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Less Than 12 Years Old With Hereditary Angioedema","Key Inclusion Criteria:\n\n1. Must be between the ages of 2 and less than 12 years, inclusive, at the time of informed consent and, as applicable, assent.\n2. Must weigh at least 9 kg at the time of informed consent and, as applicable, assent.\n3. Documented diagnosis of HAE-1\u002FHAE-2 based upon both of the following:\n\n   1. Documented clinical history consistent with HAE (SC or mucosal, non-pruritic swelling episodes without accompanying urticaria).\n   2. Diagnostic testing results that confirm HAE-1\u002FHAE-2: C1-inhibitor (C1-INH) functional level \\\u003C50% normal level AND complement factor C4 level below the lower limit of normal (LLN); OR a known pathogenic mutation in the SERPING1 gene.\n\nKey Exclusion Criteria:\n\n1. Must not have any screening laboratory abnormalities or any other clinically significant abnormalities during screening that would render a participant unsuitable for inclusion.\n2. Must not have been treated with another investigational drug, biological agent, or device within 1 month of Screening, or 5 half-lives of investigational agent, whichever is longer.\n3. Concurrent diagnosis of any other type of recurrent angioedema, including idiopathic angioedema or HAE with normal C1-INH (HAE-nC1-INH or Type III).\n\nNote: Other protocol-specified inclusion\u002Fexclusion criteria may apply.","ALL","2 Years","11 Years",{"count":172,"type":173},20,"ESTIMATED","INTERVENTIONAL",[176],"PHASE3","The purpose of this study is to evaluate the safety, tolerability and pharmacokinetics of donidalorsen in pediatric participants with hereditary angioedema (HAE) Type I (HAE-1) or Type II (HAE-2).",[179],"Hereditary Angioedema (HAE)","2026-08-03",{"date":182,"type":183},"2026-08-05","ACTUAL",{"date":185,"type":183},"2026-04-21",{"date":187,"type":173},"2029-06",{"name":5,"class":6},13]