[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100414556":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":43,"locations":53,"responsibleParty":492,"collaborators":494,"id":498,"slug":499,"hasResults":500,"nctId":501,"briefTitle":502,"officialTitle":503,"acronym":504,"eligibilityCriteria":505,"healthyVolunteers":500,"sex":506,"minAge":507,"maxAge":508,"enrollmentInfo":509,"targetDuration":25,"studyType":512,"phases":513,"briefSummary":515,"conditions":516,"keywords":518,"overallStatus":56,"whyStopped":25,"lastUpdateSubmitDate":521,"lastUpdatePostDateStruct":522,"startDateStruct":525,"completionDateStruct":527,"leadSponsor":529,"locationsCount":530},{"fullName":5,"class":6},"Major Extremity Trauma Research Consortium","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control","ACTIVE_COMPARATOR","Participants in the control group will receive standard care treatment for their injury, to include all institution specific standard treatment (prophylactic and otherwise) for preventing and treating infection. Topical antibiotics are allowed, if SOC for the institution, but are not mandated.",[13],"Drug: Standard of care",{"label":15,"type":16,"description":17,"interventionNames":18},"Treatment","EXPERIMENTAL","The patients in the SEXTANT cohort will receive 72 hours of targeted systemic antibiotic therapy (Table 2) and will have 1000 mg of Vancomycin and 1200 mg of Tobramycin administered to the wound surface, fracture site, and exposed hardware (if any) just prior to suture closure of the wound or flap.",[19],"Drug: Vancomycin and Tobramycin",[21,26],{"type":22,"name":23,"description":11,"armGroupLabels":24,"otherNames":25},"DRUG","Standard of care",[9],null,{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Vancomycin and Tobramycin","The patients in the SEXTANT cohort will receive 72 hours of targeted systemic antibiotic therapy (Table 2) and will have 1000 mg of Vancomycin and 1200 mg of Tobramycin administered to the wound surface, fracture site, and exposed hardware (if any) just prior to suture closure of the wound or flap.\n\n72-hour of systemic gram-positive and gram-negative antibiotic coverage to target the terminal wound bioburden. The antibiotics coverage proposed as the primary choice includes PO Ciprofloxacin + PO linezolid or IV Ciprofloxacin and IV Vancomycin.\n\nThe preferred antibiotic regimen will be decided by study's ID team, in cooperation with the ID and Antibiotic Stewardship teams at each site. Antibiotic recommendations will be adjusted, if needed, to account for a Site's bacteria susceptibility \u002F resistance profile, or the specific needs of an individual patient.",[15],[31,35,38,41],{"name":32,"affiliation":33,"role":34},"Micahel J Bosse, MD","Carolinas Medical Center","PRINCIPAL_INVESTIGATOR",{"name":36,"affiliation":37,"role":34},"Rachel Seymour, PhD","Atrium Health Musculoskeletal Institute Research",{"name":39,"affiliation":40,"role":34},"Renan C Castillo, PhD","Johns Hopkins Bloomberg School of Public Health",{"name":42,"affiliation":40,"role":34},"Anthony R Carlini, MS",[44,49],{"name":45,"role":46,"phone":47,"phoneExt":25,"email":48},"Suna Chung, MPH","CONTACT","4105023357","schung60@jhu.edu",{"name":50,"role":46,"phone":51,"phoneExt":25,"email":52},"Susan C Collins, MSc","410-502-8966","scolli21@jhu.edu",[54,73,87,97,112,127,140,155,165,180,194,210,224,238,251,266,280,293,307,319,333,348,362,377,392,405,415,431,447,464,478],{"facility":55,"status":56,"city":57,"state":58,"zip":59,"country":60,"countryCode":61,"cosmosGeoPoint":62,"geoPoint":67,"contacts":68},"Stanford University","RECRUITING","Redwood City","California","94063","United States","US",{"type":63,"coordinates":64},"Point",[65,66],-122.23635,37.48522,{"lat":66,"lon":65},[69],{"name":70,"role":46,"phone":71,"phoneExt":25,"email":72},"Carina Tedesco","650-723-8386","ctedesco@stanford.edu",{"facility":74,"status":56,"city":75,"state":58,"zip":76,"country":60,"countryCode":61,"cosmosGeoPoint":77,"geoPoint":81,"contacts":82},"_University of California, San Francisco","San Francisco","94110",{"type":63,"coordinates":78},[79,80],-122.41942,37.77493,{"lat":80,"lon":79},[83],{"name":84,"role":46,"phone":85,"phoneExt":25,"email":86},"Eleni Berhaneselase","415-476-2124","eleni.berhaneselase@ucsf.edu",{"facility":88,"status":56,"city":75,"state":58,"zip":76,"country":60,"countryCode":61,"cosmosGeoPoint":89,"geoPoint":91,"contacts":92},"University of California at San Francisco",{"type":63,"coordinates":90},[79,80],{"lat":80,"lon":79},[93,95],{"name":84,"role":46,"phone":25,"phoneExt":25,"email":94},"Eleni.Berhaneselase@ucsf.edu",{"name":96,"role":34,"phone":25,"phoneExt":25,"email":25},"Saam Morshed, MD",{"facility":98,"status":56,"city":99,"state":100,"zip":101,"country":60,"countryCode":61,"cosmosGeoPoint":102,"geoPoint":106,"contacts":107},"University of Colorado Anschutz Medical Campus","Aurora","Colorado","80045",{"type":63,"coordinates":103},[104,105],-104.83192,39.72943,{"lat":105,"lon":104},[108],{"name":109,"role":46,"phone":110,"phoneExt":25,"email":111},"Fahim Choudhury","(303) 724-3185","fahim.choudhury@cuanschutz.edu",{"facility":113,"status":56,"city":114,"state":115,"zip":116,"country":60,"countryCode":61,"cosmosGeoPoint":117,"geoPoint":121,"contacts":122},"St Mary's University\u002FTenent Health","West Palm Beach","Florida","33407",{"type":63,"coordinates":118},[119,120],-80.05337,26.71534,{"lat":120,"lon":119},[123],{"name":124,"role":46,"phone":125,"phoneExt":25,"email":126},"Tracy Rodriguez","561-882-6386","tracy.rodriguez@tenethealth.com",{"facility":128,"status":56,"city":129,"state":130,"zip":131,"country":60,"countryCode":61,"cosmosGeoPoint":132,"geoPoint":136,"contacts":137},"Emory University School of Medicine","Atlanta","Georgia","30303",{"type":63,"coordinates":133},[134,135],-84.38798,33.749,{"lat":135,"lon":134},[138],{"name":139,"role":34,"phone":25,"phoneExt":25,"email":25},"William Reisman, MD",{"facility":141,"status":56,"city":142,"state":143,"zip":144,"country":60,"countryCode":61,"cosmosGeoPoint":145,"geoPoint":149,"contacts":150},"Indiana University School of Medicine - Methodist Hospital","Indianapolis","Indiana","46202",{"type":63,"coordinates":146},[147,148],-86.15804,39.76838,{"lat":148,"lon":147},[151],{"name":152,"role":46,"phone":153,"phoneExt":25,"email":154},"Maricella Diaz","317.963.5034","diaz4@iu.edu",{"facility":156,"status":56,"city":142,"state":143,"zip":144,"country":60,"countryCode":61,"cosmosGeoPoint":157,"geoPoint":159,"contacts":160},"Indiana University\u002FEskenazi Health",{"type":63,"coordinates":158},[147,148],{"lat":148,"lon":147},[161],{"name":162,"role":46,"phone":163,"phoneExt":25,"email":164},"Molly Moore","317-880-3581","momfreed@iupui.edu",{"facility":166,"status":56,"city":167,"state":168,"zip":169,"country":60,"countryCode":61,"cosmosGeoPoint":170,"geoPoint":174,"contacts":175},"University of Kentucky","Lexington","Kentucky","40506",{"type":63,"coordinates":171},[172,173],-84.47772,37.98869,{"lat":173,"lon":172},[176],{"name":177,"role":46,"phone":178,"phoneExt":25,"email":179},"Matthew Eubank","(859)562-3428","mseuba01@uky.edu",{"facility":181,"status":56,"city":182,"state":183,"zip":184,"country":60,"countryCode":61,"cosmosGeoPoint":185,"geoPoint":189,"contacts":190},"LSU Health Sciences","New Orleans","Louisiana","70112",{"type":63,"coordinates":186},[187,188],-90.07507,29.95465,{"lat":188,"lon":187},[191],{"name":192,"role":46,"phone":25,"phoneExt":25,"email":193},"Jessica Rivera","jrive5@lsuhsc.edu",{"facility":195,"status":56,"city":196,"state":197,"zip":198,"country":60,"countryCode":61,"cosmosGeoPoint":199,"geoPoint":203,"contacts":204},"University of Maryland , MD Department of Orthopaedics","Baltimore","Maryland","21201",{"type":63,"coordinates":200},[201,202],-76.61219,39.29038,{"lat":202,"lon":201},[205,208],{"name":206,"role":46,"phone":25,"phoneExt":25,"email":207},"Yasmin Degani, MPH","ydegani@som.umaryland.edu",{"name":209,"role":34,"phone":25,"phoneExt":25,"email":25},"Robert O'Toole, MD",{"facility":211,"status":56,"city":212,"state":197,"zip":213,"country":60,"countryCode":61,"cosmosGeoPoint":214,"geoPoint":218,"contacts":219},"Walter Reed Military Medical Center","Bethesda","20889",{"type":63,"coordinates":215},[216,217],-77.10026,38.98067,{"lat":217,"lon":216},[220],{"name":221,"role":46,"phone":222,"phoneExt":25,"email":223},"Heather Decot","(301) 295-4568","heather.k.decot.ctr@health.mil",{"facility":225,"status":56,"city":226,"state":227,"zip":228,"country":60,"countryCode":61,"cosmosGeoPoint":229,"geoPoint":233,"contacts":234},"Harvard\u002FMass General\u002FBrigham Hospitals","Boston","Massachusetts","02115",{"type":63,"coordinates":230},[231,232],-71.05977,42.35843,{"lat":232,"lon":231},[235],{"name":236,"role":46,"phone":25,"phoneExt":25,"email":237},"Thiru Wignakumar","twignakumar@bwh.harvard.edu",{"facility":239,"status":56,"city":240,"state":241,"zip":242,"country":60,"countryCode":61,"cosmosGeoPoint":243,"geoPoint":247,"contacts":248},"Hennepin County Medical Center \u002F Minneapolis","Minneapolis","Minnesota","55415",{"type":63,"coordinates":244},[245,246],-93.26384,44.97997,{"lat":246,"lon":245},[249],{"name":250,"role":34,"phone":25,"phoneExt":25,"email":25},"Andrew Schmidt, MD",{"facility":252,"status":56,"city":253,"state":254,"zip":255,"country":60,"countryCode":61,"cosmosGeoPoint":256,"geoPoint":260,"contacts":261},"University of Mississippi Medical Center","Jackson","Mississippi","39216",{"type":63,"coordinates":257},[258,259],-90.18481,32.29876,{"lat":259,"lon":258},[262],{"name":263,"role":46,"phone":264,"phoneExt":25,"email":265},"Sandra Powe","601-815-1045","spowe@umc.edu",{"facility":267,"status":56,"city":268,"state":269,"zip":270,"country":60,"countryCode":61,"cosmosGeoPoint":271,"geoPoint":275,"contacts":276},"Dartmouth Hitchcock","Lebanon","New Hampshire","03766",{"type":63,"coordinates":272},[273,274],-72.25176,43.64229,{"lat":274,"lon":273},[277],{"name":278,"role":46,"phone":25,"phoneExt":25,"email":279},"Devin Mullin","devin.s.mullin@hitchcock.org",{"facility":281,"status":56,"city":282,"state":283,"zip":284,"country":60,"countryCode":61,"cosmosGeoPoint":285,"geoPoint":289,"contacts":290},"Jamaica Hospital Medical Center","Jamaica","New York","11418",{"type":63,"coordinates":286},[287,288],-73.80569,40.69149,{"lat":288,"lon":287},[291],{"name":292,"role":34,"phone":25,"phoneExt":25,"email":25},"Sanjit Konda, MD",{"facility":294,"status":56,"city":295,"state":296,"zip":297,"country":60,"countryCode":61,"cosmosGeoPoint":298,"geoPoint":302,"contacts":303},"University of North Carolina at Chapel Hill","Chapel Hill","North Carolina","27514",{"type":63,"coordinates":299},[300,301],-79.05584,35.9132,{"lat":301,"lon":300},[304],{"name":305,"role":46,"phone":25,"phoneExt":25,"email":306},"Nevaeh Nez","nevaeh_nez@med.unc.edu",{"facility":308,"status":56,"city":309,"state":296,"zip":310,"country":60,"countryCode":61,"cosmosGeoPoint":311,"geoPoint":315,"contacts":316},"Atrium Health Carolinas Medical Center","Charlotte","28203",{"type":63,"coordinates":312},[313,314],-80.84313,35.22709,{"lat":314,"lon":313},[317],{"name":318,"role":46,"phone":25,"phoneExt":25,"email":25},"Christine Churchill",{"facility":320,"status":56,"city":321,"state":296,"zip":322,"country":60,"countryCode":61,"cosmosGeoPoint":323,"geoPoint":327,"contacts":328},"Atrium Health Wake Forest Baptist","Winston-Salem","27157",{"type":63,"coordinates":324},[325,326],-80.24422,36.09986,{"lat":326,"lon":325},[329],{"name":330,"role":46,"phone":331,"phoneExt":25,"email":332},"Martha Holden","336.716.5457","mholden@wakehealth.edu",{"facility":334,"status":56,"city":335,"state":336,"zip":337,"country":60,"countryCode":61,"cosmosGeoPoint":338,"geoPoint":342,"contacts":343},"METROHealth","Cleveland","Ohio","44109",{"type":63,"coordinates":339},[340,341],-81.69541,41.4995,{"lat":341,"lon":340},[344],{"name":345,"role":46,"phone":346,"phoneExt":25,"email":347},"Anna Vergon","216-778-3656","avergon@metrohealth.org",{"facility":349,"status":56,"city":350,"state":336,"zip":351,"country":60,"countryCode":61,"cosmosGeoPoint":352,"geoPoint":356,"contacts":357},"Ohio State University Wexner Medical Center","Columbus","43201",{"type":63,"coordinates":353},[354,355],-82.99879,39.96118,{"lat":355,"lon":354},[358],{"name":359,"role":46,"phone":360,"phoneExt":25,"email":361},"Jessica Wiseman","614-293-2064","jessica.wiseman@osumc.edu",{"facility":363,"status":56,"city":364,"state":365,"zip":366,"country":60,"countryCode":61,"cosmosGeoPoint":367,"geoPoint":371,"contacts":372},"University of Oklahoma College of Medicine","Oklahoma City","Oklahoma","73104",{"type":63,"coordinates":368},[369,370],-97.51643,35.46756,{"lat":370,"lon":369},[373],{"name":374,"role":46,"phone":375,"phoneExt":25,"email":376},"Lyndee Nguyen","405-271-4426","lyndee-nguyen@ouhsc.edu",{"facility":378,"status":56,"city":379,"state":380,"zip":381,"country":60,"countryCode":61,"cosmosGeoPoint":382,"geoPoint":386,"contacts":387},"Temple University","Philadelphia","Pennsylvania","19140",{"type":63,"coordinates":383},[384,385],-75.16362,39.95238,{"lat":385,"lon":384},[388],{"name":389,"role":46,"phone":390,"phoneExt":25,"email":391},"Adam Lloyd-Jones","267-643-5067","adam.lloyd-jones@temple.edu",{"facility":393,"status":56,"city":394,"state":395,"zip":396,"country":60,"countryCode":61,"cosmosGeoPoint":397,"geoPoint":401,"contacts":402},"Brown University\u002FRhode Island Hospital","Providence","Rhode Island","02905",{"type":63,"coordinates":398},[399,400],-71.41283,41.82399,{"lat":400,"lon":399},[403],{"name":404,"role":34,"phone":25,"phoneExt":25,"email":25},"Roman Hayda, MD",{"facility":406,"status":56,"city":394,"state":395,"zip":396,"country":60,"countryCode":61,"cosmosGeoPoint":407,"geoPoint":409,"contacts":410},"Rhode Island Hospital\u002FBrown University",{"type":63,"coordinates":408},[399,400],{"lat":400,"lon":399},[411],{"name":412,"role":46,"phone":413,"phoneExt":25,"email":414},"MJ Crisco","401-457-2189","mjcrisco@uoi.com",{"facility":416,"status":56,"city":417,"state":418,"zip":419,"country":60,"countryCode":61,"cosmosGeoPoint":420,"geoPoint":424,"contacts":425},"Vanderbilt University Medical Center","Nashville","Tennessee","37232",{"type":63,"coordinates":421},[422,423],-86.78444,36.16589,{"lat":423,"lon":422},[426,429],{"name":427,"role":46,"phone":25,"phoneExt":25,"email":428},"Karen Trochez","karen.m.trochez@Vanderbilt.Edu",{"name":430,"role":34,"phone":25,"phoneExt":25,"email":25},"William T. Obremskey, MD",{"facility":432,"status":56,"city":433,"state":434,"zip":435,"country":60,"countryCode":61,"cosmosGeoPoint":436,"geoPoint":440,"contacts":441},"University of Texas Health Science Center - Houston","Houston","Texas","77030",{"type":63,"coordinates":437},[438,439],-95.36327,29.76328,{"lat":439,"lon":438},[442,445],{"name":443,"role":46,"phone":25,"phoneExt":25,"email":444},"Sterling Boutte","Sterling.Boutte@uth.tmc.edu",{"name":446,"role":34,"phone":25,"phoneExt":25,"email":25},"Stephen Warner, MD",{"facility":448,"status":56,"city":449,"state":450,"zip":451,"country":60,"countryCode":61,"cosmosGeoPoint":452,"geoPoint":456,"contacts":457},"University of Virginia","Charlottesville","Virginia","22903",{"type":63,"coordinates":453},[454,455],-78.47668,38.02931,{"lat":455,"lon":454},[458,462],{"name":459,"role":46,"phone":460,"phoneExt":25,"email":461},"Eric McVey","434.243.5382","EDM9U@hscmail.mcc.virginia.edu",{"name":463,"role":34,"phone":25,"phoneExt":25,"email":25},"David Weiss, MD",{"facility":465,"status":56,"city":466,"state":450,"zip":467,"country":60,"countryCode":61,"cosmosGeoPoint":468,"geoPoint":472,"contacts":473},"Inova Fairfax MEdical Campus","Falls Church","22042",{"type":63,"coordinates":469},[470,471],-77.17109,38.88233,{"lat":471,"lon":470},[474],{"name":475,"role":46,"phone":476,"phoneExt":25,"email":477},"Senay Ghidei","(703) 526-4382","Senay.Ghidei@Inova.org",{"facility":479,"status":56,"city":480,"state":450,"zip":481,"country":60,"countryCode":61,"cosmosGeoPoint":482,"geoPoint":486,"contacts":487},"Virginia Commonwealth University Medical Center","Richmond","23298",{"type":63,"coordinates":483},[484,485],-77.46026,37.55376,{"lat":485,"lon":484},[488],{"name":489,"role":46,"phone":490,"phoneExt":25,"email":491},"Caleb Bridgman","804.628.3584","Caleb.Bridgwater@vcuhealth.org",{"type":493,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[495],{"name":496,"class":497},"United States Department of Defense","FED","100414556","phase-3-evaluation-of-a-new-strategy-for-protocolized-antibiotic-care-for-severe-open-fractures-sextant-2-100414556",false,"NCT04678154","Evaluation of a New Strategy for Protocolized Antibiotic Care for Severe Open Fractures: SEXTANT 2","Evaluation of a New Strategy for Protocolized Antibiotic Care for Severe Open Fractures: SEXTANT 2 - A Continuation of the Multicenter Randomized Control Trial SEXTANT 1","SEXTANT 2","Inclusion Criteria:\n\n1. Injury meeting at least one of the following criteria:\n\n   a. Gustilo type III fractures of the tibia (OTA 41 plateau, OTA 42 shaft and OTA 43 pilon); ankle (OTA 44); calcaneus (OTA 82) and\u002For talus (OTA 81) with injury characteristics meeting at least one of the following criteria: i. All IIIB fractures ii. IIIA fractures that require a planned second debridement prior to definitive closure \u002F coverage iii. IIIA fractures with extensive contamination or muscle damage precluding definitive internal fixation at the time of initial surgery iv. IIIA fractures with extensive degloving or wound greater than 10 cm after debridement (if indicated, primary wound closure is allowed. Primary wound closure refers to the definitive closure of the wound at the initial surgical event, without plans for re-entry for additional debridement and\u002For fracture fixation) v. IIIA fractures severe fracture comminution resulting from high energy trauma (if indicated, primary wound closure\u002Fcoverage is allowed) vi. IIIA fractures with AO\u002FOTA OFC contamination level of severe with material imbedded into bone or soft tissue or with a severe high risk environmental contamination from farm, fecal, dirty water inoculation or other equivalent (if indicated, primary wound closure\u002Fcoverage is allowed) vii. IIIA Fractures where the skin could be closed after extensive muscle or bone removal (if indicated, primary wound closure\u002Fcoverage is allowed) viii. IIIA fractures with bone loss resulting in a circumferential gap of 1 cm after debridement (if indicated, primary wound closure\u002Fcoverage is allowed) ix. Fractures where fasciotomies were performed for impending or diagnosed compartment syndromes (regardless of the initial open or closed classification of the fracture x. Traumatic \"zone-of-injury\" trans-tibial amputations requiring DPC, and\u002For flap coverage\n2. Ages 18 - 64 years inclusive\n3. Patients may have risk factors for infection including diabetes, immunosuppression from steroids or other medications, HIV, or other infections.\n4. Patients may have a traumatic brain injury.\n5. Patients may have other fractures including spine, upper extremity fractures, contralateral lower extremity injuries, ipsilateral pelvis, hip, femur, or foot injuries.\n6. Patients may be treated initially at an outside institution prior to transferring to the study institution, as long as the definitive wound closure\u002Fcoverage was not performed prior to entrance into the study.\n7. Patients with bilateral injuries that meet inclusion criteria may be included, but only the limb rated as \"more severe\" by the treating surgeon will be enrolled in the study.\n8. Patients may have co-existing non-tibial or hindfoot infections, with or without antibiotic treatment.\n9. Patients may be definitively stabilized using any method (nail, plate, ex fix, or cast).\n10. Patients may have fasciotomy.\n\nExclusion Criteria:\n\n1. Patient speaks neither English or Spanish\n2. Patient in current therapy for a wound, implant or fracture site infection related to the study site.\n3. Patient is pregnant, potentially pregnant, or lactating.\n4. Patient likely to have difficulty maintaining follow-up, including:\n\n   1. Diagnosis of a severe psychiatric condition\n   2. Intellectually challenged without adequate family support\n   3. Resides outside of the hospital's catchment area, unless willing to follow-up by phone or telemedicine\n   4. Planning to follow-up at another medical center, unless willing to follow-up by phone or telemedicine\n   5. Being a prisoner\n   6. Not having a means of contact (address, cell phone, home phone, e-mail)","ALL","18 Years","64 Years",{"count":510,"type":511},600,"ESTIMATED","INTERVENTIONAL",[514],"PHASE3","The PRCT evaluates infection outcomes as well as fracture and antibiotic-related complications to include the emergence of resistant bacteria associated with two different antibiotic strategies in the treatment of Gustilo type IIIB tibia and hindfoot fractures (calcaneus and talus) and selected IIIA fractures of the tibia and trauma-related transtibial amputations that are performed in the \"zone-of-injury\". This study will be conducted in established METRC level 1 trauma centers.\n\nThe patients will be randomized as close to admission as possible to either 1) Standard of Care (SOC) prophylactic open fracture protocol, including the use of topical antibiotic as per the usual practice of the surgeon or 2) experimental protocol (SEXTANT). The SEXTANT protocol includes application of wound bioburden-targeted topical Vancomycin powder and Tobramycin powder antibiotic treatment at the time of final wound closure\u002Fcoverage combined with 72 hours of systemic antibiotic coverage targeted to both gram-positive and gram-negative pathogens. The study will compare the results of the current SOC prophylactic coverage to the strategic wound bioburden treatment (SEXTANT) protocol.\n\nUp until the time of definitive wound closure\u002Fcoverage, all patients will be treated per the usual regimen of the surgeon \u002F center and in accordance with current Trauma Quality Improvement Program (TQIP) and Surgical Quality Improvement Program (SQIP) recommendations for the care of open fractures.14,15,17 It includes the administration of systemic antibiotics as close to the time of injury as possible.\n\nIn the definitive wound closure\u002Fcoverage procedure post-operative period, participants in the intervention arm will receive 72 hours of systemic antibiotic therapy targeted at the modern wound bioburden, and patients in the usual care arm will receive post-operative care per the usual practice of their surgeon. All other activities related to follow-up and related treatments will proceed per the usual practice of the surgeon.",[517],"Post Operative Surgical Site Infection",[519,520],"Surgical site infection risk prevention","Bacterial species type and antibacterial sensitivities","2026-07-20",{"date":523,"type":524},"2026-07-22","ACTUAL",{"date":526,"type":524},"2021-05-07",{"date":528,"type":511},"2029-03-31",{"name":5,"class":6},31]