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Phenotype","THESEUS","Inclusion Criteria:\n\n* Between 40 to 80 years of age\n* Physician diagnosed chronic obstructive pulmonary disease (COPD) ≥1 year\n* Post-bronchodilator forced expiratory volume in 1 second (post-BD FEV1) ≥ 20% and ≤ 70% of predicted value and FEV1\u002FFVC (forced expiratory volume in 1 second \u002Fforced vital capacity) \\\u003C0.70\n* Former or current smokers ≥10 pack-years\n* Chronic Airways Assessment Test (CAAT) ≥10\n* ≥2 moderate or ≥1 severe COPD exacerbations in the prior year\n* Triple (ICS+LABA+LAMA) COPD therapy ≥12 consecutive weeks\n* EOS (blood eosinophil count) ≥ 150 cells\u002FμL\n* 18.0 ≤ Body Mass Index ≤ 40.0 kg\u002Fm2\n\nExclusion Criteria:\n\nParticipants are excluded from the study if any of the following criteria apply:\n\n* Asthma, including pediatric asthma, or asthma-COPD overlap syndrome (ACOS)\n* Significant pulmonary disease other than COPD\n* Long-term oxygen therapy \\>4.0 L\u002Fmin or requirement of \\>2.0 L\u002Fmin to maintain oxygen saturation \\>88% at rest\n* Unstable disorder that can impact participants safety or study outcomes\n* Active or incompletely treated tuberculosis\n* Current or past malignancies\n* Concomitant therapies:\n\n  * long-term macrolides or phosphodiesterase Type 3 (PDE-3) or PDE-4 inhibitors unless on stable therapy for \\> 6 months\n  * any biologic therapy or systemic immunosuppressant within 4 months or 5 half-lives prior to Screening\n\nThe above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.","ALL","40 Years","80 Years",{"count":2838,"type":2839},942,"ESTIMATED","INTERVENTIONAL",[2842],"PHASE3","This is a parallel, Phase 2b\u002FPhase 3, 3-arm study to investigate the efficacy, safety, and tolerability of subcutaneous (SC) treatment with lunsekimig compared with placebo in adult participants (aged 40 to 80 years, inclusive) with inadequately controlled Chronic obstructive pulmonary disease (COPD) characterized by an eosinophilic phenotype.\n\nParticipation to the study consists of 3 periods:\n\n* Screening period of up to 4 weeks\n* Randomized intervention period of approximately 48 weeks\n* Follow-up period: Approximately 8 weeks The study duration will be up to 60 weeks.",[2845],"Chronic Obstructive Pulmonary Disease","2026-09-29",{"date":2848,"type":2849},"2026-10-01","ACTUAL",{"date":2851,"type":2849},"2025-09-17",{"date":2853,"type":2839},"2030-01-22",{"name":5,"class":6},315]