235],"Psoriatic Arthritis",[1237,1238,1239],"Drug Therapy","Latitude PsA","Latitude PsA-3003","2026-09-08",{"date":1242,"type":1243},"2026-09-09","ACTUAL",{"date":1245,"type":1243},"2026-03-11",{"date":1247,"type":1229},"2029-12-18",{"name":5,"class":6},78]